Light: A Magical Tool for Controlled Drug Delivery

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(49)

Published: Sept. 9, 2020

Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal spatial control. Great progress has been achieved in the development novel light-driven strategies with both breadth depth. Light-controlled platforms can be generally categorized into three groups: photochemical, photothermal, photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, sulfides oxides, metal-organic frameworks, carbon nanomaterials, upconversion semiconductor stimuli-responsive micelles, polymer- liposome-based nanoparticles have applied light-stimulated delivery. In view increasing interest targeted delivery, we review light-responsive systems focus on recent advances, key limitations, future directions.

Language: Английский

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Self-Amplification of Tumor Oxidative Stress with Degradable Metallic Complexes for Synergistic Cascade Tumor Therapy

Nano Letters, Journal Year: 2020, Volume and Issue: 20(11), P. 8141 - 8150

Published: Oct. 14, 2020

The ferroptosis effect has been illuminated with a clear Fenton reaction mechanism that converts endogenous hydrogen peroxide (H2O2) into highly oxidative hydroxyl radicals (·OH) in ROS-amplified tumor therapy. This ferroptosis-related oxidation was then further enhanced by the enzyme-like roles of cisplatin (CDDP). CDDP-induced apoptosis promoted reverse via depletion glutathione (GSH) and prevention DNA damage repair. Here, we have developed degradable metallic complexes (PtH@FeP) containing an Fe(III)-polydopamine (FeP) core HA-cross-linked CDDP (PtH) shell, exaggerating situ toxic ROS production synergistic Fe(III). Taken together, rationally designed PtH@FeP provided new strategy for self-amplified chemotherapy/ferroptosis/photothermal therapy (PTT) antitumor effects reduced dosage facilitates clinical safety.

Language: Английский

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Nanomaterials for photothermal and photodynamic cancer therapy

Applied Physics Reviews, Journal Year: 2022, Volume and Issue: 9(1)

Published: March 1, 2022

In recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and particularly emphasized. Currently, by extraordinary development different fields medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) toxic heat generation photodynamic (PDT) reactive oxygen species, are known promising phototherapeutic techniques, which can overcome limitations conventional protocols. Moreover, nanomaterial-based PDT PTT match simultaneous immune increase system stimulation resulting from denaturation cancer cells. Nevertheless, should sufficient biocompatibility efficiency to meet requirements agents. The present review focuses on potency PDT, PTT, also their combined alternative protocols with minimal morbidity integrated into gold standard treatments surgery, chemotherapy, radiation at tumor treatment cancer-related infectious diseases. addition, for deeper understanding, photoablation effects emphasis nature, morphology, size photosensitive were studied. Finally, transportation needed carriers photosensitizers agents hard-accessed regions, example, cancerous investigated.

Language: Английский

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Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Language: Английский

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Recent Advances in the Growth Strategies, Multifunctional Properties, and Emerging Applications of Two‐Dimensional Non‐van der Waals Bismuth Oxychalcogenides and Prospective Heterostructures

Small Structures, Journal Year: 2024, Volume and Issue: 5(8)

Published: Jan. 29, 2024

With the advent of two‐dimensional (2D) van der Waals (vdW) materials, many non‐van (nvdW) materials have been synthesized and are being exploited for novel applications. Bismuth oxychalcogenides (Bi 2 O X; X is S, Se, Te), a nvdW series with moderate band gap semiconductors, possess high carrier mobility air stability. The layers in Bi stay formal bond, giving rise to distinct structural, optical, thermal, electronic properties different from conventional vdW materials. Herein, these properties, their synthesis, transfer methods 2D examined. photodetector application heterostructure (HS) surveyed special attention Se. Beyond photodetector, other emerging fields, such as gas‐bio sensors, optoelectronic imaging, integrated memory, solar cells, photothermal technology looked over. Based on ongoing research challenges, strategies future innovations presented basics miniaturized In view offsets type HS 94 vdW‐nvdW sets proposed. This review will guide studies meet increasing demands multifunctional applications laboratory industrial scale.

Language: Английский

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Progress Report on Property, Preparation, and Application of Bi₂O₂Se

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(49)

Published: Sept. 9, 2020

Abstract The study of 2D materials has been a significant and fascinating area, at least since the discovery graphene. As one layered bismuth oxychalcogenides, oxyselenide (Bi 2 O Se) drawn lot attention recently. Bi Se was mainly focused on its thermoelectric performance until ultrathin structure came to fore. New physical properties were discovered along with successful synthesis structures. Few‐layer exhibits ultrahigh mobility, outstanding stability, tunable bandgaps, excellent mechanical properties, showing remarkable in electronics optoelectronics. In this report, an overview recent advances research is provided, including structure/property modifications, synthetic methods, practical applications. Theoretical experimental results bulk/few‐layer are both discussed report. Finally, challenges outlook for evaluated based current progress.

Language: Английский

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Glue-assisted grinding exfoliation of large-size 2D materials for insulating thermal conduction and large-current-density hydrogen evolution

Materials Today, Journal Year: 2021, Volume and Issue: 51, P. 145 - 154

Published: Sept. 17, 2021

Language: Английский

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Oxidation triggered formation of polydopamine-modified carboxymethyl cellulose hydrogel for anti-recurrence of tumor

Colloids and Surfaces B Biointerfaces, Journal Year: 2021, Volume and Issue: 207, P. 112025 - 112025

Published: Aug. 6, 2021

Language: Английский

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Multi-scale optoacoustic molecular imaging of brain diseases

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2021, Volume and Issue: 48(13), P. 4152 - 4170

Published: Feb. 16, 2021

Abstract The ability to non-invasively visualize endogenous chromophores and exogenous probes sensors across the entire rodent brain with high spatial temporal resolution has empowered optoacoustic imaging modalities unprecedented capacities for interrogating under physiological diseased conditions. This rapidly transformed microscopy (OAM) multi-spectral tomography (MSOT) into emerging research tools study animal models of diseases. In this review, we describe principles showcase recent technical advances that enable high-resolution real-time observations in preclinical models. addition, advanced molecular probe designs allow efficient visualization pathophysiological processes playing a central role variety neurodegenerative diseases, tumors, stroke. We outstanding challenges methodologies propose future outlook.

Language: Английский

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Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology

ACS Bio & Med Chem Au, Journal Year: 2022, Volume and Issue: 2(3), P. 258 - 281

Published: March 1, 2022

The essence of bionanotechnology lies in the application nanotechnology/nanomaterials to solve biological problems. Quantum dots and nanoparticles hold potential biomedical applications, but their inherent problems such as low solubility associated toxicity due interactions at nonspecific target sites is a major concern. self-assembled, thermostable, ferritin protein nanocages possessing natural iron scavenging ability have emerged solution all above-mentioned by acting nanoreactor nanocarrier. Ferritins, cellular repositories, are hollow, spherical, symmetric multimeric nanocages, which sequester excess free Fe(II) synthesize biominerals (Fe2O3·H2O) inside ∼5-8 nm central cavity. electrostatics dynamics pore residues not only drives substrate Fe2+ also uptakes set other metals ions/counterions during vitro synthesis nanomaterial. current review aims report recent developments/understanding on structure (self-assembly, surface/pores electrostatics, metal ion binding sites) chemistry occurring these supramolecular cages (protein mediated uptake mineralization/nanoparticle formation) along with its surface modification exploit them for various nanobiotechnological applications. Furthermore, better understanding self-assembly would be highly useful optimizing incorporation nanomaterials via disassembly/reassembly approach. Several studies reported successful engineering order utilize synthesizing/incorporating nanocarrier delivering imaging agents/drugs cell specific sites. Therefore, combination nanoscience (nanomaterials) bioscience (ferritin protein) projects several benefits applications ranging from electronics medicine.

Language: Английский

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