Biomimetic Ti–6Al–4V alloy/gelatin methacrylate hybrid scaffold with enhanced osteogenic and angiogenic capabilities for large bone defect restoration DOI Creative Commons
Limin Ma,

Xiaolan Wang,

Zhou Ye

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(10), P. 3437 - 3448

Published: March 21, 2021

Titanium-based scaffolds are widely used implant materials for bone defect treatment. However, the unmatched biomechanics and poor bioactivities of conventional titanium-based implants usually lead to insufficient integration. To tackle these challenges, it is critical develop novel that meet bioadaptive requirements load-bearing defects. Herein, inspired by microstructure mechanical properties natural tissue, we developed a Ti-6Al-4V alloy (TC4)/gelatin methacrylate (GelMA) hybrid scaffold with dual bionic features (GMPT) repair. GMPT composed hard 3D-printed porous TC4 metal (PT) backbone, which mimics cancellous bone, soft GelMA hydrogel matrix infiltrated into pores PT microenvironment extracellular matrix. Ascribed unique design, resultant demonstrates better osteogenic angiogenic capabilities than PT, as confirmed in vitro rabbit radius experimental results. Moreover, controlling concentration (10%) can further improve osteogenesis angiogenesis GMPT. The fundamental mechanisms were revealed RNA-Seq analysis, showed significantly influenced expression osteogenesis- angiogenesis-related genes via Pi3K/Akt/mTOR pathway. results this work indicate our design represents promising strategy restoration large

Language: Английский

3D Printing Technologies in Metallic Implants: A Thematic Review on the Techniques and Procedures DOI Open Access
Shokouh Attarilar, Mahmoud Ebrahimi, Faramarz Djavanroodi

et al.

International Journal of Bioprinting, Journal Year: 2020, Volume and Issue: 7(1), P. 306 - 306

Published: Dec. 10, 2020

Additive manufacturing (AM) is among the most attractive methods to produce implants, processes are very swift and it can be precisely controlled meet patient's requirement since they produced in exact shape, dimension, even texture of different living tissues. Until now, lots have emerged used this field with diverse characteristics. This review aims comprehensively discuss 3D printing (3DP) technologies manufacture metallic especially on techniques procedures. Various based their main properties categorized, effecting parameters introduced, history AM technology briefly analyzed. Subsequently, utilization these AM-manufactured components medicine along effectual variables discussed, special attention paid production porous scaffolds, taking pore size, density, etc., into consideration. Finally, 3DP popular systems medical applications such as titanium, Ti6Al4V, cobalt-chromium alloys, shape memory alloys studied. In general, manufactured implants need comply important requirements biocompatibility, suitable mechanical (strength elastic modulus), surface conditions, custom-built designs, fast production, etc. introduce implant find new ways design more sophisticated compatible that mimic desired tissue functions.

Language: Английский

Citations

102
Advances in implant surface modifications to improve osseointegration DOI Creative Commons
Guang Zhu, Guocheng Wang, Jiao Jiao Li

et al.

Materials Advances, Journal Year: 2021, Volume and Issue: 2(21), P. 6901 - 6927

Published: Jan. 1, 2021

Presenting the latest advances in surface modification of titanium and alloy implants by physical, chemical biological methods.

Language: Английский

Citations

102
Corrosion and passivation behavior of laser powder bed fusion produced Ti-6Al-4V in static/dynamic NaCl solutions with different concentrations DOI
Qin Peng,

L.Y. Chen,

Yujing Liu

et al.

Corrosion Science, Journal Year: 2021, Volume and Issue: 191, P. 109728 - 109728

Published: July 28, 2021

Language: Английский

Citations

101
Design and perspective of amorphous metal nanoparticles from laser synthesis and processing DOI Creative Commons
Shun‐Xing Liang, Lai‐Chang Zhang, Sven Reichenberger

et al.

Physical Chemistry Chemical Physics, Journal Year: 2021, Volume and Issue: 23(19), P. 11121 - 11154

Published: Jan. 1, 2021

Pulsed laser strategies (i.e.pulsed ablation and fragmentation in liquid) have been reviewed with a focus on the synthesis processing of amorphous metal nanoparticles. The possible formation criteria mechanism discussed.

Language: Английский

Citations

86
Biomimetic Ti–6Al–4V alloy/gelatin methacrylate hybrid scaffold with enhanced osteogenic and angiogenic capabilities for large bone defect restoration DOI Creative Commons
Limin Ma,

Xiaolan Wang,

Zhou Ye

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(10), P. 3437 - 3448

Published: March 21, 2021

Titanium-based scaffolds are widely used implant materials for bone defect treatment. However, the unmatched biomechanics and poor bioactivities of conventional titanium-based implants usually lead to insufficient integration. To tackle these challenges, it is critical develop novel that meet bioadaptive requirements load-bearing defects. Herein, inspired by microstructure mechanical properties natural tissue, we developed a Ti-6Al-4V alloy (TC4)/gelatin methacrylate (GelMA) hybrid scaffold with dual bionic features (GMPT) repair. GMPT composed hard 3D-printed porous TC4 metal (PT) backbone, which mimics cancellous bone, soft GelMA hydrogel matrix infiltrated into pores PT microenvironment extracellular matrix. Ascribed unique design, resultant demonstrates better osteogenic angiogenic capabilities than PT, as confirmed in vitro rabbit radius experimental results. Moreover, controlling concentration (10%) can further improve osteogenesis angiogenesis GMPT. The fundamental mechanisms were revealed RNA-Seq analysis, showed significantly influenced expression osteogenesis- angiogenesis-related genes via Pi3K/Akt/mTOR pathway. results this work indicate our design represents promising strategy restoration large

Language: Английский

Citations

81