Recent Advances of Optical Imaging in the Second Near‐Infrared Window

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(47)

Published: Sept. 4, 2018

Abstract The near‐infrared window between 1000 and 1700 nm, commonly termed the “second (NIR‐II) window,” has quickly emerged as a highly attractive optical region for biological imaging. In contrast to conventional imaging in visible 400 700 well first NIR (NIR‐I) 900 NIR‐II offers numerous merits, including higher spatial resolution, deeper penetration depth, lower absorption scattering from substrates with minimal tissue autofluorescence. Noninvasive techniques, specifically fluorescence photoacoustic (PA) imaging, have embodied attractiveness of several agents demonstrating superior performance clinically approved NIR‐I agents. Consequently, been increasingly explored due its tremendous potential preclinical studies clinical utility. Herein, progress is reported. Starting highlighting importance spectral region, emergence latest development various PA probes their applications are then discussed. Perspectives on promises challenges facing this nascent yet exciting field given.

Language: Английский

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Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(11), P. 2967 - 3014

Published: Jan. 1, 2019

Brain cancer, especially the most common type of glioblastoma, is highly invasive and known as one devastating deadly neoplasms. Despite surgical medical advances, prognosis for brain cancer patients remains dismal median survival rarely exceeds 16 months. Drug delivery to significantly hindered by existence blood-brain barrier (BBB), which serves a protective semi-permeable membrane central nervous system. Recent breakthroughs in nanotechnology have yielded multifunctional theranostic nanoplatforms with ability cross or bypass BBB, enabling accurate diagnosis effective treatment tumours. Herein, we make our efforts present comprehensive review on latest remarkable advances BBB-crossing nanotechnology, an emphasis judicious design BBB penetration, efficient tumour accumulation, precise imaging, significant inhibition cancer. The detailed elucidation this anticipated attract broad interest from researchers diverse fields participate establishment powerful theranostics.

Language: Английский

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Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging

Chemical Science, Journal Year: 2018, Volume and Issue: 9(19), P. 4370 - 4380

Published: Jan. 1, 2018

In recent years, owing to unsatisfactory clinical imaging clarity and depths in the living body for early diagnosis prognosis, novel modalities with high bioimaging performance have been actively explored. The remarkable headway made second near-infrared region (NIR-II, 1000-1700 nm) has promoted development of biomedical significantly. NIR-II fluorescence possesses a number merits which prevail over traditional NIR-I (400-900 fundamental research, such as reduced photon scattering, well auto-fluorescence improved penetration depth. Functional probes instant precise feedback vivo information are at core this modality superb imaging. Herein, we review recently developed fluorophores including carbon nanotubes, organic small molecules, quantum dots, conjugated polymers rare-earth-doped materials present superior multifunctionality regions (1000-1700 nm).

Language: Английский

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Bright Aggregation‐Induced‐Emission Dots for Targeted Synergetic NIR‐II Fluorescence and NIR‐I Photoacoustic Imaging of Orthotopic Brain Tumors

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(29)

Published: May 28, 2018

Abstract Precise diagnostics are of significant importance to the optimal treatment outcomes patients bearing brain tumors. NIR‐II fluorescence imaging holds great promise for brain‐tumor with deep penetration and high sensitivity. This requires development organic fluorescent agents quantum yield (QY), which is difficult achieve. Herein, design synthesis a new molecule aggregation‐induced‐emission (AIE) characteristics reported orthotopic imaging. Encapsulation in polymer matrix yields AIE dots showing very QY 6.2% large absorptivity 10.2 L g −1 cm at 740 nm an emission maximum near 1000 nm. Further decoration c‐RGD targeted dots, afford specific selective tumor uptake, signal/background ratio 4.4 resolution up 38 µm. The NIR facilitates NIR‐I photoacoustic intrinsically deeper than and, more importantly, precise tumor‐depth detection through intact scalp skull. research demonstrates molecules their dual cancer diagnostics.

Language: Английский

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Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: March 9, 2020

Abstract Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose molecular design philosophy explore pure fluorophores by manipulation effects twisted intramolecular charge transfer and aggregation-induced at morphological levels. An dye emitting up 1600 nm quantum yield 11.5% NIR-II region is developed. fluorescence blood vessels deeply-located intestinal tract live mice based on dyes achieved high clarity enhanced signal-to-background ratio. We hope this study will inspire further development evolution bio-imaging.

Language: Английский

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Atomic‐Precision Gold Clusters for NIR‐II Imaging

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(46)

Published: Oct. 1, 2019

Near-infrared II (NIR-II) imaging at 1100-1700 nm shows great promise for medical diagnosis related to blood vessels because it possesses deep penetration and high resolution in biological tissue. Unfortunately, currently available NIR-II fluorophores exhibit slow excretion low brightness, which prevents their potential applications. An atomic-precision gold (Au) cluster with 25 atoms 18 peptide ligands is presented. The Au25 clusters show emission 1100-1350 the fluorescence quantum yield significantly increased by metal-atom doping. Bright can penetrate tissue be applied vivo brain vessel tumor metastasis. Time-resolved blood-flow significant differences between healthy injured mice different diseases vivo. High-resolution of cancer metastasis allows identification primary tumor, vessel, lymphatic In addition, are used monitor high-resolution kidney a depth 0.61 cm, quantitative measurement 86% cleared from body without any acute or long-term toxicity dose 100 mg kg-1 .

Language: Английский

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Recent advances in near-infrared emitting lanthanide-doped nanoconstructs: Mechanism, design and application for bioimaging

Coordination Chemistry Reviews, Journal Year: 2018, Volume and Issue: 381, P. 104 - 134

Published: Dec. 10, 2018

Language: Английский

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Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(15), P. 9243 - 9358

Published: July 20, 2021

Research related to the development and application of luminescent nanoparticles (LNPs) for chemical biological analysis imaging is flourishing. Novel materials new applications continue be reported after two decades research. This review provides a comprehensive heuristic overview this field. It targeted both newcomers experts who are interested in critical assessment LNP materials, their properties, strengths weaknesses, prospective applications. Numerous cataloged by fundamental descriptions identities physical morphology, quantitative photoluminescence (PL) PL mechanisms, surface chemistry. These include various semiconductor quantum dots, carbon nanotubes, graphene derivatives, nanodiamonds, metal nanoclusters, lanthanide-doped upconversion downshifting nanoparticles, triplet–triplet annihilation persistent-luminescence conjugated polymer semiconducting multi-nanoparticle assemblies, doped labeled including but not limited those based on polymers silica. As an exercise these ranked several application-related functional criteria. Additional sections highlight recent examples advances analysis, point-of-care diagnostics, cellular, tissue, vivo theranostics. drawn from literature organized material particular properties that leveraged advantage. Finally, perspective what comes next field offered.

Language: Английский

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Tm³⁺‐Sensitized NIR‐II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(30), P. 10153 - 10157

Published: May 30, 2019

Abstract In vivo fluorescence imaging in the second near‐infrared window (NIR‐II) affords deep‐tissue penetration and high spatial resolution. Herein, we present a new type of Tm 3+ ‐sensitized lanthanide nanocrystals with both excitation (1208 nm) emission (1525 located NIR‐II for optical information storage decoding. Taking advantage tunable lifetimes, multiplexed encoding capacity is enhanced accordingly. Micro‐devices QR codes featuring fluorescence‐lifetime were implanted into mice successfully decoded through time‐gated technology.

Language: Английский

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Perfecting and extending the near-infrared imaging window

Light Science & Applications, Journal Year: 2021, Volume and Issue: 10(1)

Published: Sept. 24, 2021

In vivo fluorescence imaging in the second near-infrared window (NIR-II) has been considered as a promising technique for visualizing mammals. However, definition of NIR-II region and mechanism accounting excellent performance still need to be perfected. Herein, we simulate photon propagation NIR (to 2340 nm), confirm positive contribution moderate light absorption by water intravital perfect 900-1880 nm, where 1400-1500 1700-1880 nm are defined NIR-IIx NIR-IIc regions, respectively. Moreover, 2080-2340 is newly proposed third (NIR-III) window, which believed provide best quality. The wide-field microscopy brain performed around region, with optical sectioning strength largest depth date. We also propose 1400 long-pass detection off-peak whose exceeds that NIR-IIb imaging, using bright fluorophores short emission wavelength.

Language: Английский

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