Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants

The Lancet, Journal Year: 2024, Volume and Issue: 404(10467), P. 2077 - 2093

Published: Nov. 1, 2024

Diabetes can be detected at the primary health-care level, and effective treatments lower risk of complications. There are insufficient data on coverage treatment for diabetes how it has changed. We estimated trends from 1990 to 2022 in prevalence 200 countries territories.

Language: Английский

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Is It Time to Move Beyond TIR to TITR? Real-World Data from Over 20,000 Users of Continuous Glucose Monitoring in Patients with Type 1 and Type 2 Diabetes

Diabetes Technology & Therapeutics, Journal Year: 2024, Volume and Issue: 26(3), P. 203 - 210

Published: March 1, 2024

The growing use of continuous glucose monitoring (CGM) has been supported by expert consensus and clinical guidelines on glycemic management in diabetes with time range (TIR 70–180 mg/dL) representing a key CGM-derived metric. Time tight (TITR) also proposed for use, spanning largely normal levels 70–140 mg/dL. However, keeping such narrow ranges can be challenging, understanding the factors modulating TITR help achieve these targets. Our real-life study aimed to evaluate relationship between average (AG) TIR/TITR large cohort (n = 22,006) CGM users, divided into four groups: self-identified as having type 1 (T1D) treated insulin using multiple daily injections (MDI) or pumps; 2 (T2D) MDI T2D basal only; not treatment. groups, regardless treatment type, displayed highest TIR values, associated lowest variability measured coefficient variation (CV; 23–30%). T1D group showed TITR, CVs (36–38%). Overall, higher CV was lower AG values below 180 140 mg/dL, respectively, reverse holding true above thresholds. discordance less pronounced compared T1D, attributed former group. It observed that advantages over assessing glycemia status progress toward more stringent A1C, particularly when approaching levels. data detail how affects TIR/TITR, which implications interpretation. In many instances rather than TIR, may preferable employ once falls mg/dL near-normal are required clinically.

Language: Английский

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Effect of Testosterone on Progression From Prediabetes to Diabetes in Men With Hypogonadism

JAMA Internal Medicine, Journal Year: 2024, Volume and Issue: 184(4), P. 353 - 353

Published: Feb. 5, 2024

The effect of testosterone replacement therapy (TRT) in men with hypogonadism on the risk progression from prediabetes to diabetes or inducing glycemic remission those is unknown.

Language: Английский

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Heterogeneities and impact profiles of early chronic obstructive pulmonary disease status: findings from the China Pulmonary Health Study

The Lancet Regional Health - Western Pacific, Journal Year: 2024, Volume and Issue: 45, P. 101021 - 101021

Published: Feb. 6, 2024

BackgroundThe prevalence, epidemiological and clinical heterogeneities, impact profiles of individuals with preserved ratio impaired spirometry (PRISm), pre-COPD, young COPD, mild COPD in general Chinese population were not known yet.MethodsData obtained from the China Pulmonary Health study (2012–2015), a nationally representative cross-sectional survey that recruited 50,991 adults aged 20 years or older. Definitions four early disease status consistent latest publications Global Initiative for Chronic Obstructive Lung Disease criteria.FindingsThe age-standardised prevalences PRISm, 5.5% (95% confidence interval, 4.3–6.9), 7.2% (5.9–8.8), 1.1% (0.7–1.8), 3.1% (2.5–3.8), respectively. In summary, was under more direct established factor exposures, such as older age, male gender, lower education level, family income, biomass use, air pollution, accumulative cigarette exposures; pre-COPD experienced personal parents’ events earlier lives, history bronchitis pneumonia childhood, frequent chronic cough parental respiratory diseases, passive smoke exposure mother exposed to while pregnant; coexisted heavier symptoms comorbidities burdens; exhibited worse airway obstruction; most harbored small dysfunction. Overall, living urban area, occupational exposure, accumulated comorbid cardiovascular gastroesophageal reflux all associated increased presence status; different additionally observed distinct entities. Over categories, less than 10% had ever taken pulmonary function test; 1% reported previously diagnosed COPD; no 13% received pharmaceutical treatment.InterpretationSignificant heterogeneities features, noted varied defining criteria unified validated definition an stage is warranted. Closer attention, better management, further research need be administrated these population.FundingChinese Academy Medical Sciences Institute Respiratory Medicine Grant Young Scholars (No. 2023-ZF-9); International Foundation Z-2017-24-2301); Innovation Fund 2021-I2M-1-049); National High Level Hospital Clinical Research Funding 2022-NHLHCRF-LX-01); Major Program Natural Science 82090011).

Language: Английский

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Effectiveness of Different Intervention Modes in Lifestyle Intervention for the Prevention of Type 2 Diabetes and the Reversion to Normoglycemia in Adults With Prediabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Journal of Medical Internet Research, Journal Year: 2025, Volume and Issue: 27, P. e63975 - e63975

Published: Jan. 29, 2025

Lifestyle interventions have been acknowledged as effective strategies for preventing type 2 diabetes mellitus (T2DM). However, the accessibility of conventional face-to-face is often limited. Digital health intervention has suggested a potential solution to overcome limitation. Despite this, there remains significant gap in understanding effectiveness digital individuals with prediabetes, particularly reducing T2DM incidence and reverting normoglycemia. This study aimed assess different modes health, face-to-face, blended interventions, benefits intervention, facilitating reversion normoglycemia adults prediabetes compared usual care. We conducted comprehensive search 9 electronic databases, namely MEDLINE, Embase, ACP Journal Club, Cochrane Central Register Controlled Trials, Database Systematic Reviews, Clinical Answers, Methodology Register, Health Technology Assessment, NHS Economic Evaluation through Ovid, from inception October 2024. review included randomized controlled trials (RCTs) that studied lifestyle prediabetes. The overall effect was synthesized using random-effects model. I² statistic used heterogeneity across RCTs. performed subgroup analysis explore control group, which received From an initial 7868 records retrieved we identified 54 articles 31 Our showed demonstrated 46% risk reduction (risk ratio [RR] 0.54, 95% CI 0.47-0.63; I²=43%; P<.001), increase (RR 1.46, 1.11-1.91; I²=82%; P=.006), when group. On other hand, were associated 12% 0.88, 0.77-1.01; I²=0.6%; P=.06). Moreover, combining 37% 0.63, 0.49-0.81;I²<0.01%; P<.001) 87% 1.87, 1.30-2.69; I²=23%; P=.001). no on reversal observed interventions. Face-to-face consistently promising both reductions these areas not sufficiently proven. Given results, further research required provide more definitive evidence prevention future. PROSPERO CRD42023414313; https://tinyurl.com/55ac4j4n.

Language: Английский

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Prediabetes Diagnosis and Management

JAMA, Journal Year: 2023, Volume and Issue: 329(14), P. 1157 - 1157

Published: April 11, 2023

Our website uses cookies to enhance your experience. By continuing use our site, or clicking "Continue," you are agreeing Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals Network Open Cardiology Dermatology Health Forum Internal Medicine Neurology Oncology Ophthalmology Otolaryngology–Head & Neck Surgery Pediatrics Psychiatry Archives of (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions LibrariansReprints Permissions Terms Use Privacy Accessibility Statement 2023 American Association. All Rights Reserved Search Archive Input Term Sign In Individual inCreate an Account Access through institution Purchase Options: Buy this article Rent Subscribe the journal

Language: Английский

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From Stability to Variability: Classification of Healthy Individuals, Prediabetes, and Type 2 Diabetes using Glycemic Variability Indices from Continuous Glucose Monitoring Data

Diabetes Technology & Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Objective: This study aims to investigate the continuum of glucose control from normoglycemia dysglycemia (HbA1c ≥ 5.7% / 39 mmol/mol) using metrics derived Continuous Glucose Monitoring (CGM). Additionally, we aim develop a machine learning-based classification model classify based on observed patterns. Methods: Data five distinct studies, each featuring at least two days CGM, were pooled. Participants included individuals classified as healthy, with prediabetes, or type 2 diabetes mellitus (T2DM). Various CGM indices extracted and compared across groups. The dataset was split 70/30 for training testing models (XGBoost Logistic Regression) differentiate between prediabetes healthy group. Results: analysis 836 participants (healthy: n=282; prediabetes: n=133; T2DM: n=432). Across all indices, progressive shift group those (p<0.001). Statistically significant differences (p<0.01) noted in mean glucose, Time Below Range, Above 140 mg/dl, Mmobility, Multiscale Complexity Index Glycemic Risk when transitioning health prediabetes. XGBoost achieved highest Receiver Operating Characteristic Area Under Curve (ROC-AUC) values test ranging 0.91 [CI: 0.87-0.95] (prediabetes identification) 0.97 0.95-0.98] (Dysglycemia identification). Conclusion: Our findings demonstrate gradual deterioration homeostasis increased glycemic variability spectrum normo- dysglycemia, evidenced by metrics. performance CGM-based classifying is promising.

Language: Английский

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Associations of healthy lifestyle and family income to poverty ratio with all-cause mortality among people with prediabetes and diabetes: a prospective cohort study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 3, 2025

Language: Английский

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Association of dietary decanoic acid intake with diabetes or prediabetes: an analysis from NHANES 2005–2016

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

With the increasing prevalence of prediabetes and diabetes, exploring dietary factors associated with diabetes has become a global health research priority. This study aimed to assess relationship between decanoic acid (DDA) intake risk prediabetes. Data from National Health Nutrition Examination Survey (NHANES) 2005-2016 included 11,477 adult participants. DDA was assessed through two 24-h recalls participants were grouped according diagnostic criteria for Multivariate regression models applied analyze prediabetes, subgroup analyses conducted explore potential interactions. Dietary significantly negatively diabetes. In fully adjusted model, each 1 g/day increase in 19% reduction odds developing (OR = 0.81, 95% CI: 0.68-0.96, p 0.015) this negative association more pronounced individuals higher education level (P interaction 0.006). Compared ≤0.18 g/day, >0.58 is related reduced progression prediabetic patients. However, not statistically significant model 0.95, 0.84-1.07, 0.404). found that may be lower among population, high strengthen relationship.

Language: Английский

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The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 16, 2025

This study aims to investigate the associations between MTNR1B rs724030 A>G variant and prediabetes risk, along with their correlations clinical features, including plasma glucose serum insulin levels during oral tolerance test (OGTT), islet function, resistance, lipid levels. In particular, we investigated whether there are sex dimorphisms in impact of this on function/insulin resistance. We included 3415 glucose-tolerant healthy 1744 individuals based OGTT. Binary logistic regression was performed evaluate relationships under additive model. Additionally, multiple linear utilized glycemic-related quantitative traits While no association observed risk overall cohort (P > 0.05), found G allele associated higher fasting 30-minute levels, decreased Insulinogenic Index (IGI), disposition index (DIo) = 0.009, 0.001, 0.007, respectively) normal (NGT) BMI Furthermore, also significant IGI, corrected response (CIR), DIo (All P < 0.001) female whose waist-to-hip ratio (WHR) is greater than 0.85, considerable heterogeneity (Phet 0.030, 0.049, male participants NGT individuals, but not impaired (IFG)/impaired (IGT) individuals. clearance 0.05). The contributes glycemic its effects have after stratifying by WHR. All these findings provide a basis for accurately assessing function populations offer new perspective precision prevention.

Language: Английский

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