Combined Bulk and Single-Cell Transcriptomic Analysis to Reveal the Potential Influences of Intestinal Inflammatory Disease on Multiple Sclerosis DOI Creative Commons
Xu Zhu, Junyu Zhu, Zhuo Ma

et al.

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Multiple sclerosis (MS) and inflammatory bowel disease (IBD) are both autoimmune disorders caused by dysregulated immune responses. Still, there is a growing awareness of the comorbidity between MS IBD. However, shared pathophysiological mechanisms these two diseases still lacking. RNA sequencing datasets (GSE126124, GSE9686, GSE36807, GSE21942) were analyzed to identify differential expressed genes (DEGs) for IBD experimental allergic encephalomyelitis (EAE). Other (GSE17048, GSE75214, GSE16879) downloaded further verification analysis. Shared pathways regulatory networks explored based on DEGs. The single-cell transcriptome central nervous system (CNS) cells sequenced from EAE brains public (PRJCA003980) characteristics Mass cytometry time-of-flight (CyTOF) peripheral blood mononuclear (PBMCs) was performed systematic response in model. Machine learning algorithms also used diagnostic biomarkers MS. We identified 74 common DEGs selected datasets, data intestinal tissues patients showed that 56 highly enriched IL1B+ macrophages. These DEGs, defined as inflammation-related (IRGs), pro-inflammatory macrophages mice patients. abundance CD14+ monocytes validated CyTOF data. IRGs response, NOD-like receptor signaling pathway, IL-18 other related pathways. In addition, 'AddModuleScore_UCell' analysis (such IL1B, S100A8, factors) mainly macrophages, which play an essential role activation multiple sclerosis, such IL-17 NF-kappa B TNF pathway. Finally, suppressors cytokine 3(SOCS3) formyl peptide 2(FPR2) potential machine learning. Two compared control, experiments revealed SOCS3 FPR2 samples. IRGs, encode cytokines, exhibit high expression levels may significant storm biomarkers, FPR2, screened out with great value

Language: Английский

Ocrelizumab-induced colitis—critical review and case series from a Romanian cohort of MS patients DOI Creative Commons

Ileana Maria Vodă,

Vlad Eugen Tiu,

Luiza Răuță

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Background Widespread use of ocrelizumab, an anti-CD20 monoclonal antibody, for treating patients with multiple sclerosis (MS), has led to increase in reported adverse events following real-world observation. Among these, drug-induced colitis is a rare, but severe side effect, prompting recent FDA statement regarding this safety concern. Objectives: We analyzed cohort ocrelizumab treated our MS center evaluate the incidence colitis. Methods present critical review available literature on diagnosis and management induced display case series 3 suspected cohort. Results Two met full criteria ocrelizumab-induced colitis, while third partially criteria. Following symptomatic treatment discontinuation showed favorable outcomes. Conclusion Ocrelizumab-induced event. Its may be higher than expected, reaching 1,95% patients. Further reporting such cases essential broaden understanding effect.

Language: Английский

Citations

0
Inflammatory bowel disease and neuropsychiatric disorders: Mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis DOI Creative Commons

Guido Petracco,

Isabella Faimann, Florian Reichmann

et al.

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108831 - 108831

Published: Feb. 1, 2025

Language: Английский

Citations

0
Immunity orchestrates a bridge in gut-brain axis of neurodegenerative diseases DOI

Yufeng Cheng,

Ce Chen, Feng Zhang

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 85, P. 101857 - 101857

Published: Jan. 17, 2023

Language: Английский

Citations

12
Myeloid‐derived suppressor cells in the therapy of autoimmune diseases DOI Open Access
Marina Bekić, Sergej Tomić

European Journal of Immunology, Journal Year: 2023, Volume and Issue: 53(12)

Published: Sept. 25, 2023

Abstract Myeloid‐derived suppressor cells (MDSCs) are well recognized as critical factors in the pathology of tumors. However, their roles autoimmune diseases still unclear, which hampers development efficient immunotherapies. The role different MDSCs subsets multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and systemic lupus erythematosus displayed mechanisms immune suppression, several studies pointed to MDSCs’ capacity induce T‐helper (Th)17 tissue damage. These results also suggested that could be present functional states utilize for controlling activity T B cells. Therefore, various therapeutic strategies should employed restore homeostasis diseases. therapies harnessing designed either cell therapy or rely on expansion activation vivo, depletion. Cumulatively, inevitable players autoimmunity, rational approaches developing required avoid adverse effects harness suppressive improve overall efficacy autoimmunity therapy.

Language: Английский

Citations

12
mRNA expression profile from whole blood revealed a cluster of 25 shared differentially expressed genes inversely related in multiple sclerosis and inflammatory bowel disease DOI

V Palanivel,

Priyanka Tiwari,

Amandeep Kaur

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 106301 - 106301

Published: Jan. 1, 2025

Language: Английский

Citations

0
Impact of Anti-CD20 therapies on the immune homeostasis of gastrointestinal mucosa and their relationship with de novo intestinal bowel disease in multiple sclerosis: a review DOI Creative Commons
Adrià Quesada-Simó, Alejandro Garrido‐Marín, Pilar Nos

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: May 30, 2023

Multiple sclerosis (MS) and inflammatory bowel disease (IBD) are autoimmune disorders characterized by episodes affecting the brain gastrointestinal (GI) tract, respectively. The frequent association between MS IBD suggests that both conditions may share common pathogenic mechanisms. However, different responses to biological therapies indicate differences in immune mechanisms of inflammation. Anti-CD20 high efficacy treatments increasingly used control bursts MS, but they alter GI homeostasis promote development inflammation susceptible individuals. This review analyzes mechanistic immunity IBD, effect anti-CD20 on gut microenvironment, provides recommendations for early detection management toxicities context B-cell depletion patients.

Language: Английский

Citations

9
Inflammatory bowel disease is associated with an increase in the incidence of multiple sclerosis: a retrospective cohort study of 24,934 patients DOI Creative Commons
Kaneschka Yaqubi, Karel Kostev,

Isabel Klein

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: March 20, 2024

Abstract Background Recent data suggest a potential pathophysiological link between inflammatory bowel disease (IBD) and multiple sclerosis (MS), two immune-mediated diseases both of which can have significant impact on patients' quality life. In the present manuscript, we investigate association IBD MS in German cohort general practice patients. These results may important implications for screening management patients with IBD, as well further research into mechanisms underlying disorders. Methods 4,934 individuals (11,140 Crohn’s (CD) 13,794 ulcerative colitis (UC)) 24,934 propensity score matched without were identified from Disease Analyzer database (IQVIA). A subsequent diagnosis was analyzed function using Cox regression models. Results After 10 years follow-up, 0.9% 0.7% CD UC but only 0.5% 0.3% non-IBD pairs diagnosed MS, respectively (p = 0.002 p < 0.001). Both (HR: 2.09; 95% CI 1.28–3.39) 2.35; 1.47–3.78) significantly associated diagnosis. Subgroup analysis revealed that more pronounced among male Conclusion The our notable findings warrant investigation clinical future.

Language: Английский

Citations

3
Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease DOI Creative Commons

Zhao Hongxiang,

Meiyan Sun, Yue Zhang

et al.

Aging and Disease, Journal Year: 2023, Volume and Issue: 15(1), P. 115 - 115

Published: May 23, 2023

As a recently discovered waste removal system in the brain, cerebral lymphatic is thought to play an important role regulating homeostasis of central nervous system. Currently, more and attention being focused on Further understanding structural functional characteristics essential better understand pathogenesis diseases explore therapeutic approaches. In this review, we summarize components More importantly, it closely associated with peripheral gastrointestinal tract, liver, kidney. However, there still gap study believe that critical mediator interactions between

Language: Английский

Citations

7
Association between inflammatory bowel disease and all-cause dementia: A two-sample Mendelian randomization study DOI Open Access

Ou-Lan Liao,

Siyuan Xie, Jun Ye

et al.

World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(1), P. 15 - 25

Published: Jan. 19, 2024

BACKGROUND Numerous observational studies have documented a correlation between inflammatory bowel disease (IBD) and an increased risk of dementia. However, the causality their associations remains elusive. AIM To assess causal relationship IBD occurrence all-cause dementia using two-sample Mendelian randomization (MR) method. METHODS Genetic variants extracted from large genome-wide association study (GWAS) for (the International Genetics Consortium, n = 34652) were used to identify link (FinnGen, 306102). The results validated via another GWAS (United Kingdom Biobank, 463372). Moreover, MR egger intercept, pleiotropy residual sum outlier, Cochran's Q test employed evaluate heterogeneity. Finally, multiple methods performed estimate effects genetically predicted on dementia, with inverse variance wei-ghted approach adopted as primary analysis. RESULTS heterogeneity tests revealed absence significant pleiotropic or across all genetic in outcome GWAS. No evidence effect was identified weighted [odds ratio (OR) 0.980, 95%CI : 0.942-1.020, P value 0.325], median (OR 0.964, 0.914-1.017, 0.180), MR-Egger 0.963, 0.867-1.070, 0.492) approaches. Consistent observed validation analyses. Reverse analysis also showed no development IBD. Furthermore, suggested that its subtypes did not causally affect four subtypes, including Alzheimer's disease, vascular other diseases classified elsewhere, unspecified CONCLUSION Taken together, our signaled subentities associated subtypes. Further prospective are warranted elucidate impact intestinal inflammation

Language: Английский

Citations

2
Investigating Causality and Shared Genetic Architecture between Neurodegenerative Disorders and Inflammatory Bowel Disease DOI Creative Commons
Ruijie Zeng, Jinghua Wang, Rui Jiang

et al.

Aging and Disease, Journal Year: 2022, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2022

Published observational studies have revealed the connection between neurodegenerative disorders and inflammatory bowel disease (IBD), whereas causal association remains largely unclear. Our study aims to assess causality identify shared genetic architecture IBD. Two-sample Mendelian randomization analyses were performed IBD (amyotrophic lateral sclerosis [ALS], Alzheimer's [AD], Parkinson's [PD], multiple [MS]). Shared loci, functional interpretation, transcriptomic profiles further investigated in ALS We identified that predisposition was suggestively associated with lower odds of (odds ratio [OR] 0.96, 95% confidence interval [CI] 0.94 0.99). In contrast, not genetically an increased risk AD, PD, or MS (and vice versa). Two loci (rs6571361 rs7154847) derived, SCFD1, G2E3, HEATR5A as novel genes enriched functions related membrane trafficking. G2E3 differentially expressed significantly correlated SCFD1 patients reveals protective role on ALS, does support findings indicate possible pathways These results provide insights into pathogenesis therapeutics disorders.

Language: Английский

Citations

12