Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(36)
Published: April 12, 2024
Abstract
Amyloid‐β
(Aβ)
pathway
is
positioned
as
the
center
for
Alzheimer's
disease
(AD)
pathophysiology.
Viable
drugs
targeting
Aβ
are
developed
with
promising
outcomes.
Meanwhile,
most
current
approaches
focused
on
inhibition
of
fibrillization
or
elimination
plaques
by
immunotherapeutic
strategies.
Here,
near‐infrared
(NIR)
photothermal
polypyrrole
nanoparticles
coated
peptide‐polyphenol
to
both
inhibit
and
disaggregate
fibrils
synergistically.
obviously
inhibited
after
being
treated
nanoparticles.
Besides
fibrillization,
amount
gradually
reduced
time
38.0%
when
co‐incubated
nanoparticles,
indicating
desired
disaggregation
capability
against
fibrils.
In
addition,
faster
more
observed
irradiation
NIR
light.
cellular
studies
also
verified
that
this
nanoparticle
able
effectively
reduce
cytotoxicity
toward
PC12
cells
through
disaggregating
toxic
aggregates
maintaining
integral
membrane
structure.
Hence,
peptide‐polyphenol‐coated
provides
a
new
perspective
fibrils,
which
can
serve
approach
anti‐amyloidosis.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(6)
Published: Nov. 1, 2023
Malignant
melanoma
is
an
aggressive
skin
cancer
with
a
high
metastatic
and
mortality
rate.
Owing
to
genetic
alterations,
cells
are
resistant
apoptosis
induction,
which
reduces
the
efficacy
of
most
adjuvant
systemic
anticancer
treatments
in
clinical.
Here,
noninvasive
strategy
for
anti-melanoma
immunotherapy
based
on
manganese-coordinated
nanomedicine
provided.
Supplemented
photoirradiation,
photon-mediated
reactive
oxygen
species
generation
by
photosensitizer
chlorin
e6
initiates
photon-controlled
pyroptosis
activation
(PhotoPyro)
promotes
antitumor
immunity.
Simultaneously,
photoirradiation-triggered
double-stranded
DNA
cytosol
would
activate
Mn
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(5), P. 1820 - 1830
Published: April 5, 2024
Pyroptosis,
an
inflammatory
form
of
programmed
cell
death,
has
attracted
growing
attention
as
a
promising
pathway
for
cancer
immunotherapy.
However,
few
molecular
design
strategies
with
near-infrared
(NIR)
photoactivated
pyroptosis
inducers
have
been
developed.
Herein,
lysosome-targeted
NIR
type
I
photoinduced
superoxide
radical
(O2–•)
generator
(ENBS)
that
can
evoke
and
antitumor
immunity
was
presented
here
the
first
time.
In
this
work,
ENBS
not
only
selectively
accumulates
in
lysosomes
disrupts
integrity
but
also
induces
gasdermin
D
(GSDMD)
mediated
pyroptosis.
As
result,
it
finally
promotes
maturation
dendritic
cells
(DCs),
achieving
T-cell-mediated
immune
activation
vivo.
To
best
our
knowledge,
is
example
generator-based
immunotherapy
system
through
caspase-1/GSDMD
pathway,
anticipated
to
provide
valuable
guidelines
pyroptosis-mediated
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(36)
Published: April 12, 2024
Abstract
Amyloid‐β
(Aβ)
pathway
is
positioned
as
the
center
for
Alzheimer's
disease
(AD)
pathophysiology.
Viable
drugs
targeting
Aβ
are
developed
with
promising
outcomes.
Meanwhile,
most
current
approaches
focused
on
inhibition
of
fibrillization
or
elimination
plaques
by
immunotherapeutic
strategies.
Here,
near‐infrared
(NIR)
photothermal
polypyrrole
nanoparticles
coated
peptide‐polyphenol
to
both
inhibit
and
disaggregate
fibrils
synergistically.
obviously
inhibited
after
being
treated
nanoparticles.
Besides
fibrillization,
amount
gradually
reduced
time
38.0%
when
co‐incubated
nanoparticles,
indicating
desired
disaggregation
capability
against
fibrils.
In
addition,
faster
more
observed
irradiation
NIR
light.
cellular
studies
also
verified
that
this
nanoparticle
able
effectively
reduce
cytotoxicity
toward
PC12
cells
through
disaggregating
toxic
aggregates
maintaining
integral
membrane
structure.
Hence,
peptide‐polyphenol‐coated
provides
a
new
perspective
fibrils,
which
can
serve
approach
anti‐amyloidosis.
