Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
35(7), P. 1015 - 1023
Published: June 21, 2024
Currently,
clinical
therapeutic
strategies
for
nasopharyngeal
carcinoma
(NPC)
confront
insurmountable
dilemmas
in
which
surgical
resection
is
incomplete
and
chemotherapy/radiotherapy
has
significant
side
effects.
Phototherapy
offers
a
maneuverable,
effective,
noninvasive
pattern
NPC
therapy.
Herein,
we
developed
lysosome-targeted
pH-responsive
nanophototheranostic
near-infrared
II
(NIR-II)
fluorescence
imaging-guided
photodynamic
therapy
(PDT)
photothermal
(PTT)
of
NPC.
A
S-D-A-D-S-type
NIR-II
phototheranostic
molecule
(IRFEM)
encapsulated
within
the
acid-sensitive
amphiphilic
DSPE-Hyd-PEG2k
to
form
IRFEM@DHP
nanoparticles
(NPs).
The
prepared
exhibits
good
accumulation
acidic
lysosomes
facilitating
release
IRFEM,
could
disrupt
lysosomal
function
by
generating
an
amount
heat
ROS
under
laser
irradiation.
Moreover,
guidelines
enhance
accuracy
PTT/PDT
avoid
damage
normal
tissues.
Remarkably,
enable
efficient
antitumor
effects
both
Micromachines,
Journal Year:
2023,
Volume and Issue:
14(9), P. 1786 - 1786
Published: Sept. 18, 2023
Exploring
bio-inspired
nanomaterials
(BINMs)
and
incorporating
them
into
micro/nanodevices
represent
a
significant
development
in
biomedical
applications.
Nanomaterials,
engineered
to
imitate
biological
structures
processes,
exhibit
distinctive
attributes
such
as
exceptional
biocompatibility,
multifunctionality,
unparalleled
versatility.
The
utilization
of
BINMs
demonstrates
potential
diverse
domains
micro/nanodevices,
encompassing
biosensors,
targeted
drug
delivery
systems,
advanced
tissue
engineering
constructs.
This
article
thoroughly
examines
the
various
BINMs,
including
those
originating
from
proteins,
DNA,
biomimetic
polymers.
Significant
attention
is
directed
toward
these
entities
subsequent
ramifications
that
arise.
review
explores
biomimicry’s
structure–function
correlations.
Synthesis
mosaics
include
bioprocesses,
biomolecules,
natural
structures.
These
nanomaterials’
interfaces
use
functionalization
geometric
adaptations,
transforming
delivery,
nanobiosensing,
organ-on-chip
cancer-on-chip
models,
wound
healing
dressing
mats,
antimicrobial
surfaces.
It
provides
an
in-depth
analysis
existing
challenges
proposes
prospective
strategies
improve
efficiency,
performance,
reliability
devices.
Furthermore,
this
study
offers
forward-thinking
viewpoint
highlighting
avenues
for
future
exploration
advancement.
objective
effectively
utilize
maximize
application
progression
thereby
propelling
rapidly
developing
field
its
promising
future.
BMEMat,
Journal Year:
2024,
Volume and Issue:
2(2)
Published: Jan. 12, 2024
Abstract
Although
immunotherapy
has
revolutionized
cancer
therapy
by
providing
efficient
tumor
growth
suppression,
long‐term
protection
from
recurrence
as
well
minimized
side
effects,
the
low
response
rate
significantly
limits
clinical
application
of
in
board
types
solid
tumors.
In
order
to
improve
therapeutic
efficacy,
conventional
therapies
including
radiotherapy,
chemotherapy,
phototherapy
and
chemodynamic
are
employed
combine
with
elicit
stronger
antitumor
immune
responses.
Polymer
nanomedicines
frequently
utilized
synergistic
other
owing
their
tunable
physiochemical
properties,
high
drug
loading
capacity,
ease
modification
toxicity.
With
elaborate
design
tailored
polymer
can
enhance
efficacy
enhancing
specificity,
priming
cells
amplifying
responses
However,
until
now,
there
is
no
review
solely
dedicated
comprehensive
development
polymer‐based
platforms
for
combinational
cancers.
Herein,
this
paper
summarizes
latest
advances
design,
fabrication
traditional
strategies
photothermal
therapy,
photodynamic
therapies.
An
outlook
on
trajectory
potential
challenges
bridging
gap
between
also
discussed.
MedComm,
Journal Year:
2025,
Volume and Issue:
6(2)
Published: Jan. 19, 2025
Abstract
The
patient‐derived
xenograft
(PDX)
model
is
a
crucial
in
vivo
extensively
employed
cancer
research
that
has
been
shown
to
maintain
the
genomic
characteristics
and
pathological
structure
of
patients
across
various
subtypes,
metastatic,
diverse
treatment
histories.
Various
strategies
utilized
PDX
models
can
offer
valuable
insights
into
mechanisms
tumor
progression,
drug
resistance,
development
novel
therapies.
This
review
provides
comprehensive
overview
establishment
applications
models.
We
present
an
history
current
status
models,
elucidate
construction
methodologies
for
different
tumors,
conduct
comparative
analysis
highlight
distinct
advantages
limitations
this
relation
other
are
elucidated
domain
comprehending
underlying
therapy,
which
highlights
broad
fields
chemotherapy,
targeted
delivery
systems,
combination
antibody–drug
conjugates
radiotherapy.
Furthermore,
with
multiomics
single‐cell
analyses
also
emphasized.
application
clinical
personalized
medicine
additionally
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(6)
Published: Dec. 20, 2023
Enzyme-powered
nanomotors
have
demonstrated
promising
potential
in
biomedical
applications,
especially
for
catalytic
tumor
therapy,
owing
to
their
ability
of
self-propulsion
and
bio-catalysis.
However,
the
fragility
natural
enzymes
limits
environmental
adaptability
also
therapeutic
efficacy
catalysis-enabled
therapy.
Herein,
polyoxometalate-nanozyme-based
light-driven
were
designed
synthesized
targeted
synergistic
photothermal-catalytic
In
this
construct,
peroxidase-like
activity
P
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(31), P. 21496 - 21508
Published: July 29, 2024
Ultrasound
(US)-mediated
piezocatalytic
tumor
therapy
has
attracted
much
attention
due
to
its
notable
tissue-penetration
capabilities,
noninvasiveness,
and
low
oxygen
dependency.
Nevertheless,
the
efficiency
of
is
limited
an
inadequate
piezoelectric
response,
separation
electron–hole
(e––h+)
pairs,
complex
microenvironment
(TME).
Herein,
ultrathin
two-dimensional
(2D)
sulfur-vacancy-engineered
(Sv-engineered)
Cu@SnS2–x
nanosheet
(NS)
with
enhanced
effect
was
constructed
via
heterovalent
substitution
strategy
Sn4+
by
Cu2+.
The
introduction
Cu2+
ion
not
only
causes
changes
in
crystal
structure
increase
polarization
but
also
generates
rich
Sv
decrease
band
gap
from
2.16
1.62
eV
inhibit
e––h+
pairs
recombination,
collectively
leading
highly
efficient
generation
reactive
species
under
US
irradiation.
Moreover,
shows
US-enhanced
TME-responsive
Fenton-like
catalytic
activity
glutathione
depletion
ability,
further
aggravating
oxidative
stress.
Both
vitro
vivo
results
prove
that
Sv-engineered
NSs
can
significantly
kill
cells
achieve
high-efficiency
a
biocompatible
manner.
Overall,
this
study
provides
new
avenue
for
sonocatalytic
broadens
application
2D
materials.
Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(8), P. 207 - 207
Published: July 25, 2024
Photothermal
therapy
(PTT)
can
overcome
cancer
treatment
resistance
by
enhancing
the
cell
membrane
permeability,
facilitating
drug
accumulation,
and
promoting
release
within
tumor
tissue.
Iron
oxide
nanoparticles
(IONPs)
have
emerged
as
effective
agents
for
PTT
due
to
their
unique
properties
biocompatibility.
Approved
of
anemia,
MRI
contrast
agents,
magnetic
hyperthermia
mediators,
IONPs
also
offer
excellent
light-to-heat
conversion
be
manipulated
using
external
fields
targeted
accumulation
in
specific
Optimizing
parameters
such
laser
wavelength,
power
density,
shape,
size,
iron
oxidation
state,
functionalization,
concentration
is
crucial
IONPs'
effectiveness.
In
addition
PTT,
enhance
other
modalities.
They
improve
oxygenation,
efficacy
radiotherapy
photodynamic
therapy.
trigger
ferroptosis,
a
programmed
death
pathway
mediated
iron-dependent
lipid
peroxidation.
Their
magneto-mechanical
effect
allows
them
exert
mechanical
force
on
cells
destroy
tumors,
minimizing
damage
healthy
This
review
outlines
strategies
management
photothermal
performance
efficiency
with
nanoparticles,
well
synergies
therapies.
