Reactions Weekly, Journal Year: 2023, Volume and Issue: 1951(1), P. 10 - 10
Published: April 6, 2023
Language: Английский
Published: June 13, 2024
Vaccine antigens must present the correct conformation of viral fusion glycoproteins to elicit effective immune responses. Virus-like particles (VLPs) serve as promising vaccine platforms because they mimic membrane-embedded conformations on native viruses. Here, we employed SARS-CoV-2 VLPs (SMEN) presenting ancestral, Beta, or Omicron spikes identify variant that elicits potent and cross-protective responses in highly sensitive K18-hACE2 mouse model. A combined intranasal intramuscular administration regimen SMEN generated was predominantly mediated by antibodies with minor contributions from T cells. Immunization an ancestral spike resulted 100, 75, 0% protection against Delta Beta VOC-induced mortality, respectively, whereas most divergent provided only limited (50%, 0%, 25%) Delta, variants, respectively. By contrast, a offered 100% variants used this study. Thus, not overcame immunity produced other but also elicited diverse response. Our findings suggest leveraging protein can enhance immunity, potentially leading more comprehensive emerging variants.
Language: Английский
Citations
2
Journal of Korean Medical Science, Journal Year: 2024, Volume and Issue: 39(42)
Published: Jan. 1, 2024
Despite their effectiveness, coronavirus disease 2019 (COVID-19) vaccines have been associated with adverse effects, underscoring the importance of continuous surveillance to ensure vaccine safety and effective management public health. Herein, characteristics risk factors vaccine-related events (AEs) were identified gain an in-depth understanding by investigating impact vaccination dose on changes in post-vaccination AEs.
Language: Английский
Citations
2
Journal of Psychosomatic Research, Journal Year: 2023, Volume and Issue: 176, P. 111567 - 111567
Published: Dec. 11, 2023
Treatment expectations reportedly shape treatment outcomes, but have not been studied in the context of multimodal therapy Crohn's disease (CD). Therefore, current study investigated role for subjective symptom changes CD patients who undergone an integrative program.
Language: Английский
Citations
4
Patient Preference and Adherence, Journal Year: 2024, Volume and Issue: Volume 18, P. 1299 - 1310
Published: June 1, 2024
Purpose: Psoriasis is a highly debilitating chronic inflammatory disease. Increased understanding of its pathophysiology has enabled development targeted treatments such as biologics. Several medical have been shown to be influenced by patients' experiences and expectations. However, only little known about with expectations towards Our objectives were identify treatment assess their trajectories over the course IL-17A inhibitor secukinumab. Moreover, we aimed document effects psoriasis, factors that influence symptomatology, prior experiences. Patients Methods: We conducted semi-structured interviews n = 24 patients moderate-to-severe plaque psoriasis employed qualitative content analysis derive thematic evaluative codes. Findings validated via peer debriefings experienced dermatologists. Results: reported burdensome physical psychological symptoms identified can improve or worsen including stress self-efficacy. Prior mostly negative. Past barriers effective included time constraints limited access. Concerning secukinumab, initially expected complete partial remission occurrence absence side effects. Closer inspection revealed three trajectories. For most patients, initial met future remained unchanged. other however, experience did not match expectation. One group then adapted according experience, while not. Conclusion: To our knowledge, this first study effectiveness effects, trajectories, interplay among patients. findings highlight value further research on subject in order optimize care for learn more general. Plain Language Summary: Patients' certain how well it will work whether occur Such wide range conditions, dermatological ones. suffering from skin disease, modern biologics offer promising options. Therefore, are likely associated high Yet, roles undergoing biologic received attention date. With study, understand perspectives these treatments, they suffer from, past biologic. end, transcribed after several months treatment. analyzed interview transcripts determine underlying categories summarized common framework. found often controlled treatments. Still, had positive regard large actual expectations, leaving them unchanged future. Another important finding was good influencing symptomatology had, like The may aid doctors clinical work, Keywords: psychodermatology, patient perspective, success, doctor-patient relationship, secukinumab
Language: Английский
Citations
1
Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 1007 - 1007
Published: Sept. 2, 2024
Virus-like particles (VLPs) are non-infectious and serve as promising vaccine platforms because they mimic the membrane-embedded conformations of fusion glycoproteins on native viruses. Here, we employed SARS-CoV-2 VLPs (SMEN) presenting ancestral, Beta, or Omicron spikes to identify variant spike that elicits potent cross-protective immune responses in highly sensitive K18-hACE2 challenge mouse model. A combined intranasal intramuscular SMEN regimen generated most effective significantly reduce disease burden. Protection was primarily mediated by antibodies, with minor but distinct contributions from T cells reducing virus spread inflammation. Immunization carrying ancestral resulted 100, 75, 0% protection against Delta, Beta variant-induced mortality, respectively. However, an provided only limited (50%), Delta (0%), (25%) challenges. By contrast, offered 100% variants used this study. Thus, not overcame immunity produced other variants, also elicited diverse humoral responses. Our findings suggest leveraging protein can enhance immunity, potentially leading a more comprehensive emerging variants.
Language: Английский
Citations
1
Public Health, Journal Year: 2024, Volume and Issue: 237, P. 299 - 306
Published: Oct. 31, 2024
Language: Английский
Citations
1
Published: Sept. 13, 2023
Background: Vaccination is one of the most effective life-saving medical interventions, and introduction SARS-CoV-2 vaccines was intended to prevent serious implications COVID-19. The objectives study were: i) observe humoral immune response BNT162b2 vaccine infection (mainly breakthrough infections), ii) demonstrate persistence anti-SARS-CoV-2 antibodies over time in relation number received doses course infection, iii) determine adverse effects after primary doses. Methods: To assess response, IgG IgA anti-S1 were quantified by ELISA assays. In total, tests carried out seven times almost two years. Results: We demonstrated strong immunogenicity (compared levels before vaccination, 150- 20-fold increases IgA, respectively) vaccine. Over time, we observed a systematic decline antibody levels, which may have contributed infections. Although they caused seroconversion similar booster, such patients fell more rapidly than re-vaccination. On other hand, individuals who did not receive booster(s) present returned pre-vaccination 20 months. commonly recognized injection site redness swelling. Conclusion: highly preventing severe outcomes COVID-19 should be performed regardless prior infection. Booster significantly enhance and, contrast those obtained remain longer.
Language: Английский
Citations
2
NeuroImmunoModulation, Journal Year: 2023, Volume and Issue: 30(1), P. 250 - 267
Published: Jan. 1, 2023
The immune system and the central nervous exchange information continuously. This communication is a prerequisite for adaptive responses to physiological psychological stressors. While implicate relationship between inflammation pain increasingly recognized in clinical cohorts, underlying mechanisms possibilities pharmacological approaches aimed at neuro-immune are not fully understood yet. calls preclinical models which build bridge from research laboratory research. Experimental of systemic (experimental endotoxemia) humans have been as an approach study direct causal effects on perception. narrative review provides overview what experimental endotoxemia studies able clarify so far. We report that results reproducible increase sensitivity, particularly pressure visceral (deep pain), reflected brain areas involved processing. Increased levels blood inflammatory cytokines required this effect, but cytokine do always predict intensity. address sex-dependent differences immunological endotoxin discuss why these necessarily translate behavioral measures. summarize cognitive factors may moderate sensitization driven by activation. Together, studying immune-driven changes during offers deeper mechanistic understanding role chronic pain. can specifically help tease out individual differences, vulnerabilities, comorbid problems syndromes. model opportunity test efficacy interventions, increasing their translational applicability personalized medical approaches.
Language: Английский
Citations
2
Vaccines, Journal Year: 2023, Volume and Issue: 11(10), P. 1578 - 1578
Published: Oct. 10, 2023
Vaccination is one of the most effective life-saving medical interventions, and introduction SARS-CoV-2 vaccines was intended to prevent serious implications COVID-19. The objectives study were (i) observe humoral immune response BNT162b2 vaccine infection (mainly breakthrough infections), (ii) demonstrate persistence anti-SARS-CoV-2 antibodies over time in relation number received doses course infection, (iii) determine adverse effects after primary doses. To assess response, IgG IgA anti-S1 quantified by ELISA assays. In total, tests carried out seven times almost two years. We demonstrated strong immunogenicity (compared levels before vaccination, 150- 20-fold increases IgA, respectively) vaccine. Over time, we observed a systematic decline antibody levels, which may have contributed infections. Although they caused seroconversion similar booster, such patients fell more rapidly than re-vaccination. On other hand, individuals who did not receive booster(s) present returned pre-vaccination 20 months. commonly recognized injection site redness swelling. highly preventing severe outcomes COVID-19 should be performed regardless prior infection. Booster significantly enhance and, contrast those obtained remain longer.
Language: Английский
Citations
2
BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 12, 2024
The outbreak of the SARS-CoV-2 pandemic has had a significant impact on human lives, and development effective vaccines been promising solution to bring an end pandemic. However, success vaccination program heavily relies portion population being vaccinated. Recent studies have indicated rise in vaccine hesitancy over time inconsistent factors affecting it. This study aimed synthesis pooled prevalence COVID-19 associated among various communities East Africa. review encompassed relevant descriptive observational conducted between January 1, 2020, December 26, 2023. We browsed databases, including PubMed, Google Scholar, Scopus, African online Journal, cross-references, Web Science. After extracted exported R data analysis was performed using version 4.2. Meta-package were used estimate hesitancy. Publication bias assessed through funnel plots, Egger's test, trim-and-fill methods. carefully screening initial pool 53,984 studies, total 79 included this systematic meta-analysis. overall 40.40% (95% CI: 35.89%; 45.47%, I2: 99.5%). Identified influencing hesitance female sex, under 40 years old, inadequate prevention practices, relying web/internet as source information, having negative attitude towards vaccine, uncertainty about safety, fear adverse effects, contracting COVID-19, belief conspiracy myths. Approximately four out ten individuals region express vaccination. A tailored approach that considers socio-demographic context could significantly reduce To achieve high coverage, comprehensive strategy is essential, necessitating substantial social, scientific, health efforts. campaigns within widespread consistent implementation interventions. Registered PROSPERO with ID: CRD42024501415.
Language: Английский
Citations
0