Translational Applications of Hydrogels

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(18), P. 11385 - 11457

Published: May 3, 2021

Advances in hydrogel technology have unlocked unique and valuable capabilities that are being applied to a diverse set of translational applications. Hydrogels perform functions relevant range biomedical purposes-they can deliver drugs or cells, regenerate hard soft tissues, adhere wet prevent bleeding, provide contrast during imaging, protect tissues organs radiotherapy, improve the biocompatibility medical implants. These make hydrogels useful for many distinct pressing diseases conditions even less conventional areas such as environmental engineering. In this review, we cover major hydrogels, with focus on novel benefits injectable how they relate applications medicine environment. We pay close attention development contemporary requires extensive interdisciplinary collaboration accomplish highly specific complex biological tasks from cancer immunotherapy tissue engineering vaccination. complement our discussion preclinical clinical mechanical design considerations needed scaling technologies application. anticipate readers will gain more complete picture expansive possibilities practical impactful differences across numerous fields

Language: Английский

---

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Materials Today Bio, Journal Year: 2021, Volume and Issue: 13, P. 100186 - 100186

Published: Dec. 9, 2021

Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left door open for further improvement their applications to revitalize impaired tissues. Hence, restoring functions. The implementation therapeutic protocols merge biomimetic scaffolds, bioactive molecules, cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended engineering other biomedical purposes. They can simulate physicochemical, mechanical, biological characters innate Also, they provide aqueous conditions cell growth, support 3D conformation, mechanical stability cells, serve potent delivery matrices molecules. Many natural artificial polymers were broadly utilized design these intelligent platforms with novel advanced characteristics tailored functionalities fit such applications. In present review, we highlighted different types smart/stimuli-responsive emphasis on synthesis scheme. Besides, mechanisms responsiveness stimuli elaborated. Their potential was discussed. Furthermore, exploitation targeted drug delivery, smart biosensors, actuators, 4D printing, culture outlined. addition, threw light self-healing biomedicine. Eventually, presented future perceptions Conclusively, current progress enhances prospective function intelligent, sophisticated systems

Language: Английский

---

Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100522 - 100522

Published: Dec. 21, 2022

Extracellular vesicles (EVs) are a collective term for nanoscale or microscale secreted by cells that play important biological roles. Mesenchymal stem class of with the potential self-healing and multidirectional differentiation. In recent years, numerous studies have shown EVs, especially those mesenchymal cells, can promote repair regeneration various tissues and, thus, significant in regenerative medicine. However, due to rapid clearance capacity circulatory system, EVs barely able act persistently at specific sites target tissues. Hydrogels good biocompatibility loose porous structural properties allow them serve as EV carriers, thereby prolonging retention certain areas slowing release EVs. When needed function sites, EV-loaded hydrogels stand an excellent approach. this review, we first introduce sources, roles, extraction characterization methods describe their current application status. We then review different types discuss factors influencing abilities carry summarize several strategies loading into characterizing hydrogels. Furthermore, applications tissue repair. This article concludes summary state research on outlook future directions, which hope will provide promising ideas researchers.

Language: Английский

---

Multiple Stimuli‐Responsive MXene‐Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing

Small, Journal Year: 2021, Volume and Issue: 18(5)

Published: Nov. 25, 2021

Chronic wound healing is an important and basic issue in medical healthcare fields. Recently, stimuli-responsive hydrogel systems have emerged as promising drug delivery carriers for management. However, given to the limited therapeutic outcomes, new efficient treatment are urgently needed. Here, development of a 2D MXene-based system highly photo- magnetic-responsive oriented deep chronic wounds repair presented. The intelligent responsive composed MXene-wrapped magnetic colloids poly(N-isopropyl acrylamide)-alginate dual-network hydrogels. It demonstrated that exhibits multiple response capability controllable ability, which can reduce toxic side effects drugs promote process well. Notably, practical performance by applying it full-thickness cutaneous subcutaneous infected rat model, indicates great prospect clinical other related biomedical

Language: Английский

---

Photothermal Hydrogel Encapsulating Intelligently Bacteria-Capturing Bio-MOF for Infectious Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(11), P. 19491 - 19508

Published: Nov. 2, 2022

Chronic wounds are characterized by long-term inflammation and persistent infection, which make them difficult to heal. Therefore, an urgent desire is develop a multifunctional wound dressing that can prevent infection promote healing creating favorable microenvironment. In this study, curcumin-based metal-organic framework (QCSMOF-Van), loaded with vancomycin coated quaternary ammonium salt chitosan (QCS), was prepared. Multifunctional composite hydrogels were conveniently synthesized combining methacrylic anhydride modified gelatin oxidized sodium alginate QCSMOF-Van through radical polymerization Schiff base reaction. It important note the could capture bacteria positive charges on surface of QCS. process, due synergistic effect broad-spectrum antibacterial Zn2+ vancomycin, metabolism well inhibited, efficient capturing rapid killing achieved. The precisely regulate balance M1/M2 phenotypes macrophages, thereby promoting regeneration nerves blood vessels, promotes chronic wounds. This advanced cascade management strategy for tissue highlights potential in dressings.

Language: Английский

---

Smart stimuli-responsive chitosan hydrogel for drug delivery: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 235, P. 123902 - 123902

Published: March 3, 2023

Language: Английский

---

Recent Advances in Stimuli‐Responsive Shape‐Morphing Hydrogels

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(39)

Published: July 14, 2022

Abstract Inspired by shape‐morphing organisms in nature, researchers have developed various hydrogels with stimuli‐responsive swelling, shrinking, bending, folding, origami, rolling, twisting, or locomotion. These smart are usually created patterning 4D printing. The shape morphing of allows the fabrication helixing, and rolling microstructures, all which hard to reproduce directly ordinary techniques. More importantly, under external stimuli (e.g., solvent, humidity, temperature, light, pH, electric/magnetic fields), many exhibit recoverable thus find promising applications grippers, sensors, valves, soft robotics, etc. Since determines functions a great number cases, herein, recent advances summarized, their types, mechanisms, methods, modes, extensive covered. conclusion perspectives also presented guide design functional hydrogels.

Language: Английский

---

Multifunctional Hydrogels for the Healing of Diabetic Wounds

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 13, 2023

Abstract The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors the process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond microenvironment accelerate wound in ways, stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, conductive real‐time monitoring properties. relationship between multiple functions also discussed. Based on wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, pro‐angiogenic strategies are combined hydrogels. application repair systematically discussed, aiming provide guidelines for fabricating exploring role therapeutic processes.

Language: Английский

---

Continuous Self‐Oxygenated Double‐Layered Hydrogel under Natural Light for Real‐Time Infection Monitoring, Enhanced Photodynamic Therapy, and Hypoxia Relief in Refractory Diabetic Wounds Healing

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(32)

Published: May 31, 2022

Abstract The human health is still threatened by refractory keratitis and diabetic foot ulcers caused bacterial infections, hypoxia, chronic inflammation, so that patients are exposed to the risk of amputation, vision loss, even death. Herein, an oxygen‐producing double‐layered hydrogel developed can visualize infections supply oxygen enhance antimicrobial photodynamic therapy (PDT) inflammation alleviation for wounds healing. inner layer (containing oxidized sodium alginate/carboxymethyl chitosan [CMCS] via Schiff‐base) incorporated with a metal–organic framework (PCN‐224) pH indicator (bromothymol blue). outer agarose CMCS) loads photosynthetic cyanobacteria continuously generate relieve hypoxia tissue PDT efficiency. Meanwhile, some unique advantages reflected continuous under natural light, such as cell migration acceleration, relief, promotion skin capillary formation, wound recovery. Therefore, self‐oxygenated offers tremendous benefits in synergistic treatment anaerobe from timely infection monitoring repair.

Language: Английский

---

Smart Nanomaterials for Biomedical Applications—A Review

Nanomaterials, Journal Year: 2021, Volume and Issue: 11(2), P. 396 - 396

Published: Feb. 4, 2021

Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, magnetic photo properties. However, biomedical field, it is still difficult use tools made for better therapeutics due limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, small blood retention), so types controlled abilities must be developed, called “smart” nanomaterials. In this context, modern scientific community developed a kind nanomaterial which undergoes large reversible changes its physical, chemical, or biological properties as consequence environmental variations. This systematic mini-review intended provide an overview newest research nanosized responding various stimuli, including up-to-date application field.

Language: Английский

---