Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122815 - 122815
Published: June 11, 2024
Language: Английский
Citations
19
Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 117, P. 473 - 492
Published: Feb. 8, 2024
The gut and brain are increasingly linked in human disease, with neuropsychiatric conditions classically attributed to the showing an involvement of intestine inflammatory bowel diseases (IBDs) displaying ever-expanding list neurological comorbidities. To identify molecular systems that underpin this gut-brain connection thus discover therapeutic targets, experimental models dysfunction must be evaluated for effects. In present study, we examine disturbances along axis a widely used murine model colitis, dextran sodium sulfate (DSS) model, using high-throughput transcriptomics unbiased network analysis strategy coupled standard biochemical outcome measures achieve comprehensive approach key disease processes both colon brain. We reproducibility colitis induction its resulting genetic programs during different phases finding DSS-induced is largely reproducible few site-specific features. focus on circulating immune system as intermediary between brain, which exhibits activation pro-inflammatory innate immunity colitis. Our provides supporting evidence suggests myelination may process vulnerable increased intestinal permeability, identifies possible role oxidative stress oxygenation. Overall, provide evaluation multiple prevalent will inform future studies others, assist identification druggable targets axis, contribute our understanding concomitance dysfunction.
Language: Английский
Citations
11
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 13, 2024
Background Gut microbiota is an important factor affecting host health. With the further study of mechanism gut microbiota, significant progress has been made in link between and epigenetics. This visualizes body knowledge research priorities epigenetics through bibliometrics. Methods Publications related to were searched Web Science Core Collection (WoSCC) database. Vosviewer 1.6.17 CiteSpace 6.1.R2 used for bibliometric analysis. Results WoSCC includes 460 articles from 71 countries. The number publications on increased each year since 2011. USA, PEOPLES R CHINA, ITALY are at center this field research. University California System, Harvard University, London main institutions. Li, X, Yu, Q, Zhang, S X top authors field. We found that current hotspots frontiers include short-chain fatty acids (SCFA) play role epigenetic mechanisms, obesity, diet, metabolism. closely colorectal cancer, breast inflammatory bowel disease. At same time, we regulates gut-brain axis impact psychiatric diseases. Therefore, probiotics can regulate improve lifestyle, reduce occurrence development Conclusion first comprehensive in-depth trends developments helps guide direction scholars their study.
Language: Английский
Citations
9
Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)
Published: Jan. 14, 2025
Digestive and psychiatric disorders tend to co-occur, yet mechanisms remain unclear. Leveraging genetic transcriptomic data integration, we conduct multi-trait analysis of GWAS (MTAG) weighted gene co-expression network (WGCNA) explore shared mechanism between gastrointestinal disorders. Significant correlations were found these disorders, especially in irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), depression (DEP), neuroticism (NE). MTAG identify 60 novel pleiotropic loci for IBS 14 GERD, predominantly located near genes associated with neurological pathways. Further WGCNA identifies multiple modules enriched involved pathways digestive tissues, some strongly preserved across brain tissues. Moreover, our suggests BSN, CELF4, NRXN1 as central players the regulation gut-brain axis (GBA). This study enhances understanding GBA underscores crucial targets future research. Genetics transcriptomics reveal highlighting loci. Genes regulate axis, revealing potential therapeutic targets.
Language: Английский
Citations
1
Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 25, 2025
Advancements in single-cell multimodal techniques have greatly enhanced our understanding of disease-relevant loci identified through genome-wide association studies (GWASs). To investigate the biological connections between eye and brain, we integrated bulk multiomic profiles with GWAS summary statistics for eight neuropsychiatric five ocular diseases. Our analysis uncovered latent factors explaining 61.7% genetic variance across these 13 diseases, revealing diverse correlational patterns among them. We 45 pleiotropic 91 candidate genes that contribute to disease risk. By integrating profiles, implicated excitatory neurons microglia as key contributors eye-brain connections. Polygenic enrichment further 15 regulons 16 were linked comorbid conditions. Functionally, neuron-specific involved axon guidance synaptic activity, while microglia-specific associated immune response cell activation. In sum, findings underscore link psychiatric disorders
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 27, 2025
The gut–brain axis, a bidirectional communication pathway, permits the central nervous system (CNS) to exert influence over gastrointestinal function in response stress, while gut microbiota regulates CNS via immune, neuroendocrine, and vagal pathways. Current research highlights importance of stress-related disorders need for further into mechanisms communication, with potential therapeutic implications wide range health conditions. This is challenge taken on this Scientific Reports Collection Gut-Brain Axis. axis has significant neurodegenerative, psychiatric, metabolic disorders. Recent studies have underscored role microbiome conditions such as Parkinson's disease (PD), evidence indicating that dysfunction pathological features can precede motor symptoms by decades. use vivo animal models demonstrated preformed α-synuclein fibrils (PFFs) travel from brain dosage-dependent manner, thereby supporting "gut-first" theory context PD, explored using vitro approaches. There also plays obesity machine learning algorithms may assist differentiating between obese overweight individuals based their data. growing interest at interface post-traumatic stress disorder (PTSD), sleep disturbances, irritable bowel syndrome (IBS). described support expand observations previous preclinical clinical investigations, providing essential novel insights drive discovery previously unexplored avenues brain-gut-microbiome interactions disease.
Language: Английский
Citations
1
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Language: Английский
Citations
1
Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 7, 2025
Although the efficacy of pharmacy in treatment attention deficit/hyperactivity disorder (ADHD) has been well established, lack predictors response poses great challenges for personalized treatment. The current study employed a comprehensive approach, combining genome-wide association analyses (GWAS) and deep learning (DL) methods, to elucidate genetic underpinnings pharmacological ADHD. Based on genotype data medication-naïve patients with ADHD who received treatments 12 weeks, performed GWAS using percentage changes ADHD-RS score as phenotype. Then, DL models were constructed predict symptom scores variants selected based four different P thresholds (E-02, E-03, E-04, E-05) inputs. results identified two significant loci (rs10880574, = 2.39E-09; rs2000900, 3.31E-09) which implicated genes, TMEM117 MYO5B, that primarily associated both brain- gut-related disorders. convolutional neural network (CNN) model, values less than E-02 (5516 SNPs), demonstrated best performance mean squared error (MSE) equals 0.012 (Accuracy 0.83; Sensitivity 0.90; Specificity 0.75) validation dataset, 0.081 an independent test dataset (Acc 0.61, 0.81; 0.26). Notably, variant contributed most CNN model was NKAIN2, ADHD-related gene, is also metabolic processes. To conclude, integration methods revealed new genes contribute responses, underscored interplay between systems processes, potentially providing critical insights into precision Furthermore, our exhibited good encouraged future studies implied potential clinical applications.
Language: Английский
Citations
1
Allergy Asthma and Clinical Immunology, Journal Year: 2025, Volume and Issue: 21(1)
Published: March 17, 2025
Abstract Background An epidemiological association among asthma, blood eosinophil level and chronic rhinosinusitis (CRS) is well established, but whether consistent genetic relationships exist, this reflects a shared etiology between CRS asthma or remains unclear. Methods Data from patients ( N = 1,255) healthy controls 1,032) were reviewed retrospectively to investigate associations clinical characteristics CRS. white cells in the UK biobank 173,480), Trans-National Asthma Genetic Consortium (127,669) 272,922) nasal polyps 264,107) FinnGen consortium used conduct study, including linkage disequilibrium score regression analysis detect aforementioned variables, Mendelian randomization (MR) causal of levels on CRS, Bayesian co-localization consolidate MR findings identify signals. Results We found that count, percentages positive correlations with (all q < 0.0001) (CRSwNP) both our observational study. Through colocalization analysis, 4 loci are CRSwNP, 7 2 unique count 3 CRSwNP. Conclusions These contribute understanding etiology, provide insights for intervention treatment target comorbid high levels.
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 13, 2023
The brain-gut axis link has attracted increasing attention, with observational studies suggesting that the relationship between common mental disorders and inflammatory bowel disease (IBD) may run in both directions. However, so far, it is not clear whether there causality which direction.We conducted a bidirectional 2-sample Mendelian randomization study to investigate IBD, including Crohn's (CD) ulcerative colitis (UC), disorders, using summary-level GWAS data. main analysis was inverse variance weighted method. IBD (including CD UC), nine were used as exposures outcomes.We found UC could significantly lead obsessive-compulsive disorder, attention deficit hyperactivity autism spectrum odds ratio (OR) of 1.245 (95% confidence intervals [CI]: 1.069-1.450; P=0.008), 1.050 (95%CI: 1.023-1.077; P=2.42×10-4), 1.041 1.015-1.068; P=0.002) respectively. In addition, we bipolar disorder schizophrenia increase OR values 1.138 1.084-1.194; P=1.9×10-7), 1.115 1.071-1.161; P=1.12×10-7), Our results also indicate especially for UC, 1.091 1.024-1.162; P=0.009), 1.124 1.041-1.214; P=0.004), respectively.Our findings involves association some guides targeted prevention, management, mechanism exploration these diseases.
Language: Английский
Citations
16