Efficacy of non-pharmacological interventions on improving sleep quality in depressed patients: A systematic review and network meta-analysis

Journal of Psychosomatic Research, Journal Year: 2023, Volume and Issue: 172, P. 111435 - 111435

Published: July 9, 2023

Language: Английский

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Acupuncture for comorbid depression and insomnia in perimenopause: A feasibility patient-assessor-blinded, randomized, and sham-controlled clinical trial

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 6, 2023

Background and objective Whilst acupuncture is widely used for treating psychosomatic diseases, there little high-quality evidence supporting its application in comorbid perimenopausal depression (PMD) insomnia (PMI) which are common complaints during climacteric. This feasibility, patient-assessor-blinded, randomized, sham-controlled clinical trial addresses this gap by investigating the efficacy safety of on depressed mood poor sleep women with PMD PMI. Methods Seventy eligible participants were randomly assigned to either real-acupuncture (RA) or sham-acupuncture (SA) groups. Either RA SA treatment delivered 17 sessions over 8 weeks. The primary outcomes changes 17-items Hamilton Depression Rating Scale (HAM-D ) Pittsburgh Sleep Quality Index (PSQI) scores, from baseline 16-week follow-up. Secondary outcome measures involved anxiety symptoms, quality life, participants' experience satisfaction treatment. Blood samples taken measure reproductive hormone levels. Intention-To-Treat Per-Protocol analyses conducted linear mixed-effects models. James' Bang's blinding indices assess adequacy blinding. Results Sixty-five completed all sessions, 54 41 eight- follow-ups, respectively. At post-treatment 8-week follow-up, group showed a significantly greater reduction PSQI scores than did; although HAM-D was significant, change not statistically different that SA. There no significant mean differences between follow-up group. between-group serum All treatments tolerable serious adverse events reported, successful. Conclusion Acupuncture safe can contribute clinically relevant improvements PMI, satisfactory short-and medium-term effects. Whether anti-depressive benefit specific non-specific remains be determined. No found any longer-term compared sham at 16 Further research required elucidate mechanisms underlying short medium term effects acupuncture.

Language: Английский

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Acupuncture and Sleep Quality Among Patients With Parkinson Disease

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(6), P. e2417862 - e2417862

Published: June 26, 2024

Importance Poor sleep quality greatly impairs of life and accelerates deterioration in patients with Parkinson disease (PD), but current remedies remain limited. Acupuncture, used as an adjunctive therapy anti-Parkinson medications, has shown positive effects PD. However, high-quality clinical evidence to support the effectiveness acupuncture for PD poor is lacking. Objective To assess safety efficacy real (RA) vs sham (SA) who have quality. Design, Setting, Participants This single-center randomized trial was performed at The First Affiliated Hospital Guangzhou University Chinese Medicine China from February 18, 2022, 2023. Patients complaints were recruited (1:1) receive RA or SA treatment 4 weeks. Data analysis April 12 August 17, Intervention Treatment Main Outcomes Measures main outcome change Disease Sleep Scale (PDSS) scores measured baseline, after weeks treatment, 8 follow-up. Results Of 83 participants enrolled, 78 (94.0%) completed intervention included analysis. Their mean (SD) age 64.1 (7.9) years; 41 (52.6%) men 37 (47.4%) women. A significant increase PDSS baseline observed both group (29.65 [95% CI, 24.65-34.65]; P < .001) (10.47 5.35-15.60]; .001). Compared group, had a (19.75 11.02-28.49]; follow-up (20.24 11.51-28.98]; Conclusions Relevance In this trial, proved beneficial improving among These findings suggest that therapeutic could continue up Trial Registration Clinical Registry Identifier: ChiCTR2200060655

Language: Английский

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Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats

Brain Research Bulletin, Journal Year: 2023, Volume and Issue: 206, P. 110838 - 110838

Published: Dec. 18, 2023

Depression is associated with lowered mood, anxiety, anhedonia, cognitive impairments, and even suicidal tendencies in severe cases. Yet few studies have directed acupuncture's mechanism toward enhancing axonal repair correlated synaptic plasticity anti-inflammatory effects related to oxidative stress the hippocampus. Male Sprague-Dawley (SD) rats were randomly divided into control group (CON), chronic unpredictable mild (CUMS) group, CUMS + electroacupuncture (EA), fluoxetine (FLX) (n = 10/group). Rats given a 28-day treatment at Shangxing (GV23) Fengfu (GV16) acupoints or (2.1 mg/kg). exposed induced depression-like behaviors spatial learning-memory impairment, changed ionized calcium binding adaptor molecule 1 (IBA-1), Vglut1, myelin basic protein (MBP), postsynaptic density 95 (PSD95) level of hippocampal, increased Nod-like receptor 3 (NLRP3), atypical squamous cell (ASC), Caspase hippocampal reactive oxygen species (ROS), prompted activation Epha4-mediated signaling an inflammatory response. Conversely, administration reduced these changes prevented impairment. Electroacupuncture also promoted expression Sirtuin1(SIRT1), Nuclear factor erythroid 2-like (Nrf2), Heme oxygenase-1 (HO-1); interleukin-1β (IL-1β), interleukin-18 (IL-18), tumor necrosis factor-alpha (TNF-α); neural damage, particularly sheath, neuroinflammation by regulating Eph A4 (EphA4) hippocampal. These results indicate that prevents impairment neuronal probably reducing EphA4, which mediates ROS hyperfunction

Language: Английский

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Effect of acupuncture versus usual care on sleep quality in cancer survivors with chronic pain: Secondary analysis of a randomized clinical trial

Cancer, Journal Year: 2023, Volume and Issue: 129(13), P. 2084 - 2094

Published: March 29, 2023

Chronic pain negatively affects sleep; it is unclear whether relief from acupuncture contributes to sleep quality improvements in cancer survivors. This study aimed evaluate the effect of versus usual care on among survivors with comorbid disturbance and chronic musculoskeletal pain.Sleep outcome data Personalized Electroacupuncture Versus Auricular Acupuncture Comparative Effectiveness (PEACE) randomized clinical trial were analyzed. or auricular was compared for improvement over 10 weeks treatment clinically significant at baseline. Sleep measured Pittsburgh Quality Index (PSQI) global score.Among 268 participants (mean [standard deviation (SD)] age, 61.4 [12.6] years; 191 women [71.3%]; mean [SD] baseline PSQI score, 10.3 [3.3] points), electroacupuncture resulted greater reductions score comparison care: 1.42 points (95% confidence interval [CI], 0.45-2.38; p = .004) 1.59 CI, 0.62-2.55; .001), respectively. The groups sustained 24 randomization. Furthermore, a proportion patients had meaningful group (41.0% 42.9% vs. 21.4%; .044).Among pain, produced relevant persistent quality. These findings suggest that may be an evidence-based nonpharmacologic intervention improve health pain.This analyzed published evaluated people who survived cancer. analysis included prespecified subgroup co-occurring found used demonstrated received care. by after ended.

Language: Английский

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Deficits in brain default mode network connectivity mediate the relationship between poor sleep quality and anxiety severity

SLEEP, Journal Year: 2023, Volume and Issue: 47(3)

Published: Nov. 21, 2023

Abstract Study Objectives Chronic insomnia disorder (CID) is a prevalent sleep that frequently cooccurs with anxiety. The association between and anxiety has been established; however, the neurobiological basis of this relationship remains unclear. This study aimed to investigate neural markers CID patients without determine whether specific connectivity mediates Methods included 180 participants, comprising (CID-A), (CID-NA), good controls. All participants completed self-reported measures quality severity underwent functional magnetic resonance imaging. Brain integration was measured using density (FCD) resting-state (rsFC). Correlation mediation analyses were used examine relationships among brain connectivity, quality, severity. Results CID-NA CID-A groups showed decreased local FCD in medial prefrontal cortex (mPFC) disrupted rsFC precuneus other regions. Only group exhibited altered long-range anterior default mode network (DMN, e.g. mPFC) posterior DMN (e.g. precuneus). Mediation analysis revealed dysconnectivity underlying poor symptoms. Conclusions identified shared distinct circuit disruptions groups, deficits as potential mechanism through which augments These findings may facilitate development personalized therapies for associated problems.

Language: Английский

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Efficacy and safety of electroacupuncture for insomnia: A systematic review and meta-analysis

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(4), P. 459 - 472

Published: May 31, 2024

Language: Английский

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The State of 21st Century Acupuncture in the United States

Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 3329 - 3354

Published: Oct. 1, 2024

Abstract: The term "acupuncture" commonly refers to a non-pharmacologic therapy that is increasingly employed by diverse segments of the population for wide variety complaints including pain, insomnia, anxiety, depression, frozen shoulder, and other issues. also used as short-hand wider medical system from which placement needles into skin therapeutic benefit related techniques evolved. Thus both technique Acupuncture Herbal Medicine (AHM). modalities included within AHM include physical mechanical manipulations, herbal medicines, dietary recommendations, lifestyle modifications. Clinically, acupuncture offered in conventional settings such hospitals, school clinics, veterans' healthcare centers, oncology facilities, rehabilitation its safety profile excellent overall. Barriers further incorporation biomedical sites insurance coverage acupuncture, education practitioners stakeholders about utility, efficacy, evidence base acupuncture. Acupuncturists United States are skilled who highly educated complex arose technical aspects utility treatment modality. training, certification, licensure, regulation acupuncturists similar providers has physician's assistants, advanced practice nurses, osteopathic doctors. While clinical use acceptance continues grow, there date no definitive composite document explaining various settings, current understanding how works, professional regulation, certification practitioners. This article will address these topics strive create reference practitioners, administrators, legislators, providers, patients their families, stakeholders. Plain Language Summary: thin, sterile stimulate healing effects, and, States, it That system, (AHM), uses advice, therapies facilitate health healing. being problems difficulty sleeping, mental concerns, issues supported growing scientific basis why works. Training licensure many process accredited overseen governmental regulatory bodies. paper aims provide an overview training acupuncturists, ways might be incorporated settings. Keywords: medicine, traditional Chinese integrative health, policy

Language: Английский

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Electroacupuncture and Tongbian decoction ameliorate CUMS-induced depression and constipation in mice via TPH2/5-HT pathway of the gut-brain axis

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111207 - 111207

Published: Jan. 14, 2025

Depression is commonly associated with gastrointestinal (GI) disorders, such as constipation, which can potentially intensify depressive symptoms. The interplay between these conditions believed to be facilitated by the gut-brain axis, suggests a complex bidirectional interaction. Current treatments, antidepressants and prokinetics, are often side effects high recurrence rates, highlighting need for effective treatments targeting both depression constipation. This study was designed assess therapeutic efficacy of electroacupuncture (EA) in conjunction Tongbian decoction (TB) management while also investigating underlying mechanisms through lens axis. Chronic unpredictable mild stress (CUMS) employed induce comorbidity model constipation mice, followed administration EA, EA + TB, fluoxetine (FLX). findings demonstrated that antidepressant combination were more pronounced than those alone. TB treatment significantly ameliorated anxiety-like behaviors, restored cognitive function, enhanced motility chronic mice. Furthermore, reduced intestinal inflammation, neuronal morphology, increased expression tryptophan hydroxylase 2 (TPH2) prefrontal cortex (PFC) colon, elevated serum levels 5-hydroxytryptophan (5-HTP)-a molecule acts connector-and promoted synthesis production serotonin (5-HT) tract brain. Contrastingly, FLX showed limited improving In conclusion, regulates TPH2/5-HT pathway via demonstrating synergistic regulation nervous systems, favorable prokinetic effects.

Language: Английский

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Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study

Nature and Science of Sleep, Journal Year: 2025, Volume and Issue: Volume 17, P. 97 - 113

Published: Jan. 1, 2025

COVID-19 has led to reports of fatigue and sleep problems. Brain function changes underlying problems (SP) post-COVID-19 are unclear. This study investigated SP-related brain functional connectivity (FC) alterations. Fifty-five survivors with SP (COVID_SP) 33 without (COVID_NSP), matched for demographics, completed PSQI underwent rs-fMRI at baseline 2-month follow-up. Correlations between FC clinical data were analyzed by Pearson correlation analysis Gaussian random field (GRF) correction. The repeated-measures variance (R-M ANOVA) was explore the interaction time. At baseline, COVID_SP exhibited elevated FC: right precentral gyrus (PrG) left lateral occipital cortex (LOcC)/right PrG, inferior parietal lobule (IPL) superior frontal (SFG), hippocampus (IFG). Higher SFG correlated scores. follow-up, decreased implicated in emotion regulation, executive function, memory; increased semantics, attention, auditory-visual processing. these regions scores PSQI, GAD, PHQ. Repeated-Measures Analysis Variance revealed a significant time effect various scales. Moreover, PrG as well that IPL also discovered effect. provides insight into associated after COVID-19. These may partially explain development SP, they changed over

Language: Английский

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