Drug Delivery Systems in Regenerative Medicine: An Updated Review

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 695 - 695

Published: Feb. 18, 2023

Modern drug discovery methods led to evolving new agents with significant therapeutic potential. However, their properties, such as solubility and administration-related challenges, may hinder benefits. Moreover, advances in biotechnology resulted the development of a generation molecules short half-life that necessitates frequent administration. In this context, controlled release systems are required enhance treatment efficacy improve patient compliance. Innovative delivery promising tools protect proteins peptides against proteolytic degradation where is achievable. The present review provides an overview different approaches used for delivery.

Language: Английский

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Applied machine learning as a driver for polymeric biomaterials design

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 10, 2023

Abstract Polymers are ubiquitous to almost every aspect of modern society and their use in medical products is similarly pervasive. Despite this, the diversity commercial polymers used medicine stunningly low. Considerable time resources have been extended over years towards development new polymeric biomaterials which address unmet needs left by current generation medical-grade polymers. Machine learning (ML) presents an unprecedented opportunity this field bypass need for trial-and-error synthesis, thus reducing invested into discoveries critical advancing treatments. Current efforts pioneering applied ML polymer design employed combinatorial high throughput experimental data availability concerns. However, lack available standardized characterization parameters relevant medicine, including degradation biocompatibility, represents a nearly insurmountable obstacle ML-aided biomaterials. Herein, we identify gap at intersection biomedical design, highlight works junction more broadly provide outlook on challenges future directions.

Language: Английский

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Zebra-inspired stretchable, biodegradable radiation modulator for all-day sustainable energy harvesters

Science Advances, Journal Year: 2023, Volume and Issue: 9(5)

Published: Feb. 1, 2023

Recent advances in passive radiative cooling systems describe a variety of strategies to enhance efficiency, while the integration such technology with bioinspired design using biodegradable materials can offer research opportunity generate energy sustainable manner, favorable for temperature/climate system planet. Here, we introduce stretchable and ecoresorbable cooling/heating engineered zebra stripe-like patterns that enable generation large in-plane temperature gradient thermoelectric generation. A comprehensive study theoretical evaluations validates ability accomplish target performances even under external mechanical strains, all eventually disappear physiological conditions. Use print selective heating demonstrates an unexpected level difference compared use emitters alone, which enables producing through resorbable silicon-based devices. The overall result suggests potential scalable, ecofriendly renewable systems.

Language: Английский

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Poly(disulfide)s: From Synthesis to Drug Delivery

Biomacromolecules, Journal Year: 2021, Volume and Issue: 23(1), P. 1 - 19

Published: Dec. 7, 2021

Bioresponsive polymers have been widely used in drug delivery because of their degradability. For example, poly(disulfide)s with repeating disulfide bonds the main chain attracted considerable research attention. The characteristics bonds, including dynamic and reversible properties responsiveness to stimuli such as reductants, light, heat, mechanical force, make them ideal platforms for on-demand delivery. This review introduces synthesis methods applications poly(disulfide)s. Furthermore, are classified on basis monomers used: oxidative step-growth polymerization dithiols, ring-opening cyclic disulfides, linear disulfides. In addition, recent advances small-molecule or biomacromolecular drugs discussed. Quantum-dot-loaded poly(disulfide) systems imaging also included. provides an overview various design strategies employed construction inspire new field

Language: Английский

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Selective removal of antibiotics over MgAl₂O₄/C₃N₄/YMnO₃ photocatalysts: Performance prediction and mechanism insight

Journal of the American Ceramic Society, Journal Year: 2022, Volume and Issue: 106(4), P. 2420 - 2442

Published: Dec. 15, 2022

Abstract A simple polyacrylamide gel method combined with low temperature sintering technology has been used to synthesize the C–O functional groups grafted MgAl 2 O 4 /C 3 N /YMnO (MAO–CN–YMO) heterojunction photocatalysts enhanced visible‐light‐induced photodegradation toward oxytetracycline hydrochloride (OTC‐HCl). variety of characterization methods are gain insight into phase purity, crystal structure, microstructure, group information, elemental composition, surface defect, light response capability, and photocatalytic activity as‐synthesized samples. The influences mass ratios m CN / YMO , MAO /( + ) in CN–YMO, CN–MAO, MAO–CN–YMO on for degradation OTC‐HCl was also discussed, optimal ratio is identified as 15 wt%. experiments confirmed that had high selectivity antibiotics. prediction made by a intelligent algorithm models. results whale optimization highly consistent experimental results. Combined energy band theory high‐performance liquid chromatography–tandem spectrometry, free radicals reaction solution preferentially attacked –CH –NCH –OH during heterostructure photocatalysts, then attack –C=O –C=O–NH finally perform ring‐opening degrade nontoxic harmless products small molecules such CO H O, NH . This work provides new idea development novel double p–n junction antibiotic multiple algorithms.

Language: Английский

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Research progress on eco-friendly superhydrophobic materials in environment, energy and biology

Chemical Communications, Journal Year: 2022, Volume and Issue: 58(80), P. 11201 - 11219

Published: Jan. 1, 2022

In the past few years, bioinspired eco-friendly superhydrophobic materials (EFSMs) have made great breakthroughs, especially in fields of environment, energy and biology, which remarkable contributions to sustainable development natural environment. However, some potential challenges still exist, urgently need be systematically summarized guide future this field. Herein, review, initially, we discuss five typical models, namely, Wenzel, Cassie, Wenzel-Cassie, "lotus", "gecko" models. Then, existence creatures nature artificial EFSMs are summarized. focus on applications environment (self-cleaning, wastewater purification, membrane distillation), (solar evaporation, heat accumulation, batteries), biology (biosensors, biomedicine, antibacterial, food packaging). Finally, developments highlighted.

Language: Английский

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Artificial apoptotic cells/VEGF-loaded injectable hydrogel united with immunomodification and revascularization functions to reduce cardiac remodeling after myocardial infarction

Nano Today, Journal Year: 2021, Volume and Issue: 39, P. 101227 - 101227

Published: June 22, 2021

Language: Английский

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Bioactive Poly(octanediol‐citrate‐polyglycol) Accelerates Skin Regeneration through M2 Polarization Immunomodulating and Early Angiogenesis

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(10)

Published: Feb. 2, 2022

Abstract The inhibition of inflammation and the promotion early angiogenesis are paid much attention in skin tissue engineering. Citric acid‐based biomaterials widely used engineering due to their bioactive structure biocompatibility, but there few studies on investigating role mechanism wound repair regeneration. Herein, potential anti‐inflammation poly(octanediol‐citrate‐polyglycol) (POCG) copolymer is reported regulating repair. It found that POCG can modulate macrophages phenotype through downregulating expression proinflammatory cytokines (tumor necrosis facor‐α ( Tnf‐α ), Interleukin‐1β IL‐1β Interleukin‐6 IL‐6 ) polarizing anti‐inflammatory (M2) phenotype. promote endothelial cell vascularization by increasing factors (vascular growth factor Vegf cluster differentiation 31CD31) mediated macrophage polarization. vivo study shows accelerate suppressing acute inducing polarization modulation. Furthermore, polymer has good biocompatibility for both immune cells cells. This may provide important theoretical support bioactivity citrate‐based expanding applications

Language: Английский

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Additive Manufacturing of Bioactive Glass and Its Polymer Composites as Bone Tissue Engineering Scaffolds: A Review

Bioengineering, Journal Year: 2023, Volume and Issue: 10(6), P. 672 - 672

Published: June 1, 2023

Bioactive glass (BG) and its polymer composites have demonstrated great potential as scaffolds for bone defect healing. Nonetheless, processing these materials into complex geometry to achieve either anatomy-fitting designs or the desired degradation behavior remains challenging. Additive manufacturing (AM) enables fabrication of BG BG/polymer objects with well-defined shapes intricate porous structures. This work reviewed recent advancements made in AM composite intended tissue engineering. A literature search was performed using Scopus database include publications relevant this topic. The properties based on different inorganic formers, well composites, are first introduced. Melt extrusion, direct ink writing, powder bed fusion, vat photopolymerization technologies that compatible were terms their advances. value lies ability produce patient-specific on-demand spatial distribution biomaterials, both contributing effective healing, by vivo studies. Based relationships among structure, physiochemical properties, biological function, AM-fabricated valuable achieving safer more efficient healing future.

Language: Английский

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Elastomer–Hydrogel Systems: From Bio-Inspired Interfaces to Medical Applications

Polymers, Journal Year: 2022, Volume and Issue: 14(9), P. 1822 - 1822

Published: April 29, 2022

Novel advanced biomaterials have recently gained great attention, especially in minimally invasive surgical techniques. By applying sophisticated design and engineering methods, various elastomer–hydrogel systems (EHS) with outstanding performance been developed the last decades. These composed of elastomers hydrogels are very attractive due to their high biocompatibility, injectability, controlled porosity often antimicrobial properties. Moreover, elastomeric properties bioadhesiveness making them suitable for soft tissue engineering. Herein, we present advances current state-of-the-art principles strategies strong interface formation inspired by nature (bio-inspiration), diverse applications different medical fields, particular, The functionalities these systems, including adhesive properties, degradability, applicable will be discussed a context future efforts towards development biomaterials.

Language: Английский

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