Small,
Journal Year:
2019,
Volume and Issue:
16(1)
Published: Dec. 5, 2019
Abstract
As
new
2D
layered
nanomaterials,
Bi
2
O
Se
nanoplates
have
unique
semiconducting
properties
that
can
benefit
biomedical
applications.
Herein,
a
facile
top‐down
approach
for
the
synthesis
of
quantum
dots
(QDs)
in
solution
is
described.
The
QDs
with
size
3.8
nm
and
thickness
1.9
exhibit
high
photothermal
conversion
coefficient
35.7%
good
stability.
In
vitro
vivo
assessments
demonstrate
possess
excellent
photoacoustic
(PA)
performance
therapy
(PTT)
efficiency.
After
systemic
administration,
accumulate
passively
tumors
enabling
efficient
PA
imaging
entire
to
facilitate
imaging‐guided
PTT
without
obvious
toxicity.
Furthermore,
which
degradability
aqueous
media
not
only
sufficient
stability
during
circulation
perform
designed
therapeutic
functions,
but
also
be
discharged
harmlessly
from
body
afterward.
results
reveal
great
potential
as
biodegradable
multifunctional
agent
medical
Advanced Functional Materials,
Journal Year:
2017,
Volume and Issue:
27(40)
Published: Aug. 25, 2017
Abstract
Currently,
most
thrombolytic
agents
are
limited
by
short
circulation
time
and
excessive
dose
needed
for
clinical
therapy,
which
increases
lethal
risk
intracranial
hemorrhage.
Here,
a
near‐infrared‐triggered,
controlled‐release
system,
using
gold@mesoporous
silica
core–shell
nanospheres
(Au@MSNs)
with
phase‐changed
material
1‐tetradecanol,
is
formulated
to
release
urokinase
plasminogen
activators
(uPA)
on
demand.
The
prepared
system
presents
sensitive
releasing
uPA,
owing
an
elevated
temperature
created
Au@MSNs‐induced
photothermal
effect.
For
in
vitro
study,
3D
printed
vein
vasculature
designed
fabricated
simulate
the
thrombolysis
of
blood
vessel.
Murine
tail
thrombus
model
also
built
evaluate
vivo.
Consequently,
localized
hyperthermia
validated
possess
effective
enhancement
thrombolysis.
Therefore,
according
results,
demonstrates
two
aspects
potential
superiority:
controlled
uPA
reducing
side
effects,
hyperthermia‐enhanced
locally
decreasing
drug
dosage.
Assisted
thermal
thrombolysis,
present
shows
high
efficiency,
on‐demand
release,
thus
safer
protocol
fits
developing
trends
precision
medicine.
Small,
Journal Year:
2018,
Volume and Issue:
14(14)
Published: Feb. 22, 2018
Abstract
Near‐infrared
light‐mediated
theranostic
agents
with
superior
tissue
penetration
and
minimal
invasion
have
captivated
researchers
in
cancer
research
the
past
decade.
Herein,
a
probe
sonication‐assisted
liquid
exfoliation
approach
for
scalable
continual
synthesis
of
colloidal
rhenium
disulfide
nanosheets,
which
is
further
explored
as
diagnosis
therapy,
reported.
Due
to
high‐
Z
element
Re
(
=
75)
significant
photoacoustic
effect,
obtained
PVP‐capped
ReS
2
nanosheets
are
evaluated
bimodality
contrast
computed
tomography
imaging.
In
addition,
utilizing
strong
near‐infrared
absorption
ultrahigh
photothermal
conversion
efficiency
(79.2%),
could
also
serve
therapeutic
ablation
tumors
tumor
elimination
rate
up
100%.
Importantly,
show
no
obvious
toxicity
based
on
cytotoxicity
assay,
serum
biochemistry,
histological
analysis.
This
work
highlights
potentials
single‐component
nanoplatform
bioimaging
antitumor
therapy.
Small,
Journal Year:
2019,
Volume and Issue:
16(1)
Published: Dec. 5, 2019
Abstract
As
new
2D
layered
nanomaterials,
Bi
2
O
Se
nanoplates
have
unique
semiconducting
properties
that
can
benefit
biomedical
applications.
Herein,
a
facile
top‐down
approach
for
the
synthesis
of
quantum
dots
(QDs)
in
solution
is
described.
The
QDs
with
size
3.8
nm
and
thickness
1.9
exhibit
high
photothermal
conversion
coefficient
35.7%
good
stability.
In
vitro
vivo
assessments
demonstrate
possess
excellent
photoacoustic
(PA)
performance
therapy
(PTT)
efficiency.
After
systemic
administration,
accumulate
passively
tumors
enabling
efficient
PA
imaging
entire
to
facilitate
imaging‐guided
PTT
without
obvious
toxicity.
Furthermore,
which
degradability
aqueous
media
not
only
sufficient
stability
during
circulation
perform
designed
therapeutic
functions,
but
also
be
discharged
harmlessly
from
body
afterward.
results
reveal
great
potential
as
biodegradable
multifunctional
agent
medical
