Don’t Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 650 - 650
Published: Jan. 14, 2025
Sphingolipidomic
mass
spectrometry
has
provided
valuable
information-and
surprises-about
sphingolipid
structures,
metabolism,
and
functions
in
normal
biological
processes
disease.
Nonetheless,
many
noteworthy
compounds
are
not
routinely
determined,
such
as
the
following:
most
of
sphingoid
bases
that
mammals
biosynthesize
de
novo
other
than
sphingosine
(and
sometimes
sphinganine)
or
acquire
from
exogenous
sources;
infrequently
considered
metabolites
bases,
N-(methyl)n-derivatives;
"ceramides"
common
N-acylsphingosines;
complex
sphingolipids
sphingomyelins
simple
glycosphingolipids,
including
glucosyl-
galactosylceramides,
which
usually
reported
"monohexosylceramides".
These
subspecies
discussed,
well
some
circumstances
when
they
likely
to
be
seen
(or
present
missed)
due
experimental
conditions
can
influence
uptake
diet
microbiome,
artifacts
produced
during
extraction
analysis.
If
these
factors
kept
mind
design
interpretation
lipidomic
studies,
investigators
surprised
by
how
often
appear
thereby
advance
knowledge
about
them.
Language: Английский
Serum antibody screening using glycan arrays
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(5), P. 2603 - 2642
Published: Jan. 1, 2024
Humans
and
other
animals
produce
a
diverse
collection
of
antibodies,
many
which
bind
to
carbohydrate
chains,
referred
as
glycans.
These
anti-glycan
antibodies
are
critical
part
our
immune
systems'
defenses.
Whether
induced
by
vaccination
or
natural
exposure
pathogen,
can
provide
protection
against
infections
cancers.
Alternatively,
when
an
response
goes
awry,
that
recognize
self-glycans
mediate
autoimmune
diseases.
In
any
case,
serum
rich
source
information
about
patient's
overall
health,
history,
disease
status.
Glycan
microarrays
high-throughput
platform
rapidly
interrogate
identify
new
biomarkers
for
variety
conditions.
addition,
glycan
enable
detailed
analysis
the
system's
vaccines
treatments.
Herein
we
review
applications
microarray
technology
antibody
profiling.
Language: Английский
The Bioactive Sphingolipid Playbook. A Primer for the Uninitiated as well as Sphingolipidologists
Journal of Lipid Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100813 - 100813
Published: April 1, 2025
Language: Английский
Glycolipidomics of Liver Flukes and Host Tissues during Fascioliasis: Insights from Mass Spectrometry Imaging
ACS Infectious Diseases,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 7, 2024
Fascioliasis,
a
zoonotic
disease
caused
by
liver
flukes
of
the
genus
Language: Английский
An open chat with… Sandro Sonnino
FEBS Open Bio,
Journal Year:
2023,
Volume and Issue:
13(9), P. 1544 - 1547
Published: Aug. 17, 2023
Sandro
Sonnino
is
one
of
the
founding
members
Editorial
Board
FEBS
Open
Bio
,
having
joined
in
2011.
He
also
a
member
Letters
and
Editor‐in‐Chief
Glycoconjugate
Journal
.
full
professor
biochemistry
School
Medicine
at
University
Milan,
where
he
was
formerly
coordinator
Interdisciplinary
Laboratory
Advanced
Technology
(LITA)
Director
Department
Medical
Chemistry,
Biochemistry,
Biotechnology.
His
research
focused
on
metabolism
biochemical
properties
gangliosides
glycosphingolipids,
their
role
cell
signaling
nervous
system.
guest
editor
this
special
“In
Limelight”
issue
glycosphingolipids
disease,
which
features
multiple
Reviews
an
original
article
related
to
field.
In
interview,
discusses
ongoing
importance
his
personal
career
journey.
Language: Английский