Microbial Dynamics: Assessing Skincare Regimens’ Impact on the Facial Skin Microbiome and Skin Health Parameters DOI Creative Commons

Nicole Wagner,

Valerie Diane Valeriano,

Samuel Diou-Hirtz

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2655 - 2655

Published: Dec. 21, 2024

The human skin microbiome, a complex ecosystem of microbes, plays pivotal role in health. This study aimed to investigate the impact two skincare regimens, with preservatives (CSPs) and preservative-free (PFPs), on microbiome correlation quality. double-blind randomized cosmetic studywith split-face design was conducted 26 female participants. Microbial diversity abundance were analyzed using 16S rRNA amplicon sequence data quality utilizing Antera 3D camera. We confirmed earlier studies identification major microbial taxa at genus level, including Cutibacterium acnes, Corynebacterium, Neisseriaceae as predominant part facial microbiome. Furthermore, profile-based subgrouping employed, which revealed that cluster, characterized by family its organism, exhibited significant reduction folds count, fine lines, redness after application PFP compared CSP. A Spearman analysis highlighted between changes specific bacteria parameters such redness, pores, texture context comparing Overall, treatment demonstrated greater number correlations bacterial CSP treatment, suggesting distinct regimen Our provides insights into different microbiome-centered approaches improve our understanding microbiome’s interplay but also highlights need for larger, comprehensive research further understand dermatology.

Language: Английский

The influence of lifestyle and environmental factors on host resilience through a homeostatic skin microbiota: An EAACI Task Force Report DOI Creative Commons
Inge Kortekaas Krohn, Chris Callewaert, Hafsa Belasri

et al.

Allergy, Journal Year: 2024, Volume and Issue: 79(12), P. 3269 - 3284

Published: Nov. 1, 2024

Abstract Human skin is colonized with microbiota that includes commensal bacteria, fungi, arthropods, archaea and viruses. The composition of the varies at different anatomical locations according to changes in body temperature, pH, humidity/hydration or sebum content. A homeostatic crucial maintain epithelial barrier functions, protect from invading pathogens interact immune system. Therefore, maintaining homeostasis holds promise be an achievable goal for microbiome‐directed treatment strategies as well a prophylactic strategy prevent development diseases, dysbiosis disruption associated inflammation. healthy microbiome likely modulated by genetic environmental lifestyle factors. In this review, we aim provide complete overview factors can contribute healthy. Awareness these could basis diseases used therapeutic approach.

Language: Английский

Citations

6
Natural light control to improve awakening quality DOI Creative Commons
Xiaorui Wang, Yangcheng Gu, Jihui Yuan

et al.

Building and Environment, Journal Year: 2025, Volume and Issue: unknown, P. 112733 - 112733

Published: Feb. 1, 2025

Language: Английский

Citations

0
Enhanced Skin Permeation of Anti‐Aging Peptides Using Bioactive Ionic Liquids at Low Concentrations DOI
Mi Wang,

Zhenyuan Wang,

Tianqi Liu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(42)

Published: June 21, 2023

Abstract Delaying aging is an eternal goal for humanity. Acetyl hexapeptide‐8 (AHP‐8) effective skin anti‐aging drug that locally interrupts the signal transmission of muscle contractions and promotes collagen production, thus smoothening wrinkles. However, its high molecular weight strong hydrophilicity limit permeation capacity. To solve this problem, ionic liquid with excellent bioactivity, MAC, synthesized from l ‐malic acid ‐carnitine used as a enhancer to improve effects AHP‐8. The ratio MAC's components optimized based on density functional theory calculations cytotoxicity experiments. Low concentrations MAC significantly increase AHP‐8 transdermal delivery, reaching maximum at 5‐10 wt% MAC. pro‐permeation mechanism investigated using dynamics simulations, penetration enhancement performance are demonstrated by conducting cellular, animal, clinical results show MAC/AHP‐8 outperforms in terms hyaluronic synthesis, anti‐inflammation, anti‐oxidation, inhibition contraction, reducing number area wrinkles increasing moisture elasticity. This study presents simple efficient vehicle application

Language: Английский

Citations

9
Facial Physiological Characteristics and Skin Microbiomes Changes are Associated with Body Mass Index (BMI) DOI Creative Commons
Laiji Ma, Huan Zhang,

Qingwen Jia

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 513 - 528

Published: March 1, 2024

Background: Overweight and obesity have become public health problems worldwide. An increasing number of research works are focusing on skin physiology the manifestations obesity-associated diseases, but little is known about correlations between body mass index (BMI), facial physiological parameters, microbiome in healthy women. Objective: To investigate BMI, parameters bacteria fungi 198 women aged 18 to 35 years Shanghai. Methods: According international BMI standard Chinese reference standard, subjects were divided into three groups, "lean" B1, "normal" B2 "overweight" B3, measured by non-invasive instrumental methods, microbiota was analyzed 16S rRNA ITS high-throughput sequencing. Results: Compared with normal group, those overweight group exhibited a significant increase trans-epidermal water loss (TEWL), which indicated that barrier impaired. The haemoglobin content significantly increased, surface pH decreased high BMI. Furthermore, α-diversity, analysed using Shannon, Chao, Sobs, Ace indexes, increased suggesting diversity species abundance bacterial fungal also increased. Moreover, had higher abundances Streptococcus, Corynebacterium, Malassezia , Candida . Notably, negatively correlated relative Malassezia, Cladosporium Besides, positively associated Staphylococcus Corynebacterium Conclusion: These results indicate differences biophysical properties skin. A affects integrity changes flora composition. Keywords: index, microbiome, pH,

Language: Английский

Citations

3
The Characteristics of the Skin Physiological Parameters and Facial Microbiome of “Ideal Skin” in Shanghai Women DOI Creative Commons
Laiji Ma, Yujie Niu,

Chunying Yuan

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2023, Volume and Issue: Volume 16, P. 325 - 337

Published: Feb. 1, 2023

Everyone pursues perfect skin, but there exist significant differences between cultures, and no commonly accepted standards have been established. Therefore, our study attempted to define the "ideal skin" of oriental women analyze relationship different skin physiological parameters microbiomes.Based on customized grading standard, VISIA CR photos 111 young aged from 18 25 in Shanghai were collected scored by severity pores, acne, spots, wrinkles. The volunteers then divided into (W1), "normal (W2), "undesirable (W3) groups. facial measured non-invasive instrumental methods, microbiome was analyzed 16S rRNA ITS high-throughput sequencing.From skin", parameters, α-diversity, composition showed noticeable regular changes. Compared with (W2) (W3), (W1) group had lower sebum content, TEWL, melanin, hemoglobin, roughness higher hydration content pH value. Furthermore, Shannon index bacteria significantly increased W1 (P = 0.004), suggesting that ideal species diversity. From W3, changed significantly. abundance Actinobacteria increased, while Proteobacteria Bacteroidetes decreased. Correspondingly, abundances lipophilic Propionibacterium Malassezia Stenotrophomonas, Pseudomonas, Ralstonia, Streptococcus, Additionally, Spearman correlation analysis revealed strong correlations microbiota. Notably, positively correlated 0.03) negatively Cutibacterium 0.000), hemoglobin 0.025), 0.5). played an important role maintaining α-diversity homeostasis.Ideal better water-oil balance barrier function, microbial diversity, more reasonable distribution. daily skincare needs control oil maintain microecological achieve conditions for 18-25 years old.

Language: Английский

Citations

7
Clinical efficacy of a multilamellar cream on skin physiology and microbiome in an epidermal stress model: A controlled double‐blinded study (Part I)1 DOI Creative Commons
Joachim W. Fluhr, Peter Menzel, Rolf Schwarzer

et al.

International Journal of Cosmetic Science, Journal Year: 2024, Volume and Issue: 46(4), P. 566 - 577

Published: Aug. 1, 2024

Abstract Introduction Stratum corneum (SC) is essential for skin barrier function, mitigating water loss and shielding against potentially harmful substances allergens. The SC's lipid matrix, arranged in a lamellar structure, integral to its protective role. Our study explores the restoration effects of multilamellar cream with an acidic pH compared basic placebo on physiology interaction microbiome after stress induction via tape stripping (TS). Materials Methods In this double‐blind study, 14 healthy participants aged 21–58 years were assessed pre‐ post‐tape stripping, followed by days application test evaluations 7, 17 sustained effects. Skin was analysed terms epidermal SC hydration surface pH. 16S rRNA amplicon sequencing gene using Illumina MiSeq, subsequent species identification. Results showed significant improvements repair verum, particularly application, while both creams initially enhanced stratum hydration. No changes surface‐pH detected. analysis revealed that TS slightly decreased alpha diversity, trend verum significantly reversed, enhancing diversity beyond baseline levels days. Overall, contributed broader microbial phyla over time, no abundance specific genera or noted between treatments. Discussion Conclusion delineates efficacy pH‐optimized recovery post‐sequential TS, contrast unstructured placebo. Verum improved function at day 14, evident treatment period. Furthermore, formulation facilitated restitution cutaneous key indicator ecology, underscoring symbiotic relationship integrity composition. These findings underscore importance emollient structures dermatological therapeutics, potential implications design advanced skincare interventions holistically support resilience homeostasis.

Language: Английский

Citations

1
Regulation of dermal circadian pathways by a novel topical formulation DOI Creative Commons
Charlene DeHaven,

Stephanie Wheeler,

Anna Langerveld

et al.

International Journal of Cosmetic Science, Journal Year: 2024, Volume and Issue: 47(1), P. 123 - 133

Published: Sept. 1, 2024

Skin health is impacted by a wide range of intrinsic and extrinsic factors (J Dermatol Sci, 2017, 85, 152), including those that impact circadian rhythm, such as sleep disruption (Textbook Aging Skin, 2016), UV (Biomed Pathol, 2013, 3, 161) blue light (Int J Cosmet 2019, 41, 558). Disruption the skin's endogenous balance, even consistently late bedtime, has deleterious effects on multiple measurements skin health, hydration, barrier protection, microbiome counts regeneration, among others (Clin Investig Dermatol, 2022, 15, 1051). repair processes occur at night help to maintain important aspects (FEBS Lett, 2021, 595, 2413). Interest increasing in development topical products restore proper function. This study demonstrates proprietary formulation regulates new established gene protein biomarkers entrainment demonstrating product's potential appropriate dermal diurnal balance.

Language: Английский

Citations

1
Efficacy and Safety of Topical Application of Plant‐Based Products on Skin Aging in Healthy Individuals: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials DOI Creative Commons
Fengrui Cheng, Jinhong Feng, Zhongren Cao

et al.

Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

ABSTRACT Background Recently, numerous topical products containing plant‐based ingredients have been reported to resist skin aging. However, there is a lack of sufficient evidence substantiate these claims. This paper presents comprehensive review and meta‐analysis evaluate the efficacy safety plants or plant extracts in anti‐aging. Methods Four databases—PubMed, Embase, Web Science, Cochrane Library (CENTRAL)—were systematically searched for articles related interventions aging, covering period from January 2000 December 2024. A total eight randomized controlled trials (RCTs) met inclusion criteria were included meta‐analysis. Results Products demonstrated statistically significant difference improving hydration elasticity, reducing melanin erythema compared other products. No statistical was observed transepidermal water loss (TEWL). Subgroup analysis revealed improvement overall elasticity (R2) during short‐term (≤ 8 weeks)treatments, while no long‐term (> weeks)treatments. Additionally, specific measurements including R5 (net elasticity) R7 (the ratio elastic recovery deformation). Regarding safety, adverse events six studies, remaining two studies did not specify whether occurred. Conclusion The results indicated that botanical preparations significantly enhanced hydration, reduced levels erythema, increased elasticity. provide support reduction (TEWL), improvements Systematic Review Registration PROSPERO (york.ac.uk) identifier: CRD42023478803

Language: Английский

Citations

1
The menstrual cycle regularity and skin: irregular menstrual cycle affects skin physiological properties and skin bacterial microbiome in urban Chinese women DOI Creative Commons
Laiji Ma,

Jiang Hong,

Tingting Han

et al.

BMC Women s Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: May 31, 2023

Abstract Background The regularity of the menstrual cycle directly affects women’s health. Many studies have focused on health; however, regularity-related variations in skin physiological characteristics and microbiota been seldom investigated. Methods To investigate 197 cases Chinese women aged 18–35 years living shanghai 2021. Based a self-evaluation questionnaire, volunteers were divided into three groups C1 (those with regular cycle), C2 less cycle) C3 an irregular cycle). parameters facial measured by non-invasive methods microbiome was analyzed 16S rRNA high-throughput sequencing. Results In group, hydration content significantly decreased ( p < 0.05), TEWL increased sebum > indicating that barrier integrity weakened irregularity. Additionally, melanin level, L value b 0.05) but 0.001), which indicated color became darker. Furthermore, diversity increasing irregularity, differences not significant. composition showed proportion Firmicutes, Acinetobacter, Staphylococcus Cutibacterium those cycle, alterations ratio bacterial phyla and/or genera might disturb homeostasis. Spearman correlation analysis revealed strong correlations between parameters. associations among hormones, microbiota, it is possible parameters, as well microbial composition, change hormonal fluctuations during cycle. Conclusions An can affect microbiota. Female should strengthen care practices use products moisturising soothing effects to protect their skin.

Language: Английский

Citations

3
Skin biophysical parameters and serum dermokine levels in airline pilots: a comparative study with office workers DOI Open Access
Piercarlo Minoretti,

Andrés Santiago Sáez,

Ángel F. García Martín

et al.

Advances in Dermatology and Allergology, Journal Year: 2023, Volume and Issue: 40(6), P. 757 - 761

Published: Jan. 1, 2023

Concerns are growing in the aviation industry about occupational skin diseases like malignant melanoma (MM) among airline pilots (APs), due to unique working environment that exposes them various stressors.

Language: Английский

Citations

2