Engineering nanosystems for ROS-bridged cancer cascade therapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 473, P. 145415 - 145415

Published: Aug. 12, 2023

Language: Английский

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Ratiometric optical probes for biosensing

Theranostics, Journal Year: 2023, Volume and Issue: 13(8), P. 2632 - 2656

Published: Jan. 1, 2023

Biosensing by optical probes is bringing about a revolution in our understanding of physiological and pathological states.Conventional for biosensing are prone to inaccurate detection results due various analyte-independent factors that can lead fluctuations the absolute signal intensity.Ratiometric provide built-in self-calibration correction more sensitive reliable detection.Probes specifically developed ratiometric have been shown significantly improve sensitivity accuracy biosensing.In this review, we focus on advancements sensing mechanism including photoacoustic (PA) probes, fluorescence (FL) bioluminescence (BL) chemiluminescence (CL) afterglow probes.The versatile design strategies these discussed along with broad range applications such as pH, enzymes, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), metal ions, gas molecules hypoxia factors, well resonance energy transfer (FRET)-based immunoassay biosensing.Finally, challenges perspectives discussed.

Language: Английский

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Inflammation‐Activated Endogenous Macrophage‐Mediated Prodrug Delivery System Overcoming Biological Barriers for Enhanced Oral Meningitis Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: May 25, 2024

Abstract Significant health risks are posed by meningitis due to its rapid progression, and challenges encountered in intravenous antibiotic administration, especially crossing the blood‐brain barrier. To address this, an inflammation‐activated, endogenous macrophage (MΦ)‐mediated oral prodrug delivery system is developed for targeted therapeutic interventions bacterial treatment. This guided inflammation‐derived chemoattractants triggers drug release through inflammation‐induced reactive oxygen species (ROS). Comprised of naturally derived β‐glucans conjugated with cefotaxime (CTX) using a ROS‐responsive linker, nanoparticles (βGlus–CTX NPs) formed aqueous solutions. In mouse model Klebsiella pneumoniae ‐induced meningitis, orally administered βGlus–CTX NPs traversed intestinal microfold cells, surpassing intestine‐epithelial barrier, absorbed resident MΦ. These MΦ‐mediated vehicles then traveled lymphatic circulatory systems, compromised ultimately reaching inflamed brain tissues, their chemoattractants. ROS‐rich tissue environments, linkers cleaved, releasing CTX localized Targeted treatment offered this oral, system, overcoming robust gut‐to‐brain biological barriers potentially enhancing effectiveness comfortable home‐based

Language: Английский

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Nanomaterials for Disease Treatment by Modulating the Pyroptosis Pathway

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 25, 2023

Pyroptosis differs significantly from apoptosis and cell necrosis as an alternative mode of programmed death. Its occurrence is mediated by the gasdermin protein, leading to characteristic outcomes including swelling, membrane perforation, release contents. Research underscores role pyroptosis in etiology progression many diseases, making it a focus research intervention scientists explore ways regulate pathways disease management. Despite numerous reviews detailing relationship between mechanisms, few delve into recent advancements nanomaterials mechanism for modulating pathway mitigate effects. Therefore, there urgent need fill this gap elucidate path use promising technology field treatment. This review article delves developments management through modulation, details mechanisms which drugs interact with pathways, highlights promise that nanomaterial holds driving forward

Language: Английский

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Stimuli-responsive polymer-based nanosystems for cardiovascular disease theranostics

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(15), P. 3805 - 3825

Published: Jan. 1, 2024

Stimuli-responsive polymer-based nanosystems have gained significant attention for cardiovascular disease theranostics. This review summarizes various stimuli-responsive used diagnosing and treating diseases.

Language: Английский

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MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma

Theranostics, Journal Year: 2016, Volume and Issue: 6(8), P. 1105 - 1118

Published: Jan. 1, 2016

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Language: Английский

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Evolution in optical molecular imaging techniques guided nerve imaging from 2009 to 2023: a bibliometric and visualization analysis

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 22, 2025

Background Recent years, the use of optical molecular imaging (OMI) techniques guided nerve has made significant progress. However, a comprehensive bibliometric analysis in this field is currently lacking. In study, we aim to shed light on current status, identify emerging hot topics, and provide valuable insights for researchers within field. Methods collected 414 research via Web Science Core Collection (WoSCC) from 2009 2023. CiteSpace, VOSviewer R package “bibliometrix” were used countries, institutions, journals, etc., evaluate trends. Results The amounts publications relation OMI been increasing. United States China contributed over 60% publications. Shanghai Jiao Tong University highest number Investigative Ophthalmology Visual considered most prestigious prolific journal It also widely regarded as cited journal. Among top 10 authors terms output, Hehir CAT citations. “neurosciences neurology,” “science technology other topics,” “ophthalmology” are representative areas. main cluster keywords includes “axonal regeneration,” “mouse,” “optical coherence tomography.” Conclusion This investigation offers portrayal structure knowledge progression patterns, presents an all-encompassing synthesis findings, discerns illustrates forefront first time. will reference relevant scholars.

Language: Английский

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Theranostic Advances and the Role of Molecular Imprinting in Disease Management

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112186 - 112186

Published: March 10, 2025

Molecular imprinting has become an effective technology in the realm of diagnosing diseases, providing unparalleled specificity and sensitivity. This method is a promising trend current medical research. review examines utilization molecularly imprinted polymers (MIPs) theranostic that integrates diagnostic functionalities for personalized medicine. The present work briefly discusses fundamental concepts molecular how it evolved into versatile platform. Subsequently, MIPs advancement biosensors focused, specifically emphasizing their contribution to detection diagnosis diseases. therapeutic potential MIPs, focusing on targeted drug delivery controlled release systems integration platforms explored through case studies, showcasing technology's ability simultaneously diagnose treat Finally, we address challenges facing discuss future perspectives, this revolutionize next generation.

Language: Английский

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Innovative Smart Biosensors for Cancer Theranostics: A New Frontier in Detection, Diagnosis, and Beyond

Cancer Treatment and Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 100911 - 100911

Published: March 1, 2025

Language: Английский

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Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract In recent years, nanomaterials have demonstrated broad prospects in the diagnosis and treatment of retinal diseases due to their unique physicochemical properties, such as small‐size effects, high biocompatibility, functional surfaces. Retinal are often accompanied by complex pathological microenvironments, where conventional diagnostic therapeutic approaches face challenges low drug delivery efficiency, risks associated with invasive procedures, difficulties real‐time monitoring. Nanomaterials hold promise addressing these limitations traditional therapies, thereby improving precision efficacy. The applications diagnostics summarized, they enable high‐resolution imaging carrying fluorescent probes or contrast agents act biosensors sensitively detect disease‐related biomarkers, facilitating early dynamic therapeutics, functionalized nanocarriers can precisely deliver drugs, genes, antioxidant molecules target cells, significantly enhancing outcomes while reducing systemic toxicity. Additionally, nanofiber materials possess properties that make them particularly suitable for regeneration tissue engineering. By loading neurotrophic factors into scaffolds, regenerative effects be amplified, promoting repair neurons. Despite immense potential, clinical translation still requires long‐term biosafety, scalable manufacturing processes, optimization targeting efficiency.

Language: Английский

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