The preservation of reproductive health of the population is an important factor of demographic policy of the state. According to some authors from 14 to 30% of couples of reproductive age suffer from infertility; male factor in such marriages is detected in more than half of the cases. As you know, in recent years there has been a significant deterioration in the main indicators of reproductive function of men. Increased the number of andrological diseases, morphological disorders of the male reproductive system, almost halved the production of sperm in men of reproductive age. The reason probably lies behind a whole …
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(7), P. 2129 - 2129
Published: April 7, 2024
Background:
The
use
of
selective
serotonin
reuptake
inhibitors
(SSRIs)
has
been
associated
with
potential
effects
on
male
fertility,
although
the
exact
mechanisms
are
not
fully
understood.
aim
this
study
was
to
understand
relationship
between
SSRIs
and
infertility;
Methods:
A
retrospective
chart
review
Saudi
males
who
were
treated
attended
an
infertility
clinic
in
KSMC
undertaken.
medical
records
men
from
reviewed
screen
quality
sperm
parameters
patients
taking
SSRIs;
Results:
In
total,
299
identified,
whom
29
(9.6%)
exposed
SSRIs,
while
270
(90.4%)
did
receive
defined
as
control
infertile
group.
When
comparing
mean
ages,
a
notable
disparity
observed
group
(34.2
±
6.9
years)
using
(41.5
3.2
(p
<
0.001).
Regarding
analysis
impact
showed
no
significant
differences
liquefaction
=
0.1),
motility
0.17),
viscosity
0.16),
or
count
0.069)
escitalopram,
fluoxetine,
paroxetine
use;
Conclusions:
Our
difference
SSRI
non-SSRI
cohorts.
However,
warrants
further
investigation
consideration
clinical
practice.
International Journal of Endocrinology,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 13
Published: April 28, 2022
Proton
pump
inhibitors
(PPIs)
are
frequently
prescribed
as
gastric
acid-suppressing
agents.
Nevertheless,
there
is
limited
evidence
supporting
the
risk
of
detrimental
effects
PPIs
on
male
fertility.
The
purpose
current
study
was
to
evaluate
effect
subchronic
use
proton
Seventy
adult
Wistar
rats
were
assigned
into
seven
groups.
normal
control
group
orally
received
solvent
only.
Groups
2,
3,
and
4
given
esomeprazole
while
groups
5,
6,
7
lansoprazole
at
2.5,
10
mg/kg/day,
respectively.
After
45
days
treatment,
blood
samples,
epididymis,
testis
collected.
Sperm
count,
motility,
morphology
determined.
level
hormones
such
testosterone,
follicle-stimulating
hormone
(FSH),
luteinizing
(LH)
oxidative
status
tissue,
superoxide
dismutase,
catalase,
reduced
glutathione,
malondialdehyde
(MDA),
nitric
oxide
(NO)
estimated.
Results
demonstrated
a
significant
decline
in
sperm
morphology,
catalase
mg/kg/day
GSH
2.5
mg/kg/day.
A
increase
FSH,
LH,
MDA
NO
found
compared
group.
pathological
alterations
specifically
dilation
Leydig
cells,
vacuolization,
degeneration
seminiferous
tubules
also
evident.
It
concluded
that
had
caused
reproductive
toxicity
due
altered
levels
elevated
NO,
stress.
To
evaluate
the
selenium
status
and
oxidative
stress
in
male
infertility
cases
selected
from
a
private
human
reproduction
center
state
of
Ceará,
Brazil.
Medical Science Monitor,
Journal Year:
2020,
Volume and Issue:
27
Published: Dec. 14, 2020
BACKGROUND:Studies
have
shown
that
diabetes
mellitus
(DM)
has
a
negative
impact
on
male
reproductive
function,
which
may
lead
to
changes
in
the
testis
and
epididymis
decline
semen
quality.
MATERIAL
AND
METHODS:We
performed
animal
experiments
with
6
diabetic
db/db
mice
as
model
group
(group
B)
C57BL/6J
control
A).
After
adaptive
feeding
for
7
days,
sperm
quality
of
each
was
measured.
Concurrently,
morphology
mouse
observed
by
hematoxylin-eosin
(H&E)
staining.
The
expression
PI3K,
Akt,
FoxO1,
FasL,
IL-6,
Stat3
proteins
mRNAs
testicular
tissue
detected
western
blotting
RT-qPCR.
RESULTS:The
number
spermatozoa
motility
A
significantly
higher
than
B
(P<0.05).
H&E
staining
showed
seminiferous
tubules
were
damaged
varying
degrees
sparsely
arranged.
Compared
those
A,
levels
lower
(P<0.05),
while
IL-6
CONCLUSIONS:This
study
demonstrated
DM
inhibited
FoxO1
pathway
promoted
mRNAs,
leading
abnormal
apoptosis
cells
functional
damage,
eventually
spermatogenic
dysfunction.
Evidence-based Complementary and Alternative Medicine,
Journal Year:
2019,
Volume and Issue:
2019, P. 1 - 10
Published: Aug. 14, 2019
Background.
In
this
study,
the
male
fertility-enhancing
activity
of
100,
200,
and
400
mg/kg/day
Hunteria
umbellata
water
seed
extract
(
HU
)
in
Wistar
rats
was
studied
for
60
days.
doing
this,
effect
repeated
doses
on
weight
gain
pattern,
gonadosomatic
index
(GSI),
serum
follicle
stimulating
hormone
(FSH),
luteinizing
(LH),
testosterone
(TS),
prolactin
(PRL),
estradiol
(ES)}
as
well
testicular
antioxidant
status
treated
a
way
elucidating
mechanism(s)
action
.
Method.
Thirty-six
(36)
were
randomly
divided
into
six
groups
(I-VI)
per
group.
Group
I
gavaged
with
10
ml/kg/day
distilled
served
an
untreated
control;
II
0.3
clomiphene
water;
Groups
III-V
received
100
mg/kg/day,
200
,
respectively,
VI
20
Vitamin
C
all
water.
All
treatments
days
after
which
humanely
sacrificed.
Sera
blood
samples
processed
above
stated
hormonal
profile.
Similarly,
tissues
obtained
semen
analysis
complete
profile
-treated
testicles
by
assaying
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
(GSH),
reductase
(GSR),
peroxidase
(GSH-Px),
Thiobarbituric
Reactive
Species
(TBARS).
Results
Prolonged
induced
dose
dependent
reductions
pattern
most
significant
(p<0.001)
recorded
highest
Conversely,
increase
GSI
at
same
dose.
Clomiphene
also
(p<0.01,
p<0.001)
increases
total
sperm
count,
%live
sperm,
but
reverse
effects
%dead
%abnormal
sperm.
On
profile,
oral
treatment
profound
(p<0.05,
p<0.01,
related
sera
TS,
LH,
FSH
while
it
caused
PRL
no
alterations
ES
levels.
vitamin
100-400
enzyme
activities.
Conclusion.
Overall,
prolonged
mg/kg
body
significantly
improved
function
mediated
via
enhanced
spermatogenesis,
steroidogenesis,
mechanisms.
Al-Ameed Journal for Medical Research and Health Sciences,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: July 24, 2024
Background:
Male
infertility
is
issue
a
prevalent,
involves
various
factors.
Sperm
quality,
particularly
influenced
by
smoking,
crucial
for
fertility.
DNA
fragmentation,
indicating
damage
to
strands
in
sperm
cells,
gaining
importance
male
research,
especially
concerning
abnormal
morphology.
University of Thi-Qar Journal of Science,
Journal Year:
2023,
Volume and Issue:
10(1), P. 73 - 80
Published: June 28, 2023
Limited
studies
have
been
conducted
on
the
probable
causes
and
risk
factors
for
male
infertility,
despite
evidence
of
diminishing
sperm
counts
globally
increasing
infertility
rates.
Because
there
are
few
primary
treatments
unproductiveness,
knowing
reason
characteristics
will
help
identify
particular
ways
to
prevent
it.
Detect
gaps
possible
risks
reasons
affecting
enable
further
specialized
innovation
research
summarized
in
this
review
article.
The
covered
from
scholarly/scientific
journals
that
addressed
