Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 28, 2025
The
management
of
bone
defects,
particularly
in
aging
populations,
remains
a
major
clinical
challenge.
immune
microenvironment
plays
an
important
role
the
repair
defects
and
favorable
environment
can
effectively
promote
defects.
However,
is
closely
associated
with
chronic
low-grade
systemic
inflammation,
which
adversely
affects
healing.
Persistent
inflammation
critically
regulates
through
all
stages.
This
review
explores
potential
3D-printed
bioceramic
scaffolds
defect
repair,
focusing
on
their
capacity
to
modulate
counteract
effects
aging.
not
only
provide
structural
support
for
regeneration
but
also
serve
as
effective
carriers
anti-osteoporosis
drugs,
offering
novel
therapeutic
strategy
treating
osteoporotic
By
regulating
improving
response,
may
significantly
enhance
context
age-related
degeneration.
approach
underscores
advanced
biomaterials
addressing
dual
challenges
dysregulation,
promising
avenues
development
treatments
elderly.
We
hope
concepts
discussed
this
could
offer
strategies
suggest
future
optimization
scaffolds.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(10)
Published: Jan. 1, 2023
Abstract
Diabetic
foot
ulcer
(DFU)
is
one
of
the
most
common
complications
diabetes,
bringing
physical
and
mental
challenges
for
patients
due
to
lack
efficient
curative
therapy.
Despite
considerable
advances
in
pharmacological
surgical
approaches,
clinical
trials
DFU
remain
disappointing
local
overactive
excessive
inflammation.
Immunomodulatory
hydrogels
has
significant
advantages
overcome
challenge
DFUs
Here,
recent
fabrication
regenerative
utilization
functional
altering
immune
microenvironment
are
comprehensively
reviewed.
The
pathological
features
healing
processes
DFUs,
followed
by
summarizing
physicochemical
properties
essential
design
immunomodulation
briefly
introduced.
Then,
potential
immuno‐therapeutic
modalities
emerging
trends
used
treat
via
multitherapeutic
approaches
enhanced
efficacy
safety
discussed.
Taken
together,
linking
structural
their
functions
therapy
with
a
particular
focus
on
immunomodulatory
stimuli,
this
review
can
promote
further
designing
advanced
resulting
improved
diabetic
wound
repair
through
translation
into
setting
near
future.
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(2), P. 96 - 96
Published: Feb. 9, 2023
Tissue-engineered
scaffolds
are
an
effective
method
for
the
treatment
of
bone
defects,
and
their
structure
function
essential
regeneration.
Digital
light
processing
(DLP)
printing
technology
has
been
widely
used
in
tissue
engineering
(BTE)
due
to
its
high
resolution
gentle
process.
As
commonly
bioinks,
synthetic
polymers
such
as
polyethylene
glycol
diacrylate
(PEGDA)
Pluronic
F127
(F127DA)
have
satisfactory
printability
mechanical
properties
but
usually
lack
sufficient
adhesion
cells
tissues.
Here,
a
compound
BTE
scaffold
based
on
PEGDA,
F127DA,
gelatin
methacrylate
(GelMA)
was
successfully
prepared
using
DLP
technology.
The
not
only
facilitated
proliferation
cells,
also
effectively
promoted
osteogenic
differentiation
mesenchymal
stem
osteoinductive
environment.
Moreover,
volume/total
volume
(BV/TV)
GelMA/PEGDA/F127DA
(GPF)
vivo
49.75
±
8.50%,
higher
than
value
37.10
7.27%
PEGDA/F127DA
(PF)
20.43
2.08%
blank
group.
Therefore,
GPF
provides
new
approach
defects.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
22, P. 100741 - 100741
Published: July 20, 2023
Treatment
of
large
bone
defects
represents
a
great
challenge
in
orthopedic
and
craniomaxillofacial
surgery.
Traditional
strategies
tissue
engineering
have
focused
primarily
on
mimicking
the
extracellular
matrix
(ECM)
terms
structure
composition.
However,
synergistic
effects
other
cues
from
microenvironment
during
regeneration
are
often
neglected.
The
is
sophisticated
system
that
includes
physiological
(e.g.,
neighboring
cells
such
as
macrophages),
chemical
oxygen,
pH),
physical
factors
mechanics,
acoustics)
dynamically
interact
with
each
other.
Microenvironment-targeted
increasingly
recognized
crucial
for
successful
offer
promising
solutions
advancing
engineering.
This
review
provides
comprehensive
overview
current
microenvironment-targeted
challenges
further
outlines
prospective
directions
approaches
construction
organoids.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(15), P. 18658 - 18670
Published: April 8, 2024
Three-dimensional
(3D)-printed
biodegradable
polymer
scaffolds
are
at
the
forefront
of
personalized
constructs
for
bone
tissue
engineering.
However,
it
remains
challenging
to
create
a
biological
microenvironment
growth.
Herein,
we
developed
novel
yet
feasible
approach
facilitate
biomimetic
mineralization
via
self-adaptive
nanotopography,
which
overcomes
difficulties
in
surface
biofunctionalization
3D-printed
polycaprolactone
(PCL)
scaffolds.
The
building
blocks
nanotopography
were
PCL
lamellae
that
formed
on
scaffold
surface-directed
epitaxial
crystallization
and
acted
as
linker
nucleate
generate
hydroxyapatite
crystals.
Accordingly,
uniform
robust
mineralized
layer
was
immobilized
throughout
scaffolds,
strongly
bound
strands
had
no
effect
mechanical
properties
In
vitro
cell
culture
experiments
revealed
resulting
biocompatible
enhanced
proliferation
osteogenic
differentiation
mouse
embryolous
osteoblast
cells.
Furthermore,
demonstrated
showed
strong
capability
accelerate
vivo
regeneration
using
rabbit
defect
model.
This
study
provides
valuable
opportunities
enhance
application
repair,
paving
way
translation
other
orthopedic
implants.
Bone
defects,
whether
caused
by
trauma,
cancer,
infectious
diseases,
or
surgery,
can
significantly
impair
people's
quality
of
life.
Although
autografts
are
the
gold
standard
for
treating
bone
they
often
fall
short
in
adequately
forming
tissue.
The
field
tissue
engineering
has
made
strides
using
scaffolds
with
various
biomaterials,
stem
cells,
and
growth
factors
to
enhance
healing.
However,
some
biological
structures
do
not
yield
satisfactory
therapeutic
outcomes
new
formation.
Recent
studies
have
shed
light
on
crucial
role
immunomodulation,
specifically
interaction
between
implanted
scaffold
host
immune
systems,
regeneration.
Immune
particularly
macrophages,
pivotal
inflammatory
response,
angiogenesis,
osteogenesis.
This
review
delves
into
system's
mechanism
toward
foreign
bodies
recent
advancements
scaffolds'
physical
properties
that
foster
regeneration
modulating
macrophage
polarization
an
anti-inflammatory
phenotype
enhancing
osteoimmune
microenvironment.
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(11), P. 3976 - 3997
Published: Jan. 1, 2023
Bioceramic
scaffolds
used
in
bone
tissue
engineering
suffer
from
a
low
concentration
of
ceramic
particles
(<50
wt%),
because
the
high
increases
brittleness
composite.
3D
printed
flexible
PCL/HA
with
particle
concentrations
(84
wt%)
were
successfully
fabricated
this
study.
However,
hydrophobicity
PCL
weakens
composite
scaffold
hydrophilicity,
which
may
limit
osteogenic
ability
to
some
extent.
Thus,
as
less
time-consuming,
labour
intensive,
and
more
cost-effective
treatment
method,
alkali
(AT)
was
employed
modify
surface
hydrophilicity
scaffold,
its
regulation
immune
responses
regeneration
investigated
vivo
vitro.
Initially,
several
NaOH
(0.5,
1,
1.5,
2,
2.5,
5
mol
L-1)
tests
determine
appropriate
for
AT.
Based
on
comprehensive
consideration
results
mechanical
experiments
2
L-1
2.5
selected
further
investigation
The
PCL/HA-AT-2
dramatically
reduced
foreign
body
reactions
compared
PCL/HA-AT-2.5
scaffolds,
promoted
macrophage
polarization
towards
M2
phenotype
enhanced
new
formation.
Wnt/β-catenin
pathway
might
participate
signal
transduction
underlying
hydrophilic
surface-modified
scaffold-regulated
osteogenesis,
according
immunohistochemical
staining.
In
conclusion,
can
regulate
promote
regeneration,
is
potential
candidate
repair.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 4200 - 4200
Published: Feb. 20, 2023
The
immuno-compatibility
of
implant
materials
is
a
key
issue
for
both
initial
and
long-term
integration.
Ceramic
implants
have
several
advantages
that
make
them
highly
promising
medical
solutions.
These
beneficial
characteristics
include
such
things
as
the
material
availability,
possibility
to
manufacture
various
shapes
surface
structures,
osteo-inductivity
osteo-conductivity,
low
level
corrosion
general
biocompatibility.
an
essentially
depends
on
interaction
with
local
resident
immune
cells
and,
first
all,
macrophages.
However,
in
case
ceramics,
these
interactions
are
insufficiently
understood
require
intensive
experimental
examinations.
Our
review
summarizes
state
art
variants
ceramic
implants:
mechanical
properties,
different
chemical
modifications
basic
material,
structures
modifications,
porosity.
We
collected
available
information
about
ceramics
system
highlighted
studies
reported
ceramic-specific
or
systemic
effects
system.
disclosed
gaps
knowledge
outlined
perspectives
identification
using
advanced
quantitative
technologies.
discussed
approaches
modification
pointed
out
need
data
integration
mathematic
modelling
multiple
their
contribution
bio-
immuno-compatibility.
