Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 261, P. 116453 - 116453
Published: May 28, 2024
Language: Английский
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 481, P. 148317 - 148317
Published: Dec. 23, 2023
Language: Английский
Citations
51
Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 141, P. 101679 - 101679
Published: April 23, 2023
Language: Английский
Citations
45
Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 185 - 202
Published: March 5, 2024
Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose multi-functional composite hydrogel engineered overcome such conditions through recruitment and activation macrophages with adapted degradation the hydrogel. The (G-TSrP) is created by combining gelatin methacryloyl (GelMA) nanoparticles (TSrP) composed tannic acid (TA) Sr2+. These are prepared using one-step mineralization process assisted metal-phenolic network formation. G-TSrP exhibits ability eliminate reactive oxygen species direct polarization toward M2 phenotype. It has been observed that liberation TA Sr2+ from actively facilitate up-regulation expression extracellular matrix remodeling genes macrophages, thereby, coordinate vivo G-TSrP. Most significantly, accelerates angiogenesis despite TA's inhibitory properties, which counteracted released Moreover, enhances wound closure under promotes normal tissue formation strong vessel growth. Genetic analysis confirms macrophage-mediated Collectively, these findings pave way for development biomaterials promote creating regenerative environment.
Language: Английский
Citations
29
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(3), P. 1514 - 1551
Published: Jan. 1, 2024
Assembly strategy and application direction of protein-based bioactive coatings.
Language: Английский
Citations
25
Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)
Published: April 11, 2024
Abstract The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) developed, where first and second networks are formed dynamic imine bonds non‐dynamic photo‐crosslinked respectively. single before photo‐crosslinking exhibits excellent injectability thus can be printed in situ to form hydrogels. DN‐SPD has demonstrated desirable mechanical properties adhesion. More importantly, “operando” comparison hydrogels loaded or diethylenetriamine (DETA), sham molecule resembling shown similar physical properties, but quite different biological functions. Specifically, outcomes 3 sets vivo animal experiments demonstrate that not only reduce inflammation caused implanted exogenous biomaterials reactive oxygen species also promote polarization macrophages toward regenerative M2 phenotype, DN‐DETA hydrogel. Moreover, immunoregulation translate into faster more natural healing both acute wounds diabetic wounds. Hence, local administration affords simple elegant approach attenuate foreign body reactions induced treat chronic refractory
Language: Английский
Citations
22
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(35), P. 24189 - 24208
Published: Aug. 22, 2024
Polypeptides have the same or similar backbone structures as proteins and peptides, rendering them suitable important biomaterials. Amino acid N-carboxyanhydrides (NCA) ring-opening polymerization has been most efficient strategy for polypeptide preparation, with continuous advance in design of initiators, catalysts reaction conditions. This Perspective first summarizes recent progress NCA synthesis purification. Subsequently, we focus on various initiators polymerization, accelerating enhancing controllability advances approach polymerization. Finally, discuss future research directions open challenges.
Language: Английский
Citations
20
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)
Published: April 26, 2024
The foreign body response (FBR) is an immune-mediated reaction that can occur with most biomaterials and biomedical devices. FBR initiates a deterioration in the performance of implantable devices, representing longstanding challenge consistently hampers their optimal utilization. Over last decade, significant strides are achieved based on either hydrogel design or surface modifications to mitigate FBR. This review delves into recent material strategies aimed at mitigating Further, authors look forward future novel anti-FBR materials from perspective clinical translation needs. Such prospective hold potential attenuate local immune responses, thereby significantly enhancing overall
Language: Английский
Citations
17
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101615 - 101615
Published: Feb. 25, 2025
Language: Английский
Citations
2
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: July 21, 2022
Abstract Despite its apparent simplicity, water behaves in a complex manner and is fundamental controlling many physical, chemical biological processes. The molecular mechanisms underlying interaction of with materials, particularly polymer networks such as hydrogels, have received much attention the research community. this, large gulf still exists applying what known to rationalize how organization on within these materials impacts In this perspective, we outline importance biomaterials science whole give indications for future directions towards emergence complete picture water, biology.
Language: Английский
Citations
59
Biomaterials, Journal Year: 2022, Volume and Issue: 284, P. 121478 - 121478
Published: March 28, 2022
Language: Английский
Citations
51