Recent progress of soft and bioactive materials in flexible bioelectronics

Cyborg and Bionic Systems, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 1, 2025

Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical chemical mismatch between implants ultimately results device failure corrosion by biofluids associated foreign body response. Of particular interest development of bioactive materials at level chemistry mechanics high-performance, minimally invasive function, simultaneously tissue-like compliance vivo biocompatibility. This review summarizes most recent progress these purposes, an emphasis on material properties such as response, integration schemes biological tissues, their use bioelectronic platforms. The article begins overview emerging classes platforms bio-integration proven utility live animal models, high performance different form factors. Subsequent sections various flexible, soft materials, ranging from self-healing hydrogel/elastomer bio-adhesive composites materials. Additional discussions highlight examples active systems support electrophysiological mapping, stimulation, drug delivery treatments related diseases, spatiotemporal resolutions span cellular organ-scale dimension. Envisioned applications involve advanced brain, cardiac, other organ systems, offer stability human subjects models. Results will inspire continuing advancements functions benign thus yielding therapy diagnostics healthcare.

Language: Английский

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Bio-inspired poly-DL-serine materials resist the foreign-body response

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Sept. 7, 2021

Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content low immunogenic silk sericin, the D-serine as neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials mitigating FBR. Here we report highly water soluble, biocompatible easily accessible PSer hydrogels that cause negligible inflammatory after subcutaneous implantation mice for 1 week 2 weeks. No obvious collagen capsulation found surrounding 4 weeks, 3 months 7 post implantation. Histological analysis on cytokines RNA-seq assay both indicate show FBR, comparable Mock group. anti-FBR performance at all time points surpass poly(ethyleneglycol) widely utilized bio-inert materials, implying potent wide application implantable biomaterials biomedical devices.

Language: Английский

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Rationally designed drug delivery systems for the local treatment of resected glioblastoma

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 177, P. 113951 - 113951

Published: Aug. 27, 2021

Language: Английский

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Pore Size of 3D-Printed Polycaprolactone/Polyethylene Glycol/Hydroxyapatite Scaffolds Affects Bone Regeneration by Modulating Macrophage Polarization and the Foreign Body Response

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(18), P. 20693 - 20707

Published: May 2, 2022

3D-printed porous bioactive ceramic scaffolds have been widely used in bone defect repair. However, material implantation is often accompanied by a foreign body response (FBR), which may affect host tissue regeneration. The physical properties of biomaterials, including shape, pore size, and porosity, control the relevant immune responses during To best our knowledge, effect size on bone-biomaterial integration has not studied vivo. Polycaprolactone/polyethylene glycol/hydroxyapatite (PCL/PEG/HA) with different sizes, 209.9 ± 77.1 μm (P200), 385.5 28.6 (P400), 582.1 27.2 (P600), were prepared pneumatic extrusion 3D printer. Compared other P600 significantly reduced FBR induced more M2 macrophage infiltration, vascular ingrowth, new formation. Immunohistochemical staining revealed that MyD88 protein might be involved polarization-related signal transduction to size. Based these results, regeneration requires active participation response, PCL/PEG/HA scaffold preferable candidate for repair defects.

Language: Английский

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Phosphatidylserine liposome multilayers mediate the M1-to-M2 macrophage polarization to enhance bone tissue regeneration

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 154, P. 583 - 596

Published: Oct. 21, 2022

Language: Английский

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