Small Science,
Journal Year:
2024,
Volume and Issue:
4(11)
Published: Sept. 3, 2024
Degenerative
joint
diseases,
as
a
global
public
health
issue,
impose
significant
burdens
on
patients'
lives
and
substantial
economic
costs
society.
Currently,
the
primary
modalities
include
physical
therapy,
pharmaceutical
intervention,
surgical
procedures.
None
of
these
approaches
can
alter
course
this
degenerative
process.
Due
to
their
commendable
biocompatibility,
biodegradability,
heightened
efficacy
in
drug
delivery,
hydrogels
present
themselves
novel
noninvasive
remedy
for
ailments.
However,
clinical
application
still
faces
some
challenges,
including
uncontrolled
discharge
encapsulated
medications,
absence
adequate
mechanical
reinforcement
destabilized
joints,
adaptability
fluctuating
microenvironments.
Recently,
nanocomposite
hydrogels,
formed
by
introducing
nanomaterials
into
or
chemical
means,
improve
limitations
extend
potential
biological
applications
diseases.
In
study,
pathologic
features
diseases
multiple
different
types
targeting
are
briefly
described.
It
also
concludes
with
an
outlook
use
settings
discusses
challenges
limitations.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: May 21, 2024
The
repair
and
regeneration
of
cartilage
has
always
been
a
hot
topic
in
medical
research.
Cartilage
organoids
(CORGs)
are
special
tissue
created
using
engineering
techniques
outside
the
body.
These
engineered
tissues
provide
models
that
simulate
complex
biological
functions
cartilage,
opening
new
possibilities
for
regenerative
medicine
treatment
strategies.
However,
it
is
crucial
to
establish
suitable
matrix
scaffolds
cultivation
CORGs.
In
recent
years,
utilizing
hydrogel
culture
stem
cells
induce
their
differentiation
into
chondrocytes
emerged
as
promising
method
vitro
construction
this
review,
methods
establishing
CORGs
summarized
an
overview
advantages
limitations
matrigel
such
provided.
Furthermore,
importance
ECM
alternative
substitutes
Matrigel,
alginate,
peptides,
silk
fibroin,
DNA
derivatives
discussed,
pros
cons
these
hydrogels
outlined.
Finally,
challenges
future
directions
research
discussed.
It
hoped
article
provides
valuable
references
design
development
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 1 - 30
Published: April 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 4, 2025
The
development
of
mechanically
robust
super-lubrication
hydrogel
materials
with
sustained
lubricity
at
high
contact
pressures
is
challenging.
In
this
work,
inspired
by
the
durable
feature
earthworm
epidermis,
a
multilevel
structural
(MS-SLH)
system,
so-called
lubricant
self-pumping
hydrogel,
developed.
MS-SLH
system
manufactured
chemically
dissociating
double
network
to
generate
and
wrinkled
lubrication
layer,
then
laser
etching
was
used
cylindrical
texture
pores
as
gland-like
pockets
for
storing
lubricants.
surface
shows
ultrafast
hydration
characteristics
reversible
pore-closing
pore-opening
behavior.
current
excellent
SL
features,
follows:
very
low
COF
(~0.0079)
pressure
condition
(P:
11.32
MPa);
stable
lifespan
(COF:
~0.0028,
P:
8.48
MPa,
100k
cylces)
without
wear;
period
(3700
cycles)
limited
volume
(5
μL)
in
air.
likely
attributed
synergy
from
strong
electrostatic
repulsion
effect
sliding
interface,
but
compliant
modulus
dissociation
release
pocket
during
dynamic
shearing
process.
demonstration
experiments
based
on
self-built
equipments
intuitively
exhibit
behavior
system.
This
work
provides
an
easy
strategy
large-scale
manufacture
high-performance
water-lubrication
coatings
suitable
high-end
medical
devices
or
moving
parts.
Developing
hydrogels
challenging
desirable.
Here,
authors
report
layered
lubricants,
lubricity.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 16, 2025
RNA
interference
(RNAi)
and
oxidative
stress
inhibition
therapeutic
strategies
have
been
extensively
utilized
in
the
treatment
of
osteoarthritis
(OA),
most
prevalent
degenerative
joint
disease.
However,
synergistic
effects
these
approaches
on
attenuating
OA
progression
remain
largely
unexplored.
In
this
study,
matrix
metalloproteinase-13
siRNA
(siMMP-13)
was
incorporated
onto
polyethylenimine
(PEI)-polyethylene
glycol
(PEG)
modified
Fe3O4
nanoparticles,
forming
a
nucleic
acid
nanocarrier
termed
si-Fe
NPs.
Subsequently,
poly(vinyl
alcohol)
(PVA)
crosslinked
phenylboronic
(PBA)-modified
hyaluronic
(HA)
hydrogel
(HPP)
used
to
encapsulate
NPs,
resulting
bifunctional
(si-Fe-HPP)
with
reactive
oxygen
species
(ROS)-responsive
RNAi
properties.
Studies
vitro
demonstrated
that
si-Fe-HPP
exhibited
excellent
biocompatibility,
anti-inflammatory
prolonged
stable
retention
time
knee
joint.
Intra-articular
injection
significantly
attenuated
cartilage
degradation
mice
destabilization
medial
meniscus
(DMM)-induced
OA.
The
not
only
notably
alleviated
synovitis,
osteophyte
formation
subchondral
bone
sclerosis,
but
also
markedly
improved
physical
activity
reduced
pain
DMM-induced
mice.
This
study
reveals
si-Fe-HPP,
its
ROS-responsive
abilities,
can
protect
chondrocytes
attenuate
progression,
providing
novel
insights
directions
for
development
materials
treatment.
Journal of Orthopaedic Surgery and Research,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 30, 2025
Abstract
Objectives
This
study
aimed
to
examine
the
relationships
between
kinesiophobia
and
injury
severity,
balance
ability,
knee
pain
intensity,
self-efficacy,
functional
status
in
patients
with
meniscus
injuries
identify
key
predictors
of
kinesiophobia.
Design
A
single-center,
prospective
cross-sectional
study.
Methods
involving
123
diagnosed
at
Fujian
Provincial
Hospital
was
conducted.
The
range
motion
test
used
determine
limitations
joint
mobility,
whereas
magnetic
resonance
imaging
(MRI)
assess
severity
damage.
Several
validated
scales
were
administered:
Tampa
Scale
Kinesiophobia
(TSK-17)
measure
kinesiophobia,
visual
analog
scale
(VAS)
general
self-efficacy
(GSES)
evaluate
Lysholm
score
(LKS)
status.
Additionally,
ability
assessed
using
Huber
360
Neuromuscular
Control
Training
Assessment
System
(DJO,
USA).
Spearman’s
correlation
analysis
applied
explore
factors
associated
simple
linear
regression
its
predictors.
Results
Among
participants
included
study,
60.16%
identified
as
experiencing
these
participants,
69.10%
had
grade
III
injuries,
33.3%
exhibited
limited
movement.
clinical
characteristics
follows:
median
VAS
4
(IQR
2–6),
GSES
22
20–29),
LKS
45
38–55).
significantly
correlated
movement,
other
parameters
(
P
<
0.05).
However,
no
significant
detected
limits
stability.
Simple
(R²=0.917)
revealed
several
including
(β
=
2.08),
intensity
0.882),
Romberg
quotient
(RQ)
3.239),
movement
0.868).
In
contrast,
=-0.455)
negatively
Furthermore,
Grade
RQ
found
be
markedly
higher
levels
Conclusion
is
strongly
RQ,
which
are
Clinical
interventions
should
focus
on
enhance
rehabilitation
outcomes.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 923 - 923
Published: April 22, 2024
This
review
critically
evaluates
advancements
in
multifunctional
hydrogels,
particularly
focusing
on
their
applications
osteoarthritis
(OA)
therapy.
As
research
evolves
from
traditional
natural
materials,
there
is
a
significant
shift
towards
synthetic
and
composite
known
for
superior
mechanical
properties
enhanced
biodegradability.
spotlights
novel
such
as
injectable
microneedle
technology,
responsive
which
have
revolutionized
OA
treatment
through
targeted
efficient
therapeutic
delivery.
Moreover,
it
discusses
innovative
hydrogel
including
protein-based
superlubricating
potential
to
reduce
joint
friction
inflammation.
The
integration
of
bioactive
compounds
within
hydrogels
augment
efficacy
also
examined.
Furthermore,
the
anticipates
continued
technological
deeper
understanding
hydrogel-based
therapies.
It
emphasizes
provide
tailored,
minimally
invasive
treatments,
thus
highlighting
critical
role
advancing
dynamic
field
biomaterial
science
management.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(30)
Published: May 1, 2024
Abstract
Osteoarthritis
(OA),
a
prevalent
joint
disease
affecting
many
people
globally,
presents
significant
challenge
in
current
treatments,
which
often
only
manage
symptoms
without
halting
progression.
This
review
illuminates
novel
approaches
OA
therapy,
focusing
mainly
on
intra‐articular
injection
of
nanomaterials.
The
innovative
materials,
designed
to
either
mimic
or
augment
natural
lubrication,
show
promise
restoring
biomechanics
and
alleviating
pain.
delves
into
an
array
biomimetic
lubricants,
including
polymer
brush,
nanocomposite
hydrogel,
nanoparticles,
underscoring
their
roles
anti‐inflammation,
targeting,
cartilage
repair,
drug
delivery.
Furthermore,
the
potential
mesenchymal
stem
cells
differentiate
chondrocytes,
coupled
with
delivery
these
exosomes
via
nanomaterials,
has
promoted
cell
therapy
avenues
for
OA.
also
highlights
function
non‐coding
RNAs
such
as
miRNA,
siRNA,
circRNA,
lncRNA,
antisense
oligonucleotides
impeding
progression,
nanomaterials
facilitating
delivery,
thus
advanced
therapeutic
possibilities
immune
evasion
bone
proliferation.
Overall,
this
encapsulates
evolution
treatment
from
material
cell,
ultimately
gene
forecasting
future
where
evolve
toward
integrated,
personalized
diagnostics
therapeutics
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
42, P. 85 - 111
Published: Aug. 29, 2024
Hemophilic
articular
cartilage
damage
presents
a
significant
challenge
for
surgeons,
characterized
by
recurrent
intraarticular
bleeding,
severe
inflammatory
microenvironment,
and
limited
self-repair
capability
of
tissue.
Currently,
there
is
lack
tissue
engineering-based
integrated
therapies
that
address
both
early
hemostasis,
anti-inflammation,
long-lasting
chondrogenesis
hemophilic
defects.
Herein,
we
developed
an
adhesive
hydrogel
using
oxidized
chondroitin
sulfate
gelatin,
loaded
with
exosomes
derived
from
bone
marrow
stem
cells
(BMSCs)
(Hydrogel-Exos).
This
demonstrated
favorable
injectability,
self-healing,
biocompatibility,
biodegradability,
swelling,
frictional
mechanical
properties,
providing
comprehensive
approach
to
treating
The
hydrogel,
featuring
dynamic
Schiff
base
bonds
hydrogen
bonds,
exhibited
excellent
wet
adhesiveness
hemostatic
properties.
In
pig
model,
the
could
be
smoothly
injected
into
knee
joint
defect
site
gelled
Biofabrication,
Journal Year:
2024,
Volume and Issue:
16(2), P. 022006 - 022006
Published: Jan. 26, 2024
Abstract
The
knee
meniscus
is
the
cushioning
fibro-cartilage
tissue
present
in
between
femoral
condyles
and
tibial
plateau
of
joint.
It
largely
avascular
nature
suffers
from
a
wide
range
tears
injuries
caused
by
accidents,
trauma,
active
lifestyle
populace
old
age
individuals.
Healing
especially
difficult
due
to
its
avascularity
hence
requires
invasive
arthroscopic
approaches
such
as
surgical
resection,
suturing
or
implantation.
Though
various
engineering
are
proposed
for
treatment
tears,
three-dimensional
(3D)
printing/bioprinting,
injectable
hydrogels
physical
stimulation
involving
modalities
gaining
forefront
past
decade.
A
plethora
new
printing
direct
light
photopolymerization
volumetric
printing,
biomaterials
loaded
with
growth
factors
low-intensity
ultrasound
being
added
portfolio
along
contemporary
tear
mitigation
measures.
This
review
discusses
on
necessary
design
considerations,
3D
modeling
practices
meniscal
treatments
within
scope
regeneration.
Also,
suitable
materials,
cell
sources,
factors,
fixation
lubrication
strategies,
mechanical
approaches,
strategies
management
have
been
elaborated.
We
also
summarized
potential
technologies
framework
that
could
be
herald
future
repair
approaches.
