Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(24)

Published: April 26, 2019

Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target variety of biological tissues processes. This review focuses on summarizing organic dyes emitting at transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with surrounding allows photons travel nearly unperturbed throughout body. NIR-II fluorescence imaging overcomes penetration/contrast bottleneck in visible region, making it remarkable modality early diagnosis cancer highly sensitive tumor surgery. Due their convenient bioconjugation peptides/antibodies, molecular are desirable candidates targeted imaging, significantly overcoming autofluorescence/scattering issues deep tissue imaging. To promote clinical translation bioimaging, advancements high-performance small molecule-derived probes critically important. Here, molecules potential discussed, synthesis chemical structures dyes, optical properties behavior whole body detection surgery, as well microscopy A key perspective direction surgery is also discussed.

Language: Английский

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Supramolecular materials based on AIE luminogens (AIEgens): construction and applications

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(4), P. 1144 - 1172

Published: Jan. 1, 2020

This review presents comprehensive discussions on the recent development in supramolecular materials based luminogens with aggregation-induced emission (AIE) characteristics.

Language: Английский

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Design of superior phototheranostic agents guided by Jablonski diagrams

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

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Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(30), P. 16294 - 16308

Published: Aug. 12, 2020

The development of fluorophores for the second near-infrared window (NIR-II, 1000-1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, biomedical engineering. wavelength, brightness, stability are three crucial factors that determine performance NIR-II fluorophore. Up to now, significant progress has been made fluorescence molecular probes, including synthesis D-A-D D-π-A with improved imaging construction off-on probes ratiometric via energy transfer or structure modification. In this review, we summarize most recent advances engineering design strategies then highlight a selection bioimaging biosensing applications. We also provide perspectives on potential challenges opportunities emerging field.

Language: Английский

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J-Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(49), P. 19221 - 19225

Published: Nov. 20, 2019

Light in the second near-infrared window, especially beyond 1500 nm, shows enhanced tissue transparency for high-resolution vivo optical bioimaging due to decreased scattering, absorption, and autofluorescence. Despite some inorganic luminescent nanoparticles have been developed improve around it is still a great challenge synthesize organic molecules with absorption emission toward this region. Here, we present J-aggregates 1360 nm 1370 formed by self-assembly of amphiphilic cyanine dye FD-1080 1,2-dimyristoyl-sn-glycero-3-phosphocholine. Molecular dynamics simulations were further employed illustrate process. Superior spatial resolution high signal-to-background ratio demonstrated noninvasive brain hindlimb vasculature nm. The efficacy evaluation clinically used hypotensor successfully achieved dynamic vascular imaging J-aggregates.

Language: Английский

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GSH‐Depleted PtCu₃ Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 30(4)

Published: Nov. 13, 2019

Abstract The ultrahigh concentration of glutathione (GSH) inside tumors destroys reactive oxygen species (ROS)‐based therapy, improving the outcome chemodynamic therapy (CDT)‐enhanced sonodynamic (SDT) by depleting GSH is full great challenge. Herein, PtCu 3 nanocages are first reported as acting a sonosensitizer with highly efficient ROS generation under ultrasound irradiation. In addition, can act horseradish peroxidase‐like nanozymes, catalyzing decomposition H 2 O into • OH acidic conditions for CDT. Surprisingly, another kind nanozyme, mimicking peroxidase (GSH‐Px), which plays an important role in accelerating depletion oxidizing molecules, further weakening capacity tumor cells scavenging GSH. Both vitro and vivo studies demonstrate that perform well reducing level CDT‐enhanced SDT. Moreover, utilizing high absorption near‐infrared region strong X‐ray attenuation ability, able to conduct photoacoustic/computed tomography dual‐modal imaging‐guided combined cancer therapy. It worth mentioning cause minimal toxicity normal tissues at therapeutic doses. This work highlights use effective SDT via depletion.

Language: Английский

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Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: March 9, 2020

Abstract Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose molecular design philosophy explore pure fluorophores by manipulation effects twisted intramolecular charge transfer and aggregation-induced at morphological levels. An dye emitting up 1600 nm quantum yield 11.5% NIR-II region is developed. fluorescence blood vessels deeply-located intestinal tract live mice based on dyes achieved high clarity enhanced signal-to-background ratio. We hope this study will inspire further development evolution bio-imaging.

Language: Английский

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Room‐Temperature Phosphorescence Resonance Energy Transfer for Construction of Near‐Infrared Afterglow Imaging Agents

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(52)

Published: Nov. 11, 2020

Abstract Afterglow imaging that detects photons after cessation of optical excitation avoids tissue autofluorescence and thus possesses higher sensitivity than traditional fluorescence imaging. Purely organic molecules with room‐temperature phosphorescence (RTP) have emerged as a new library benign afterglow agents. However, most RTP luminogens only emit visible light shallow penetration, constraining their in vivo applications. This study presents an nanoprobe (mTPA‐N) emission the NIR range for Such probe is composed molecule (mTPA) phosphorescent generator NIR‐fluorescent dye energy acceptor to enable resonance transfer (RT‐PRET), ultimately resulting redshifted at 780 nm. Because elimination background noise luminescence biologically transparent window, mTPA‐N permits lymph nodes living mice high signal‐to‐noise ratio. opens up universal approach develop into agents via construction RT‐PRET.

Language: Английский

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Atomic‐Precision Gold Clusters for NIR‐II Imaging

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(46)

Published: Oct. 1, 2019

Near-infrared II (NIR-II) imaging at 1100-1700 nm shows great promise for medical diagnosis related to blood vessels because it possesses deep penetration and high resolution in biological tissue. Unfortunately, currently available NIR-II fluorophores exhibit slow excretion low brightness, which prevents their potential applications. An atomic-precision gold (Au) cluster with 25 atoms 18 peptide ligands is presented. The Au25 clusters show emission 1100-1350 the fluorescence quantum yield significantly increased by metal-atom doping. Bright can penetrate tissue be applied vivo brain vessel tumor metastasis. Time-resolved blood-flow significant differences between healthy injured mice different diseases vivo. High-resolution of cancer metastasis allows identification primary tumor, vessel, lymphatic In addition, are used monitor high-resolution kidney a depth 0.61 cm, quantitative measurement 86% cleared from body without any acute or long-term toxicity dose 100 mg kg-1 .

Language: Английский

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NIR‐II AIEgens: A Win–Win Integration towards Bioapplications

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(14), P. 7476 - 7487

Published: June 9, 2020

Fluorescence imaging in the second near-infrared (NIR-II) window facilitated by aggregation-induced emission luminogens (AIEgens) is an emerging research field. NIR-II AIEgens overcome limitations imposed penetration depth and fluorescence efficiency, offering high-performance with enhanced precision. Some reported demonstrate capabilities for photoacoustic bimodal imaging, guided photothermal therapy, which not only improves diagnosis accuracy but provides efficient theranostic platform to accelerate preclinical translation as well. This minireview summarizes recent efforts on exploiting regard molecular design strategies bioapplications, puts forward current challenges promising prospects. timely sketch should benefit further exploitation of diverse multifunctional a wide array applications.

Language: Английский

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