Toughening Double‐Network Hydrogels by Polyelectrolytes

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(26)

Published: March 20, 2023

The Hoffmeister effect of inorganic salts is verified as a promising way to toughen hydrogels, however, the high concentration may be accompanied by poor biocompatibility. In this work, it found that polyelectrolytes can obviously elevate mechanical performances hydrogels through effect. introduction anionic poly(sodium acrylate) into poly(vinyl alcohol) (PVA) hydrogel induces aggregation and crystallization PVA boost properties resulting double-network hydrogel: elevation 73, 64, 28, 135, 19 times in tensile strength, compressive Young's modulus, toughness, fracture energy compared with poly(acrylic acid), respectively. It noteworthy flexibly tuned variation polyelectrolyte concentration, ionization degree, relative hydrophobicity ionic component, type wide range. This strategy work for other Hoffmeister-effect-sensitive polymers polyelectrolytes. Also, urea bonds further improve antiswelling capability hydrogels. As biomedical patch, advanced efficiently inhibit hernia formation promote regeneration soft tissues an abdominal wall defect model.

Language: Английский

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A tough, antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds

Bioactive Materials, Journal Year: 2024, Volume and Issue: 34, P. 269 - 281

Published: Jan. 1, 2024

Wound management is an important issue that places enormous pressure on the physical and mental health of patients, especially in cases infection, where increased inflammatory response could lead to severe hypertrophic scars (HSs). In this study, a hydrogel dressing was developed by combining high strength toughness, swelling resistance, antibacterial antioxidant capabilities. The matrix composed double network polyvinyl alcohol (PVA) agarose with excellent mechanical properties. Hyperbranched polylysine (HBPL), highly effective cationic polymer, tannic acid (TA), strong molecule, were added as functional components. Examination properties confirmed full play efficacy HBPL TA. vivo studies methicillin-resistant Staphylococcus aureus (MRSA) had shown obvious promotion wound healing, more profoundly, significant suppression scar formation. Due common raw materials simple preparation methods, can be mass produced used for accelerating healing while preventing HSs infected wounds.

Language: Английский

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Super strong and tough anisotropic hydrogels through synergy of directional freeze-casting, metal complexation and salting out

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 463, P. 142414 - 142414

Published: March 15, 2023

Language: Английский

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A Biomimetic “Salting Out—Alignment—Locking” Tactic to Design Strong and Tough Hydrogel

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 22, 2024

Abstract Recently, hydrogel‐based soft materials have demonstrated huge potential in robotics, flexible electronics as well artificial skins. Although various methods are developed to prepare tough and strong hydrogels, it is still challenging simultaneously enhance the strength toughness of especially for protein‐based hydrogels. Herein, a biomimetic “salting out—alignment—locking” tactic (SALT) introduced enhancing mechanical properties through synergy alignment salting out effect. As typical example, tensile modulus initially brittle gelatin hydrogels increase 940 folds 10.12 ± 0.50 MPa 2830 34.26 3.94 MPa, respectively, increases up 1785 14.28 3.13 MJ m −3 . The obtained hold records previously reported gelatin‐based hydrogel close tendons. It further elucidated that effect engenders hydrophobic domains, while prestretching facilitates chain alignment, both synergistically contributing outstanding properties. noteworthy SALT demonstrates remarkable versatility across different salt types polymer systems, thus opening new avenues engineering strong, tough, stiff

Language: Английский

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Evolutionary Reinforcement of Polymer Networks: A Stepwise‐Enhanced Strategy for Ultrarobust Eutectogels

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Nov. 8, 2023

Abstract Gel materials are appealing due to their diverse applications in biomedicine, soft electronics, sensors, and actuators. Nevertheless, the existing synthetic gels often plagued by feeble network structures inherent defects associated with solvents, which compromise mechanical load‐bearing capacity cast persistent doubts about reliability. Herein, combined attractive deep eutectic solvent (DES), a stepwise‐enhanced strategy is presented fabricate ultrarobust eutectogels. It focuses on continuous modulation optimization of polymer networks through complementary annealing exchange processes, drives progressive increase both quantity mass interconnected chains at microscopic scale, hence contributing evolutionary enhancement structure. The resultant eutectogel exhibits superb properties, including record‐breaking strength (31.8 MPa), toughness (76.0 MJ m −3 ), Young's modulus (25.6 together exceptional resistance ability tear crack propagation. Moreover, this able be further programmed photolithography situ create patterned for imparting specific functionalities. Enhanced its broad applicability various DES combinations, poised serve as crucial template methodology future development robust gels.

Language: Английский

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High tensile properties, wide temperature tolerance, and DLP-printable eutectogels for microarrays wearable strain sensors

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 481, P. 149004 - 149004

Published: Jan. 23, 2024

Language: Английский

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Tough Supramolecular Hydrogels Crafted via Lignin‐Induced Self‐Assembly

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Abstract Supramolecular hydrogels are typically assembled through weak non‐covalent interactions, posing a significant challenge in achieving ultra strength. Developing higher strength based on molecular/nanoscale engineering concepts is potential improvement strategy. Herein, super‐tough supramolecular hydrogel by gradually diffusing lignosulfonate sodium (LS) into polyvinyl alcohol (PVA) solution. Both simulations and analytical results indicate that the assembly subsequent enhancement of crosslinked network primarily attributed to LS‐induced formation gradual densification strong crystalline domains within hydrogel. The optimized exhibits impressive mechanical properties with tensile ≈20 MPa, Young's modulus ≈14 toughness ≈50 MJ m⁻ 3 , making it strongest lignin‐PVA/polymer known so far. Moreover, LS provides excellent low‐temperature stability (<‐60 °C), antibacterial, UV‐blocking capability (≈100%). Interestingly, diffusion ability demonstrated for self‐restructuring damaged hydrogel, 3D patterning surfaces, enhancing local freeze‐thaw PVA goal foster versatile platform combining eco‐friendly biocompatible PVA, paving way innovation interdisciplinarity biomedicine, materials, forestry science.

Language: Английский

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Conductive Hyaluronic Acid/Deep Eutectic Solvent Composite Hydrogel as a Wound Dressing for Promoting Skin Burn Healing Under Electrical Stimulation

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)

Published: April 3, 2024

Abstract Burns can cause severe damage to the skin due bacterial infection and inflammation. Although conductive hydrogels as electroactive burn‐wound dressings achieve remarkable effects on accelerating wound healing, issues such imbalance between their high conductivity mechanical properties, easy dehydration, low transparency must be addressed. Herein, a double‐network eutectogel is fabricated by integrating polymerizable deep eutectic solvents (PDESs)including acrylamide/choline chloride/glycerol (acrylamide‐polymerization crosslink) thiolated hyaluronic acid (disulfide‐bonding crosslink). The introduction of PDESs provides with (up 0.25 S·m −1 ) strength (tensile strain 59–77%) simulating those natural human skin, well satisfactory tissue adhesiveness, self‐healing ability, antibacterial properties. When combined exogenous electrical stimulation, exhibits ability reduce inflammation, stimulate cell proliferation migration, promote collagen deposition angiogenesis, facilitate remodeling. This shows great potential dressing for healing major burn wounds.

Language: Английский

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Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(18)

Published: Jan. 20, 2024

Abstract Therapeutic deep eutectic solvents (THEDES) are an emerging family of mixtures gaining increasing interest in the biomedical space. The immobilization THEDES into polymer networks allows bioactive eutectogels to expand their application scope topical drug delivery. Herein, this work presents first set elastomeric constructed by supporting a therapeutic system with skin permeation ability protein scaffold dynamically crosslinked natural polyphenol. In ionic eutectic, gelatin undergoes gelation through unexpected mechanism striking contrast classical hydrogels, which is herein thoroughly studied. Interestingly, polyphenol controls conformation structure, enabling tuning up mechanical and viscoelastic behavior dynamic eutectogel from elastic hyperelastic. resultant exhibit strain‐hardening behavior, thermoreversible gel‐to‐sol transition, excellent adhesive performance. Furthermore, these versatile materials retain bioactivity liquid favor occlusion, assisting delivery both hydrophilic hydrophobic substances ex vivo porcine time‐dependent penetration process. These ultrastretchable show new interplays between scaffolds mixtures, paving way for innovative soft materials.

Language: Английский

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Stretchable ionic conductive gels for wearable human-activity detection

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 489, P. 151231 - 151231

Published: April 17, 2024

Language: Английский

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