Physiological, Pathological, and Circadian Factors Impacting Skin Hydration

Cureus, Journal Year: 2022, Volume and Issue: unknown

Published: Aug. 4, 2022

This manuscript focuses on the physiological, environmental, nutritional, circadian, and aging factors affecting skin tissue water hydration parameters. The literature findings indicate a multiplicity of interacting processes among these parameters, ultimately impacting in normal playing role conditions such as atopic dermatitis psoriasis. maintenance adequate hydration, aided by proper functioning skin’s protective barrier, is facilitated stratum corneum integrity with presence tight junctions lipids ceramides, each which impacted changes most evaluated Abnormalities aquaporin 3 (AQP3) expression associated deficits appear to have AQP3 hydration-related aspects are influenced circadian rhythms via modulations CLOCK genes that alter protein expression. Ultraviolet exposure, aging, low temperatures those affect ceramide composition, potentially leading increased transepidermal loss negatively hydration. Vitamin C, collagen, probiotics may increase production improve extent different affects varies but usually large enough consider their potential effects when investigating research clinical settings.

Language: Английский

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tauFisher predicts circadian time from a single sample of bulk and single-cell pseudobulk transcriptomic data

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 7, 2024

As the circadian clock regulates fundamental biological processes, disrupted clocks are often observed in patients and diseased tissues. Determining time of patient or tissue focus is essential medicine research. Here we present tauFisher, a computational pipeline that accurately predicts from single transcriptomic sample by finding correlations between rhythmic genes within sample. We demonstrate tauFisher's performance adding timestamps to both bulk single-cell samples collected multiple types experimental settings. Application tauFisher at cell-type level RNAseq dataset mouse dermal skin implies greater phase heterogeneity may explain dampened rhythm collective core gene expression immune cells compared fibroblasts. Given its robustness generalizability across assay platforms, setups, types, as well potential application data analysis, promising tool facilitates

Language: Английский

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Crosstalk between circadian clocks and pathogen niche

PLoS Pathogens, Journal Year: 2024, Volume and Issue: 20(5), P. e1012157 - e1012157

Published: May 9, 2024

Circadian rhythms are intrinsic 24-hour oscillations found in nearly all life forms. They orchestrate key physiological and behavioral processes, allowing anticipation response to daily environmental changes. These manifest across entire organisms, various organs, through intricate molecular feedback loops that govern cellular oscillations. Recent studies describe circadian regulation of pathogens, including parasites, bacteria, viruses, fungi, some which have their own while others influenced by the rhythmic environment hosts. Pathogens target specific tissues organs within host optimize replication. Diverse compositions interplay among cell types create unique microenvironments different tissues, distinctive biology. Hence, residing pathogens exposed cyclic conditions, can profoundly impact host–pathogen interactions. This review explores influence mammalian tissue-specific interactions on dynamics pathogen–host relationships. Overall, this demonstrates between body’s internal timekeeping system its susceptibility has implications for future infectious disease research treatment.

Language: Английский

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The circadian metabolome of atopic dermatitis

Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 153(4), P. 1148 - 1154

Published: Jan. 21, 2024

Language: Английский

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The Emerging Role of Visible Light in Melanocyte Biology and Skin Pigmentary Disorders: Friend or Foe?

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(23), P. 7488 - 7488

Published: Dec. 4, 2023

Electromagnetic radiation, notably visible light (VL), has complicated effects on human skin, particularly pigmentation, which have been largely overlooked. In this review, we discuss the photobiological mechanisms, pathological effects, clinical applications and therapeutic strategies of VL at varying wavelengths melanocyte biology skin pigmentary disorders. Different may impose positive or negative depending their interactions with specific chromophores, photoaging, ROS production, circadian rhythm other photon-mediated reactions. Further in vivo vitro studies are required to establish pathologic mechanisms application principles disorders, as well optimal photoprotection coverage against wavelengths.

Language: Английский

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Enhancing Skin Anti-Aging through Healthy Lifestyle Factors

Cosmetics, Journal Year: 2023, Volume and Issue: 10(5), P. 142 - 142

Published: Oct. 12, 2023

Lifestyle health has been recognized as an evidence-based innovation that defines how everyday behaviors and routines influence the avoidance therapy of illness provides important adjunctive component to overall health. Specifically, approach with small changes over time can have a dramatic impact on well-being individuals not only, in general, but also be applied skin However, lifestyle factors improve discussed extensively and/or well promulgated. The narrative for this overview focuses providing summary topic background information, more importantly, presents four dermal [i.e., factor 1: nutrition—diet; 2: rest (sleep); 3: movement/physical exercise, 4: social community associations]. This was accomplished by identifying preceding journal reports/reviews covering especially last five years (January 2018 July 2023; 164 out 205 references cited or 80%) using scientific search databases. main conclusions encourage concept such nutrition/diet, rest/sleep, community/social interactions support enhanced aging. Plus, media interventions aim promote dietary, sleep physical activity might application future.

Language: Английский

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How and Why the Circadian Clock Regulates Proliferation of Adult Epithelial Stem Cells

Stem Cells, Journal Year: 2023, Volume and Issue: 41(4), P. 319 - 327

Published: Feb. 6, 2023

Abstract First described in the early 20th century, diurnal oscillations stem cell proliferation exist multiple internal epithelia, including gastrointestinal tract, and epidermis. In mouse epidermis, 3- to 4-fold more cells are S-phase during night than day. More recent work showed that an intact circadian clock intrinsic keratinocytes is required for these epidermal proliferation. The also regulates DNA excision repair damage response ultraviolet B radiation. During skin inflammation, increased suspended. Here we discuss possible reasons evolution of this phenomenon. We argue coordinates intermediary metabolism cycle minimize accumulation from metabolism-generated reactive oxygen species. Circadian disruption, common modern society, leads asynchrony between cycle, speculate will lead oxidative damage, dysfunction cells, aging.

Language: Английский

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Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 6, 2023

Cutaneous pigmentation was recently shown to be an event regulated by clock proteins. Cryptochrome (CRY) is a key protein composing the feedback loop of circadian clock, however, function CRY in melanocytes remains unclear. Here, we found that KL001, synthetic small molecule modulator CRY1, inhibited melanin synthesis, as well reduced melanocyte dendrite elongation and melanosome transport. In addition, dominant role CRY1 KL001-induced anti-melanogenesis revealed interfering RNA transfection. Cellular tyrosinase activity expression level melanogenic proteins, including tyrosinase, TRP-1, TRP-2, transport proteins like Rab27a, Cdc42 Myosin Va induced α-MSH were remarkably reversed after KL001 treatment. Mechanistically, activation melanogenesis through CREB-dependent downregulation MITF CREB phosphorylation mediated classical cAMP/PKA pathway. other activator, KL044 also suppressed cAMP/PKA/CREB pathway melanogenesis. Finally, anti-melanogenic efficacy confirmed determination contents UVB-tanning model brown guinea pigs, which indicated targeting activity, via topical application can utilized therapeutically manage human pigmentary disorders.

Language: Английский

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Circadian Oscillations in Skin and Their Interconnection with the Cycle of Life

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5635 - 5635

Published: March 15, 2023

Periodically oscillating biological processes, such as circadian rhythms, are carefully concerted events that only beginning to be understood in the context of tissue pathology and organismal health, well molecular mechanisms underlying these interactions. Recent reports indicate light can independently entrain peripheral clocks, challenging currently prevalent hierarchical model. Despite recent progress has been made, a comprehensive overview periodic processes skin is lacking literature. In this review, clock machinery factors govern it have highlighted. Circadian rhythm closely linked immunological homeostasis, its desynchrony perturbation skin. The interplay between annual, seasonal oscillations, impact on skin, described. Finally, changes occur over lifespan presented. This work encourages further research into occurring lays foundation for future strategies combat adverse effects desynchrony, which would likely implications other tissues influenced by oscillatory processes.

Language: Английский

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Identification of key circadian rhythm genes in skin aging based on bioinformatics and machine learning

Aging, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 30, 2023

Skin aging is often accompanied by disruption of circadian rhythm and abnormal expression rhythm-related genes. In this study, we downloaded skin datasets from the GEO database utilized bioinformatics machine learning methods to explore genes pathways involved in aging, revealing pathological molecular mechanisms aging. Results showed that 39 (CRGs) were identified these CRGs enriched signaling such as glucagon pathway, insulin resistance, thyroid hormone adipocytokine pathway. Three key aging-related CRGs, SIRT1, ARNTL, ATF4, based on learning. Additionally, found was associated with infiltration immune cells including NK activated, Macrophages M1, Mast resting, T CD4 memory M2, three correlated cells. Finally, ATF4 all down-regulated had a good ability distinguish young tissue tissue. conclusion, which are closely related obtained technology screening. These potential risk for also changes microenvironment The language used paragraph follows guidelines scientific writing specified SCI, making it clear concise.

Language: Английский

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