Clinics and Practice,
Journal Year:
2025,
Volume and Issue:
15(1), P. 16 - 16
Published: Jan. 13, 2025
Chronic
non-cancer
pain,
defined
by
the
Center
for
Disease
Control
and
Prevention
(CDC)
as
lasting
beyond
three
months,
significantly
affects
individuals’
quality
of
life
is
often
linked
to
various
medical
conditions
or
injuries.
Its
management
complex.
Cannabis,
containing
key
compounds
Delta-9-tetrahydrocannabinol
(THC)
cannabidiol
(CBD),
has
garnered
interest
its
potential
in
pain
management,
though
it
remains
controversial
due
psychoactive
effects
illegal
status
many
countries.
THC
provides
relief
blocking
nociceptive
stimuli
but
may
potentially
induce
dependency.
CBD
calming
antipsychotic
properties.
The
inhalation
cannabis
offers
quick
poses
respiratory
risks,
while
oral
administrations
are
safer
act
more
slowly.
Short-term
use
can
impair
cognition
motor
skills,
long-term
lead
dependency
cognitive
decline,
especially
if
used
from
an
early
age.
Adverse
vary
gender
prior
use,
with
addiction
mainly
influenced
genetics.
Despite
these
patients
report
benefits,
such
improved
reduced
opioid
although
evidence
inconclusive.
legal
landscape
varies
globally,
some
positive
public
health
outcomes
like
opioid-related
issues
areas
where
legalized.
Cannabis
shows
promise
managing
chronic
risks
necessitate
cautious
use.
Future
research
should
prioritize
clinical
trials
establish
optimal
dosing,
efficacy,
safety,
aiding
development
informed
guidelines
safe
management.
This
review
examines
focusing
on
drawbacks,
mechanisms,
delivery
methods,
impact
life.
JAMA Psychiatry,
Journal Year:
2015,
Volume and Issue:
72(12), P. 1235 - 1235
Published: Oct. 21, 2015
Laws
and
attitudes
toward
marijuana
in
the
United
States
are
becoming
more
permissive
but
little
is
known
about
whether
prevalence
rates
of
use
disorders
have
changed
21st
century.To
present
nationally
representative
information
on
past-year
use,
disorder,
disorder
among
users
US
adult
general
population
this
has
between
2001-2002
2012-2013.Face-to-face
interviews
conducted
surveys
2
samples
adults:
National
Epidemiologic
Survey
Alcohol
Related
Conditions
(data
collected
April
2001-April
2002;
N
=
43,093)
Conditions-III
2012-June
2013;
36,309).
Data
were
analyzed
March
through
May
2015.Past-year
DSM-IV
(abuse
or
dependence).The
was
4.1%
(SE,
0.15)
9.5%
0.27)
2012-2013,
a
significant
increase
(P
<
.05).
Significant
increases
also
found
across
demographic
subgroups
(sex,
age,
race/ethnicity,
education,
marital
status,
income,
urban/rural,
region).
The
1.5%
(0.08)
2.9%
0.13)
2012-2013
With
few
exceptions,
statistically
.05)
subgroups.
However,
decreased
significantly
from
(35.6%;
SE,
1.37)
to
(30.6%;
1.04).The
than
doubled
there
large
during
that
time.
While
not
all
experience
problems,
nearly
3
10
manifested
2012-2013.
Because
risk
for
did
users,
owing
an
population.
Given
changing
laws
marijuana,
balanced
presentation
likelihood
adverse
consequences
policy
makers,
professionals,
public
needed.
American Journal of Psychiatry,
Journal Year:
2016,
Volume and Issue:
173(6), P. 588 - 599
Published: March 4, 2016
Attitudes
toward
marijuana
are
changing,
the
prevalence
of
DSM-IV
cannabis
use
disorder
has
increased,
and
DSM-5
modified
criteria.
Therefore,
updated
information
is
needed
on
prevalence,
demographic
characteristics,
psychiatric
comorbidity,
disability,
treatment
for
disorder.
JAMA Psychiatry,
Journal Year:
2017,
Volume and Issue:
74(6), P. 579 - 579
Published: April 26, 2017
Over
the
last
25
years,
illicit
cannabis
use
and
disorders
have
increased
among
US
adults,
28
states
passed
medical
marijuana
laws
(MML).
Little
is
known
about
MML
adult
or
considered
over
time.
World Psychiatry,
Journal Year:
2017,
Volume and Issue:
16(3), P. 299 - 307
Published: Sept. 21, 2017
Substance
use
is
a
major
cause
of
disability
globally.
This
has
been
recognized
in
the
recent
United
Nations
Sustainable
Development
Goals
(SDGs),
which
treatment
coverage
for
substance
disorders
identified
as
one
indicators.
There
have
no
estimates
this
cross‐nationally,
making
it
difficult
to
know
what
baseline
that
SDG
target.
Here
we
report
data
from
World
Health
Organization
(WHO)'s
Mental
Surveys
(WMHS),
based
on
representative
community
household
surveys
26
countries.
We
assessed
12‐month
prevalence
(alcohol
or
drug
abuse/dependence);
proportion
people
with
these
who
were
aware
they
needed
and
wished
receive
care;
those
seeking
care
received
it;
such
met
minimal
standards
quality
(“minimally
adequate
treatment”).
Among
70,880
participants,
2.6%
criteria
disorders;
was
higher
upper‐middle
income
(3.3%)
than
high‐income
(2.6%)
low/lower‐middle
(2.0%)
Overall,
39.1%
need;
recognition
more
common
(43.1%)
(35.6%)
(31.5%)
need,
61.3%
made
at
least
visit
service
provider,
29.5%
latter
minimally
exposure
(35.3%
high,
20.3%
upper‐middle,
8.6%
countries).
only
7.1%
past‐year
treatment:
10.3%
high
income,
4.3%
1.0%
These
suggest
small
minority
even
treatment.
At
three
barriers
are
involved:
awareness/perceived
accessing
once
need
recognized,
compliance
(on
part
both
provider
client)
obtain
Various
factors
likely
be
involved
each
barriers,
all
addressed
improve
disorders.
provide
global
monitoring
progress
an
indicator
within
SDGs.
Expert Review of Neurotherapeutics,
Journal Year:
2016,
Volume and Issue:
16(11), P. 1263 - 1277
Published: June 27, 2016
Introduction:
The
first
two
alpha2delta
ligands
–
gabapentin
(GBP)
and
pregabalin
(PGB)
were
initially
synthesized
as
antiepileptics;
however,
they
later
also
found
to
be
useful
for
the
treatment
of
additional
conditions.Areas
covered:
Relevant
publications
describing
potential
underlying
mechanisms,
clinical
pharmacokinetics/pharmacokinetics,
efficacy
safety
these
drugs
in
various
disease
conditions
searched
PubMed
Scopus
included
this
review.Expert
commentary:
GBP
PGB
are
effective
neuropathic
pain,
fibromyalgia
epilepsy;
addition,
may
reduction
postoperative
pain.
is
generalized
anxiety
disorder
restless
legs
syndrome.
considered
a
option
pain
associated
with
Guillain-Barré
Syndrome
phantom
limb
management
uremic
pruritus.
Mirogabalin
(MGB),
recently
developed,
being
investigated
peripheral
fibromyalgia,
showing
promising
results
patients
diabetic
neuropathy.
Their
most
frequent
adverse
reactions
neuropsychiatric
nature
include
fatigue,
dizziness,
sedation,
somnolence,
ataxia;
edema
weight
gain
frequently
described.
Pharmacokinetic
interactions
scarce;
pharmacodynamic
have
been
described
association
CNS-depressant
effects.
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy,
Journal Year:
2016,
Volume and Issue:
36(5), P. 511 - 535
Published: March 30, 2016
Cannabis
is
the
most
commonly
used
illicit
substance
in
United
States.
Rates
of
cannabis
use
and
disorder
(CUD)
have
increased
past
decade,
paralleling
changes
legal
political
climate
favoring
legalization.
Almost
20
million
people
12
years
or
older
report
past‐month
use,
8
daily
near‐daily
use.
Concurrently,
perception
that
poses
a
significant
risk
negative
consequences
has
decreased.
Contrary
to
this
perception,
heavy
associated
with
cognitive
impairment,
for
psychotic
disorders
other
mental
health
problems,
lower
education
attainment,
unemployment.
Clinical
trials
various
treatments
CUD
likewise
increased,
focusing
primarily
on
psychotherapy
treatments,
specifically
motivational
enhancement
therapy,
behavioral
contingency
management.
Their
findings
suggest
combination
these
three
modalities
produces
best
abstinence
outcomes,
although
rates
remain
modest
decline
after
treatment.
More
recently,
pharmacotherapy
been
conducted
as
adjunctive
interventions
psychosocial
N
‐acetylcysteine
gabapentin
are
two
promising
medications,
no
pharmacologic
treatment
emerged
clearly
efficacious.
In
review,
we
provide
detailed
summary
clinical
evaluated
treating
discuss
emerging
areas
research
cannabis‐specific
barriers