Energy storage materials, Journal Year: 2025, Volume and Issue: unknown, P. 104229 - 104229
Published: April 1, 2025
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)
Published: Feb. 9, 2024
Abstract Delayed re‐epithelization and weakened skin contractions are the two primary factors that hinder wound closure in large‐scale acute or chronic wounds. However, effective strategies for targeting these aspects concurrently still lacking. Herein, an antioxidative active‐shrinkage hydrogel (AHF@AS Gel) is constructed can integratedly promote constriction to accelerate diabetic closure. The AHF@AS Gel encapsulated by amino‐ hydroxyl‐modified C 70 fullerene (AHF) a thermosensitive active shrinkage (AS Gel). Specifically, AHF relieves overactivated inflammation, prevents cellular apoptosis, promotes fibroblast migration vitro reducing excessive reactive oxygen species (ROS). Notably, achieved ≈2.7‐fold ≈1.7‐fold better wounds wounds, respectively, significantly contributing promotion of Using proteomic profiling mechanistic studies, it identified efficiently promoted transition inflammatory proliferative phases remodeling phase. demonstrated AS alone activates mechanosensitive epidermal growth factor receptor/Akt (EGFR/Akt) pathway cell proliferation. offers comprehensive strategy via biochemistry regulation integrating with mechanical forces stimulation.
Language: Английский
Citations
47
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149386 - 149386
Published: Feb. 5, 2024
Language: Английский
Citations
18
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)
Published: Nov. 5, 2023
Abstract Hydrogel adhesion materials are widely reported for tissue engineering repair applications, however, wet surface moisture can reduce the wet‐adhesion properties and mechanical strength of hydrogels limiting their application. Here, anti‐hydration gelatin–acrylic acid–ethylene dimethacrylate (GAE) with hydrophobic cross‐linked chains constructed. The prepared GAE hydrogel is soaked in PBS (3 days) a volume change 0.6 times original adhesive strength, Young's modulus, toughness, burst pressure maintained by ≈70% original. A simple universal method used to introduce as cross‐linking points prepare anti‐hydration, high state adhesion. not only restrict movement molecular but also hinder intrusion water molecules. Antihydration exhibit good biocompatibility, slow drug release, dynamic oral wet‐state properties. Therefore, has excellent properties, prospects biological applications.
Language: Английский
Citations
28
Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(2), P. 473 - 488
Published: Feb. 6, 2024
Language: Английский
Citations
16
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149631 - 149631
Published: Feb. 13, 2024
Language: Английский
Citations
16
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(3), P. 1429 - 1434
Published: March 6, 2024
Gel-based wound dressings have gained popularity within the healthcare industry for prevention and treatment of bacterial fungal infections. Gels based on deep eutectic solvents (DESs), known as eutectogels, provide a promising alternative to hydrogels they are non-volatile highly tunable can solubilize therapeutic agents, including those insoluble in hydrogels. A choline chloride:glycerol-cellulose eutectogel was loaded with numerous antimicrobial agents silver nanoparticles, black phosphorus nanoflakes, commercially available pharmaceuticals (octenidine dihydrochloride, tetracycline hydrochloride, fluconazole). The eutectogels caused >97% growth reduction Gram-positive methicillin-resistant Staphylococcus aureus Gram-negative Pseudomonas aeruginosa bacteria species Candida albicans.
Language: Английский
Citations
15
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)
Published: July 29, 2024
Abstract As a natural “binder,” lignin fixes cellulose in plants to foster growth and longevity. However, isolated has poor binding ability, which limits its biomedical applications. In this study, inspired by mussel adhesive proteins, acidic/basic amino acids (AAs) are introduced alkali (AL) form ionic‐π/spatial correlation interactions, followed demethylation create catechol residues for enhanced adhesion activity. Atomic force microscopy reveals that the primary structures, with basic AAs exhibiting superior synergistic effects compared acidic AAs. Demethylated lysine‐grafted AL exhibits strongest toward skin tissue. Molecular dynamic simulation density functional theory calculations indicate against tissue mainly results from hydrogen bonds cation‐π mechanism being based on Gibbs free energy of Schiff base reaction. summary, biomimetic electrode proteins is prepared; presented method offers straightforward strategy development adhesives. Furthermore, mussel‐inspired can be used as wearable bioelectrode
Language: Английский
Citations
11
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 16, 2024
Abstract Self‐adaptive hydrogels that can specifically respond to pathological cues and match the highly ordered tissue regeneration process are significantly on‐demand for effective wound management. Herein, multifunctional marine‐derived gold clusterzyme (AuNCs)‐based self‐adaptive with microenvironment triggered release behavior elaborately fabricated antioxidant, anti‐inflammatory immunoregulation. The marine mussel‐derived catechol ligands (L‐3,4‐dihydroxyphenylalanine) endow AuNCs enhanced superoxide dismutase‐mimic activity due their high affinity anion free radical (O 2 − •) unique electron transfer mechanism, leading 100% inhibition of O •. Upon uniformly crosslinking phenylboronic acid‐modified sodium alginate (PBA‐Sa), obtained AuNCs@PBA‐Sa exhibit outstanding self‐healing property, tunable degradation good removability. Meanwhile, greatly enhance mechanical property confer hydrogel favorable adhesion rapid hemostasis. Furthermore, injectable not only adapt shape irregular wound, but also smartly microstructure physiological diabetic responsive upon break boronate ester bonds. released clusterzymes actively induce generation M2‐macrophage, demonstrating an pro‐regeneration effect. Therefore, present clusterzyme‐based hold great potential remolding dynamic smart
Language: Английский
Citations
10
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract Hydrogels, which mimic the properties of natural tissues, are essential for flexible electronics in human‐machine interfaces (HMIs). However, traditional hydrogels suffer from dehydration, compromising stability and functionality. To address this issue, a stratum corneum‐inspired, water‐retaining hydrogel is developed using hygroscopic polymers bound water. Three types hydrophilic monomers (non‐ionic, mono‐ionic, zwitterionic) explored, with polyzwitterions, particularly N,N‐dimethyl (acrylamidopropyl) ammonium propane sulfonate (DMAAPS), forming quasi‐hydrogel that retains softness flexibility conventional hydrogels. Water acts as plasticizer, enhancing polymer chain mobility reducing stiffness. The DMAAPS maintains 100% weight retention under specific humidity conditions shows skin‐like across wide range. Young's modulus increases 54 to 118 kPa relative decreases 80% 40%. absence free water confers intrinsic anti‐freezing properties. A triple crosslinking mechanism conductive endow stretchability (> 2000%), toughness, elasticity, self‐healing, stable sensing capabilities. functions an excellent sensor real‐time, sensitive detection human motion physiological signals. An intelligent handwriting recognition platform high accuracy also established double‐channel signal collection machine learning algorithms, offering insights next‐generation durable, biomimetic, smart HMIs.
Language: Английский
Citations
1
Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103496 - 103496
Published: March 1, 2025
Language: Английский
Citations
1