Deleted Journal,
Journal Year:
2023,
Volume and Issue:
1(2)
Published: Feb. 21, 2023
Abstract
Phototherapy,
mainly
including
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
can
kill
cancer
cells
by
generating
heat
or
reactive
oxygen
species,
which
has
the
advantages
of
being
minimally
invasive,
high
efficiency,
low
toxicity.
However,
traditional
phototherapeutic
agents
face
challenges
such
as
poor
tumor
targeting,
susceptibility
to
passive
immune
clearance,
suboptimal
biocompatibility,
limit
their
clinical
application.
Recently,
cell
membrane
biomimetic
technology
endows
with
unique
biological
functions,
promoted
escape,
prolonged
in
vivo
circulation
time,
improved
enhanced
anti‐tumor
efficacy.
In
addition,
phototherapy
mediated
(CCM)
membrane‐modified
promote
broad
immunity.
this
review,
we
deeply
analyze
mechanisms
PTT
PDT,
systematically
discuss
synthesis
strategies
functions
nanomaterials,
focus
on
progress
based
nanomaterials
synergistic
therapies
chemotherapy,
radiotherapy,
immunotherapy,
sonodynamic
therapy.
Finally,
address
opportunities
future
prospects
field
phototherapy.
This
comprehensive
review
is
expected
provide
insights
into
promoting
translation
agents.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: May 14, 2022
Immunotherapeutic
interventions
represent
a
promising
approach
to
treating
cancer,
with
strategies
such
as
immune
checkpoint
blockade
(ICB),
immunogenic
sonodynamic
therapy
(SDT),
and
adjuvant
T
cell
delivery
having
exhibited
clinical
promise.
In
this
report,
we
describe
the
use
of
cancer
membrane-coated
triphenylphosphonium
(TPP)
decorated
nano-metal-organic
framework
(nMOF)
constructs
[Zr-TCPP(TPP)/R837@M]
that
were
used
generate
homologous,
mitochondria-targeted
platforms
high
rate
sonosensitizer
loading.
This
construct
was
utilized
simultaneously
promote
tumor
antigen
presentation
via
enhancing
SDT
while
synergistically
promoting
dendritic
(DC)
maturation
through
Toll-like
receptor
agonist
R837.
vitro,
these
functionalized
nMOFs
readily
internalized
by
homologous
cells
in
which
they
efficiently
targeted
mitochondria,
DC
activation
induction
death
(ICD)
following
ultrasound
exposure.
Moreover,
nanoplatform
able
achieve
vivo
synergy
anti-CTLA-4
ICB
reverse
immunosuppression
microenvironment
(TME),
thus
achieving
more
robust
antitumor
efficacy
capable
suppressing
metastatic
disease
progression
facilitating
development
durable
memory
responses.
Together,
results
highlight
enhanced
activity
overcoming
an
immunosuppressive
TME,
thereby
immunity.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
17, P. 221 - 233
Published: Jan. 26, 2022
Osteosarcoma
is
a
refractory
bone
disease
in
young
people
that
needs
the
updating
and
development
of
effective
treatment.
Although
nanotechnology
widely
applied
cancer
therapy,
poor
targeting
inadequate
efficiency
hinder
its
development.
In
this
study,
we
prepared
alendronate
(ALD)/K7M2
cell
membranes-coated
hollow
manganese
dioxide
(HMnO2)
nanoparticles
as
nanocarrier
to
load
Ginsenoside
Rh2
(Rh2)
for
Magnetic
Resonance
imaging
(MRI)-guided
immuno-chemodynamic
combination
osteosarcoma
therapy.
Subsequently,
ALD
K7M2
membranes
were
successively
modified
on
surface
HMnO2
loaded
with
Rh2.
The
tumor
microenvironment
(TME)-activated
Rh2@HMnO2-AM
have
good
tumor-targeting
tumor-homing
capabilities,
excellent
GSH-sensitive
drug
release
profile
MRI
capability,
attractive
combined
therapeutic
efficiency.
can
effectively
trigger
immunogenic
death
(ICD),
activate
CD4+/CD8+
T
cells
vivo,
upregulate
BAX,
BCL-2
Caspase-3
cellular
level.
Further
results
revealed
enhanced
secretion
IL-6,
IFN-γ
TNF-α
serum
inhibited
generation
FOXP3+
(Tregs)
tumors.
Moreover,
treatment
significant
restricted
growth
in-situ
tumor-bearing
mice.
Therefore,
may
serve
an
bio-friendly
nanoparticle
platform
immunotherapy
chemodynamic
therapy
provide
novel
approach
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 695 - 695
Published: Feb. 18, 2023
Modern
drug
discovery
methods
led
to
evolving
new
agents
with
significant
therapeutic
potential.
However,
their
properties,
such
as
solubility
and
administration-related
challenges,
may
hinder
benefits.
Moreover,
advances
in
biotechnology
resulted
the
development
of
a
generation
molecules
short
half-life
that
necessitates
frequent
administration.
In
this
context,
controlled
release
systems
are
required
enhance
treatment
efficacy
improve
patient
compliance.
Innovative
delivery
promising
tools
protect
proteins
peptides
against
proteolytic
degradation
where
is
achievable.
The
present
review
provides
an
overview
different
approaches
used
for
delivery.
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
1(2)
Published: Feb. 21, 2023
Abstract
Phototherapy,
mainly
including
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
can
kill
cancer
cells
by
generating
heat
or
reactive
oxygen
species,
which
has
the
advantages
of
being
minimally
invasive,
high
efficiency,
low
toxicity.
However,
traditional
phototherapeutic
agents
face
challenges
such
as
poor
tumor
targeting,
susceptibility
to
passive
immune
clearance,
suboptimal
biocompatibility,
limit
their
clinical
application.
Recently,
cell
membrane
biomimetic
technology
endows
with
unique
biological
functions,
promoted
escape,
prolonged
in
vivo
circulation
time,
improved
enhanced
anti‐tumor
efficacy.
In
addition,
phototherapy
mediated
(CCM)
membrane‐modified
promote
broad
immunity.
this
review,
we
deeply
analyze
mechanisms
PTT
PDT,
systematically
discuss
synthesis
strategies
functions
nanomaterials,
focus
on
progress
based
nanomaterials
synergistic
therapies
chemotherapy,
radiotherapy,
immunotherapy,
sonodynamic
therapy.
Finally,
address
opportunities
future
prospects
field
phototherapy.
This
comprehensive
review
is
expected
provide
insights
into
promoting
translation
agents.
