Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5604 - 5640

Published: Jan. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Language: Английский

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Recent advances in wet adhesives: Adhesion mechanism, design principle and applications

Progress in Polymer Science, Journal Year: 2021, Volume and Issue: 116, P. 101388 - 101388

Published: March 10, 2021

Language: Английский

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Recent advances in conductive hydrogels: classifications, properties, and applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(2), P. 473 - 509

Published: Dec. 9, 2022

Hydrogel-based conductive materials for smart wearable devices have attracted increasing attention due to their excellent flexibility, versatility, and outstanding biocompatibility. This review presents the recent advances in multifunctional hydrogels electronic devices. First, with different components are discussed, including pure single network based on polymers, additional additives (i.e., nanoparticles, nanowires, nanosheets), double additives. Second, a variety of functionalities, self-healing, super toughness, self-growing, adhesive, anti-swelling, antibacterial, structural color, hydrophobic, anti-freezing, shape memory external stimulus responsiveness introduced detail. Third, applications flexible illustrated strain sensors, supercapacitors, touch panels, triboelectric nanogenerator, bioelectronic devices, robot). Next, current challenges facing summarized. Finally, an imaginative but reasonable outlook is given, which aims drive further development future.

Language: Английский

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Bioinspired Underwater Adhesives

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(44)

Published: Sept. 17, 2021

Abstract Underwater adhesives are in high demand both commercial and industrial sectors. Compared with used dry (air) environments, for wet or submerged surfaces aqueous environments have specific challenges development performance. In this review, focus is on demonstrating macroscopic adhesion to wet/underwater substrates. The current strategies first introduced different types of underwater adhesives, then an overview provided the performance based mechanisms strategies. Finally, possible research directions prospects discussed.

Language: Английский

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Barnacle Cement Proteins‐Inspired Tough Hydrogels with Robust, Long‐Lasting, and Repeatable Underwater Adhesion

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 31(11)

Published: Dec. 28, 2020

Abstract The development of adhesives that can achieve robust and repeatable adhesion to various surfaces underwater is promising; however, this remains a major challenge primarily because the surface hydration layer weakens interfacial molecular interactions. Herein, strategy proposed develop tough hydrogels are robust, reusable, long‐lasting for adhesion. Hydrogels from cationic aromatic monomers with an aromatic‐rich composition inspired by amino acid residuals in barnacle cement proteins synthesized. mechanically strong (elastic modulus 0.35 MPa, fracture stress 1.0 strain 720%), owing interchain π–π cation–π In water, firmly adhere diverse through electrostatic hydrophobic interactions (adhesion strength 180 kPa), which allows instant reversibility (50 times). Moreover, hydrogel shows water months (100 days). Novel adhesive may be useful many applications, including transfer, water‐based devices, repair, soft robots.

Language: Английский

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Tissue adhesive hydrogel bioelectronics

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(22), P. 4423 - 4443

Published: Jan. 1, 2021

Flexible bioelectronics have promising applications in electronic skin, wearable devices, biomedical electronics, etc. Hydrogels unique advantages for due to their tissue-like mechanical properties and excellent biocompatibility. Particularly, conductive tissue adhesive hydrogels can self-adhere bio-tissues great potential implantable bioelectronics. This review focuses on the recent progress hydrogel bioelectronics, including mechanism preparation of hydrogels, fabrication strategies applications. Some perspectives are provided at end review.

Language: Английский

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Hydrogel tapes for fault-tolerant strong wet adhesion

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Dec. 9, 2021

Fast and strong bio-adhesives are in high demand for many biomedical applications, including closing wounds surgeries, fixing implantable devices, haemostasis. However, most rely on the instant formation of irreversible covalent crosslinks to provide surface binding. Repositioning misplaced adhesives during surgical operations may cause severe secondary damage tissues. Here, we report hydrogel tapes that can form physical interactions with tissues seconds gradually bonds hours. This timescale-dependent adhesion mechanism allows robust wet be combined fault-tolerant convenient operations. Specifically, inspired by catechol chemistry discovered mussel foot proteins, develop an electrical oxidation approach controllably oxidize catecholquinone, which reacts slowly amino groups tissue surface. We demonstrate show fast reversible at initial stage ultrastrong after linkages over hours various electronic devices. Given biocompatible, easy use, bio-adhesion, anticipate they find broad clinical applications.

Language: Английский

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Ultrafast Fabrication of Self-Healing and Injectable Carboxymethyl Chitosan Hydrogel Dressing for Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(20), P. 24095 - 24105

Published: May 17, 2021

Herein, a new type of injectable carboxymethyl chitosan (CMCh) hydrogel wound dressing with self-healing properties is constructed. First, CMCh samples are homogeneously synthesized in alkali/urea aqueous solutions. Subsequently, trivalent metal ions Fe3+ and Al3+ introduced to form coordination bonds CMCh, leading an ultrafast gelation process. A series hydrogels can be obtained by altering the concentration relative content ions. Owing dynamic reversible characteristics bonds, exhibits self-healing, self-adaption, thermoresponsive ability. Moreover, due interaction between amino groups on SO42–, undergoes phase separation painlessly detached from skin little residue. Taking advantage all these characteristics, used as significantly accelerate tissue regeneration closure. This has great potential application engineering.

Language: Английский

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Mussel foot protein inspired tough tissue-selective underwater adhesive hydrogel

Materials Horizons, Journal Year: 2020, Volume and Issue: 8(3), P. 997 - 1007

Published: Dec. 9, 2020

Novel underwater tissue-selective adhesive hydrogels with adhesion energy to wet porcine skin of ∼1011 J m⁻² were made by bio-mimicking Mfps.

Language: Английский

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Porous Janus materials with unique asymmetries and functionality

Materials Today, Journal Year: 2021, Volume and Issue: 51, P. 626 - 647

Published: Aug. 13, 2021

Language: Английский

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