High Seroprevalence of Anti-SARS-CoV-2 Antibodies in Children in Vietnam: An Observational, Hospital-Based Study DOI Creative Commons

Dien Minh Tran,

Uyen Tu Thi Vu,

Canh Ngoc Hoang

et al.

Pathogens, Journal Year: 2022, Volume and Issue: 11(12), P. 1442 - 1442

Published: Nov. 30, 2022

Background: The robustness of sero-surveillance has delineated the high burden SARS-CoV-2 infection in children; however, these existing data showed wide variation. This study aimed to identify serostatus antibodies against and associated factors among children following fourth pandemic wave Vietnam. Methods: A cross-sectional was conducted at Vietnam National Children’s Hospital (VNCH) between March 13 April 3, 2022. Thus, 4032 eligible seeking medical care for any condition not related acute COVID-19 were tested IgG by ADVIA Centaur® (sCOVG) assay using residuals routine blood samples. Results: median age enrolled 39 (IQR = 14−82) months. overall seropositive prevalence 59.2% (95%CI 57.6−60.7) antibody titer 4.78 2.38−9.57) UI/mL. risk seropositivity gender (58.6% versus 60.1%, 4.9 4.6 UI/mL, all p > 0.05). Children aged ≤12 months likely be compared 36 <60 (59.2% 57.5%, 0.49) those ≥144 65.5%, 0.16). exhibited a significantly higher protective than other groups (p < 0.001). In multivariate logistic regression, we observed independent with seropositivity, including <36 (OR 1.29, 95%CI 1.06−1.56, 0.01), 60 <144 0.79, 0.67−0.95, 1.84, 1.21−2.8, 0.005), presence infected household members 2.36, 2.06−2.70, 0.001), participants from Hanoi 1.54, 1.34−1.77, underlying conditions 0.71, 0.60−0.85, ≤ corticosteroids or immunosuppressants 0.64, 0.48−0.86, 0.003). Conclusions: highlights seroprevalence non-acute COVID-19-related tertiary children’s hospital Hanoi, context reopening in-person schools future emerging variants, this point will also key message about necessity “rush-out” immunization coverage children, especially under five years.

Language: Английский

Infection and transmission risks of COVID-19 in schools and their contribution to population infections in Germany: A retrospective observational study using nationwide and regional health and education agency notification data DOI Creative Commons
Torben Heinsohn, Berit Lange, Patrizio Vanella

et al.

PLoS Medicine, Journal Year: 2022, Volume and Issue: 19(12), P. e1003913 - e1003913

Published: Dec. 20, 2022

School-level infection control measures in Germany during the early Coronavirus Disease 2019 (COVID-19) pandemic differed across 16 federal states and lacked a dependable evidence base, with available limited to regional data restricted short phases of pandemic. This study aimed assess (a) risks students staff; (b) transmission routes schools; (c) effects school-level on school population dynamics; (d) contribution contacts schools cases.

Language: Английский

Citations

26
Heterogeneous evolution of SARS-CoV-2 seroprevalence in school-age children DOI Creative Commons
Sarah R. Haile, Alessia Raineri,

Sonja Rueegg

et al.

Schweizerische medizinische Wochenschrift, Journal Year: 2023, Volume and Issue: 153(1), P. 40035 - 40035

Published: Jan. 30, 2023

Much remains unknown regarding the evolution of SARS-CoV-2 seroprevalence and variability in seropositive children districts, schools classes as only a few school-based cohort studies exist. Vaccination children, initiated at different times for age groups, adds additional complexity to understanding how developed school aged population.We investigated its Switzerland from June/July 2020 November/December 2021.In this study, antibodies were measured primary secondary randomly selected canton Zurich October/November 2020, March/April 2021 2021. Seroprevalence was estimated using Bayesian logistic regression adjust test sensitivity specificity. Variability between expressed maximum minus minimum class summarised median (interquartile range).1875 287 43 tested, with 12 years (range 6-17), 51% 12+ vaccinated. increased 5.6% (95% credible interval [CrI] 3.5-7.6%) 31.1% CrI 27.0-36.1%) unvaccinated 46.4% 42.6-50.9%) all (including vaccinated). Earlier pandemic, seropositivity rates similar or slightly higher (<5%) than those schools, but by late 2021, had 12.3% (44.3%) lower (all) subjects. among districts more two-fold over time, 11% 7-17%) 40% 22-49%).Seroprevalence greatly, especially following introduction vaccines. high substantially suggesting complex transmission chains.

Language: Английский

Citations

13
Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts DOI Creative Commons
Carlota Dobaño, Selena Alonso, Marta Vidal

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 27, 2022

COVID-19 affects children to a lesser extent than adults but they can still get infected and transmit SARS-CoV-2 their contacts. Field deployable non-invasive sensitive diagnostic techniques are needed evaluate the infectivity dynamics of in pediatric populations guide public health interventions, particularly if this population is not fully vaccinated. We evaluated utility high-throughput Luminex assays quantify saliva IgM, IgA IgG antibodies against five spike (S) nucleocapsid (N) antigens contacts longitudinal study 122 individuals (52 70 adults). compared versus serum/plasma samples diagnosed by weekly RT-PCR over 35 days (n=62), those who consistently tested negative same follow up period (n=60), Summer 2020 Barcelona, Spain. Saliva antibody levels positive were significantly higher correlated with measured sera/plasmas. Asymptomatic had anti-S symptomatic individuals, suggesting protective anti-disease role for antibodies. Higher IgM saliva, respectively, could also be related stronger clinical immunity them. Among children, males N RBD females. Despite overall correlation, individual clustering analysis suggested that responses may detected blood patent vice versa. In conclusion, measurement SARS-CoV-2-specific should considered as complementary assay determine prevalence transmission before after vaccination campaigns.

Language: Английский

Citations

22
SARS-CoV-2 Seroprevalence Compared with Confirmed COVID-19 Cases among Children, Colorado, USA, May–July 2021 DOI Creative Commons

Shannon C. O’Brien,

Lyndsey D. Cole,

Bernadette Albanese

et al.

Emerging infectious diseases, Journal Year: 2023, Volume and Issue: 29(5)

Published: April 18, 2023

To compare SARS-CoV-2 antibody seroprevalence among children with seropositive confirmed COVID-19 case counts (case ascertainment by molecular amplification) in Colorado, USA, we conducted a cross-sectional serosurvey during May-July 2021. For convenience sample of 829 Colorado children, was 36.7%, compared prevalence 6.5% according to individually matched test results reported public health. Compared non-Hispanic White higher Hispanic, Black, and other race significantly lower Hispanic Black children. This accurately estimated revealed substantial racial/ethnic disparities infections ascertainment. Continued efforts address racial ethnic differences disease burden overcome potential barriers ascertainment, including access testing, may help mitigate these ongoing disparities.

Language: Английский

Citations

11
A longitudinal seroepidemiology study to evaluate antibody response to SARS-CoV-2 virus infection and vaccination in children in Calgary, Canada from July 2020 to April 2022: Alberta COVID-19 Childhood Cohort (AB3C) Study DOI Creative Commons
Emily J. Doucette,

Joslyn Gray,

Kevin Fonseca

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(4), P. e0284046 - e0284046

Published: April 6, 2023

Measurement of SARS-CoV-2 antibody seropositivity is important to accurately understand exposure infection and/or vaccination in specific populations. This study aimed estimate the serologic response virus and children Calgary, Alberta over a two-year period.Children with or without prior infections, were enrolled Canada 2020. Venous blood was sampled 4 times from July 2020 April 2022 for nucleocapsid spike antibodies. Demographic clinical information obtained including testing results records.1035 88.9% completed all visits; median age 9 years (IQR: 5,13); 519 (50.1%) female; 815 (78.7%) Caucasian. Before enrolment, 118 (11.4%) had confirmed probable SARS-CoV-2. By 2022, 39.5% previously uninfected participants infection. Nucleocapsid declined 16.4% infected after more than 200 days post diagnosis. Spike antibodies remained elevated 93.6% unvaccinated 408 (95.6%) 12 older received 2 vaccine doses, 241 (61.6%) 5 11 year-old doses. At that time, 685 vaccinated antibodies, compared 94/176 (53.4%) children.In our population, first peak Omicron variant infections introduction COVID-19 vaccines children, but just one-half indicating vaccination, highlighting benefit vaccination. It not yet known whether high proportion at present time predicts sustained population-level protection against future transmission, severe outcomes children.

Language: Английский

Citations

10
Pediatric COVID-19 severity by SARS-CoV-2 lineage and vaccine status in Canada: an IMPACT study DOI
Daniel S. Farrar, Julie A. Bettinger, Aaron Campigotto

et al.

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

Citations

0
Neutralizing antibodies to SARS-CoV-2 variants of concern: a pediatric surveillance study DOI Creative Commons
Douglas D. Fraser, Devika Singh,

Ester Cela

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 4, 2025

Language: Английский

Citations

0
Severe Acute Respiratory Syndrome Coronavirus 2 Infections in Children DOI
Eric J. Chow, Janet A. Englund

Infectious Disease Clinics of North America, Journal Year: 2022, Volume and Issue: 36(2), P. 435 - 479

Published: Feb. 1, 2022

Language: Английский

Citations

13
The COVID-19 pandemic in children and young people during 2020-2021: Learning about clinical presentation, patterns of spread, viral load, diagnosis and treatment DOI Creative Commons
Igor Rudan, Davies Adeloye, Srinivasa Vittal Katikireddi

et al.

Journal of Global Health, Journal Year: 2021, Volume and Issue: 11

Published: Dec. 25, 2021

Language: Английский

Citations

17
Using human-centred design to tackle COVID-19 vaccine hesitancy for children and youth: a protocol for a mixed-methods study in Montreal, Canada DOI Creative Commons
Britt McKinnon,

Krystelle Abalovi,

Ashley Vandermorris

et al.

BMJ Open, Journal Year: 2022, Volume and Issue: 12(4), P. e061908 - e061908

Published: April 1, 2022

Introduction To successfully combat COVID-19 vaccine hesitancy and increase uptake, research has demonstrated that interventions are most effective when tailored to meet local needs through active engagement co-development with communities. This mixed-methods project uses a human-centred design (HCD) approach understand perspectives of develop strategies enhance confidence for children adolescents. Methods analysis Project ECHO (Étude Communautaire sur l’Hésitation vaccinale contre la COVID-19) combines population-based surveys parents adolescents community-based participatory action pilot in two underserved ethnoculturally diverse neighbourhoods Montreal, Canada. Two conducted 6 months apart primary secondary schools used monitor acceptance its social determinants among youth. Analyses survey data include descriptive inferential statistical approaches. Community-led teams youth from the participating neighbourhoods, supported by academic researchers, thinking experts community partners, use an HCD to: (1) gather decision-making their frame challenge (inspiration phase); (2) intervention address (ideation phase) (3) (implementation phase). Strategies evaluate community-led will be co-developed during implementation phase. Ethics dissemination study been approved ethics boards Sainte-Justine University Hospital Centre Montreal. Community involved findings knowledge translation initiatives foster dialogue related vaccination community, school public health stakeholders. Findings disseminated peer-reviewed publications, conference presentations, forums, policy briefs, media content.

Language: Английский

Citations

11