Diabetes Metabolic Syndrome and Obesity,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1575 - 1585
Published: May 1, 2025
The
prevalence
of
metabolic
syndrome
(MetS)
continues
to
increase.
severity
MetS
can
be
defined
by
the
number
components
or,
more
recently,
a
continuous
score
(MetSSS).
However,
studies
that
examine
lifestyle
factors
predictive
severity,
in
general,
are
lacking.
This
study
aims
compare
behaviors
(eg,
physical
activity
and
diet),
health
perceptions
overall
mental
perceptions),
psychosocial
outcomes
perceived
stress
social
support)
among
people
with
varied
evaluate
associations
MetSSS.
cross-sectional
utilized
baseline
data
from
randomized
controlled
trial
618
participants
recruited
5
different
sites
across
US
We
collected
using
accelerometers,
standard
questionnaires,
bloodwork,
doing
measurements.
used
series
separate
linear
regression
models
(unadjusted
adjusted)
differences
behaviors,
perceptions,
between
3,
4,
components.
conducted
additional
assess
association
these
same
variables
Lifestyle
were
not
adjusted
models,
lower
MetSSS
was
associated
average
daily
steps
(β
=
-631.69,
p
<
0.001),
healthier
perception
-0.14,
0.014),
support
for
friends
-0.89,
0.011)
healthy
eating
-0.42,
0.015).
shown
sensitive
modifiable
compared
components,
indicating
importance
interventions
targeting
achieve
remission.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2251 - 2251
Published: Feb. 13, 2024
This
review
focuses
on
the
question
of
metabolic
syndrome
(MS)
being
a
complex,
but
essentially
monophyletic,
galaxy
associated
diseases/disorders,
or
just
related
rather
independent
pathologies.
The
human
nature
MS
(its
exceptionality
in
Nature
and
its
close
interdependence
with
action
evolution)
is
presented
discussed.
text
also
describes
components,
special
emphasis
description
their
interrelations
(including
syndromic
development
recruitment),
as
well
consequences
upon
energy
handling
partition.
main
theories
MS’s
origin
are
relation
to
hepatic
steatosis,
type
2
diabetes,
obesity,
encompass
most
components
described
so
far.
differential
effects
sex
biological
considered
under
light
social
needs
evolution,
which
directly
epidemiology,
severity,
relations
senescence.
triggering
maintenance
factors
discussed,
especial
inflammation,
complex
process
affecting
different
levels
organization
critical
element
for
development.
Inflammation
operation
connective
tissue
adipose
organ)
widely
studied
acknowledged
influence
diet.
role
diet
composition,
including
transcendence
anaplerotic
Krebs
cycle
from
dietary
amino
acid
supply
(and
timing),
developed
context
testosterone
β-estradiol
control
insulin-glycaemia
core
system
carbohydrate-triacylglycerol
handling.
high
probability
acting
unique
(essentially
monophyletic)
presented,
together
additional
perspectives/considerations
treatment
this
‘very’
disease.
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(12), P. 3113 - 3113
Published: Dec. 2, 2022
Many
people
infected
with
the
SARS-CoV-2
suffer
long-term
symptoms,
such
as
"brain
fog",
fatigue
and
clotting
problems.
Explanations
for
"long
COVID"
include
immune
imbalance,
incomplete
viral
clearance
potentially,
mitochondrial
dysfunction.
As
conditions
sub-optimal
function
are
associated
initial
severity
of
disease,
their
prior
health
could
be
key
in
resistance
to
long
COVID
recovery.
The
SARs
virus
redirects
host
metabolism
towards
replication;
response,
can
metabolically
react
control
virus.
Resolution
is
normally
achieved
after
stress
activates
a
hormetic
negative
feedback
mechanism.
It
therefore
possible
that,
some
individuals
function,
"tip"
into
chronic
inflammatory
cycle.
This
might
explain
main
including
platelet
Long
thus
described
virally
induced
self-perpetuating
imbalanced
non-resolving
state
characterised
by
dysfunction,
where
reactive
oxygen
species
continually
drive
inflammation
shift
glycolysis.
would
suggest
that
sufferer's
needs
"tipped"
back
using
stimulus,
physical
activity,
calorie
restriction,
or
chemical
compounds
mimic
these
enhancing
perhaps
combination
inhibitors
quell
response.
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(7), P. 1582 - 1582
Published: July 2, 2022
The
concept
of
insulin
resistance
has
been
around
since
a
few
decades
after
the
discovery
itself.
To
allude
to
classic
Charles
Dicken's
novel
published
62
years
before
insulin,
in
some
ways,
this
is
best
times,
as
expanded
include
brain,
with
realization
that
life
beyond
regulation
glucose.
In
other
it
worst
times
implicated
devastating
diseases,
including
diabetes
mellitus,
obesity,
and
Alzheimer's
disease
(AD)
affect
brain.
Peripheral
affects
nearly
quarter
United
States
population
adults
over
age
20.
More
recently,
AD,
degree
brain
correlating
cognitive
decline.
This
led
investigation
or
central
nervous
system
(CNS)
question
relation
between
CNS
peripheral
resistance.
While
both
may
involve
dysregulated
signaling,
two
conditions
are
not
identical
always
interlinked.
review,
we
compare
contrast
similarities
differences
We
also
discuss
how
an
apolipoprotein
involved
signaling
related
E
(apoE),
distinct
pools
periphery
can
indirectly
each
system.
As
these
systems
separated
but
linked
via
blood-brain
barrier
(BBB),
role
BBB
mediating
connections
tissues.
BMJ,
Journal Year:
2024,
Volume and Issue:
unknown, P. e076612 - e076612
Published: Oct. 28, 2024
Abstract
The
understanding
of
acute
respiratory
distress
syndrome
(ARDS)
has
evolved
greatly
since
it
was
first
described
in
a
1967
case
series,
with
several
subsequent
updates
to
the
definition
syndrome.
Basic
science
advances
and
clinical
trials
have
provided
insight
into
mechanisms
lung
injury
ARDS
led
reduced
mortality
through
comprehensive
critical
care
interventions.
This
review
summarizes
current
epidemiology,
pathophysiology,
management
ARDS.
Key
highlights
include
recommended
new
global
updated
guidelines
for
managing
on
backbone
established
interventions
such
as
low
tidal
volume
ventilation,
prone
positioning,
conservative
fluid
strategy.
Future
priorities
investigation
are
also
highlighted.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(7), P. 835 - 835
Published: July 11, 2024
Long
COVID,
a
name
often
given
to
the
persistent
symptoms
following
acute
SARS-CoV-2
infection,
poses
multifaceted
challenge
for
health.
This
review
explores
intrinsic
relationship
between
comorbidities
and
autoimmune
responses
in
shaping
trajectory
of
long
COVID.
Autoantibodies
have
emerged
as
significant
players
COVID-19
pathophysiology,
with
implications
disease
severity
progression.
Studies
show
immune
dysregulation
persisting
months
after
marked
by
activated
innate
cells
high
cytokine
levels.
The
presence
autoantibodies
against
various
autoantigens
suggests
their
potential
comorbid
factors
Additionally,
formation
complexes
may
lead
severe
progression,
highlighting
urgency
early
detection
intervention.
Furthermore,
COVID
is
highly
linked
cardiovascular
complications
neurological
symptoms,
posing
challenges
diagnosis
management.
Multidisciplinary
approaches,
including
vaccination,
tailored
rehabilitation,
pharmacological
interventions,
are
used
mitigating
COVID’s
burden.
However,
numerous
persist,
from
evolving
diagnostic
criteria
addressing
psychosocial
impact
predicting
outcomes.
Leveraging
AI-based
applications
holds
promise
enhancing
patient
management
improving
our
understanding
As
research
continues
unfold,
unravelling
complexities
remains
paramount
effective
intervention
care.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(7), P. 1388 - 1388
Published: March 26, 2022
Obesity,
and
obesity-associated
conditions
such
as
hypertension,
chronic
kidney
disease,
type
2
diabetes,
cardiovascular
are
important
risk
factors
for
severe
Coronavirus
disease-2019
(COVID-19).
The
common
denominator
is
metaflammation,
a
portmanteau
of
metabolism
inflammation,
which
characterized
by
chronically
elevated
levels
leptin
pro-inflammatory
cytokines.
These
induce
the
“Suppressor
Of
Cytokine
Signaling
1
3”
(SOCS1/3),
deactivates
receptor
also
other
SOCS1/3
sensitive
cytokine
receptors
in
immune
cells,
impairing
I
III
interferon
early
responses.
By
upregulating
SOCS1/3,
Severe
Acute
Respiratory
Syndrome
(SARS-CoV)-2
adds
significant
boost
to
this.
ensuing
consequence
delayed
but
over-reactive
response,
high-grade
inflammation
(e.g.,
storm),
endothelial
damage,
hypercoagulation,
thus
leading
COVID-19.
Superimposing
an
acute
disturbance,
SARS-CoV-2
infection,
on
metaflammation
severely
tests
resilience.
In
long
run,
causes
“typical
western”
associated
with
metabolic
syndrome.
COVID-19
serious
infectious
diseases
can
be
added
list
its
short-term
consequences.
Therefore,
preventive
measures
should
include
not
only
vaccination
well-established
actions
intended
avoid
dietary
lifestyle
interventions
aimed
at
improving
body
composition
preventing
or
reversing
metaflammation.
American Heart Journal,
Journal Year:
2024,
Volume and Issue:
270, P. 136 - 155
Published: Jan. 10, 2024
Prevalence
of
metabolic
syndrome
(MetS)
increased
from
one-quarter
to
one-third
the
U.S.
adult
population
over
8
years
and
is
spreading
young
adults
Asian
Hispanic
Americans.
Diagnosed
when
>3
out
5
cardiometabolic
risk
factors
are
present,
there
widespread
agreement
that
its
fundamental
roots
in
a
lifestyle
characterized
by
poor
dietary
quality
physical
inactivity.
Past
trials
for
MetS
produce
benefits
have
limited
sustainability,
suggesting
need
new
treatment
approaches.