A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling DOI Creative Commons
Yinghong Liu, Xiaojuan Yang

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 6, 2024

Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease affecting various body organs and systems. The diagnosis of SLE its complications based on evident clinical symptoms, serological marker levels, pathological findings. Some markers have low sensitivity specificity, biopsy procedures are invasive in nature. Hence, metabolomics has emerged as valuable tool for screening categorization. Its application contributed significantly to identifying pathogenesis, improving diagnosis, developing treatment approaches. This review provides an overview the utilization study SLE, focusing advancements understanding disease’s aiding monitoring efficacy.

Language: Английский

Endometriosis and autoimmunity DOI

Luz P. Blanco,

Noemi Salmeri, Sarah M. Temkin

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103752 - 103752

Published: Jan. 1, 2025

Language: Английский

Citations

4
Overview of Oxidative Stress in Systemic Lupus Erythematosus DOI Creative Commons
Ancuţa Ignat, Gabriela Stoleriu, Alin Horațiu Nedelcu

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 303 - 303

Published: March 1, 2025

Systemic lupus erythematosus (SLE) is an autoimmune disease that frequently diagnosed in female patients, caused by multiple interacting factors. It has a complex pathogenesis which can affect almost any organ, from the kidneys to cardiovascular, pulmonary, neurological, osteoarticular, and hematological systems. The present narrative review seeks elucidate role of reactive oxygen species (ROS) SLE. central question guiding this study what extent these serum protein modifications correlate with activity organ damage characterized decreased apoptosis increased necrosis T cells NETosis granulocytes. Given impact SLE diagnosis on one's life, aims evaluate intricacies oxidative stress its relevance treatment disease. Topics such as understanding processes stress, their damaging pathways, biomarkers, future assistance clinical decisions will be discussed article. accurate determination biomarkers taught improve both management disease, while antioxidant therapy may open new door for treatment.

Language: Английский

Citations

1
Remodeling of T-cell mitochondrial metabolism to treat autoimmune diseases DOI Creative Commons

Liyan Lin,

Ruyu Ren,

Qiao Xiong

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(6), P. 103583 - 103583

Published: June 1, 2024

T cells are key drivers of the pathogenesis autoimmune diseases by producing cytokines, stimulating generation autoantibodies, and mediating tissue cell damage. Distinct mitochondrial metabolic pathways govern direction T-cell differentiation function rely on specific nutrients enzymes. Metabolic substrate uptake metabolism form foundational elements for activation, proliferation, differentiation, effector function, contributing to dynamic interplay between immunological signals in coordinating adaptive immunity. Perturbations availability enzyme activity may impair immunosuppressive fostering autoreactive responses disrupting immune homeostasis, ultimately disease pathogenesis. A growing body studies has explored how processes regulate diverse subsets such as systemic lupus erythematosus (SLE), multiple sclerosis (MS), hepatitis (AIH), inflammatory bowel (IBD), psoriasis. This review describes coordination biology metabolism, including electron transport chain (ETC), oxidative phosphorylation, amino acid fatty one‑carbon metabolism. study elucidated intricate crosstalk programs, signal transduction pathways, transcription factors. summarizes potential therapeutic targets signaling diseases, providing insights future studies.

Language: Английский

Citations

6
Neuropsychiatric manifestations in systemic lupus erythematosus and Sjogren's disease DOI
Amanda Carolina Miranda Costa,

Diego de Paula Ferreira Nunes,

Paulo Rogério Júlio

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103756 - 103756

Published: Jan. 1, 2025

Language: Английский

Citations

0
How (Ultra‐)Rare Gene Variants Improve Our Understanding of More Common Autoimmune and Inflammatory Diseases DOI Creative Commons
Alexandre Bélot,

Maud Tusseau,

Jade Cognard

et al.

ACR Open Rheumatology, Journal Year: 2025, Volume and Issue: 7(2)

Published: Feb. 1, 2025

The aim of this study was to explore the impact rare and ultra‐rare genetic variants on understanding treatment autoimmune autoinflammatory diseases with a focus systemic lupus erythematosus (SLE) Behçet syndrome. This review summarizes current research monogenic causes SLE syndrome, highlighting various pathways that can be responsible for these unique phenotypes. In SLE, identification complement DNASE1L3 deficiencies has elucidated mechanisms apoptotic body accumulation extracellular nucleic acid sensing. Type I interferonopathies underline specific role DNA/RNA sensing interferon overexpression in development autoimmunity. Other significant defects include Toll‐like receptor hypersignaling JAK/STATopathies, which contribute breakdown immune tolerance. To date, directly affecting B T cell biology only account minority identified lupus, importance tight regulation mechanistic target rapamycin RAS (Rat sarcoma GTPase)/MAPK (mitogen‐activated protein kinase) signaling lupus. TNFAIP3, RELA , NFKB1 genes have been identified, underscoring NF‐κB overactivation. Additional such as ELF4, WDR1 mutations trisomy 8 further illustrate complexity condition. Observations from studies syndrome highlight inflammatory distinct molecular caused by single‐gene promote or syndromes, often unrecognizable their genetically complex “classical” forms. Insights gained studying enhance our function health disease, paving way targeted therapies personalized medicine.

Language: Английский

Citations

0
Immunometabolic shifts in autoimmune disease: Mechanisms and pathophysiological implications DOI
Yue Chen, Qingqing Lin, Hui Cheng

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 24(3), P. 103738 - 103738

Published: Dec. 30, 2024

Language: Английский

Citations

3
Adaptive immunity and metabolism DOI
Katherine Verbist, Piyush Sharma,

Helen M. Beere

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 157 - 190

Published: Jan. 1, 2025

Language: Английский

Citations

0
Rebalancing redox homeostasis: A pivotal regulator of the cGAS-STING pathway in autoimmune diseases DOI

Yuchen Zhao,

Tianhao Xu, Zhenzhen Wu

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(6), P. 103823 - 103823

Published: April 24, 2025

Language: Английский

Citations

0
Integrating genomics and AI to uncover molecular targets for mRNA vaccine development in lupus nephritis DOI Creative Commons
Lisha Mou, Ying Lü,

Zijing Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

Lupus nephritis (LN), a complex complication of systemic lupus erythematosus, requires in-depth cellular and molecular analysis for advanced treatment strategies, including mRNA vaccine development. In this study, we analyzed single-cell RNA sequencing data from 24 LN patients 10 healthy controls, supplemented by bulk RNA-seq additional controls. By applying non-negative matrix factorization (NMF), identified four distinct leukocyte meta-programs in LN, highlighting diverse immune functions potential targets. Utilizing 12 machine learning algorithms, developed 417 predictive models incorporating gene sets linked to key biological pathways, such as MTOR signaling, autophagy, Toll-like receptor, adaptive immunity pathways. These were instrumental identifying targets Our functional network further revealed intricate interactions, providing novel insights into the basis LN. Additionally, validated expression levels across multiple cohorts correlated them with clinical parameters glomerular filtration rate (GFR) pathological stage. This study represents significant advance research merging genomics precision NMF learning, broadening our understanding at levels. More importantly, findings shed light on development targeted vaccines, offering new possibilities diagnostics therapeutics autoimmune disease.

Language: Английский

Citations

0
A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling DOI Creative Commons
Yinghong Liu, Xiaojuan Yang

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 6, 2024

Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease affecting various body organs and systems. The diagnosis of SLE its complications based on evident clinical symptoms, serological marker levels, pathological findings. Some markers have low sensitivity specificity, biopsy procedures are invasive in nature. Hence, metabolomics has emerged as valuable tool for screening categorization. Its application contributed significantly to identifying pathogenesis, improving diagnosis, developing treatment approaches. This review provides an overview the utilization study SLE, focusing advancements understanding disease’s aiding monitoring efficacy.

Language: Английский

Citations

0