Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(13)
Published: Jan. 28, 2023
Abstract
Photothermal
hydrogel
adhesives
have
yielded
promising
results
for
wound
closure
and
infected
treatment
in
recent
years.
However,
photothermal
bioadhesives
with
on‐demand
removability
without
additional
nanomaterials‐based
agents
rarely
been
reported
the
literature.
In
this
work,
an
injectable
intrinsic
bioadhesive
removal
trait
is
developed
through
dynamic
cross‐linking
of
gelatin
(Gel),
tannic
acid
(TA)
quinone,
borax
closing
skin
incisions
accelerating
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
healing.
The
TA
quinone
containing
polyphenol
groups
multifunctional
adhesiveness
performance
confer
adhesive
near‐infrared
(NIR)
responsive
antibacterial
activity.
pH‐sensitive
boronic
ester
(polyphenol−B)
Schiff
base
bonds
endow
great
self‐healing
capacity
removability.
Moreover,
possesses
good
biocompatibility,
injectability,
hemostasis.
vivo
experiment
a
rat
cutaneous
incision
model
full‐thickness
MRSA‐infected
indicate
that
smart
can
close
wounds
efficiently
treat
ones,
demonstrating
its
superiority
noninvasive
enhancing
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(4), P. 7078 - 7093
Published: March 25, 2021
The
design
and
development
of
a
smart
bioadhesive
hydrogel
sealant
with
self-healing
excellent
antibacterial
activity
to
achieve
high
wound
closure
effectiveness
post-wound-closure
care
is
highly
desirable
in
clinical
applications.
In
this
work,
series
adhesive
antioxidant
hydrogels
promising
traits
were
designed
through
dual-dynamic-bond
cross-linking
among
ferric
iron
(Fe),
protocatechualdehyde
(PA)
containing
catechol
aldehyde
groups
quaternized
chitosan
(QCS)
enable
the
skin
incisions
promotion
methicillin-resistant
Staphylococcus
aureus
(MRSA)-infected
healing.
pH-sensitive
coordinate
bond
(catechol–Fe)
dynamic
Schiff
base
bonds
reversible
breakage
re-formation
equips
autonomous
healing
on-demand
dissolution
or
removal
properties.
Additionally,
presents
injectability,
good
biocompatibility
activity,
multifunctional
adhesiveness,
hemostasis
as
well
NIR
responsiveness.
vivo
evaluation
rat
incision
model
infected
full-thickness
revealed
hydrogels,
demonstrating
its
great
potential
dealing
wounds.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(10)
Published: Feb. 9, 2022
Skin
wound
repair
is
a
multistage
process
involving
multiple
cellular
and
molecular
interactions,
which
modulate
the
cell
behaviors
dynamic
remodeling
of
extracellular
matrices
to
maximize
regeneration
repair.
Consequently,
abnormalities
in
functions
or
pathways
inevitably
give
rise
side
effects,
such
as
dysregulated
inflammation,
hyperplasia
nonmigratory
epithelial
cells,
lack
response
growth
factors,
impedes
angiogenesis
fibrosis.
These
issues
may
cause
delayed
healing
even
non-healing
states.
Current
clinical
therapeutic
approaches
are
predominantly
dedicated
preventing
infections
alleviating
topical
symptoms
rather
than
addressing
modulation
microenvironments
achieve
targeted
outcomes.
Bioactive
materials,
relying
on
their
chemical,
physical,
biological
properties
carriers
bioactive
substances,
can
affect
promote
at
level.
By
mechanisms
from
perspective
behaviors,
this
review
discusses
how
materials
within
wounds
during
stages
hemostasis,
anti-inflammation,
tissue
deposition,
matrix
remodeling.
A
deeper
understanding
bound
development
more
efficient
for
applications.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(34)
Published: June 17, 2021
Abstract
Real‐time
monitoring
of
wound
healing
remains
a
major
challenge
in
clinical
tissue
regeneration,
calling
the
need
for
development
biomaterial‐guided
on‐site
technology.
In
this
study,
multifunctional
double
colorimetry‐integrated
polyacrylamide‐quaternary
ammonium
chitosan‐carbon
quantum
dots
(CQDs)‐phenol
red
hydrogels
are
presented,
aiming
to
simultaneously
detect
pH
level,
reduce
bacterial
infection,
and
promote
healing.
The
hybridization
CQDs
indicator
(phenol
red)
with
enables
their
high
responsiveness,
reversibility,
accurate
indication
variability
reflect
dynamic
status
context
both
ultraviolet
visible
light.
Furthermore,
these
visual
images
can
be
collected
by
smartphones
converted
into
signals,
allowing
real‐time
evaluation
conditions
remote
approach.
Notably,
exhibit
excellent
hemostatic
adhesive
properties,
maintain
sufficient
moisture,
via
antibacterial
activity
(against
Staphylococcus
Aureus
,
Escherichia
Coli
)
skin
repair
function.
Overall,
resulting
have
potential
as
novel
smart
flexible
dressing
platform
theranostic
regeneration.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(10)
Published: Feb. 9, 2022
Wound
healing
is
a
long-term,
multistage
biological
process
that
includes
hemostasis,
inflammation,
proliferation,
and
tissue
remodeling
requires
intelligent
designs
to
provide
comprehensive
convenient
treatment.
The
complexity
of
wounds
has
led
lack
adequate
wound
treatment
materials,
which
must
systematically
regulate
unique
microenvironments.
Hydrogels
have
significant
advantages
in
due
their
ability
spatiotemporal
control
over
the
process.
Self-assembling
peptide-based
hydrogels
are
particularly
attractive
innate
biocompatibility
biodegradability
along
with
additional
including
ligand-receptor
recognition,
stimulus-responsive
self-assembly,
mimic
extracellular
matrix.
materials
self-assemble
response
physiological
environment,
resulting
functionalized
microscopic
structures,
makes
them
conducive
This
review
introduces
several
self-assembling
systems
various
emphasizes
recent
advances
allow
for
precise
during
different
stages
healing.
Moreover,
development
multifunctional
can
remodel
immune
microenvironment
therapy
also
been
summarized.
Overall,
this
sheds
light
on
future
clinical
practical
applications
hydrogels.
Science Advances,
Journal Year:
2022,
Volume and Issue:
8(27)
Published: July 8, 2022
The
treatment
of
difficult-to-heal
wounds
remains
a
substantial
clinical
challenge
due
to
deteriorative
tissue
microenvironment
including
the
loss
extracellular
matrix
(ECM),
excessive
inflammation,
impaired
angiogenesis,
and
bacterial
infection.
Inspired
by
chemical
components,
fibrous
structure,
biological
function
natural
ECM,
antibacterial
environment-responsive
glycopeptide
hybrid
hydrogel
was
developed
for
chronic
wound
healing.
can
facilitate
cell
proliferation
macrophage
polarization
M2
phenotype,
show
potent
efficacy
against
both
Gram-negative
Gram-positive
bacteria.
Significantly,
accelerated
reconstruction
methicillin-resistant
Staphylococcus
aureus
(MRSA)-infected
full-thickness
diabetic
scalding
skin
orchestrating
pro-regenerative
response
indicated
abundant
M2-type
macrophages,
attenuated
promoted
angiogenesis.
Collectively,
ECM-mimetic
immunomodulatory
is
promising
multifunctional
dressing
reshape
damaged
environment
without
additional
drugs,
exogenous
cytokines,
or
cells,
providing
an
effective
strategy
repair
regeneration
cutaneous
wounds.
Small,
Journal Year:
2022,
Volume and Issue:
18(17)
Published: March 23, 2022
Abstract
Diabetic
wound
treatment
faces
significant
challenges
in
clinical
settings.
Alternative
approaches
are
needed.
Continuous
bleeding,
disordered
inflammatory
regulation,
obstruction
of
cell
proliferation,
and
disturbance
tissue
remodeling
the
main
characteristics
diabetic
healing.
Hydrogels
made
either
naturally
derived
or
synthetic
materials
can
potentially
be
designed
with
a
variety
functions
for
managing
healing
process
chronic
wounds.
Here,
hemostatic
anti‐inflammatory
hydrogel
patch
is
promoting
The
from
dual‐cross‐linked
methacryloyl‐substituted
Bletilla
Striata
polysaccharide
(B)
gelatin
(G)
via
ultraviolet
(UV)
light.
It
demonstrated
that
B–G
effectively
regulate
M1/M2
phenotype
macrophages,
significantly
promote
proliferation
migration
fibroblasts
vitro,
accelerate
angiogenesis.
boost
closure
by
normalizing
epidermal
regeneration
depositing
collagen
appropriately
vivo
without
exogenous
cytokine
supplementation.
Overall,
bioactive
simple,
economical,
effective,
safe
manner.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(43)
Published: Aug. 2, 2021
Abstract
Despite
clinical
applications
of
the
first‐generation
tissue
adhesives
and
hemostats,
correlation
among
microstructure
hemostasis
hydrogels
with
wound
healing
is
less
understood
it
elusive
to
design
high‐performance
meet
worldwide
growing
demands
in
closure,
hemostasis,
healing.
Inspired
by
extracellular
matrix
mussel‐mimetic
chemistry,
two
kinds
coordinated
covalent
glycopolypeptide
are
fabricated,
which
present
tunable
adhesion
strength
(14.6–83.9
kPa)
microporous
structure
(8–18
µm),
lower
hemolysis
<1.5%.
Remarkably,
size
mainly
controls
those
larger
pores
16–18
µm
achieve
fastest
≈14
s
lowest
blood
loss
≈6%
than
fibrin
glue
others.
Moreover,
both
biocompatibility
affect
performance,
as
assessed
hemolysis,
cytotoxicity,
subcutaneous
implantation,
assays.
Importantly,
hydrogel‐treated
rat‐skin
defect
model
achieves
full
closure
regenerates
thick
dermis
epidermis
some
hair
follicles
on
day
14.
Consequently,
this
work
not
only
establishes
a
versatile
method
for
constructing
structure,
fast
superior
functions,
but
also
discloses
useful
rationale
designing
hemostatic
hydrogels.
