The Relationships Between Lifestyle Behaviors, Health Perceptions, and Psychosocial Outcomes of Metabolic Syndrome Severity DOI Creative Commons
Bryce T. Daniels, Sumihiro Suzuki, Kelly Karavolos

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 1575 - 1585

Published: May 1, 2025

The prevalence of metabolic syndrome (MetS) continues to increase. severity MetS can be defined by the number components or, more recently, a continuous score (MetSSS). However, studies that examine lifestyle factors predictive severity, in general, are lacking. This study aims compare behaviors (eg, physical activity and diet), health perceptions overall mental perceptions), psychosocial outcomes perceived stress social support) among people with varied evaluate associations MetSSS. cross-sectional utilized baseline data from randomized controlled trial 618 participants recruited 5 different sites across US We collected using accelerometers, standard questionnaires, bloodwork, doing measurements. used series separate linear regression models (unadjusted adjusted) differences behaviors, perceptions, between 3, 4, components. conducted additional assess association these same variables Lifestyle were not adjusted models, lower MetSSS was associated average daily steps (β = -631.69, p < 0.001), healthier perception -0.14, 0.014), support for friends -0.89, 0.011) healthy eating -0.42, 0.015). shown sensitive modifiable compared components, indicating importance interventions targeting achieve remission.

Language: Английский

The Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients DOI Open Access
G. S. Gupta

Inflammation, Journal Year: 2022, Volume and Issue: 45(6), P. 2091 - 2123

Published: May 19, 2022

Language: Английский

Citations

89
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey DOI
Raffaele Izzo, Valentina Trimarco, Pasquale Mone

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 183, P. 106360 - 106360

Published: July 19, 2022

Language: Английский

Citations

78
The Metabolic Syndrome, a Human Disease DOI Open Access
M. Alemany

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2251 - 2251

Published: Feb. 13, 2024

This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.

Language: Английский

Citations

32
Understanding Long COVID; Mitochondrial Health and Adaptation—Old Pathways, New Problems DOI Creative Commons
Alistair V.W. Nunn,

Geoffrey W. Guy,

Wolfgang Brysch

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(12), P. 3113 - 3113

Published: Dec. 2, 2022

Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as "brain fog", fatigue and clotting problems. Explanations for "long COVID" include immune imbalance, incomplete viral clearance potentially, mitochondrial dysfunction. As conditions sub-optimal function are associated initial severity of disease, their prior health could be key in resistance to long COVID recovery. The SARs virus redirects host metabolism towards replication; response, can metabolically react control virus. Resolution is normally achieved after stress activates a hormetic negative feedback mechanism. It therefore possible that, some individuals function, "tip" into chronic inflammatory cycle. This might explain main including platelet Long thus described virally induced self-perpetuating imbalanced non-resolving state characterised by dysfunction, where reactive oxygen species continually drive inflammation shift glycolysis. would suggest that sufferer's needs "tipped" back using stimulus, physical activity, calorie restriction, or chemical compounds mimic these enhancing perhaps combination inhibitors quell response.

Language: Английский

Citations

56
Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites DOI Creative Commons
Elizabeth M. Rhea, William A. Banks, Jacob Raber

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(7), P. 1582 - 1582

Published: July 2, 2022

The concept of insulin resistance has been around since a few decades after the discovery itself. To allude to classic Charles Dicken's novel published 62 years before insulin, in some ways, this is best times, as expanded include brain, with realization that life beyond regulation glucose. In other it worst times implicated devastating diseases, including diabetes mellitus, obesity, and Alzheimer's disease (AD) affect brain. Peripheral affects nearly quarter United States population adults over age 20. More recently, AD, degree brain correlating cognitive decline. This led investigation or central nervous system (CNS) question relation between CNS peripheral resistance. While both may involve dysregulated signaling, two conditions are not identical always interlinked. review, we compare contrast similarities differences We also discuss how an apolipoprotein involved signaling related E (apoE), distinct pools periphery can indirectly each system. As these systems separated but linked via blood-brain barrier (BBB), role BBB mediating connections tissues.

Language: Английский

Citations

40
Acute respiratory distress syndrome DOI
Katherine D. Wick, Lorraine B. Ware, Michael A. Matthay

et al.

BMJ, Journal Year: 2024, Volume and Issue: unknown, P. e076612 - e076612

Published: Oct. 28, 2024

Abstract The understanding of acute respiratory distress syndrome (ARDS) has evolved greatly since it was first described in a 1967 case series, with several subsequent updates to the definition syndrome. Basic science advances and clinical trials have provided insight into mechanisms lung injury ARDS led reduced mortality through comprehensive critical care interventions. This review summarizes current epidemiology, pathophysiology, management ARDS. Key highlights include recommended new global updated guidelines for managing on backbone established interventions such as low tidal volume ventilation, prone positioning, conservative fluid strategy. Future priorities investigation are also highlighted.

Language: Английский

Citations

12
Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches DOI Creative Commons
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 835 - 835

Published: July 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

Citations

11
Obesity and Leptin Resistance in the Regulation of the Type I Interferon Early Response and the Increased Risk for Severe COVID-19 DOI Open Access
Frits A.J. Muskiet, Pedro Carrera‐Bastos, Leo Pruimboom

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(7), P. 1388 - 1388

Published: March 26, 2022

Obesity, and obesity-associated conditions such as hypertension, chronic kidney disease, type 2 diabetes, cardiovascular are important risk factors for severe Coronavirus disease-2019 (COVID-19). The common denominator is metaflammation, a portmanteau of metabolism inflammation, which characterized by chronically elevated levels leptin pro-inflammatory cytokines. These induce the “Suppressor Of Cytokine Signaling 1 3” (SOCS1/3), deactivates receptor also other SOCS1/3 sensitive cytokine receptors in immune cells, impairing I III interferon early responses. By upregulating SOCS1/3, Severe Acute Respiratory Syndrome (SARS-CoV)-2 adds significant boost to this. ensuing consequence delayed but over-reactive response, high-grade inflammation (e.g., storm), endothelial damage, hypercoagulation, thus leading COVID-19. Superimposing an acute disturbance, SARS-CoV-2 infection, on metaflammation severely tests resilience. In long run, causes “typical western” associated with metabolic syndrome. COVID-19 serious infectious diseases can be added list its short-term consequences. Therefore, preventive measures should include not only vaccination well-established actions intended avoid dietary lifestyle interventions aimed at improving body composition preventing or reversing metaflammation.

Language: Английский

Citations

32
Enhancing Lifestyles in the Metabolic syndrome (ELM) multisite behavioral efficacy trial. Design and baseline cohort DOI Creative Commons
Lynda H. Powell, Bryce T. Daniels,

Betty M. Drees

et al.

American Heart Journal, Journal Year: 2024, Volume and Issue: 270, P. 136 - 155

Published: Jan. 10, 2024

Prevalence of metabolic syndrome (MetS) increased from one-quarter to one-third the U.S. adult population over 8 years and is spreading young adults Asian Hispanic Americans. Diagnosed when >3 out 5 cardiometabolic risk factors are present, there widespread agreement that its fundamental roots in a lifestyle characterized by poor dietary quality physical inactivity. Past trials for MetS produce benefits have limited sustainability, suggesting need new treatment approaches.

Language: Английский

Citations

7
Endocrine Follow-up During Post-Acute COVID-19: Practical Recommendations Based on Available Clinical Evidence DOI Open Access
Rimesh Pal, Ameya Joshi, Sanjay Kumar Bhadada

et al.

Endocrine Practice, Journal Year: 2022, Volume and Issue: 28(4), P. 425 - 432

Published: Feb. 11, 2022

Language: Английский

Citations

25