ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Circadian
rhythm
disruption,
commonly
caused
by
factors
such
as
jet
lag
and
shift
work,
is
increasingly
recognized
a
critical
factor
impairing
wound
healing.
Although
melatonin
known
to
regulate
circadian
rhythms
has
potential
in
repair,
its
clinical
application
limited
low
bioavailability.
To
address
these
challenges,
we
developed
an
alginate-based
dual-network
hydrogel
delivery
system
for
melatonin,
ensuring
stable
sustained
release
at
the
site.
This
approach
enhances
efficacy
of
modulating
healing
process.
We
investigated
effects
disruption
on
microenvironment
under
influence
melatonin-loaded
with
focus
biocompatibility,
hemostatic
properties,
antioxidant
response
functions.
Additionally,
elucidated
mechanisms
which
promotes
Our
findings
provide
insights
into
relationship
between
healing,
offering
promising
strategy
management
chronic
wounds
associated
disorders.
Journal of Investigative Dermatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
All
skin
layers
and
cutaneous
appendages
harbor
a
robust
circadian
clock,
whose
phase
is
under
the
influence
of
light
through
central
clock
in
suprachiasmatic
nucleus.
The
coordinates
fundamental
biological
processes,
including
metabolism
stem
cell
activation.
It
also
prominently
modulates
activity
skin-resident
immune
cells
inflammatory
response.
Numerous
diurnally
regulated
genes
have
been
implicated
diseases
GWASs.
Therefore,
mouse
powerful
model
for
understanding
diverse
roles
biology
maintaining
tissue
health
initiation
propagation
disease
states.
When
planning
experiments
to
study
skin,
multiple
technical
factors
must
be
carefully
considered.
In
this
paper,
we
provide
comprehensive
guidance
on
general
experimental
design
associated
housing
mice.
We
highlight
importance
aligning
sample
collection
with
desired
hair
cycle
stage
animal
age.
introduce
methods
disrupt
altering
feeding
schedules
as
well
using
transgenic
models.
Finally,
discuss
use
transcriptomic
data,
both
bulk
single
cell,
studies.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 6, 2025
Circadian
rhythms,
intrinsic
24-h
cycles
regulating
physiological
processes,
are
crucial
for
skin
homeostasis.
Disruptions
in
these
rhythms
linked
to
various
disorders
and
impaired
barrier
function.
can
be
modulated
by
botanical
compounds,
which
hold
therapeutic
potential.
However,
the
effect
of
cinnamomi
cortex
(CC),
an
anti-inflammatory,
antioxidant,
antimicrobial
agent,
on
circadian
rhythm
keratinocytes
remains
unclear.
This
study
aimed
examine
effects
CC
extract
its
18
individual
components
HaCaT,
immortalized
human
keratinocyte
line.
bioactive
epicatechin
(EC)
linalool
(LO)
significantly
enhanced
amplitude
without
altering
period.
Gene
expression
analysis
revealed
that
extract,
EC,
LO
altered
mRNA
protein
levels
clock
genes
a
time-dependent
manner.
During
molecular
docking
simulations,
both
EC
exhibited
strong
binding
affinities
RORA,
key
nuclear
receptor
involved
regulation.
Enhanced
BMAL1
promoter
activity
following
treatments
corroborated
findings.
Furthermore,
demonstrated
significant
antioxidant
activities,
as
evidenced
reduced
reactive
oxygen
species
increased
enzymes.
also
upregulated
barrier-related
ceramide
synthesis
cellular
longevity-promoting
genes.
In
conclusion,
particularly
LO,
oxidative
stress,
function
keratinocytes.
These
findings
highlight
potential
novel
dermatological
improve
health
combat
aging.
NAR Genomics and Bioinformatics,
Journal Year:
2022,
Volume and Issue:
4(4)
Published: Oct. 6, 2022
The
skin
is
the
largest
human
organ
with
a
circadian
clock
that
regulates
its
function.
Although
rhythms
in
specific
functions
are
known,
proximal
output,
gene
expression,
have
not
been
thoroughly
explored.
This
work
reports
24
h
expression
two
layers,
epidermis
and
dermis,
cohort
of
young,
healthy
adults,
who
maintained
natural,
regular
sleep-wake
schedules.
10%
expressed
genes
showed
such
diurnal
at
population
level,
which
only
third
differed
between
layers.
Amplitude
phases
varied
more
across
subjects
than
amplitude
being
variable
phases.
Expression
amplitudes
were
larger
subject-variable,
while
they
smaller
consistent
dermis.
Core
was
similar
layers
population-level,
but
heterogeneous
their
variability
subjects.
We
also
identified
small
sets
biomarkers
for
internal
phase
each
layer,
consisted
layer-specific
non-core
genes.
provides
valuable
resource
to
advance
our
understanding
presents
novel
methodology
quantify
sources
rhythms.
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2022,
Volume and Issue:
Volume 15, P. 1051 - 1063
Published: June 1, 2022
Late
bedtime
is
a
common
form
of
unhealthy
sleep
pattern
in
adulthood,
which
influences
circadian
rhythm,
and
negatively
affects
health.
However,
little
known
about
the
effect
regular
late
on
skin
characteristics,
particularly
microbiome.To
investigate
changes
effects
physiological
parameters
facial
bacterial
microbiome
219
cases
Chinese
women
aged
18-38
years
living
Shanghai.Based
Self-Evaluation
Questionnaire,
was
categorized
as
11:00
PM;
thus,
volunteers
were
divided
into
early
group
(S0)
(S1).
The
measured
by
non-invasive
instrumental
methods,
analyzed
16S
rRNA
high-throughput
sequencing.The
exhibited
significant
decrease
hydration
content,
firmness
(F4)
elasticity
(R2),
while
TEWL,
sebum
wrinkle
significantly
increased.
result
indicated
that
impaired
integrity
barrier,
damaged
structure,
disrupted
water-oil
balance.
Furthermore,
analysis
α-diversity,
Sobs,
Ace
Chao
index
found
to
(P
<
0.05)
group,
suggesting
reduced
both
abundance
diversity
microbiota.
Moreover,
Pseudomonas
increased
significantly,
Streptococcus,
Stenotrophomonas,
Acinetobacter,
Haemophilus,
Actinomyces
Neisseria
decreased
significantly.
In
addition,
Spearman
correlation
revealed
strong
correlations
between
microbiota
parameters.
Notably,
positively
correlated
with
elasticity,
but
hemoglobin
melanin
content
hydration.Bedtime
an
important
factor
maintaining
Regular
not
only
damages
barrier
structure
also
reduces
composition
microbiome.
Microorganisms,
Journal Year:
2022,
Volume and Issue:
10(2), P. 229 - 229
Published: Jan. 21, 2022
Adverse
childhood
experiences
(ACEs),
which
can
include
child
trafficking,
are
known
to
program
children
for
disrupted
biological
cycles,
premature
aging,
microbiome
dysbiosis,
immune-inflammatory
misregulation,
and
chronic
disease
multimorbidity.
To
date,
the
has
not
been
a
major
focus
of
deprogramming
efforts
despite
its
emerging
role
in
every
aspect
ACE-related
dysbiosis
dysfunction.
This
article
examines:
(1)
utility
incorporating
microorganism-based,
anti-aging
approaches
combat
ACE-programmed
diseases
(also
as
noncommunicable
conditions,
NCDs)
(2)
regulation
core
systems
biology
cycles
that
affect
NCD
comorbid
risk.
In
this
review,
microbiota
influence
over
three
key
cyclic
rhythms
(circadian
sleep
cycle,
lifespan/longevity
cycle)
well
tissue
inflammation
oxidative
stress
discussed
an
opportunity
deprogram
ACE-driven
disorders.
Microbiota,
particularly
those
gut,
have
shown
host-microbe
interactions
regulating
circadian
clock,
quality,
immune
function/senescence,
inflammation.
The
microimmunosome
is
one
several
targets
gut
regulation.
Furthermore,
correcting
misregulated
increased
protecting
telomere
length
extending
what
become
healthspan.
review
concludes
reverse
tragedy
NCDs
managing
human
holobiont
should
routine
part
healthcare
preventative
medicine
across
life
course.
Dermatitis,
Journal Year:
2023,
Volume and Issue:
35(S1), P. S7 - S12
Published: Sept. 27, 2023
Abstract:
Atopic
dermatitis
(AD)
is
a
chronic
burdensome
inflammatory
skin
disease
with
well-established
cutaneous
and
systemic
comorbidities
burden.
AD
particularly
has
profound
impacts
on
sleep
in
individuals
of
all
ages.
Sleep
disturbances
(SDs)
affect
6.2%
school-age
children
33–87.1%
adults
AD.
This
narrative
review
addresses
the
burden
SD
patients,
as
well
biological
mechanisms
AD,
including
clocks
influencing
sleep,
inflammation,
behavior.
Approaches
for
early
detection,
diagnosis,
objective
quantification,
patient
education,
management
are
reviewed.
It
imperative
to
break
itch–scratch
cycle
reduce
SDs
improve
quality
life
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(6), P. 3883 - 3892
Published: Feb. 22, 2024
Abstract
Sleep
is
crucial
for
preserving
both
physical
and
mental
health,
including
skin
health.
Presently,
there
a
burgeoning
interest
in
the
use
of
herbal
natural
ingredients
to
mitigate
adverse
effects
sleep
disorders.
In
this
4‐week,
randomized,
double‐blind,
controlled
trial,
70
subjects
with
disorders
were
randomly
assigned
receive
either
placebo
or
Poria
cocos
,
Ziziphus
spinose
GABA
(PZG)
supplement
(10
mL
per
day).
Total
duration
was
detected
by
wrist
actigraphy,
quality
assessed
Pittsburgh
Quality
Index
(PSQI).
Skin
conditions
evaluated
based
on
assessments
hydration,
glossiness
elasticity,
color,
severity
wrinkles,
roughness.
After
4
weeks,
total
significantly
increased
12.96%
(
p
=
.006)
PSQI
score
notably
decreased
59.94%
.000)
compared
baseline.
Notably,
baseline
conditions,
radiance,
firmness,
wrinkle
severity,
roughness
improved
PZG
group.
addition,
group
demonstrated
greater
improvements
than
terms
changes
from
duration,
score,
The
present
results
that
combined
intake
herbs
can
improve
enhance
health
without
effects.
