Causality between autoimmune diseases and schizophrenia: a bidirectional Mendelian randomization study DOI Creative Commons
Lincheng Duan, Shiyin Li, Dennis Chen

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 16, 2024

Observational studies have shown a link between autoimmune diseases and schizophrenia, with conflicting conclusions. Due to the existence of confounding factors, causal schizophrenia is still unknown. We conducted comprehensive Mendelian randomization (MR) analysis ten common in individuals European descent using genome-wide association (GWASs). To evaluate relationships inverse variance weighted, MR-RAPS, Bayesian weighted MR, constrained maximum likelihood, debiased IVW, MR-Egger, median were utilized. Several sensitivity analyses performed ensure reliability study's results. Our findings reveal that genetically predicted ankylosing spondylitis related an increased risk whereas celiac disease, type 1 diabetes, systemic lupus erythematosus are associated lower schizophrenia. In reverse MR analysis, our study indicated linked higher risks spondylitis, Crohn's ulcerative colitis, inflammatory bowel psoriasis. Neither multiple sclerosis nor rheumatoid arthritis been vice versa. Despite contradicting some other observational reports, this showed support for gain better understanding mechanisms underlying development immune-mediated additional research required identify potential identified studies.

Language: Английский

Immune dysregulation in bipolar disorder DOI

Benney M.R. Argue,

Lucas G. Casten, S.C. McCool

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Global evolving patterns and cross-country inequalities of inflammatory bowel disease burden from 1990 to 2019: a worldwide report DOI
Lina Cao, Alimu Dayimu, Xiao Guan

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(2), P. 277 - 287

Published: Jan. 7, 2024

Language: Английский

Citations

4
Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis DOI
Jing Wang,

Guangyu Luo,

Tian Tian

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: April 2, 2024

Background The comorbidity between schizophrenia (SCZ) and inflammatory bowel disease (IBD) observed in epidemiological studies is partially attributed to genetic overlap, but the magnitude of shared components causality relationship them remains unclear. Methods By leveraging large-scale genome-wide association study (GWAS) summary statistics for SCZ, IBD, ulcerative colitis (UC), Crohn's (CD), we conducted a comprehensive pleiotropic analysis uncover loci, genes, or biological processes SCZ each UC, CD, independently. Univariable multivariable Mendelian randomization (MR) analyses were applied assess across these two disorders. Results genetically correlated with IBD ( r g = 0.14, p 3.65 × 10 −9 ), UC 0.15, 4.88 −8 CD 0.12, 2.27 −6 all surpassed Bonferroni correction. Cross-trait meta-analysis identified 64, 52, 66 significantly independent loci associated respectively. Follow-up gene-based found 11 novel genes KAT5 , RABEP1 ELP5 CSNK1G1 etc) joint phenotypes. Co-expression pathway enrichment illustrated those mainly involved core immune-related signal transduction cerebral disorder-related pathways. In univariable MR, predisposition was an increased risk (OR 1.11, 95% CI 1.07–1.15, 1.85 ). Multivariable MR indicated causal effect liability on Actinobacteria 1.06–1.16, 1.34 ) BMI 1.04–1.18, 1.84 −3 Conclusions We confirmed basis, loci/genes, providing insights into mechanism therapeutic targets underlying

Language: Английский

Citations

4
Therapeutic potential of CBD in Autism Spectrum Disorder DOI
João Francisco Cordeiro Pedrazzi, Lucas Hassib, Frederico Rogério Ferreira

et al.

International review of neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 149 - 203

Published: Jan. 1, 2024

Language: Английский

Citations

4
Two-sample Mendelian randomization analyses support cross-talk between air pollution exposure and gut microbiome DOI Creative Commons

Shaowei Gu,

Yan Cui,

Hui Chen

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Background Various studies have suggested the intriguing potential of air pollution exposure to influence gut microbiota diversity. It can impact not only by directly entering intestine, but also through gut-lung axis when deposited in lungs. Nevertheless, scarcity compelling genetic causal evidence remains conspicuous. Our objective was evaluate whether a relationship exists between and microbiota, along with implications this connection. Method This study designed investigate link pollutant (encompassing PM2.5, PM10, PM2.5−10, NO2, NOx) alterations microbiome using two-sample Mendelian randomization method based on summary-level GWAS study. To explore effect pollutants we conducted MR analyses across five specific feature levels, including phylum, class, order, family, genus. The main analytical approach employed inverse variance weighting (IVW), which examined outcome assessing single nucleotide polymorphisms (SNPs) linked pollution.. Additional sensitivity analyses, such as Cochran Q test, MR-Egger regression, leave-one-out analysis, were robustness findings. Results A statistically noteworthy association observed NO2 an uptick genus Eubacterium fissicatena group [IVW-odds ratio (OR) = 2.20; 95% confidence interval (CI), 1.42–3.41; P 4.36*10− 4], Gordonibacter (IVW-OR 2.29; 95%CI: 1.48–3.56; 2.17*10− 4), LachnosPiraceae (IVW-OR 1.82; 1.32–2.51; 2.37*10− 4). Contrarily, decrease abundance Holdemania 0.616; 0.47–0.81; 6.58*10− 4) Ruminococcus gauvreauii 0.663; 0.53–0.83; 4.63*10− exposure. Furthermore, PM2.5 associated lower presence Family XIII 0.691; 0.55–0.87; 1.47*10− 3). Conclusion findings indicate pollutants, particularly appeared microbiota's composition, especially for group, genus, may offer valuable insights further investigations into mechanisms clinical pollution-induced dysbiosis microbiome.

Language: Английский

Citations

0
Inflammatory bowel disease and neuropsychiatric disorders: Mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis DOI Creative Commons

Guido Petracco,

Isabella Faimann, Florian Reichmann

et al.

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108831 - 108831

Published: Feb. 1, 2025

Language: Английский

Citations

0
Multi-omics insight into the molecular networks of mental disorder related genetic pathways in the pathogenesis of inflammatory bowel disease DOI Creative Commons

Meng Zhang,

Jianhui Zhao,

Haosen Ji

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 21, 2025

Abstract Mental disorders are associated with inflammatory bowel disease (IBD), but the genetic pathophysiology is not fully understood. We obtained data on mental disorder-related gene methylation, expression, protein levels, and summary statistics of IBD, performed Summary data-based Mendelian randomization colocalization analyses to explore causal associations shared variants between multiple molecular traits IBD. Integrating multi-omics data, we found QDPR , DBI MAX ulcerative colitis (UC) risk, while HP linked IBD risk. Inverse methylation (cg0880851 cg26689483) expression observed in consistent their detrimental role UC. Methylation (cg11066750) protects against UC by enhancing expression. Higher levels (OR = 0.79, 95%CI 0.69–0.90) 0.74, 0.62–0.90) encoded proteins inversely higher 1.17, 1.07–1.28) 1.09, 1.04–1.14) increase Our findings advance understanding IBD’s pathogenic mechanisms gut-brain interaction.

Language: Английский

Citations

0
The Burden of Psychiatric Manifestations in Inflammatory Bowel Diseases: A Systematic Review With Meta-analysis DOI
Sara Massironi, Alessandro Pigoni, Elena Vegni

et al.

Inflammatory Bowel Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Abstract Background Psychiatric disorders in patients with inflammatory bowel disease (IBD) represent a significant but uncertain facet of the disease, unsolved questions regarding their overall magnitude, impact on intestinal and whole burden psychiatric manifestations. Aim This systematic review summarizes evidence prevalence disorders, including depression, anxiety, bipolar disorder (BD), schizophrenia, among IBD. Methods A search across PubMed/MEDLINE, Embase, Scopus databases from January 2010 to 2023 was performed identify relevant studies. The focus studies exploring specific IBD compared general population that reported outcome measures. subsequent meta-analysis (MA) assessed strength association between these data reliability ensured through rigorous extraction quality assessment. Results Out 3,209 articles, 193 met inclusion criteria only 26 provided complete for comprehensive analysis. These showed significantly higher comorbidities population. MA depression (pooled OR 1.42, 95% CI = 1.33-1.52, P < .0001) anxiety 1.3, 1.22-1.44, .0001). BD 1.64, 1.20-2.24, considerable heterogeneity (I2 94.01%). Only 3 examined schizophrenia IBD, providing widely heterogeneous results, an inconclusive OR, estimated at 0.93 (95% 0.62-1.39, .73). Conclusions highlights high particularly patients, which exceeds rates is proving be important under-researched area. sparse contradictory requires further investigation. findings highlight need better understanding, early detection, tailored mental health interventions management improve patients’ life.

Language: Английский

Citations

3
Inflammatory bowel disease and allergic diseases: A Mendelian randomization study DOI
Jiawei Li, Lijun Wang,

Yuqi Ma

et al.

Pediatric Allergy and Immunology, Journal Year: 2024, Volume and Issue: 35(5)

Published: May 1, 2024

Abstract Background Inflammatory bowel disease (IBD) and allergic diseases possess similar genetic backgrounds pathogenesis. Observational studies have shown a correlation, but the exact direction of cause effect remains unclear. The aim this Mendelian randomization (MR) study is to assess bidirectional causality between inflammatory diseases. Method We comprehensively analyzed causal relationship (IBD), Crohn's (CD), ulcerative colitis (UC) (asthma, Hay fever, eczema) as whole, conjunctivitis (AC), atopic dermatitis (AD), asthma (AAS), rhinitis (AR) by performing using summary‐level data from genome‐wide association studies. analysis results mainly came random‐effects model inverse variance weighted (IVW‐RE). In addition, multivariate (MVMR) was conducted adjust body mass index (BMI) on instrumental variables. Results IVW‐RE method revealed that IBD genetically increased risk whole (OR = 1.03, 95% CI 1.01–1.04, fdr. p .015), AC 1.04, 1.01–1.06, .011), AD 1.06, 1.02–1.09, .004). Subgroup further confirmed CD 1.02, 1.00–1.03, .031), 1.01–1.05, .012), 2E−05), AAS 1.05, 1.02–1.08, .002) AR 1.00–1.07, .025), UC 0.98–1.07, .038). MVMR showed after taking BMI secondary exposure, effects AC, AD, AAS, were still statistically significant. No significant observed in reverse MR analysis. Conclusion This randomized demonstrated factor for diseases, which largely attributed its subtype increasing ASS, AR. Further investigations are needed explore IBD.

Language: Английский

Citations

2
Gut Microbiota and Gastrointestinal Symptoms in the Global Assessment of Obsessive–Compulsive Disorder: A Narrative Review of Current Evidence and Practical Implications DOI Creative Commons
Giacomo Grassi, Ilenia Pampaloni

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 539 - 539

Published: May 24, 2024

A growing body of literature suggests a link between bowel syndromes (e.g., irritable syndrome and inflammatory disease), gut microbiome alterations, psychiatric disorders. This narrative review aims to explore the potential role in pathogenesis clinical presentation obsessive–compulsive disorder (OCD) whether there is sufficient evidence warrant considering gastrointestinal symptoms their implication for during assessment treatment OCD. For this purpose, PubMed search studies focusing on OCD, microbiota, syndrome, disease was conducted by two independent reviewers. While current issues OCD remains limited, emerging alterations high rates population. These findings emphasize importance incorporating comprehensive assessments into “global OCD”. Such should encompass various factors, including physical comorbidities symptoms, nutritional habits, fluid intake, exercise patterns, dysfunctions inflammation. Considering implications, interventions targeting health, such as probiotics dietary modifications, may hold promise improving patients with comorbid problems. Further research area warranted better understand interplay health effectiveness targeted outcomes.

Language: Английский

Citations

2