Supramolecular engineering of hydrogels for drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 171, P. 240 - 256

Published: Feb. 7, 2021

Supramolecular binding motifs are increasingly employed in the design of biomaterials. The ability to rationally engineer specific yet reversible associations into polymer networks with supramolecular chemistry enables injectable or sprayable hydrogels that can be applied via minimally invasive administration. In this review, we highlight two main areas where being used drug delivery systems: engineering network mechanics and tailoring drug–material affinity. Throughout, many established emerging chemistries useful for applications.

Language: Английский

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The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(7), P. 602 - 602

Published: June 29, 2020

Porous scaffolds have been employed for decades in the biomedical field where researchers seeking to produce an environment which could approach one of extracellular matrixes supporting cells natural tissues. Such three-dimensional systems offer many degrees freedom modulate cell activity, ranging from chemistry structure and architectural properties such as porosity, pore, interconnection size. All these features can be exploited synergistically tailor cell–material interactions, further, tissue growth within voids scaffold. Herein, overview materials generate porous well various techniques that are used process them is supplied. Furthermore, scaffold parameters behavior identified under distinct aspects: architecture inert (i.e., pore size, mechanical properties, etc.) alone on functions followed by comparison with bioactive grasp most relevant driving regeneration. Finally, vivo outcomes highlighted comparing accordance between vitro results order tackle future translational challenges repair

Language: Английский

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Synthetic extracellular matrices with function-encoding peptides

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(7), P. 518 - 536

Published: April 25, 2023

Language: Английский

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New insights into nanocomposite hydrogels; a review on recent advances in characteristics and applications

Advanced Industrial and Engineering Polymer Research, Journal Year: 2023, Volume and Issue: 7(1), P. 54 - 78

Published: July 6, 2023

The study of nanocomposite hydrogels in their various scientific areas has grown remarkably along the years with emergence theoretical and experimental techniques. Therefore, this review is categorized to provide a comprehensive guide on fabrication hydrogels. In regard, type amounts nanomaterial, hydrogel network formation have significant impact improvement physical, chemical, biological properties It be noted that these parameters are dependent application orientation range nanomaterials, product characteristics, sufficient information materials, need considered obtain successful material. article, advances field hydrogels, focusing types based nanoparticle types, new perspective rheology, self-healing behavior, thermal stability, biologic, morphology investigated. Eventually, applicability materials collected table fields such as biomedical, enhanced oil recovery, agriculture, etc. for first time presents comparisons more details.

Language: Английский

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Osteoimmunomodulatory bioinks for 3D bioprinting achieve complete regeneration of critical-sized bone defects

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 273, P. 111256 - 111256

Published: Jan. 29, 2024

Language: Английский

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Three‐dimensional bioprinting biphasic multicellular living scaffold facilitates osteochondral defect regeneration

Interdisciplinary materials, Journal Year: 2024, Volume and Issue: 3(5), P. 738 - 756

Published: June 2, 2024

Abstract Due to tissue lineage variances and the anisotropic physiological characteristics, regenerating complex osteochondral tissues (cartilage subchondral bone) remains a great challenge, which is primarily due distinct requirements for cartilage bone regeneration. For regeneration, significant amount of newly generated chondrocytes required while maintaining their phenotype. Conversely, regeneration necessitates inducing stem cells differentiate into osteoblasts. Additionally, construction interface crucial. In this study, we fabricated biphasic multicellular bioprinted scaffold mimicking natural employing three‐dimensional (3D) bioprinting technology. Briefly, gelatin‐methacryloyl (GelMA) loaded with articular marrow mesenchymal (ACs/BMSCs), serving as layer, preserved phenotype ACs promoted differentiation BMSCs through interaction between BMSCs, thereby facilitating GelMA/strontium‐substituted xonotlite (Sr‐CSH) regulated osteoblasts enhanced secretion matrix by in layer slow release bioactive ions from Sr‐CSH. GelMA, material, contributed reconstruction interface. Ultimately, demonstrated satisfactory simultaneous defects. promising strategy application 3D technology was proposed.

Language: Английский

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Food-derived tripeptide–copper self-healing hydrogel for infected wound healing

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

The field of infected wound management continues to face challenges, and traditional methods used cope with wounds include debridement, gauze coverage, medication, others. Currently, synthetic natural biomaterials are readily available today, enabling the creation new dressings that substantially enhance healing. Considerable attention is being paid hydrogels based on materials, which have good biocompatibility degradability properties, while exhibiting higher similarity extracellular matrix as compared materials. In this study, we extracted active ingredients oxidized konjac glucomannan (OKGM) fresh egg white (EW) from 2 foods, konjac, egg, respectively, formed a self-repairing hydrogel cross-linking Schiff base. Subsequently, peptide, glycyl-l-histidyl-l-lysine-Cu (GHK-Cu), was loaded, an all-natural composite dressing, EW/OKGM@GHK-Cu (GEK), developed. GEK hydrogel, both antibacterial anti-inflammatory plays hemostatic role by adhering tissues promoting neovascularization serves optimal dressing for skin regeneration. Taken together, derived food sources therefore constitute efficient cost-effective strategy managing healing significant potential clinical application transformation.

Language: Английский

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Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: in vitro models and preclinical innovations

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101596 - 101596

Published: Feb. 18, 2025

Language: Английский

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Inspired by Nature: Facile Design of Nanoclay–Organic Hydrogel Bone Sealant with Multifunctional Properties for Robust Bone Regeneration

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(43)

Published: Sept. 2, 2020

Bone repair is a complex process involving the sophisticated interplay of osteogenic stem cells, extracellular matrix, and osteoinductive factors, it affected by bacterial toxins oxidative stress. Inspired nature plant-derived phytochemicals inorganic-organic analogues bone we report herein facile design nanoclay-organic hydrogel sealant (NoBS) that integrates multiple physico-chemical cues for regeneration into single system. Assembly phytochemical-modified organic chitosan silica-rich inorganic nanoclay serves as highly biocompatible osteoconductive matrix mimics. The decorated phytochemical exerts inherent bactericidal antioxidant activities, acts an intermolecular networking precursor gelation with injectable self-healing capabilities. Moreover, NoBS effects mediated nanoclay, which regulates Wnt/β-catenin pathway, along addition signals, resulting in non-healing cranial defect. Engineering this integrated graft substitute multifunctional properties inspired natural materials may suggest promising effective approach creating favorable microenvironment optimal healing.

Language: Английский

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Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Sept. 24, 2021

Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex that faithfully recapitulate tumour biology are urgently needed. These may especially benefit the management pancreatic ductal adenocarcinoma (PDAC), where therapy failure has been ascribed to its high stem cell (CSC) content and density stromal cells extracellular matrix (ECM). To date, these features only partially reproduced using organoid sphere cultures. We now developed more comprehensive highly tuneable model PDAC based on 3D co-assembly peptide amphiphiles (PAs) with custom ECM components (PA-ECM). cultures maintain patient-specific transcriptional profiles exhibit CSC functionality, including strong tumourigenicity. User-defined modification system enables control over niche-dependent phenotypes such as epithelial-to-mesenchymal transition deposition. Indeed, proteomic analysis reveals improved matrisome recapitulation compared organoids. Most importantly, drug responses better self-assembled than other models. findings support use self-assembling platforms research pave way future precision medicine approaches.

Language: Английский

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