Therapeutic patterns and outcomes in older patients (aged≥65 years) with stage III-IVB inoperable oral cavity squamous cell carcinoma (OCSCC): an investigational study from the SEER database DOI

Wangyan Zhong,

Hang Yuan, Ting Li

et al.

Expert Review of Anticancer Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Background The aim of this retrospective study is to explore therapeutic patterns and survival outcomes for a cohort older patients with stage III-IVB inoperable oral squamous cell carcinoma (OCSCC) receiving radiation therapy (RT) or without chemotherapy (CT).

Language: Английский

Salivary miRNAs and cytokines associated with diagnosis and prognosis of oral squamous cell carcinoma DOI Creative Commons
Yuxiao Qin, Xiaodan Dong, Bo Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 22, 2025

Oral squamous cell carcinoma (OSCC) is the most common malignant tumour in oral and maxillofacial region. Early diagnosis can significantly improve 5-year survival rate of patients with OSCC. Therefore, it extremely important to differentiate OSCC early, easily quickly. Human saliva contains a variety components that be used as biomarkers for prognosis Studies have shown salivary microRNAs (miRNAs) cytokines are closely associated progression The aim this review summarize research progress (miRNAs cytokines) past 3 years, explore possibility using miRNAs

Language: Английский

Citations

2
Seizing the fate of lymph nodes in immunotherapy: To preserve or not? DOI
Zhenyu Xu, Zi‐Zhan Li, Lei‐Ming Cao

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216740 - 216740

Published: Feb. 27, 2024

Language: Английский

Citations

15
Differential Expression of MicroRNA MiR-145 and MiR-155 Downstream Targets in Oral Cancers Exhibiting Limited Chemotherapy Resistance DOI Open Access

Conner Belnap,

Tyler Divis,

Karl Kingsley

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2167 - 2167

Published: Feb. 10, 2024

New evidence has suggested that non-coding microRNAs play a significant role in mediating and modulating chemotherapy resistance, particularly among oral cancers. One recent study found the upregulation of miR-145 downregulation miR-155 strongly correlated with limited resistance to Cisplatin, 5-Fluorouracil, Paclitaxel, although mechanism(s) responsible for these observations remain unidentified. Using commercially available cell lines squamous carcinoma, RNA was isolated, converted into cDNA, subsequently screened expression downstream targets using qPCR. These results demonstrated miR-21, miR-125, miR-133, miR-365, miR-720, miR-1246, as well miR-140, miR-152, miR-218, miR-221, miR-224. This screening also confirmed differential regulation mir-145 (SCC15). In addition, several specific were upregulated by all cancer lines, such MBTD1 FSCN1, or downregulated CLCN3, FLI-1, MRTFB, DAB, SRGAP1, ABHD17C. However, three identified least chemotherapy-resistant cells, exhibiting KCNA4 SRGAP2, FAM135A, this pattern not detected any other lines. data support may be related chemosensitivity line. The potential involvement must further investigated determine how whether mechanisms cellular pathways involved observed lack resistance. important design treatments reduce improve patient treatment outcomes.

Language: Английский

Citations

5
Comparative analysis of elastosonography and 18 F-FDG PET/CT in differentiating benign and malignant salivary gland tumors: a systematic review and meta-analysis DOI Creative Commons
Zhibing Jiang, Jinjing Guo,

Liang Hu

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 1, 2025

Language: Английский

Citations

0
Neck dissection in cN0 oral squamous cell carcinoma: a chance for immunotherapy DOI
Lin‐Lin Bu, Zhengyang Xu, Zong‐Keng Kuo

et al.

International Journal of Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Application of CT and MRI images based on artificial intelligence to predict lymph node metastases in patients with oral squamous cell carcinoma: a subgroup meta-analysis DOI Creative Commons

Cheng Deng,

Jun Hu, Ping Tang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: June 18, 2024

Background The performance of artificial intelligence (AI) in the prediction lymph node (LN) metastasis patients with oral squamous cell carcinoma (OSCC) has not been quantitatively evaluated. purpose this study was to conduct a systematic review and meta-analysis published data on diagnostic CT MRI based AI algorithms for predicting LN metastases OSCC. Methods We searched Embase, PubMed (Medline), Web Science, Cochrane databases studies use Binary accuracy were extracted obtain outcomes interest, namely, area under curve (AUC), sensitivity, specificity, compared that radiologists. Subgroup analyses performed regard different types imaging modalities. Results Fourteen eligible included meta-analysis. AUC, specificity models diagnosis 0.92 (95% CI 0.89–0.94), 0.79 0.72–0.85), 0.90 0.86–0.93), respectively. Promising observed subgroup algorithm [machine learning (ML) or deep (DL)] modalities (CT vs. MRI). pooled significantly better than experienced Discussion In conclusion, good OSCC thus potential clinical application. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/#recordDetails , PROSPERO (No. CRD42024506159).

Language: Английский

Citations

1
The prognostic role of salivary miRNAs in oral squamous cell carcinoma: technical challenges and clinical perspectives DOI Creative Commons
Chiara Romani,

Claudia Assoni,

Davide Mattavelli

et al.

Acta Otorhinolaryngologica Italica, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 6

Published: Sept. 1, 2024

In management of oral squamous cell carcinoma (OSCC), only a few biomarkers, ranging from clinical and histopathological features to molecular alterations, have been demonstrated prognostic utility. The intent this narrative review is present current findings on the use salivary microRNAs (miRNAs) as oncologic biomarkers in patients with OSCC. ability predict survival or recurrence during follow-up by quantification specific miRNAs saliva has shown number studies, serves possible feature address future well-designed studies confirm their value. non-invasiveness liquid biopsy techniques, ease collection, abundance stability such biologic fluid make it an attractive combination improve For be used routine practice, however, methodological sampling standardisation are still needed increase power accuracy results obtained.

Language: Английский

Citations

1
Global research on oral cancer: A bibliometric analysis based on 82 highly cited publications from 2014 to 2024 DOI
Shuai Li,

Ting-Ting Zhao,

NengMing Liu

et al.

Oral Oncology, Journal Year: 2024, Volume and Issue: 159, P. 107094 - 107094

Published: Nov. 13, 2024

Language: Английский

Citations

1
Downstream Target Analysis for miR-365 among Oral Squamous Cell Carcinomas Reveals Differential Associations with Chemoresistance DOI Creative Commons

Brendon Yu,

N Kruse,

Katherine M. Howard

et al.

Life, Journal Year: 2024, Volume and Issue: 14(6), P. 741 - 741

Published: June 10, 2024

Expression of microRNAs, such as miR-365, is known to be dysregulated in many tumors, including oral cancers, although little about their role or functions. The objective this project evaluate the downstream targets miR-365 determine any potential pathways effects. Downstream for (miRdatabase target scores > 90) were used qPCR screening cancer cell lines (SCC4, SCC9, SCC15, SCC25, CAL27). Each line expressed molybdenum cofactor synthesis-2 (MOCS2), erythropoietin receptor (EPOR), IQ motif containing-K (IQCK), carboxypeptidase A3 (CPA3), solute carrier family 24 member-3 (SLC24A3), and coiled-coil domain containing 47 (CCDC47)-although expression levels varied somewhat. However, differential results observed with ubiquitin protein ligase E3 component n-recognin-3 (UBR3), nudix hydrolase-12 (NUDT12), zinc finger CCHC-type containing-14 (ZCCHC14), homeobox leucine zipper encoding (HOMEZ). These data suggest that are cancers screened, UBR3, ZCCHC14, HOMEZ, NUDT12, which may correlated chemoresistance among two specific (SCC25, SCC9). signal patient treatment tumors exhibiting chemotherapeutic resistance.

Language: Английский

Citations

0
Therapeutic patterns and outcomes in older patients (aged≥65 years) with stage III-IVB inoperable oral cavity squamous cell carcinoma (OCSCC): an investigational study from the SEER database DOI

Wangyan Zhong,

Hang Yuan, Ting Li

et al.

Expert Review of Anticancer Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Background The aim of this retrospective study is to explore therapeutic patterns and survival outcomes for a cohort older patients with stage III-IVB inoperable oral squamous cell carcinoma (OCSCC) receiving radiation therapy (RT) or without chemotherapy (CT).

Language: Английский

Citations

0