Advances in Our Understanding of Cardiovascular Diseases After Preeclampsia

Circulation Research, Journal Year: 2025, Volume and Issue: 136(6), P. 583 - 593

Published: March 13, 2025

Preeclampsia is a syndrome of hypertension in association with target organ dysfunction, including proteinuria, which manifests during pregnancy and the immediate postpartum period. The pathophysiology preeclampsia originates from impaired trophoblastic invasion placental resulting malperfusion involves multiple mechanistic pathways that include anti-angiogenic factors, endothelial immune dysregulation. caries an increased risk subclinical cardiovascular disease left ventricular remodeling, diastolic coronary artery calcification, peripheral vascular abnormalities, microvascular dysfunction clinical stroke, heart failure, myocardial infarction, death cause. This review will highlight several common shared between diseases provide insight into potential targets for reduction process mitigation can be examined future trials.

Language: Английский

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Hypertension in Pregnancy and Postpartum: Current Standards and Opportunities to Improve Care

Circulation, Journal Year: 2025, Volume and Issue: 151(7), P. 490 - 507

Published: Feb. 17, 2025

Hypertension in pregnancy contributes substantially to maternal morbidity and mortality, persistent hypertension, rehospitalization. Hypertensive disorders of are also associated with a heightened risk cardiovascular disease, timely recognition modification factors is crucial optimizing long-term health. During pregnancy, there expected physiologic alterations blood pressure (BP); however, pathophysiologic may occur, leading preeclampsia gestational hypertension. The diagnosis effective management hypertension during essential mitigate risks, such as acute kidney injury, stroke, heart failure, while balancing potential fetal growth restriction preterm birth due altered uteroplacental perfusion. In the postpartum period, innovative multidisciplinary care solutions that include health clinics can help optimize short- through enhanced BP management, screening factors, discussion lifestyle modifications for disease prevention. As an adjunct or distinct from clinics, home monitoring programs have been shown improve ascertainment across diverse populations lower months after delivery. Because concerns about pregnant patients being vulnerable population research, little evidence trials examining treatment individuals. result, national international guidelines differ their recommendations, more studies needed bolster future establish best practices achieve optimal pregnancy. Future research should focus on refining thresholds range peripartum evaluating interventions outcomes would advance evidence-based worldwide people hypertensive

Language: Английский

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Third-Trimester NT-proBNP for Pre-eclampsia Risk Prediction

JACC Advances, Journal Year: 2025, Volume and Issue: 4(4), P. 101671 - 101671

Published: March 19, 2025

The association between lower first-trimester N-terminal pro B-type natriuretic peptide (NT-proBNP) levels and increased pre-eclampsia risk remains poorly understood, contrasting with the elevated NT-proBNP observed at time of diagnosis. aim this study was to assess utility third-trimester for assessing before onset. soluble Fms-like tyrosine kinase 1 placental growth factor ratio (sFlt-1/PlGF) were measured in 1,476 pregnant individuals from Odense Child Cohort a median gestational age 29 weeks (Q1-Q3: 28.4-29.4). Pre-eclampsia cases categorized by timing: 11 (0.7%) developed within 4 weeks, while 110 (7.5%) more than after sampling. Higher significantly associated but reduced beyond weeks. After adjusting age, body mass index, nulliparity, systolic blood pressure, sFlt-1/PlGF ratio, adjusted OR 2.18 (95% CI: 0.88-5.42, P = 0.09) onset 0.72 0.55-0.93, 0.012) However, combining did not improve predictive accuracy short- or long-term compared alone. Unselected screening early third trimester has limited clinical value predicting when angiogenic biomarkers.

Language: Английский

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Text phrase‐mining in identifying and classifying maternal proteins and genes across preeclampsia and similar pathologies

Physiological Reports, Journal Year: 2025, Volume and Issue: 13(6)

Published: March 1, 2025

Abstract This study aims to demonstrate that text phrase‐mining and natural language processing (NLP) can annotate huge quantities of obstetrics textual data for the discovery evaluation maternal protein/gene (MPG)‐disease interactions involved in preeclampsia pathway. We employ a phrase‐mining/NLP pipeline evaluate unique MPGs six cardiovascular derangements with overlapping presentations during pregnancy. The diseases were matched Medical Subject Headings. A corpus was developed from abstracts these terms through PubMed. Fourty‐four identified respect diseases. Processing performed, scores each MPG‐disease pair. Components score calculated weighted distinctness, integrity, popularity. Statistical analyses conducted examination protein‐disease relationships. known associations disease pathways among 6 shared across greatest number states implicated in: (1) angiogenesis vasoconstriction, (2) hemodynamic regulation, (3) hormonal regulation metabolism, (4) inflammation. NLP are successfully applied Obstetrics accuracy speed. approach holds promise synthesizing large volumes presenting trends Obstetric literature identification promising biomarkers.

Language: Английский

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Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Pre-eclampsia (PE) and pregnancy hypertension (PH) are common serious complications during pregnancy, which can lead to maternal fetal death in severe cases. Therefore, further research on the potential therapeutic targets of PE PH is great significance for developing new treatment strategies. This study used summary data-based Mendelian randomization (SMR) method analyze expression quantitative trait loci (eQTL) data from blood, aorta, uterus with Genome-wide association studies (GWAS) PH, exploring genetic involved PH. Since proteinuria a clinical manifestation PE, we also analyzed genes related kidney PE. The HEIDI test was heterogeneity testing, results were adjusted using FDR. cis-eQTL obtained blood summary-level eQTLGen Consortium aorta V8 release GTEx eQTL data. GWAS FinnGen Documentation R10 release. utilized STROBE-MR checklist reporting Randomization (MR) studies. identified several by integrating uterus, as well Additionally, discovered some roles offering insights into shared pathological mechanisms these two conditions. These findings not only provide clues pathogenesis but offer crucial foundational development future revealed multiple providing basic experimental mitigate consequences Not applicable.

Language: Английский

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Advances in the Pathogenesis and Potential Biomarkers of Preeclampsia

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 2795 - 2804

Published: Jan. 1, 2025

Language: Английский

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Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two‐Sample Mendelian Randomization Analysis

International Journal of Hypertension, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Preeclampsia, a pregnancy complication marked by hypertension after 20 weeks of gestation, arises from placental factors that impair maternal vascular function. C-type natriuretic peptide (CNP), known for its vasodilatory role, may help counter preeclampsia-related dysfunction. This study aimed to explore the effect CNP on preeclampsia risk using Mendelian randomization (MR) framework. Methods: Genetic instrumental variables mimic effects signaling (through receptor 2 [NPR2] activation or reduced NPR3-mediated clearance) were identified in genes encoding two receptors. discovery emerged multiancestry genome-wide association (GWAS) involving over 5 million individuals. Female-specific genetic estimates obtained individual-level data comprising 198,402 female participants UK Biobank. Two-sample MR analyses conducted investigate NPR2 and NPR3 function preeclampsia, utilizing largest publicly available GWAS which included 296,824 participants. Results: Genetically proxied was associated with lower (odds ratio (OR): 0.46, 95% confidence interval 0.30-0.69). In contrast, genetically increased lacked significant association, likely due underpowered instruments. Sensitivity indicated robust findings minimal pleiotropy, meaning variants used primarily influenced through intended biological pathway rather than affecting multiple unrelated traits. Conclusion: employed paradigm provide evidence supporting protective function) preeclampsia. However, it is important gather additional other sources before moving forward clinical development efforts as potential treatment

Language: Английский

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Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia

Circulation Genomic and Precision Medicine, Journal Year: 2024, Volume and Issue: 17(5)

Published: Aug. 9, 2024

BACKGROUND: Preeclampsia is a leading cause of maternal and perinatal morbidity mortality. However, the current understanding its underlying biological pathways remains limited. METHODS: In this study, we performed cross-platform proteome- transcriptome-wide genetic analysis aimed at evaluating causal relevance >2000 circulating proteins with preeclampsia, supported by data on expression over 15 000 genes across 36 tissues leveraging large-scale preeclampsia association from women European ancestry. RESULTS: We demonstrate associations 18 (SULT1A1 [sulfotransferase 1A1], SH2B3 [SH2B adapter protein 3], SERPINE2 [serpin family E member 2], RGS18 [regulator G-protein signaling 18], PZP [pregnancy zone protein], NOTUM [notum, palmitoleoyl-protein carboxylesterase], METAP1 [methionyl aminopeptidase 1], MANEA [mannosidase endo-alpha], jun-D [JunD proto-oncogene], GDF15 [growth differentiation factor 15], FGL1 [fibrinogen like FGF5 [fibroblast growth 5], FES [FES APOBR [apolipoprotein B receptor], ANP [natriuretic peptide A], ALDH-E2 [aldehyde dehydrogenase 2 member], ADAMTS13 [ADAM metallopeptidase thrombospondin type 1 motif 13], 3MG [N-methylpurine DNA glycosylase]), among which 11 were either directly or indirectly gene data, 9 Bayesian colocalization analyses, 5 (SERPINE2, PZP, FGF5, FES, ANP) all lines evidence examined. Protein interaction mapping identified potential shared through natriuretic signaling, blood pressure regulation, immune tolerance, thrombin activity regulation. CONCLUSIONS: This investigation multiple targetable linked to cardiovascular, inflammatory, coagulation pathways, SERPINE2, as pivotal likely roles in development preeclampsia. The identification these targets may guide targeted therapies for

Language: Английский

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Placental Origins of Preeclampsia: Insights from Multi-Omic Studies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9343 - 9343

Published: Aug. 28, 2024

Preeclampsia (PE) is a major cause of maternal and neonatal morbidity mortality worldwide, with the placenta playing central role in disease pathophysiology. This review synthesizes recent advancements understanding molecular mechanisms underlying PE, focusing on placental genes, proteins, genetic variants identified through multi-omic approaches. Transcriptomic studies bulk tissue have many dysregulated genes PE placenta, including signature gene, Fms-like tyrosine kinase 1 (

Language: Английский

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Proteogenomic analyses identify coagulation factor XI as a thromboinflammatory mediator of long COVID

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 18, 2024

The authors have withdrawn their manuscript due to analytical errors invalidating the main study findings. of this work discovered after submitting initial version preprint. Therefore, do not wish be cited as reference for project. If you any questions, please contact corresponding author.

Language: Английский

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