Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(3)
Published: Nov. 6, 2021
Wound
healing
represents
a
major
clinical
and
public
healthcare
problem
that
is
frequently
challenged
by
infection
risks,
detrimental
consequences
on
the
surrounding
tissues,
difficulties
to
monitor
process.
Here
we
report
novel
self-healing,
antibacterial,
multifunctional
wound
dressing
for
sutureless
closure
real-time
monitoring
of
parameters.
The
self-healing
elastomer
contains
cetyltrimethylammonium
bromide
(CTAB)
has
high
mechanical
toughness
(35
MJ
m-3
),
biocompatibility,
outstanding
antibacterial
activity
(bactericidal
rate
≈90%
in
12
h),
enabling
effectively
inhibit
bacterial
growth
accelerate
infected
healing.
In
vivo
tests
based
full-thickness
skin
incision
model
shows
can
help
contracting
edges
facilitate
healing,
as
could
be
evidenced
notably
dense
well-organized
collagen
deposition.
test
provides
an
evidence
integrated
sensor
array
within
temperature,
pH,
glucose
level
area
real-time,
providing
reliable
timely
information
condition
wound.
Ultimately,
reported
would
value
managing
burden
associated
with
via
personalised
treatment
approaches,
digital
other
people-centred
solutions
health
care.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(8), P. 12687 - 12722
Published: Aug. 10, 2021
Hydrogels,
due
to
their
excellent
biochemical
and
mechnical
property,
have
shown
attractive
advantages
in
the
field
of
wound
dressings.
However,
a
comprehensive
review
functional
hydrogel
as
dressing
is
still
lacking.
This
work
first
summarizes
skin
healing
process
relates
evaluation
parameters
then
reviews
advanced
functions
dressings
such
antimicrobial
adhesion
hemostasis,
anti-inflammatory
anti-oxidation,
substance
delivery,
self-healing,
stimulus
response,
conductivity,
recently
emerged
monitoring
feature,
strategies
adopted
achieve
these
are
all
classified
discussed.
Furthermore,
applications
for
treatment
different
types
wounds
incisional
excisional
summarized.
Chronic
also
mentioned,
focus
attention
on
infected
wounds,
burn
diabetic
Finally,
future
directions
further
proposed.
Nano-Micro Letters,
Journal Year:
2021,
Volume and Issue:
14(1)
Published: Dec. 2, 2021
Abstract
Conductive
biomaterials
based
on
conductive
polymers,
carbon
nanomaterials,
or
inorganic
nanomaterials
demonstrate
great
potential
in
wound
healing
and
skin
tissue
engineering,
owing
to
the
similar
conductivity
human
skin,
good
antioxidant
antibacterial
activities,
electrically
controlled
drug
delivery,
photothermal
effect.
However,
a
review
highlights
design
application
of
for
engineering
is
lacking.
In
this
review,
fabrication
methods
with
various
structural
forms
including
film,
nanofiber,
membrane,
hydrogel,
sponge,
foam,
acellular
dermal
matrix
applications
corresponding
mechanism
promoting
process
were
summarized.
The
approaches
that
realize
their
value
wounds
via
three
main
strategies
(electrotherapy,
dressing,
assessment)
reviewed.
as
dressing
when
facing
different
acute
chronic
(infected
diabetic
wound)
monitoring
discussed
detail.
challenges
perspectives
designing
developing
multifunctional
are
proposed
well.
Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
8, P. 341 - 354
Published: June 23, 2021
With
the
increasing
prevalence
of
drug-resistant
bacterial
infections
and
slow
healing
chronically
infected
wounds,
development
new
antibacterial
accelerated
wound
dressings
has
become
a
serious
challenge.
In
order
to
solve
this
problem,
we
developed
photo-crosslinked
multifunctional
adhesive
anti-oxidant
hemostatic
hydrogel
based
on
polyethylene
glycol
monomethyl
ether
modified
glycidyl
methacrylate
functionalized
chitosan
(CSG-PEG),
methacrylamide
dopamine
(DMA)
zinc
ion
for
disinfection
bacteria
promoting
healing.
The
mechanical
properties,
rheological
properties
morphology
hydrogels
were
characterized,
biocompatibility
these
was
studied
through
cell
compatibility
blood
tests.
These
tested
in
vitro
blood-clotting
ability
whole
showed
good
mouse
liver
hemorrhage
model
mouse-tail
amputation
model.
addition,
it
been
confirmed
that
have
inherent
against
Methicillin-resistant
Staphylococcus
aureus
(MRSA).
full-thickness
skin
defect
with
MRSA,
closure
ratio,
thickness
granulation
tissue,
number
collagen
deposition,
regeneration
vessels
hair
follicles
measured.
inflammation-related
cytokines
(CD68)
angiogenesis-related
(CD31)
expressed
during
studied.
All
results
indicate
better
effects
than
commercially
available
Tegaderm™
Film,
revealing
they
promising
alternative
wounds.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
123(2), P. 834 - 873
Published: Aug. 5, 2022
Biomaterials
with
the
ability
to
self-heal
and
recover
their
structural
integrity
offer
many
advantages
for
applications
in
biomedicine.
The
past
decade
has
witnessed
rapid
emergence
of
a
new
class
self-healing
biomaterials
commonly
termed
injectable,
or
printable
context
3D
printing.
These
injectable
biomaterials,
mostly
hydrogels
other
soft
condensed
matter
based
on
reversible
chemistry,
are
able
temporarily
fluidize
under
shear
stress
subsequently
original
mechanical
properties.
Self-healing
distinct
compared
traditional
biomaterials.
Most
notably,
they
can
be
administered
locally
targeted
minimally
invasive
manner
through
narrow
syringe
without
need
surgery.
Their
moldability
allows
patient-specific
intervention
shows
great
prospects
personalized
medicine.
Injected
facilitate
tissue
regeneration
multiple
ways
owing
viscoelastic
diffusive
nature,
ranging
from
simple
support,
spatiotemporally
controlled
delivery
cells
therapeutics,
local
recruitment
modulation
host
promote
regeneration.
Consequently,
have
been
at
forefront
cutting-edge
strategies.
This
study
provides
critical
review
current
state
As
key
challenges
toward
further
maturation
this
exciting
research
field,
we
identify
(i)
trade-off
between
injectability
vs
physical
stability,
(ii)
lack
consensus
rheological
characterization
quantitative
benchmarks
hydrogels,
particularly
regarding
capillary
flow
syringes,
(iii)
practical
limitations
translation
therapeutically
effective
formulations
specific
tissues.
Hence,
here
chemical
design
strategies
provide
guide
analysis,
showcase
applicability
various
tissues
printing
complex
organoids.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5604 - 5640
Published: Jan. 13, 2022
Tissue
engineering
is
a
promising
and
revolutionary
strategy
to
treat
patients
who
suffer
the
loss
or
failure
of
an
organ
tissue,
with
aim
restore
dysfunctional
tissues
enhance
life
expectancy.
Supramolecular
adhesive
hydrogels
are
emerging
as
appealing
materials
for
tissue
applications
owing
their
favorable
attributes
such
tailorable
structure,
inherent
flexibility,
excellent
biocompatibility,
near-physiological
environment,
dynamic
mechanical
strength,
particularly
attractive
self-adhesiveness.
In
this
review,
key
design
principles
various
supramolecular
strategies
construct
comprehensively
summarized.
Thereafter,
recent
research
progress
regarding
applications,
including
primarily
dermal
repair,
muscle
bone
neural
vascular
oral
corneal
cardiac
fetal
membrane
hepatic
gastric
systematically
highlighted.
Finally,
scientific
challenges
remaining
opportunities
underlined
show
full
picture
hydrogels.
This
review
expected
offer
comparative
views
critical
insights
inspire
more
advanced
studies
on
pave
way
different
fields
even
beyond
applications.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(12), P. 18895 - 18930
Published: Dec. 6, 2021
Light
is
an
attractive
tool
that
has
a
profound
impact
on
modern
medicine.
Particularly,
light-based
photothermal
therapy
(PTT)
and
photodynamic
(PDT)
show
great
application
prospects
in
the
prevention
of
wound
infection
promoting
healing.
In
addition,
hydrogels
have
shown
advantages
field
dressings
due
to
their
excellent
biochemical
effects.
Therefore,
multifunctional
photoresponsive
(MPRHs)
integrate
light
are
increasingly
used
biomedicine,
especially
repair.
However,
comprehensive
review
MPRHs
for
regeneration
still
lacking.
This
first
focuses
various
types
prepared
by
diverse
photosensitizers,
agents
(PHTAs)
including
transition
metal
sulfide/oxides
nanomaterials,
nanostructure-based
PHTAs,
carbon-based
conjugated
polymer
or
complex-based
and/or
(PHDAs)
such
as
ZnO-based,
black-phosphorus-based,
TiO2-based,
small
organic
molecule-based
PHDAs.
We
also
then
discuss
how
PTT,
PDT,
photothermal/photodynamic
synergistic
can
modulate
microenvironments
bacteria
inhibit
infection.
Overall,
with
both
therapeutic
tissue
capabilities
been
discussed
existing
challenges,
well
future
research
directions
management
argued.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(5), P. 7486 - 7502
Published: May 9, 2022
Hypoxia,
excessive
reactive
oxygen
species
(ROS),
impaired
angiogenesis,
lasting
inflammation,
and
bacterial
infection,
are
key
problems
impeding
diabetic
wound
healing.
Particularly,
controllable
release
ROS
scavenging
capacities
critical
during
the
healing
process.
Here,
an
injectable
hydrogel
based
on
hyaluronic
acid-graft-dopamine
(HA-DA)
polydopamine
(PDA)
coated
Ti3C2
MXene
nanosheets
is
developed
catalytically
cross-linked
by
oxyhemoglobin/hydrogen
(HbO2/H2O2)
system
combined
with
mild
photothermal
stimulation
for
HbO2
not
only
acts
as
a
horseradish
peroxidase-like
to
catalyze
formation
but
also
carrier
controllably
when
activated
heat
produced
from
near-infrared
(NIR)
irradiation.
Specifically,
can
provide
repeatedly
binding
in
air
NIR
off.
The
stable
photoresponsive
heating
behavior
of
ensures
repeatable
release.
Additionally,
artificial
nonenzymatic
antioxidant
proposed
scavenge
nitrogen
including
H2O2,
O2•-,
•OH,
keeping
intracellular
redox
homeostasis
alleviating
oxidative
stress,
eradicate
bacteria
avoid
infection.
antibacterial
abilities
further
improved
PDA
coating,
which
promotes
cross-linking
into
network
hydrogel.
HA-DA
molecules
endow
capacity
regulate
macrophage
polarization
M1
M2
achieve
anti-inflammation.
More
importantly,
MXene-anchored
multifunctions
tissue
adhesion,
self-healing,
injectability,
hemostasis,
stimulation,
greatly
human
umbilical
vein
endothelial
cell
proliferation
migration
notably
facilitates
infected
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(11)
Published: Feb. 22, 2022
Polydopamine
(PDA)
nanoparticles
have
emerged
as
an
attractive
biomimetic
photothermal
agent
in
antibacterial
therapy
due
to
their
ease
of
synthesis,
good
biodegradability,
long-term
safety,
and
excellent
photostability.
However,
the
therapeutic
effects
PDA
are
generally
limited
by
low
conversion
efficiency
(PCE).
Herein,
PDA@Ag
synthesized
via
growing
Ag
on
surface
then
encapsulated
into
a
cationic
guar
gum
(CG)
hydrogel
network.
The
optimized
CG/PDA@Ag
platform
exhibits
high
PCE
(38.2%),
which
is
more
than
two
times
higher
that
pure
(16.6%).
More
importantly,
formulated
with
many
active
groups
can
capture
kill
bacteria
through
effective
interactions
between
bacteria,
thereby
benefiting
effect.
As
anticipated,
designed
system
combined
advantages
(high
PCE)
(preventing
aggregation
possessing
inherent
ability)
demonstrated
superior
efficacy
both
vitro
vivo.
This
study
develops
facile
approach
boost
for
therapy,
providing
significant
step
forward
advancing
application
nano-photothermal
agents.
