A 3 M Evaluation Protocol for Examining Lymph Nodes in Cancer Patients: Multi-Modal, Multi-Omics, Multi-Stage Approach DOI Creative Commons
R F Wang, Zhiyan Zhang, Mengyun Zhao

et al.

Technology in Cancer Research & Treatment, Journal Year: 2024, Volume and Issue: 23

Published: Jan. 1, 2024

Through meticulous examination of lymph nodes, the stage and severity cancer can be determined. This information is invaluable for doctors to select most appropriate treatment plan predict patient prognosis; however, any oversight in nodes may lead metastasis poor prognosis. In this review, we summarize a significant number articles supported by statistical data clinical experience, proposing standardized evaluation protocol nodes. begins with preoperative imaging assess presence node metastasis. Radiomics has replaced single-modality approach, deep learning models have been constructed assist image analysis superior performance that human eye. The focus review lies intraoperative lymphadenectomy. Multiple international authorities recommended specific numbers lymphadenectomy various cancers, providing surgeons clear guidelines. These are calculated applying methods real-world data. third chapter, mention growing concern about immune impairment caused dissection, as lack CD8 memory T cells negative impact on postoperative immunotherapy. Both excessive less dissection led conflicting findings conclusion, propose referenced surgeons. With systematic management control tumor progression greatest possible likelihood, optimize process, reduce risks, improve quality life.

Language: Английский

Metal-dependent cell death resistance contribute to lymph node metastasis of oral squamous cell carcinoma DOI Creative Commons
Xuan-Hao Liu, Guang-Rui Wang, Nian‐Nian Zhong

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 27, 2025

Ferroptosis and cuproptosis can be summarized as metal-dependent cell death. This study aimed to explore the expression of death resistance (MCDR) characteristics in tumor cells oral squamous carcinoma (OSCC) its relationship with lymph node metastasis (LNM). By integrating single-cell data OSCC from public databases, an matrix comprising 127,149 was constructed. Gene set scores were calculated using irGSEA package, GO KEGG analyses performed identify enriched pathways. The R package monocle3 employed calculate trajectory infer evolutionary patterns. MuSiC2 enable evaluation proportions. Cell-cell interaction information analyzed CellChat package. cathepsin V (CTSV), glutathione peroxidase 4 (GPX4), cyclin-dependent kinase inhibitor 2A (CDKN2A) validated via immunohistochemistry multiplex mucosa (OM), non-metastatic primary tumors (nPT), metastatic (mPT). Additionally, oncoPredict utilized potential drug sensitivities. malignant divided into five subtypes, among which Epi_2 existed more mPT had higher MCDR characteristics. In addition, multiple malignant-related pathways such HEDGEHOG, NOTCH, MYC. spatial transcriptome bulk RNA verified that proportion than nPT. Cell communication analysis showed effect on endothelial enhanced, mainly reflected VEGFR CXCL signaling Immunohistochemical results characteristic markers CTSV GPX4 significantly Multiplex immunohistochemical co-expression CTSV, CDKN2A those patients high may have immunotherapy anti-EGFR treatment resistance. Doramapimod identified a sensitive drug. There is type MDCR OSCC, related LNM It provides predictive marker for early diagnosis LNM.

Language: Английский

Citations

1
Lymph node metastasis diagnosis of postoperative OSCC patients by analyzing extracellular vesicles in drainage fluid based on microfluidic isolation DOI Creative Commons
Zi‐Zhan Li,

Ze‐Min Cai,

Wen-Tao Zhu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 28, 2024

Language: Английский

Citations

5
Less is more: Exploring neoadjuvant immunotherapy as a de-escalation strategy in head and neck squamous cell carcinoma treatment DOI
Lei‐Ming Cao, Nian‐Nian Zhong, Yang Chen

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217095 - 217095

Published: July 2, 2024

Language: Английский

Citations

4
Lymphatic collection and cell isolation from mouse models for multiomic profiling DOI
Marie Sabatier, Ani Solanki,

Sangeetha Thangaswamy

et al.

Nature Protocols, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

Citations

0
Neck Dissection and Survival Among Head and Neck Cancer Patients Undergoing Adjuvant Immunotherapy DOI Creative Commons
Aman M. Patel, Afash Haleem,

Paul T. Cowan

et al.

Laryngoscope Investigative Otolaryngology, Journal Year: 2025, Volume and Issue: 10(2)

Published: March 18, 2025

ABSTRACT Background Some studies suggest that neck dissection (ND) should be avoided in candidates for immunotherapy because lymph nodes are primary sites activation. Our study investigates ND utilization and associated differences overall survival (OS) among patients with head cancer (HNC) undergoing adjuvant immunotherapy. Methods The 2013–2018 National Cancer Database was retrospectively reviewed HNC surgery curative intent, Multivariable binary logistic Cox regression models adjusted patient demographics, clinicopathologic features, treatment. Results Of 1335 satisfying inclusion criteria, 679 (50.9%) underwent ND: 94 (13.8%) had pN0, 109 (16.1%) pN1, 411 (60.5%) pN2, 60 (8.8%) pN3, 5 (0.7%) pNx classification. On multivariable regression, academic treatment facility, cT4, cN1–3 classification were higher odds of ( p < 0.05); salivary, sinonasal, oropharyngeal, hypopharyngeal, laryngeal decreased 0.05). Compared those observation, worse OS (49.4% vs. 61.5%, 0.001) on Kaplan–Meier but not (adjusted hazard ratio [aHR] 1.00, 95% confidence interval [CI] 0.82–1.24, = 0.968) regression. alone, the addition radiotherapy (aHR 0.64, CI 0.44–0.93) chemoradiotherapy 0.56, 0.37–0.86) 0.025). Conclusion utilized approximately 51% OS, possibly related to high rate pN1–3 Level Evidence 4

Language: Английский

Citations

0
Neoadjuvant Chemoimmunotherapy for Resectable Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-analysis DOI
Lei‐Ming Cao, Yi-Fu Yu, Zi‐Zhan Li

et al.

Annals of Surgical Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
A Retrospective Analysis of 8457 Glossectomy Cases Over 15 Years—The Boon and Bane of Radical Neck Dissection DOI
Leonard Knoedler,

Helena Baecher,

Michael Alfertshofer

et al.

Journal of Craniofacial Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Glossectomy is a commonly performed procedure in head and neck oncology, primarily for the treatment of squamous cell carcinoma tongue. Radical dissection (RND) still being combined with glossectomy to manage lymph node metastases, yet its impact on postoperative outcomes patients remains largely underexplored. This study utilized data from American College Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) analyze 30-day 8457 who underwent partial or extended glossectomy, without concurrent RND, between 2008 2022. No significant differences complications were found groups (P=0.571). However, RND was associated longer operative times (P<0.001), increased length hospital stay (P=0.045), higher complication rates (P=0.008). In patients, linked mortality (P=0.022). Multivariable analysis identified smoking status, obesity, inpatient setting as risk factors across all subgroups. While extent did not influence immediate outcomes, significantly risks patients. These findings emphasize importance individualized assessment tailored surgical planning enhance patient procedures.

Language: Английский

Citations

0
NR2F2 and its contribution to lymph node metastasis in oral squamous cell carcinoma DOI
Xuan-Hao Liu, Nian‐Nian Zhong,

Jing‐Rui Yi

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 132, P. 111814 - 111814

Published: April 20, 2025

Language: Английский

Citations

0
Intratumoral Immunotherapy in Breast Cancer DOI Creative Commons
Camille C. Baumrucker, Nicole C. Harris,

Susan Hoover

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 429 - 429

Published: April 19, 2025

Breast cancer remains the most frequently diagnosed and second highest cause of death in females. Metastatic recurrence that is resistant to traditional therapies presents a major challenge, necessitating development an innovative treatment strategy. Immunotherapy has gained popularity cancer, particularly melanoma, lung more recently breast cancer. Major developments immunotherapy have been made with better understanding tumor microenvironment how can be manipulated induce anti-tumor immune response. Intratumorally delivered used create local This review provides comprehensive overview intratumoral for its resultant changes microenvironment. The discussed immunotherapeutics include oncolytic viruses, nucleic acids, innate agonists, bacteria, chimeric antigen receptor T cells, dendritic cells. also evaluates completed clinical trials using these therapies. Lastly, offers future perspectives immunotherapy.

Language: Английский

Citations

0
Extracellular Vesicles: Hermes Between Cancers and Lymph Nodes DOI
Lei‐Ming Cao, Yuan-ye Qiu, Zi‐Zhan Li

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217735 - 217735

Published: April 1, 2025

Language: Английский

Citations

0