Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Sept. 18, 2024
Humans are commonly exposed to plastic through their dietary intake and food consumption patterns. Plastic-associated chemicals (PAC), such as bisphenols phthalates, recognized endocrine-disrupting associated with increased risk of cardiovascular disease metabolic syndrome. However, accurate methods assess exposure products PAC inadequate, limiting interrogation health impacts.
Language: Английский
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(5), P. 1948 - 1956
Published: Jan. 24, 2024
Organic electrochemical transistors with signal amplification and good stability are expected to play a more important role in the detection of environmental pollutants. However, bias voltage at gate may have an effect on activity vulnerable biomolecules. In this work, novel organic photoelectrochemical transistor (OPECT) aptamer biosensor was developed for di(2-ethylhexyl) phthalate (DEHP) by combining analysis transistor, where MXene/Bi2S3/CdIn2S4 employed as photoactive material, target-dependent DNA hybridization chain reaction used unit, Ru(NH3)63+ selected enhancement molecule. The poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)-based OPECT modulated photosensitive material achieved high current gain nearly thousand times zero voltage. signal-on sensing platform realized sensitive specific DEHP, range 1–200 pM minimum limit 0.24 under optimized experimental conditions, its application real water samples also evaluated satisfactory results. Hence, construction biosensing not only provides promising tool DEHP but reveals great potential other toxins.
Language: Английский
Citations
14
Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29684 - e29684
Published: April 1, 2024
Phthalates, widely utilized in industrial products, are classified as endocrine-disrupting chemicals (EDCs). Although certain phthalate and their metabolites have been implicated cancer development, the reported findings exhibited inconsistencies. Therefore, we conducted comprehensive literature search to assess association between risk by identifying original studies measuring phthalates or reporting correlation with until July 4, 2023. The Odds Ratios (ORs) corresponding 95% confidence intervals (CIs) were extracted analyzed estimate risk. Pooled data from eleven studies, including 3101 patients 6858 controls, using a fixed- random-effects model based on heterogeneity tests. When comparing extreme categories of different metabolites, observed significant urinary (MEHHP, MECPP, DBP MBzP) our meta-analysis reinforce existing evidence that is strongly associated development. Further investigations warranted elucidate underlying mechanisms this association. These results may offer novel insights into
Language: Английский
Citations
9
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 15, 2024
Diabetes and its complications significantly affect individuals’ quality of life. The etiology diabetes mellitus associated is complex not yet fully understood. There an increasing emphasis on investigating the effects endocrine disruptors diabetes, as these substances can impact cellular processes, energy production, utilization, ultimately leading to disturbances in homeostasis. Mitochondria play a crucial role generation, any impairment organelles increase susceptibility diabetes. This review examines most recent epidemiological pathogenic evidence concerning link between including complications. analysis suggests that disruptor-induced mitochondrial dysfunction—characterized by disruptions electron transport chain, dysregulation calcium ions (Ca 2+ ), overproduction reactive oxygen species (ROS), initiation signaling pathways related apoptosis—may be key mechanisms connecting development
Language: Английский
Citations
8
Environmental Pollution, Journal Year: 2023, Volume and Issue: 340, P. 122714 - 122714
Published: Oct. 14, 2023
Language: Английский
Citations
14
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: Sept. 25, 2024
Non-alcoholic fatty liver disease (NAFLD) is the most common disease. Phthalates have been suggested to influence development of NAFLD due their endocrine-disrupting properties, but studies based on nationally representative populations are insufficient, and existing seem reached conflicting conclusions. Due changes in legislation, use traditional phthalates has gradually decreased, substitutes getting more attention. This study aims delve deeper into how choice diagnostic approach influences observed correlations concern about alternatives phthalates, thereby offering precise references for prevention treatment NAFLD. A cohort 641 participants, sourced from National Health Nutrition Examination Survey (NHANES) 2017-2018 database, was evaluated using three methods: Hepatic Steatosis Index (HSI), US Fatty Liver Indicator (US.FLI), Vibration Controlled Transient Elastography (VCTE). The urinary metabolite concentrations Di-2-ethylhexyl phthalate (DEHP), Di-isodecyl (DIDP), Di-isononyl (DINP), Di-n-butyl (DnBP), Di-isobutyl (DIBP), Di-ethyl (DEP) Di-n-octyl (DnOP) were detected. association between metabolites through univariate multivariate logistic regression analyses, considering different concentration gradients phthalates. Univariate analysis found significant specific metabolites, such as Mono-(2-ethyl-5-oxohexyl) (MEOHP), Mono-(2-ethyl-5-hydroxyhexyl) (MEHHP), Mono-2-ethyl-5-carboxypentyl (MECPP), Mono-(carboxyisoctyl) (MCiOP), across criteria. In a adjusting only demographic data, MEOHP (OR = 3.26, 95% CI 1.19-8.94, p 0.029), MEHHP 3.98, 1.43-11.1, 0.016), MECPP 3.52, 1.01-12.2, 0.049), MCiOP 4.55, 1.93-10.7, 0.005) positively related defined by HSI VCTE. correlation strength varied with indicating potential dose-response relationship. Adjusting all covariates regression, 4.22, 1.10-16.2, 0.044), an oxidative DINP, remained significantly associated under VCTE criterion, suggesting its role risk factor research highlights DINP These findings underscore need further investigation pathogenesis importance criteria research.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4599 - 4599
Published: April 23, 2024
Early life exposure lays the groundwork for risk of developing cardiovascular-kidney-metabolic (CKM) syndrome in adulthood. Various environmental chemicals to which pregnant mothers are commonly exposed can disrupt fetal programming, leading a wide range CKM phenotypes. The aryl hydrocarbon receptor (AHR) has key role as ligand-activated transcription factor sensing these chemicals. Activating AHR through been documented its adverse impacts on cardiovascular diseases, hypertension, diabetes, obesity, kidney disease, and non-alcoholic fatty liver evidenced by both epidemiological animal studies. In this review, we compile current human evidence findings from models that support connection between antenatal chemical exposures focusing particularly signaling. Additionally, explore potential modulators aimed at preventing syndrome. As pioneering review present advocating avoidance toxic during pregnancy deepening our understanding signaling, mitigate global burden future.
Language: Английский
Citations
4
Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125830 - 125830
Published: Feb. 1, 2025
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 14, 2025
Pesticides, polycyclic aromatic hydrocarbons (PAHs), and phthalates are recognized as potential contributors to metabolic disorders. Nevertheless, the combined effect of simultaneous exposure these chemicals on syndrome (MetS) remains elusive. To explore impacts pesticides, PAHs identify critical MetS. Based National Health Nutrition Examination Survey (NHANES) database from 2007—2012, our study included 4030 non-pregnant individuals aged 20 years or older. We used weighted linear regression model, variable selection models (including LASSO BMA models), well a mixture model (WQS model) investigate correlation between Additionally, stratified analyses were performed based gender age. The generalized revealed positive 2-hydroxyphenanthrene (2-PHEN) with MetS (OR: 1.37, 95% CI: 1.19–1.59, P < 0.001). Both identified 2-PHEN significant chemical positively associated WQS showed association overall three categories MetS, highest being 2-PHEN. Stratified demonstrated different subgroups. Notably, in subgroup female (OR = 1.40, 1.08–1.83, 0.05), 2-PHEN, 2,5-dichlorophenol (2,5-DCP), 2-hydroxynaphthalene (2-NAP), mono-ethyl phthalate (MEP) primary contributions Combined groups was an increased risk group exhibiting most pronounced emerging key chemical, underscoring public health concerns regarding risks endocrine-disrupting (EDCs) diseases.
Language: Английский
Citations
0
Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121186 - 121186
Published: Feb. 1, 2025
Language: Английский
Citations
0
Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4118 - 4118
Published: April 9, 2025
This study is a review of current knowledge on microplastics (MPs) in aquatic environments. In addition to identifying the sources contamination by MPs water and hazards their presence, an attempt made systematize terminology polymeric microparticles according size describe other parameters characteristic MPs, i.e., shape color. Special focus was placed most important methods used extract from environmental matrices, as well latest effective analytical methods, highlighting advantages disadvantages. The value paper pointing out developments analytics, existing inaccuracies limitations field providing practical guidance. Thanks its comprehensive approach, this article valuable resource for researchers concerned with problem pollution.
Language: Английский
Citations
0