MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: July 20, 2024
Abstract
Nanomaterials
have
aroused
great
interests
in
drug
delivery
due
to
their
nanoscale
structure,
facile
modifiability,
and
multifunctional
physicochemical
properties.
Currently,
stimuli‐responsive
nanomaterials
that
can
respond
endogenous
or
exogenous
stimulus
display
strong
potentials
biomedical
applications.
In
comparison
with
conventional
nanomaterials,
improve
therapeutic
efficiency
reduce
the
toxicity
of
drugs
toward
normal
tissues
through
specific
targeting
on‐demand
release
at
pathological
sites.
this
review,
we
summarize
responsive
mechanism
a
variety
stimulus,
including
pH,
redox,
enzymes
within
microenvironment,
as
well
such
thermal
effect,
magnetic
field,
light,
ultrasound.
After
that,
applications
(e.g.,
delivery,
imaging,
theranostics)
diverse
array
common
diseases,
cardiovascular
cancer,
neurological
disorders,
inflammation,
bacterial
infection,
are
presented
discussed.
Finally,
remaining
challenges
outlooks
future
research
directions
for
also
We
hope
review
provide
valuable
guidance
developing
accelerate
diseases
diagnosis
treatment.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(19), P. 12049 - 12095
Published: May 2, 2024
Cancer,
as
one
of
the
leading
causes
death
worldwide,
drives
advancement
cutting-edge
technologies
for
cancer
treatment.
Transition-metal-based
nanozymes
emerge
promising
therapeutic
nanodrugs
that
provide
a
reference
therapy.
In
this
review,
we
present
recent
breakthrough
First,
comprehensively
outline
preparation
strategies
involved
in
creating
transition-metal-based
nanozymes,
including
hydrothermal
method,
solvothermal
chemical
reduction
biomimetic
mineralization
and
sol–gel
method.
Subsequently,
elucidate
catalytic
mechanisms
(catalase
(CAT)-like
activities),
peroxidase
(POD)-like
oxidase
(OXD)-like
activities)
superoxide
dismutase
(SOD)-like
along
with
their
activity
regulation
such
morphology
control,
size
manipulation,
modulation,
composition
adjustment
surface
modification
under
environmental
stimulation.
Furthermore,
elaborate
on
diverse
applications
anticancer
therapies
encompassing
radiotherapy
(RT),
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
photothermal
(PTT),
sonodynamic
(SDT),
immunotherapy,
synergistic
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
The
purpose
review
is
to
offer
scientific
guidance
will
enhance
clinical
based
transition
metals.
Abstract
Cuproptosis,
the
current
form
of
regulated
cell
death
characterized
by
copper
overload,
oligomerization
lipoacylated
proteins,
and
loss
Fe–S
cluster
has
been
proposed
to
function
closely
with
human
diseases,
including
cancer.
Since
its
first
identification
in
2022,
many
strategies
have
developed
induce
cuproptosis
for
cancer
therapy,
such
as
small‐molecule
drugs
nanomaterials.
Although
reviews
related
reported,
they
remain
at
a
basic
mechanism
level,
summary
covering
recent
progress
field
nanotechnologies
cuproptosis‐based
therapy
not
yet
presented.
Therefore,
it
is
time
fill
gap
shed
light
on
future
directions
application
this
promising
tool
fight
against
In
minireview,
we
expounded
action
emphasized
feasibility
triggering
therapy.
The
treatments
based
nanoparticle‐induced
was
then
described.
Finally,
challenges
development
emerging
are
also
discussed.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(31)
Published: May 10, 2023
Abstract
Biomarkers
are
primary
indicators
for
precise
diagnosis
and
treatment.
The
early
identification
of
health
biomarkers
has
been
sustained
by
the
evolutionary
success
in
sensor
technologies.
Among
them,
graphene
field‐effect
transistor
(GFET)
biosensors
have
exhibited
major
advantages
such
as
an
ultrashort
response
time,
high
sensitivity,
easy
operation,
capability
integration,
label‐free
detection.
Owing
to
atomic
thickness,
restricts
charge
carrier
flow
merely
at
material
surface
responds
foreign
stimuli
directly,
leading
effective
signal
acquisition
transmission.
Here,
this
review
summarizes
latest
advances
GFET
a
comprehensive
manner
that
contains
device
design,
working
principle,
functionalization,
proof‐of‐concept
applications.
It
provides
survey
with
regard
biomarker
analysis
single‐device
level
integrated
prototypes
include
wearable
sensors,
biomimetic
systems,
healthcare
electronics,
diagnostic
platforms.
Moreover,
there
is
discussion
on
long‐standing
research
efforts
outlook
future
development
systems
from
lab
fab.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(48)
Published: Oct. 6, 2024
Rheumatoid
arthritis
(RA)
represents
an
insidious
autoimmune
inflammatory
disorder
that
severely
lowers
the
life
quality
by
progressively
destructing
joint
functions
and
eventually
causing
permanent
disability,
posing
a
serious
public
health
problem.
Here,
advanced
theranostic
probe
is
introduced
integrates
activatable
second
near-infrared
(NIR-II)
fluorescence
imaging
for
precise
RA
diagnosis
with
multi-pronged
treatments.
A
novel
molecular
comprising
long-wavelength
aggregation-induced
emission
unit
manganese
carbonyl
cage
motif
synthesized,
which
enables
NIR-II
activation
concurrently
releasing
therapeutic
carbon
monoxide
(CO)
gas
in
inflamed
microenvironment.
This
self-assembles
into
biocompatible
nanoprobe,
subsequently
conjugated
anti-IL-6R
antibody
to
afford
active-targeting
ability
of
RA.
The
nanoprobe
exhibits
significant
turn-on
signal
at
lesion,
enabling
highly
sensitive
real-time
monitoring.
combination
ROS
scavenging,
on-demand
CO
release,
IL-6
signaling
blockade
results
potent
effect
synergistic
immunomodulation
impact,
significantly
alleviating
symptoms
preventing
destruction.
research
introduces
paradigm
development
high-performance,
strategies
facilitate
detection
enhanced
treatment
RA-related
diseases.
Nanotheranostics,
Journal Year:
2024,
Volume and Issue:
8(3), P. 344 - 379
Published: Jan. 1, 2024
Modern
medicine
relies
on
a
small
number
of
key
biologics,
which
can
be
found
in
nature
but
require
further
characterization
and
purification
before
they
used.Since
the
herbal
remedy
is
given
through
dated
ineffective
method
drug
administration,
its
effectiveness
diminished.The
novel
form
delivery
has
potential
to
increase
substances
while
decreasing
their
side
effects.This
main
idea
behind
utilising
different
ways
treatments.Several
benefits
arise
from
formulations
compounds
as
compared
conventional
counterparts.These
include
enhanced
penetrating
ability
into
tissues,
constant
effective
doses,
resistance
physical
chemical
degradation.Controlled
targeted
that
components
allow
for
more
traditional
dosing
simultaneously
increasing
efficacy.Enhancing
biodistribution
target
site
accumulation
systemically
administered
medicines
goal
nanomedicine
formulations.The
field
nanotheranostics
made
significant
advancements
development
by
combining
diagnostic
therapeutic
functions
single
nanoscale
platform.It
critically
important
create
theranostic
nanoplatform
derived
plants
intrinsically
"all-in-one"
molecules.In
addition
examining
mechanistic
approach
nanoparticle
synthesis,
this
review
highlights
effects
phytochemical
systems.Furthermore,
we
have
evaluated
scope
future
field,
discussed
several
nanoparticles
been
developed
recently
imaging,
provided
experimental
evidence
supports
usage.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(17)
Published: Feb. 26, 2024
As
an
indispensable
part
of
the
human
sensory
system,
visual
acuity
may
be
impaired
and
even
develop
into
irreversible
blindness
due
to
various
ocular
pathologies.
Among
diseases,
fundus
neovascularization
diseases
(FNDs)
are
prominent
etiologies
impairment
worldwide.
Intravitreal
injection
anti-vascular
endothelial
growth
factor
drugs
remains
primary
therapy
but
is
hurdled
by
common
complications
incomplete
potency.
To
renovate
current
therapeutic
modalities,
nanomedicine
emerged
as
times
required,
which
endowed
with
advanced
capabilities,
able
fulfill
effective
drug
delivery
achieve
precise
release
control,
thus
further
improving
effect.
This
review
provides
a
comprehensive
summary
advances
in
for
FND
management
from
state-of-the-art
studies.
First,
modalities
FNDs
thoroughly
introduced,
focusing
on
key
challenges
delivery.
Second,
nanocarriers
comprehensively
reviewed
posterior
based
nanostructures:
polymer-based
nanocarriers,
lipid-based
inorganic
nanoparticles.
Thirdly,
characteristics
microenvironment,
their
pathological
changes
during
FNDs,
corresponding
strategies
constructing
smart
elaborated.
Furthermore,
prospects
discussed.
Cancer Medicine,
Journal Year:
2025,
Volume and Issue:
14(3)
Published: Jan. 27, 2025
Photodynamic
therapy
(PDT)
is
a
noninvasive
cancer
treatment
that
works
by
using
light
to
stimulate
the
production
of
excessive
cytotoxic
reactive
oxygen
species
(ROS),
which
effectively
eliminates
tumor
cells.
However,
therapeutic
effects
PDT
are
often
limited
hypoxia,
prevents
effective
cell
elimination.
The
(O2)
consumption
during
can
further
exacerbate
leading
post-treatment
adverse
events.
This
review
aims
explore
potential
cuproptosis,
recently
discovered
copper-dependent
form
programmed
death,
enhance
anticancer
PDT.
Cuproptosis
highly
dependent
on
mitochondrial
respiration,
specifically
tricarboxylic
acid
(TCA)
cycle,
and
increase
O2
ROS
levels
or
decrease
glutathione
(GSH)
levels,
thereby
improving
outcomes.
discusses
latest
research
advancements
in
field,
detailing
mechanisms
regulate
cuproptosis
It
also
explores
how
nanoparticle
(NP)-based
strategies
be
used
exploit
synergistic
between
article
examines
prospects
activity
guided
nanodelivery
systems,
could
overcome
challenges
associated
with
hypoxia
treatment.
combination
PDT,
facilitated
NP-based
delivery
presents
promising
approach
effectiveness
therapy.
concludes
discussing
future
directions
for
this
therapy,
highlighting
need
investigation
into
optimization
improve
outcomes
