A Review on Recent Advances of Cerebral Palsy

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 20

Published: July 30, 2022

This narrative review summarizes the latest advances in cerebral palsy and identifies where more research is required. Several studies on were analyzed to generate a general idea of prevalence of, risk factors associated with, classification (CP). Different systems used for CP functional basis also analyzed. Diagnosis along with prevention techniques discussed. State-of-the-art treatment strategies Statistical distribution was performed based selected studies. Prevalence found be 2-3/1000 lives; that can correlated are gestational age birth weight. The identified preconception, prenatal, perinatal, postnatal categories. According evidence, classified into spastic (80%), dyskinetic (15%), ataxic (5%) forms. approaches clinical investigation neurological examinations include magnetic resonance imaging (MRI), biomarkers, cranial ultrasound. procedures medical surgical interventions, physiotherapy, occupational therapy, umbilical milking, nanomedicine, stem cell therapy. Technological advancements most common neuromotor disability lives. highest contributing factor prematurity being underweight. preventions diagnostic like MRI ultrasound used. Treatment cord blood nanomedicine therapy needs investigated further future apply practice. Future indicated context technological among children.

Language: Английский

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Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants

Cochrane library, Journal Year: 2024, Volume and Issue: 2024(2)

Published: Feb. 13, 2024

Language: Английский

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Cord Blood Treatment for Children With Cerebral Palsy: Individual Participant Data Meta-Analysis

PEDIATRICS, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

CONTEXT Umbilical cord blood (UCB) is a novel treatment for cerebral palsy (CP), with trials indicating UCB can improve gross motor function. However, heterogeneity has limited the ability to interpret findings. OBJECTIVE Assess safety and efficacy of improving function in children CP, including exploring cell dose effect responder subgroups. DATA SOURCES Individual participant data from published reports registered identified via systematic searches. STUDY SELECTION Studies administering individuals CP collecting Gross Motor Function Measure (GMFM) scores. Data EXTRACTION A 1-stage individual meta-analysis was conducted R obtain pooled on GMFM using linear mixed models. Responder subgroups were also investigated. RESULTS Four hundred ninety-eight records obtained 11 studies. Main analysis 170 participants treated 171 controls demonstrated increased mean GMFM-66 score compared by 1.36 points at 6 months (95% CI, 0.41–2.32; P = .005) 1.42 12 0.31–2.52; .012). Mean size increasing 3 (P < .001) .047). severity baseline age associated size. The rate serious adverse events similar between groups. LIMITATIONS Heterogeneity across variables time points, reducing subanalysis power. CONCLUSIONS safe provides benefit some higher doses Younger (aged approximately <5 years) milder showed benefit. Findings will help design future precision.

Language: Английский

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Preterm Brain Injury and Neurodevelopmental Outcomes: A Meta-analysis

PEDIATRICS, Journal Year: 2022, Volume and Issue: 150(6)

Published: Nov. 4, 2022

CONTEXT Preterm brain injuries are common; neurodevelopmental outcomes following contemporary neonatal care continually evolving. OBJECTIVE To systematically review and meta-analyze among preterm infants after intraventricular hemorrhage (IVH) white matter injury (WMI). DATA SOURCES Published grey literature were searched across 10 databases between 2000 2021. STUDY SELECTION Observational studies reporting 3-year for with IVH or WMI compared without injury. EXTRACTION Study characteristics, population outcome data extracted. RESULTS Thirty eight included. There was an increased adjusted risk of moderate-severe impairment grade 1 to 2 (adjusted odds ratio 1.35 [95% confidence interval 1.05–1.75]) 3 4 4.26 [3.25–5.59]). Children had higher risks cerebral palsy (odds [OR] 1.76 [1.39–2.24]), cognitive (OR 1.79 [1.09–2.95]), hearing 1.83 [1.03–3.24]), visual 1.77 [1.08–2.9]). markedly 4.98 [4.13–6.00]), motor 2.7 [1.52–4.8]), 2.3 [1.67–3.15]), 2.44 [1.42–4.2]), 5.42 [2.77–10.58]). much 14.91 [7.3–30.46]), 5.3 [3–9.36]), 3.48 [2.18–5.53]). LIMITATIONS Heterogeneity data. CONCLUSIONS Mild IVH, severe associated adverse outcomes. Utilization core sets availability open-access study would improve our understanding the nuances these

Language: Английский

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Development and Validation of a Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants at High Risk

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(7), P. e2221325 - e2221325

Published: July 11, 2022

Early identification of cerebral palsy (CP) is important for early intervention, yet expert-based assessments do not permit widespread use, and conventional machine learning alternatives lack validity.

Language: Английский

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Neurodevelopmental Therapy for Cerebral Palsy: A Meta-analysis

PEDIATRICS, Journal Year: 2022, Volume and Issue: 149(6)

Published: May 24, 2022

BACKGROUND AND OBJECTIVE Bobath therapy, or neurodevelopmental therapy (NDT) is widely practiced despite evidence other interventions are more effective in cerebral palsy (CP). The objective to determine the efficacy of NDT children and infants with CP high risk CP. METHODS Cumulative Index Nursing Allied Health Literature, Cochrane Library, Embase, Medline were searched through March 2021. Randomized controlled trials comparing any no intervention included. Meta-analysis was conducted standardized mean differences calculated. Quality assessed by using Risk Bias tool-2 certainty Grading Recommendations Assessment, Development, Evaluation. RESULTS Of 667 records screened, 34 studies (in 35 publications, 1332 participants) met inclusion. Four meta-analyses assessing motor function. We found effect between control (pooled size 0.13 [−0.20 0.46]), a moderate favoring activity-based approaches (0.76 [0.12 1.40]) body function structures (0.77 [0.19 1.35]) over higher- lower-dose (0.32 [−0.11 0.75]). A strong recommendation against use at dose made. Studies not all Consolidated Standards Reporting Trials-compliant. versus comparator had considerable heterogeneity (I2 = 80%) reflecting varied measures. CONCLUSIONS that structure than for improving function, control, higher-dose lower-dose. Deimplementation required.

Language: Английский

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Motherese Directed at Prelinguistic Infants at Risk for Neurological Disorders: An Exploratory Study

Journal of Child Language, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: Jan. 10, 2025

Abstract To investigate how a high risk for infant neurological impairment affects the quality of verbal interactions, and in particular properties infant-directed speech, spontaneous interactions between 14 mothers their 4.5-month-old infants at disorders (7 female) were recorded acoustically compared with those dyads typically developing (8 female). Mothers at-risk had proportionally less voicing, proportion voicing decreased increasing severity infants’ long-term outcome. Follow-up analysis based on manual annotation phonation style revealed breathy as more common toward severe outcomes (N=7; 44.7% speech) than controls (N=14; 22.0%; p =0.005) or typical mildly abnormal 16.5%; =0.002). The results indicate that maternal during early dyadic is affected by infant’s condition.

Language: Английский

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From eligibility to diagnosis: candidacy and the complex journey of cerebral palsy diagnosis within primary care

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 12, 2025

Language: Английский

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Upper limb training for young children with unilateral cerebral palsy using video coaching: An explorative retrospective clinical study

Australian Occupational Therapy Journal, Journal Year: 2025, Volume and Issue: 72(2)

Published: March 24, 2025

Abstract Introduction Young children with unilateral cerebral palsy (CP) received a home‐based training program using video coaching for parents. The primary aim of our study was to evaluate the effectiveness on use affected arm and hand during bimanual activities explore factors that affect treatment response. Secondary, we evaluated whether effects were retained after an 8‐week break, if data available, explored second uni‐ or block. Furthermore, adherence evaluated. Methods Explorative retrospective clinical evaluating first block (Mini‐) Assisting Hand Assessment ((Mini‐) AHA) unit score in 81 aged 8–36 months. Pre‐ post‐intervention (T0–T1) follow‐up measurements (T2) evaluated, influencing response explored, linear mixed models (LMM). Additionally, 31 original children, contingent upon availability, T3–T4 included. Adherence, measured as percentage duration, explored. Results Mini‐AHA AHA scores significantly improved between T0 T1, but did not change T1 T2. In 18 months older, baseline related scores. <18 months, no predictors identified. LMM showed significant improvement T1–T3 T1–T4 Adherence rates 85% 81% Conclusions Our suggest upper limb can improve infants toddlers CP, break further enhancement following Individual results differed, controlled studies are needed strengthen evidence. High program's feasibility. Consumer Community Involvement Statement There direct consumer community involvement design. PLAIN LANGUAGE SUMMARY Cerebral is caused by brain injury around birth most common physical disability affecting their movement. Children one side body often less, making daily harder. Training 2 years life important because still very adaptable. study, young palsy, blocks 8 weeks therapy We looked at how well hand. also lasted use. Lastly, families continued train. found older than poorer start made more progress, while especially younger demonstrated Most parents able continue coaching. Early help Video seems effective motivate program. varied. need larger studies.

Language: Английский

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The screening Hand Assessment for Infants: Feasibility, validity, and reliability based on parents' recordings

Developmental Medicine & Child Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

To evaluate the concurrent validity and interrater reliability of remote screening Hand Assessment for Infants (s-HAI) in infants aged 3.5 to 12 months at risk unilateral cerebral palsy (CP), assess feasibility parents administering recording s-HAI play session using a smartphone app. In this observational study, 30 (10 females) CP were assessed with s-HAI, administered by their parents, compared HAI conducted clinical setting. The quality recordings was parents' experiences collected questionnaire. Spearman's rank correlation coefficient (rs) calculated Each Sum score corresponding six-item HAI. intraclass coefficient2,1. Parents recorded good found it feasible. A strong rs = 0.86 (p < 0.001) between Interrater 0.96 (95% confidence interval [CI] 0.92-0.99) affected hand, 0.95 CI 0.90-0.98) non-affected moderate excellent individual items. measures same construct as HAI, demonstrating reliable scoring raters when remotely making viable tool early identification CP.

Language: Английский

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