Technology Roadmap for Flexible Sensors

ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5211 - 5295

Published: March 9, 2023

Humans rely increasingly on sensors to address grand challenges and improve quality of life in the era digitalization big data. For ubiquitous sensing, flexible are developed overcome limitations conventional rigid counterparts. Despite rapid advancement bench-side research over last decade, market adoption remains limited. To ease expedite their deployment, here, we identify bottlenecks hindering maturation propose promising solutions. We first analyze achieving satisfactory sensing performance for real-world applications then summarize issues compatible sensor-biology interfaces, followed by brief discussions powering connecting sensor networks. Issues en route commercialization sustainable growth sector also analyzed, highlighting environmental concerns emphasizing nontechnical such as business, regulatory, ethical considerations. Additionally, look at future intelligent sensors. In proposing a comprehensive roadmap, hope steer efforts towards common goals guide coordinated development strategies from disparate communities. Through collaborative efforts, scientific breakthroughs can be made sooner capitalized betterment humanity.

Language: Английский

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Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: Sept. 13, 2022

Hydrogels with multifunctionalities, including sufficient bonding strength, injectability and self-healing capacity, responsive-adhesive ability, fault-tolerant repeated tissue adhesion, are urgently demanded for invasive wound closure healing. Motivated by the adhesive mechanism of mussel brown algae, bioinspired dynamic bonds cross-linked multifunctional hydrogel is designed based on sodium alginate (SA), gelatin (GT) protocatechualdehyde, ferric ions added, sutureless post-wound-closure. The through Schiff base bond, catechol-Fe coordinate bond strong interaction between GT temperature-dependent phase transition SA, endows resulting mechanical strength efficient closure, reopened wounds. Moreover, properties endowed mispositioning to be removed/repositioned, which conducive adhesion adhesives during surgery. Besides, hydrogels present good biocompatibility, near-infrared-assisted photothermal antibacterial activity, antioxidation thermo-responsive reversible hemostatic effect. in vivo incision evaluation demonstrated their capability promote post-wound-closure healing incisions, indicating that developed dressing could serve as versatile sealant.

Language: Английский

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Infant Skin Friendly Adhesive Hydrogel Patch Activated at Body Temperature for Bioelectronics Securing and Diabetic Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 8662 - 8676

Published: May 13, 2022

Adhesive-caused injury is a great threat for infants with premature skin or diabetic patients fragile because extra-strong adhesion might incur pain, inflammation, and exacerbate trauma upon removal. Herein, we present skin-friendly adhesive hydrogel patch based on protein–polyphenol complexation strategy, which leads to thermoresponsive network sensitive body temperature. The of the smartly activated after contacting warm skin, whereas painless detachment easily realized by placing an ice bag surface hydrogel. exhibits immunomodulatory performance that prevents irritation allergic reactions during long-period contact skin. Thus, works as conformable nonirritating interface guarantee nondestructively securing bioelectronics infant healthcare. Furthermore, provides gentle wounded favorable environment speed up healing process managing wounds.

Language: Английский

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Engineering Smart Composite Hydrogels for Wearable Disease Monitoring

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 15, 2023

Growing health awareness triggers the public's concern about problems. People want a timely and comprehensive picture of their condition without frequent trips to hospital for costly cumbersome general check-ups. The wearable technique provides continuous measurement method monitoring by tracking person's physiological data analyzing it locally or remotely. During process, different kinds sensors convert signals into electrical optical that can be recorded transmitted, consequently playing crucial role in techniques. Wearable application scenarios usually require possess excellent flexibility stretchability. Thus, designing flexible stretchable with reliable performance is key technology. Smart composite hydrogels, which have tunable properties, mechanical biocompatibility, multi-stimulus sensitivity, are one best sensitive materials monitoring. This review summarizes common synthetic optimization strategies smart hydrogels focuses on current field

Language: Английский

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Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure

Science Advances, Journal Year: 2023, Volume and Issue: 9(33)

Published: Aug. 16, 2023

Tissue adhesives have garnered extensive interest as alternatives and supplements to sutures, whereas major challenges still remain, including weak tissue adhesion, inadequate biocompatibility, uncontrolled biodegradation. Here, injectable biocompatible hydrogel are developed via catalyst-free o-phthalaldehyde/amine (hydrazide) cross-linking reaction. The hydrogels demonstrate rapid firm adhesion various tissues, an o-phthalaldehyde-mediated mechanism is established. show controlled degradation profiles of 6 22 weeks in vivo through the incorporation disulfide bonds into network. In liver blood vessel injury, effectively seal incisions rapidly stop bleeding. rat rabbit models full-thickness skin incision, quickly close accelerate wound healing, which exhibit efficacies superior those commercially available fibrin glue cyanoacrylate glue. Thus, great potential for sutureless closure, hemostasis sealing, prevention leakage surgical applications.

Language: Английский

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A natural biological adhesive from snail mucus for wound repair

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 24, 2023

Abstract The discovery of natural adhesion phenomena and mechanisms has advanced the development a new generation tissue adhesives in recent decades. In this study, we develop biological adhesive from snail mucus gel, which consists network positively charged protein polyanionic glycosaminoglycan. malleable bulk matrix can adhere to wet through multiple interactions. biomaterial exhibits excellent haemostatic activity, biocompatibility biodegradability, it is effective accelerating healing full-thickness skin wounds both normal diabetic male rats. Further mechanistic study shows effectively promotes polarization macrophages towards anti-inflammatory phenotype, alleviates inflammation chronic wounds, significantly improves epithelial regeneration angiogenesis. Its abundant heparin-like glycosaminoglycan component main active ingredient. These findings provide theoretical material insights into bio-inspired bioengineered scaffold designs.

Language: Английский

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A smart adhesive Janus hydrogel for non-invasive cardiac repair and tissue adhesion prevention

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Dec. 12, 2022

Abstract Multifunctional hydrogel with asymmetric and reversible adhesion characteristics is essential to handle the obstructions towards bioapplications of trauma removal postoperative tissue synechia. Herein, we developed a responsively asymmetrically adhesive Janus that enables on-demand stimuli-triggered detachment for efficient myocardial infarction (MI) repair, synchronously prevents synechia inflammatory intrusion after surgery. In contrast most irreversibly hard-to-removable adhesives, this exhibited capability can be noninvasively detached just by slight biologics. It interesting behaves molecularly encoded adhesion-adaptive stiffening feature similar self-protective stress–strain effect biological tissues. vitro in vivo experiments demonstrated promote maturation functions cardiomyocytes, facilitate MI repair reducing oxidative damage response, reconstructing electrical conduction blood supply infarcted area. Furthermore, no secondary injury were triggered transplantation hydrogel. This smart reported herein offers potential strategy clinically transformable cardiac patch anti-postoperative barrier.

Language: Английский

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Peptide-enhanced tough, resilient and adhesive eutectogels for highly reliable strain/pressure sensing under extreme conditions

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 5, 2022

Abstract Natural gels and biomimetic hydrogel materials have been able to achieve outstanding integrated mechanical properties due the gain of natural biological structures. However, nearly every structure relies on water as solvents or carriers, which limits possibility in extreme conditions, such sub-zero temperatures long-term application. Here, peptide-enhanced eutectic were synthesized by introducing α-helical “molecular spring” into deep solvent. The gel takes full advantage structure, achieving high tensile/compression, good resilience, superior fracture toughness, excellent fatigue resistance strong adhesion, while it also inherits benefits solvent solves problems volatilization freezing. This enables unprecedentedly long stable sensing human motion movement. electrical signal shows almost no drift even after 10,000 deformations for 29 hours −20 °C 80 temperature range.

Language: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075

Published: April 24, 2022

Language: Английский

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Tuning Water-Resistant Networks in Mussel-Inspired Hydrogels for Robust Wet Tissue and Bioelectronic Adhesion

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 2745 - 2760

Published: Feb. 3, 2023

Hydrogels with robust wet adhesion are desirable for applications in aqueous environments. Wet arising from synergy between hydrophobic and catechol components mussel foot proteins has been highlighted. However, optimizing hydrogels multiple is challenging because of their complex structure–property relationships. Herein, high-throughput screening a series alkyl monomers adhesive derivatives was used to systematically develop hydrogels. Short chains promote by repelling water at the interface, whereas long form strong interactions inside hydrogel network that impede or dissipate energy adhesion. The optimized hydrogel, containing short chain, applied rapid hemostasis wound healing synergistic effect groups its immunomodulation ability, which revealed through transcriptomic analysis. Conductive nanocomponents were incorporated into produce wearable device, continuous monitoring human electrocardiogram (ECG) during swimming, situ epicardial ECG on porcine living beating heart. This study demonstrated an efficient generalized molecular design strategy multifunctional

Language: Английский

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