Genes and Pathways Underpinning Klinefelter Syndrome at Bulk and Single-Cell Levels DOI

Linlin Tian,

Yan Yu,

Ziqing Mao

et al.

Biochemical Genetics, Journal Year: 2024, Volume and Issue: 62(6), P. 4851 - 4866

Published: Feb. 19, 2024

Language: Английский

Testicular aging, male fertility and beyond DOI Creative Commons

Shijue Dong,

Chen Chen, Jiali Zhang

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 13, 2022

Normal spermatogenesis and sperm function are crucial for male fertility. The effects of healthy testicular aging premature on spermatogenesis, function, the microenvironment cannot be ignored. Compared with younger men, testis older men tends to have disturbed spermatogenic processes, abnormalities, dysfunction, impaired Sertoli Leydig cells, which ultimately results in infertility. Various exogenous endogenous factors also contribute pathological aging, such as adverse environmental stressors gene mutations. Mechanistically, Y-chromosomal microdeletions, increase telomere length oxidative stress, accumulation DNA damage decreased repair ability, alterations epigenetic modifications, miRNA lncRNA expression been associated fertility due aging. In recent years, key molecules signaling pathways that regulate identified, thereby providing new strategies diagnosis treatment. This review provides a comprehensive overview underlying mechanisms spermatogenesis. Furthermore, potential rescue measures reproductive discussed. Finally, inadequacy research future directions envisaged aid treatment

Language: Английский

Citations

53
The PI3K/AKT signaling pathway: How does it regulate development of Sertoli cells and spermatogenic cells? DOI

Kuang-Qi Chen,

Banghong Wei,

Shuang-Li Hao

et al.

PubMed, Journal Year: 2022, Volume and Issue: 37(7), P. 621 - 636

Published: July 1, 2022

The PI3K/AKT signaling pathway is one of the most crucial regulatory mechanisms in animal cells, which can mainly regulate proliferation, survival and anti-apoptosis cell lines. In seminiferous epithelium, studies were concentrated on role immature Sertoli cells (SCs) spermatogonia stem (SSCs). facilitate proliferation spermatogenic cells. Besides, mature this disintegrate structure blood-testis barrier (BTB) via protein synthesis cytoskeleton All these effects directly indirectly maintain promote spermatogenesis male testis.

Language: Английский

Citations

29
Betaine alleviates spermatogenic cells apoptosis of oligoasthenozoospermia rat model by up-regulating methyltransferases and affecting DNA methylation DOI
Qiyan Lin, Xiyu Ge, Leilei Gao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155713 - 155713

Published: May 6, 2024

Language: Английский

Citations

6
The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways DOI Creative Commons
Chenyu Jiang, Z. J. Chen, Weilin Liao

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(11), P. 1531 - 1531

Published: May 31, 2024

Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus widely consumed and highly nutritious. Moreover, their constituents have attracted attention for health-promoting properties. In East Asia, there three varieties of (

Language: Английский

Citations

6
Effects of Bu Shen Hua Zhuo formula on the LPS/TLR4 pathway and gut microbiota in rats with letrozole-induced polycystic ovary syndrome DOI Creative Commons
Yang Wang, Hui Xiao, Yanxia Liu

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 9, 2022

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in gynecology. Traditional Chinese medicine (TCM) widely used for treatment PCOS China. The Bu Shen Hua Zhuo formula (BSHZF), a TCM decoction, has shown great therapeutic efficacy clinical practice. However, mechanism underlying BSHZF function remains unclear. This study aimed to identify potential mechanisms action PCOS. PCOS-model rats treated with letrozole were administered different doses BSHZF, metformin, and 1% carboxymethylcellulose. Serum sex hormones, fasting blood glucose, insulin levels measured, morphology ovaries was observed each group, including normal group. structure abundance gut microbiota measured using 16S ribosomal RNA gene sequencing. Toll-like receptor 4 (TLR4) phospho-NF-κB p65 ovarian tissue detected Western blotting. Furthermore, lipopolysaccharide (LPS) inflammatory cytokines TNF-α, IL-6, IL-8 serum by ELISA. results showed that administration associated decrease body weight, insulin, testosterone changes rats. Moreover, an increase α-diversity microbiota, relative Firmicutes , Lactobacillus short chain fatty acid–producing bacteria ( Allobaculum Bacteroides Ruminococcaceae_UCG-014 ). may promote carbohydrate protein metabolism. In addition, level LPS TLR4 expression, thereby inhibiting activation NF-κB signaling–mediated response tissue. Therefore, beneficial effects on pathogenesis are its ability normalize inhibit PCOS-related inflammation.

Language: Английский

Citations

25
The mechanisms of tripterygium glycosides-induced reproductive toxicity and detoxification strategies DOI

Zechen Niu,

Huanhuan Zhang,

Chunzhou Cai

et al.

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: 132, P. 108830 - 108830

Published: Jan. 6, 2025

Language: Английский

Citations

0
Semen Cuscutae-Fructus Lycii attenuates tripterygium glycosides-induced spermatogenesis dysfunction by inhibiting oxidative stress-mediated ferroptosis via the Nrf2/HO-1 pathway DOI
Yutian Zhu, Jiacheng Zhang, Qiuning Liu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156221 - 156221

Published: Nov. 9, 2024

Language: Английский

Citations

4
To study the mechanism of Cuscuta chinensis Lam. And Lycium barbarum L. in the treatment of asthenospermia based on network pharmacology DOI
Jisheng Wang, Binghao Bao, Fanchao Meng

et al.

Journal of Ethnopharmacology, Journal Year: 2021, Volume and Issue: 270, P. 113790 - 113790

Published: Jan. 18, 2021

Language: Английский

Citations

25
Lycium barbarum berry extract improves female fertility against aging-related oxidative stress in the ovary DOI
Chenyu Jiang, Z. J. Chen,

Hao‐Ming Xiong

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(19), P. 9779 - 9795

Published: Jan. 1, 2024

Reproductive aging in female mammals is characterized by ovarian senescence, leading to a significant fertility decline.

Language: Английский

Citations

3
Effect of Goji Berry (Lycium barbarum) Supplementation on Reproductive Performance of Rabbit Does DOI Creative Commons

Egon Andoni,

Giulio Curone, Stella Agradi

et al.

Animals, Journal Year: 2021, Volume and Issue: 11(6), P. 1672 - 1672

Published: June 3, 2021

Goji berry shows a wide range of beneficial properties in human health, but only few studies evaluated its effects livestock animals. The objective this research was to assess the goji supplementation on hormonal profile, productive, and reproductive performance does. Two months before artificial insemination, 105 nulliparous does were randomly divided into three groups (n = 35) based dietary treatment: commercial diet (C), or supplemented with either 1% (G1), 3% (G3) berry, respectively. results showed that receptivity higher G1 than C group (p < 0.05). Trends toward significance for differences between G3 marginal means LH concentrations 0.059), AUC values 0.078), evidenced. Estrogen more fluctuating trend significant interaction effect 0.001). litter weight at birth 0.008) weaning 0.001), as well size 0.020). also exhibited highest mean milk production 0.01). In conclusion, influenced productive performance, probably via modulating patterns rabbits. However, further are needed validate these preliminary results.

Language: Английский

Citations

19