Phthalate exposure and the metabolic syndrome: A systematic review and meta-analysis

Environmental Pollution, Journal Year: 2023, Volume and Issue: 333, P. 121957 - 121957

Published: June 15, 2023

Phthalates are chemicals widely used in plastic-based consumer products, and human exposure is universal. They classified as endocrine disruptors, specific phthalate metabolites have been associated with an increased risk of cardiometabolic diseases. The aim this study was to assess the association between metabolic syndrome general population. A comprehensive literature search performed four databases (Web Science, Medline, PubMed, Scopus). We included all observational studies that evaluate available until January 31st, 2023. Pooled Odds Ratios (OR) their 95% confidence intervals were calculated by using inverse-variance weighted method. Nine cross-sectional 25,365 participants aged from 12 80 included. Comparing extreme categories exposure, pooled ORs for were: 1.08 (95% CI, 1.02-1.16, I2 = 28%) low molecular weight phthalates, 1.11 1.07-1.16, 7%) high phthalates. For individual metabolites, achieved statistical significance 1.13 1.00-1.27, 24%) MiBP; 1.89 1.17-3.07, 15%) MMP men; 1.12 1.00-1.25, 22%) MCOP; 1.09 0.99-1.20, 0%) MCPP; 1.16 1.05-1.28, 6%) MBzP; 1.09-1.24, 14%) DEHP (including ΣDEHP its metabolites). In conclusion, both phthalates 8 11% higher prevalence MetS, respectively. six a MetS.

Language: Английский

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Impact of Microplastics on the Ocular Surface

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3928 - 3928

Published: Feb. 15, 2023

Plastics are synthetic materials made from organic polymers that ubiquitous in daily living and especially important the healthcare setting. However, recent advances have revealed pervasive nature of microplastics, which formed by degradation existing plastic products. Although impact on human health has yet to be fully characterised, there is increasing evidence microplastics can trigger inflammatory damage, microbial dysbiosis, oxidative stress humans. limited studies investigating their effect ocular surface, other organs provide some insights. The prevalence waste also triggered public outcry, culminating development legislation aimed at reducing commercial We present a review outlining possible sources leading exposure, analyse mechanisms surface damage. Finally, we examine utility consequences current surrounding microplastic regulation.

Language: Английский

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Association between urinary metabolites of volatile organic compounds and cardiovascular disease in the general population from NHANES 2011–2018

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 264, P. 115412 - 115412

Published: Sept. 14, 2023

Volatile organic compounds (VOCs) contain hundreds of chemicals and human exposure to VOCs is pervasive. However, most studies have considered only a single chemical or class similar chemicals.We aimed investigate the association between urinary volatile compound metabolites (mVOCs) risk cardiovascular disease (CVD) in general population.The data this study were collected from National Health Nutrition Examination Survey 2011-2018. Eligible patients aged ≥20 years for whom complete 20 types mVOCs CVD outcomes available. Multivariate logistic regression models used elucidate CVD. Generalized additive examine nonlinear relationships CVD.6814 indiviuals included final analysis, 508 had Higher concentrations N-acetyl-S-(2-carboxyethyl)-L-cysteine (CEMA) N-Acetyl-S-(2-cyanoethyl)-l-cysteine (CYMA) lower concentration 2-aminothiazoline-4-carboxylic acid (ATCA) associated with after adjustment potential confounding factors. A relationship threshold effect observed N-acetyl-S-(N-methylcarbamoyl)-l-cysteine (AMCC) among mVOCs. There was significantly positive correlation AMCC when >2.32 g/mL.The findings suggested significant VOC Urinary may indicate hazardous distinct metabolic traits

Language: Английский

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Prenatal phthalate exposure and sex steroid hormones in newborns: Taiwan Maternal and Infant Cohort Study

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0297631 - e0297631

Published: March 14, 2024

Background Newborn anogenital distance (AGD) has been associated with prenatal exposure of phthalates. The association between phthalate and sex steroid hormones in newborns is unclear. Object This study aimed to examine whether cord-blood hormone levels were newborn (AGD). Methods In the Taiwan Maternal Infant Cohort Study, we recruited 1,676 pregnant women their third trimester 2012–2015 Taiwan. We determined 11 urinary metabolites women, three maternal five sex-hormone concentrations. Five hundred sixty-five mother-infant pairs sufficient data included. Trained neonatologists measured 263 newborns’ AGD. examined associations metabolite AGD using linear regression models evaluated correlations Results Compared male exposed at first tertile, was -3.75, -3.43, -3.53 mm shorter among those median tertile di-2-ethylhexyl (DEHP) metabolites, monobenzyl (MBzP), monomethyl (MMP), respectively. who had follicle-stimulating (FSH) decreased higher MMP, mono-n-butyl (MnBP), MBzP DEHP, female mono(2-ethyl-5-hydroxyhexyl) phthalate. However, did not observe significant or AGDs. Conclusions Alterations exposures, particularly newborns. Women aspiring be should alerted need reducing exposure.

Language: Английский

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Phthalate metabolites and sex steroid hormones in relation to obesity in US adults: NHANES 2013-2016

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Background Obesity and metabolic syndrome pose significant health challenges in the United States (US), with connections to disruptions sex hormone regulation. The increasing prevalence of obesity might be associated exposure phthalates (PAEs). Further exploration impact PAEs on is crucial, particularly from a perspective. Methods A total 7780 adult participants National Health Nutrition Examination Survey (NHANES) 2013 2016 were included study. Principal component analysis (PCA) coupled multinomial logistic regression was employed elucidate association between urinary metabolite concentrations likelihood obesity. Weighted quartiles sum (WQS) utilized consolidate mixed levels (total testosterone (TT), estradiol hormone-binding globulin (SHBG)). We also delved into machine learning models accurately discern status identify key variables contributing most these models. Results Component 1 (PC1), characterized by mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-hydroxyhexyl) (MEHHP), mono(2-ethyl-5-oxohexyl) (MEOHP) as major contributors, exhibited negative Conversely, PC2, monocarboxyononyl (MCNP), monocarboxyoctyl (MCOP), mono(3-carboxypropyl) (MCPP) showed positive Mixed decreased TT increased SHBG. During interrelations among obesity, hormones, PAEs, based Random Forest (RF) eXtreme Gradient Boosting (XGBoost) algorithms demonstrated best classification efficacy. In both models, hormones highest variable importance, certain metabolites made contributions model’s performance. Conclusions Individuals exhibit lower SHBG, accompanied elevated levels. Exposure disrupts levels, an risk US adults. interrelationships three factors, RF XGBoost algorithm superior performance, displaying higher importance.

Language: Английский

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Association of polycystic ovary syndrome with cardiovascular disease among female hospitalizations in the United States

European Journal of Endocrinology, Journal Year: 2023, Volume and Issue: 188(6), P. 555 - 563

Published: June 1, 2023

Polycystic ovary syndrome (PCOS) is a complex disorder characterized by wide range of symptoms related to ovulatory dysfunction and androgen overproduction. Although PCOS associated with multiple cardiovascular disease (CVD)-risk factors, previous studies have reported controversial associations between different types CVD events. We sought determine the association various outcomes among hospitalized women.All women hospitalizations ages 15 65 years recorded in National Inpatient Sample database, 2017 were analyzed sampling-weighted logistic regression analysis. The International Classification Diseases, 10th revision, codes used define including composite CVD, major adverse events (MACEs), coronary heart (CHD), stroke/cerebrovascular accident (CVA), failure (HF), arterial fibrillation (AF) or arrhythmia, pulmonary (PHD), myocardial infarction, cardiac arrest, diabetes.Among total women, 13 896 (0.64) had diagnosis. was found be most outcomes, (adjusted odds ratio [aOR] = 1.73, 95% CI, 1.55-1.93, P < .001), MACE (aOR 1.31, 1.12-1.53, CHD 1.65, 1.35-2.01, stroke/CVA 1.46, 1.08-1.98, .014), HF 1.30, 1.07-1.57, .007), AF/arrhythmia 2.20, 1.88-2.57, PHD 1.58, 1.23-2.03, .001) an age ≤40 years. However, mediated obesity metabolic conditions.Polycystic conditions, particularly aged United States.

Language: Английский

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Association between urinary phthalate metabolites and nephrolithiasis in adults: A cross-sectional analysis with NHANES 2007–2018

Chemosphere, Journal Year: 2023, Volume and Issue: 337, P. 139436 - 139436

Published: July 6, 2023

Language: Английский

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The association of urinary heavy metal exposure with frailty susceptibility and mortality in middle-aged and older adults: a population-based study

Archives of Public Health, Journal Year: 2024, Volume and Issue: 82(1)

Published: March 27, 2024

Abstract Heavy metals’ presence as environmental pollutants has a close link to adverse health effects. Frailty, clinical syndrome hallmarked by elevated vulnerability stressors, presents substantial challenge in healthcare. However, the association between exposure heavy metals and frailty largely remains unexplored. Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2003–2018 correlated with U.S. Death Index (NDI) 2019, we investigated mortality outcomes. Logistic regression, Cox Kaplan-Meier survival curves, weighted quantile-sum (WQS) Bayesian kernel machine regression (BKMR) were employed assess metal incidence frail population. Eight measured urine using inductively coupled plasma mass spectrometry values adjusted for urinary creatinine, which was used reflect exposure. The cohort incorporated 5370 female participants aged 45 above, 1518 diagnosed frailty. findings indicated correlation specific metals, namely tungsten (odds ratio [OR]: 1.94, 95% confidence interval [CI]: 1.31–2.89), cobalt (OR: 1.64, CI: 1.40–1.93), cadmium 1.93, 1.52–2.43), uranium 7.36, 1.53–35.28), an risk of WQS BKMR models identified cadmium, cobalt, main contributors analysis, after adjustment covariates, suggested that higher levels lead, death patients, associated hazard ratios (HR) 1.96 (1.53, 2.52) 1.30 (1.13, 1.49), respectively. Our study revealed significant positive mixtures onset middle-aged older adults, along increased patients. Cobalt, emerged prominent frailty, directly impacting long-term life expectancy

Language: Английский

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Associations of sex hormone ratios with metabolic syndrome and inflammation in US adult men and women

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

Sex hormones play a critical role in sex differences and cardiovascular disease risk associated with metabolic syndrome (MS) inflammation. However, the associations of hormone ratios inflammatory markers are unclear according to age differences. We evaluated MS inflammation among males females.

Language: Английский

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Identifying cardiovascular disease risk in the U.S. population using environmental volatile organic compounds exposure: A machine learning predictive model based on the SHAP methodology

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117210 - 117210

Published: Oct. 23, 2024

Language: Английский

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