Unveiling the Chemistry of Citrus Peel: Insights into Nutraceutical Potential and Therapeutic Applications

Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1681 - 1681

Published: May 27, 2024

The recent millennium has witnessed a notable shift in consumer focus towards natural products for addressing lifestyle-related disorders, driven by their safety and cost-effectiveness. Nutraceuticals functional foods play an imperative role meeting nutritional needs offering medicinal benefits. With increased scientific knowledge awareness, the significance of healthy lifestyle, including diet, reducing disease risk is widely acknowledged, facilitating access to diverse safer diet longevity. Plant-based rich phytochemicals are increasingly popular effectively utilized management. Agricultural waste from plant-based being recognized as valuable source nutraceuticals dietary interventions. Citrus peels, known flavonoids, emerging promising health-promoting ingredient. Globally, citrus production yields approximately 15 million tons by-products annually, highlighting substantial potential utilizing phyto-therapeutic nutraceutical applications. peels with concentrations ranging 2.5 5.5 g/100 g dry weight, depending on variety. most abundant flavonoids peel include hesperidin naringin, well essential oils monoterpenes like limonene. extracts exhibit high antioxidant capacity, DPPH radical scavenging activities 70 90%, comparable synthetic antioxidants BHA BHT. Additionally, present have been found properties, which can help reduce oxidative stress 30% cardiovascular 25%. Potent anti-inflammatory effects also demonstrated, inflammatory markers such IL-6 TNF-α up 40% cell culture studies. These findings highlight diet-based therapies.

Language: Английский

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Connecting precision nutrition with the Food is Medicine approach

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Development of a statewide network hub for screening, referral, and enrollment into food as medicine programs across Kentucky

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 7, 2025

Widespread recognition of food as medicine interventions' role in reducing insecurity and improving health outcomes has recently emerged. Several states have released In Lieu Services, state-approved alternative services that may be offered by managed care organizations place covered benefits, or 1,115 Medicaid waivers, which allow for expanded nutrition to reduce improve outcomes. However, there are significant gaps understanding how create a statewide system delivering "healthcare food" interventions. The University Kentucky Food Health Alliance first piloted the development hub facilitating referral to, enrollment in, evaluation programs across two healthcare providers (one urban one rural). We then used quasi experimental study design examine effects on systolic diastolic blood pressure target population eligible individuals aged 18-64 with high and/or type 2 diabetes rural areas. Participant allocation was based geographic location each program arm no control group. This feasibility case aims to: (1) outline between providers; (2) describe enrollment; (3) summarize lessons learned from network blueprint other states; (4) present clinical three programs. Ninety-two referrals were received UK HealthCare 21 enrolled medically tailored meals 28 grocery prescription (53% rate). Thirty-two Appalachian Regional Healthcare 26 meal kits (81% On average, reduction 9.67 mmHg among participants 6.89 participants. Creating address requires key support host stakeholders. Policy steps moving forward need consider funding infrastructure screening, referral, engagement hubs improved ClinicalTrials.gov, NCT06033664.

Language: Английский

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Health-Related Social Needs Intervention for Adolescents and Young Adults With Type 2 Diabetes and Their Caregivers: An Exploratory Study Using Human-Centered Design

Community Health Equity Research & Policy, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Youth-onset type 2 diabetes (T2D) is increasingly common and projected to impact over 200,000 adolescents young adults by 2060. Youth with T2D frequently experience health-related social needs (HRSN) that increase their risk for poor outcomes. Using human-centered design methodology, we explored how best address HRSN in pediatric endocrinology clinics. We conducted two parallel, six-session group meetings youth ( n = 4) caregivers of 6), as well individual interviews 12 clinicians. An inductive thematic data analysis approach was used. Participants described are pervasive especially impactful after diagnosis. thought addressing healthcare settings important but emphasized interventions need be affirming provide tangible, relevant resources. Engagement community health workers trained around management needed, structural change disrupt disparities. Future research clinical transformation discussed.

Language: Английский

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Can Prevention Save Money?

JAMA Health Forum, Journal Year: 2025, Volume and Issue: 6(4), P. e251464 - e251464

Published: April 3, 2025

This JAMA Forum discusses some key considerations for addressing the question of whether and when prevention interventions are worth cost.

Language: Английский

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Medicaid Nutrition Supports Associated With Reductions In Hospitalizations And ED Visits In Massachusetts, 2020–23

Health Affairs, Journal Year: 2025, Volume and Issue: 44(4), P. 413 - 421

Published: April 1, 2025

The Massachusetts Medicaid and Children's Health Insurance Program launched the Flexible Services to address food insecurity through partnerships with social service organizations under its Section 1115 demonstration waiver. We evaluated effects of nutritional services (or Food Is Medicine programs) on health care use costs during first three-year program cycle (January 2020-March 2023). Our analyses pooled data 20,403 participants from seventeen accountable organizations. In propensity score-weighted analyses, participation was associated a 23 percent reduction in hospitalizations 13 emergency department visits compared number for 2,108 eligible nonparticipants. Modestly lower were not statistically significant. $1,721 among after COVID-19 (2022-23) $2,502 adults more than ninety days enrollment all study years (2020-23). These findings are important policy nationwide as other state programs pursue similar demonstrations.

Language: Английский

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Diet in food insecurity: a mediator of metabolic health?

Journal of the Endocrine Society, Journal Year: 2024, Volume and Issue: 8(6)

Published: April 2, 2024

Abstract Objective Food insecurity (FI) is associated with poor metabolic health. It assumed that energy intake and diet quality underlie this association. We tested the hypothesis dietary factors (quantity quality) mediate association of FI excess weight, waist circumference glycemic control [glycohemoglobin (A1C)]. Methods A mediation analysis was performed on data from National Health And Nutrition Examination Survey using as an independent variable; body mass index (BMI), circumference, A1C outcome variables total intake, macronutrients, measured by Healthy Eating Index-2015 (HEI-2015) potential mediators. Results Despite a greater prevalence obesity in participants experiencing FI, daily reported similar food-secure -insecure subjects. In adjusted analyses overall cohort, none examined mediated associations between outcomes. race-stratified analyses, sugar consumption partial mediator BMI non-Hispanic Whites, while measures (HEI-2015 score added subscore) were mediators BMI, respectively, for those “other” ethnic group. Conclusion Dietary are not main underlying Future studies should investigate whether other social determinants health commonly present context play role

Language: Английский

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A theoretical explanation for how a nutrition counseling and medically tailored meal delivery program benefitted participants living with lung cancer

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(7)

Published: June 13, 2024

Abstract Purpose The purpose of this study was to assess participants’ perceptions and experiences while participating in a Food is Medicine medically tailored meal plus intensive nutrition counseling intervention create theoretical explanation about how the worked. Methods This interpretive qualitative included use semi-structured interviews with active participants randomized controlled trial aimed at understanding worked for vulnerable individuals lung cancer treated four centers across USA. During 8-month long study, arm were asked be interviewed, which recorded, transcribed verbatim, analyzed using conventional content analysis principles grounded theory. Results Twenty participated. Data resulted intervention’s mechanism action. explanatory process includes three linked propositional categories leading patient resilience: engaging treatment, adjusting diagnosis, coping. meals engaged throughout helped adjust their coping through intentional self-care, behavior change, improved quality life. Conclusions These findings provide evidence that may buffer some adversity related diagnosis pathway experience post-traumatic growth, develop resilience, change behaviors actively cope cancer. Medically informed by motivational interviewing supported individuals’ adjustment perceived positive change.

Language: Английский

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Feasibility of self-investment in a medically tailored meals program by a large health enterprise: Cleveland Clinic experience

Nutrition and Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Background: Medically tailored meals (MTMs) are personalized designed to meet the therapeutic needs of patients with chronic diseases. Most MTM programs rely on philanthropic support, and optimal parameters for these not well-defined. Aim: To assess feasibility an program developed by a major healthcare institution using internal investments online platform meal ordering. Methods: Single-arm prospective cohort project implemented between August 2021 June 2022. Each participant received 14 frozen per week over 3 months via courier system. Participants answered several questionnaires utilization was abstracted from electronic medical records up 6 post-intervention. Results: Sixty participants were enrolled. Emergency department (ED) visits inpatient days significantly decreased in 180 post-intervention compared pre-intervention (ED visits: 1.2 vs 1.7, P = 0.005; days: 3.2 5.1, 0.02). saved average $12,046 costs. Despite challenges implementation, including upfront costs sustainability, client service outcomes highly favorable. Patients overwhelmingly satisfied program, although there no quantitative improvement global mental health (GMH) or physical (GPH) scores. Conclusion: run institutions can enhance patient satisfaction, reduce hospital visits, lower costs, particularly vulnerable populations. Providing healthy, extended period is feasible, though it requires significant initial investment. Large should consider implementing such prioritize primary prevention US

Language: Английский

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Estimating the Impact of Addressing Food Needs on Diabetes Outcomes

SSM - Population Health, Journal Year: 2024, Volume and Issue: 27, P. 101709 - 101709

Published: Sept. 1, 2024

To estimate the association between food needs and diabetes outcomes.

Language: Английский

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