Bacteria-responsive programmed self-activating antibacterial hydrogel to remodel regeneration microenvironment for infected wound healing

National Science Review, Journal Year: 2024, Volume and Issue: 11(4)

Published: Jan. 29, 2024

ABSTRACT There is still an urgent need to develop hydrogels with intelligent antibacterial ability achieve on-demand treatment of infected wounds and accelerate wound healing by improving the regeneration microenvironment. We proposed a strategy hydrogel dressing bacteria-responsive self-activating property multiple nanozyme activities remodel microenvironment in order significantly promote healing. Specifically, pH-responsive H2O2 self-supplying composite (MSCO) pH/enzyme-sensitive triblock micelles encapsulated lactate oxidase (PPEL) were prepared composed L-arginine-modified chitosan (CA) phenylboronic acid-modified oxidized dextran (ODP) form cascade platform. The respond multifactorial changes bacterial metabolic biofilm eradication through transformation metabolites, chemodynamic therapy enhanced activity conjunction self-driven nitric oxide (NO) release. showed ‘self-diagnostic’ for Through infection stage self-adaptive oxidative stress relief angiogenesis post-infection stage, it promotes closure, accelerates collagen deposition angiogenesis, completely improves regeneration, which provides new method design dressings.

Language: Английский

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Injectable Antiswelling and High-Strength Bioactive Hydrogels with a Wet Adhesion and Rapid Gelling Process to Promote Sutureless Wound Closure and Scar-free Repair of Infectious Wounds

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 22015 - 22034

Published: Oct. 20, 2023

Developing injectable antiswelling and high-strength bioactive hydrogels with wet tissue adhesiveness a rapid gelling process to meet the requirements for hemostasis, sutureless wound closure, scar-free repair of infected skin wounds continues have ongoing challenges. Herein, injectable, antibacterial, antioxidant hydrogel adhesives based on poly(citric acid-co-polyethylene glycol)-g-dopamine amino-terminated Pluronic F127 (APF) micelles loaded astragaloside IV (AS) are prepared. The H2O2/horseradish peroxidase (HRP) system is used cause cross-linking network through oxidative coupling between catechol groups chemical group amino group. exhibit process, high mechanical strength, an effect, good property, H2O2 release behavior, degradability. In addition, present adhesiveness, bursting pressure, excellent antibacterial activity, long-term sustained AS, biocompatibility. perform hemostasis mouse liver, rat rabbit femoral vein bleeding models achieve much better closure healing incisions than biomedical glue surgical sutures. Furthermore, dressing significantly improved MRSA-infected full thickness defect by modulating inflammation, regulating ratio collagen I/III, improving vascularization granulation formation. Thus, AS-loaded show huge potential as multifunctional dressings in vivo wounds.

Language: Английский

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Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 266, P. 110985 - 110985

Published: Sept. 9, 2023

Language: Английский

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CuCo₂O₄ Nanoflowers with Multiple Enzyme Activities for Treating Bacterium-Infected Wounds via Cuproptosis-like Death

ACS Nano, Journal Year: 2024, Volume and Issue: 18(24), P. 15845 - 15863

Published: June 4, 2024

Nanozyme-driven catalytic therapy provides a promising treatment strategy for bacterial biofilm-infected wounds. However, the single functionality and limited efficiency of nanozyme-based materials often restrict effectiveness wound infection treatment. In this study, CuCo2O4 nanoflowers with multiple enzymatic activities were prepared antibacterial/antibiofilm by cuproptosis-like death. exhibited peroxidase-like (POD-like) oxidase-like (OXD-like) dual enzyme that generated large amounts •OH O2•–. Moreover, glutathione (GSH-Px-like) activity was able to reduce overexpression GSH in microenvironment, enhancing therapeutic effects reactive oxygen species (ROS). The morphology modified using hydrothermal method PEG4000 as solvent, resulting exposure more active center sites significant improvement activity. vitro results demonstrated pronounced disruption effect on biofilms formed bacteria. vivo, significantly promoted angiogenesis, collagen deposition, cell proliferation. Transcriptome sequencing revealed elevated ROS levels bacteria led membrane damage metabolic disruption. addition, Cu2+ overload induces lipid peroxidation accumulation disrupts respiratory chain tricarboxylic acid (TCA) cycle, ultimately leading This strategy, which combines synergistic enzyme-like death, an approach treating biofilm infections.

Language: Английский

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A Hybrid Hydrogel with Intrinsic Immunomodulatory Functionality for Treating Multidrug-Resistant Pseudomonas aeruginosa Infected Diabetic Foot Ulcers

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2533 - 2547

Published: May 24, 2024

Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing

Language: Английский

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Supramolecular hydrogels for wound repair and hemostasis

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(1), P. 37 - 101

Published: Oct. 27, 2023

The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.

Language: Английский

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Microenvironment‐Responsive Hydrogels with Detachable Skin Adhesion and Mild‐Temperature Photothermal Property for Chronic Wound Healing

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(51)

Published: Aug. 27, 2023

Abstract Chronic wounds have emerged as a global healthcare burden that inability to heal within an expected time frame owing the complex pathophysiological microenvironment, bacterial infection, multidrug resistance, and fragile skin tissue. Tailored features of chronic wounds, multifunctional hydrogel (GA) composed ethylenediamine‐modified gelatin (Gela‐amino) oxidized sodium alginate (Alg─CHO) is reported. The thermosensitivity Schiff base bonds endow GA hydrogels with physiological temperature‐enhanced nonirritating tissue adhesion low‐temperature‐triggered nondestructive separation, beneficial for management vulnerable sensitive wounds. In addition, exhibit pH‐responsive degradation adapt acidic wound microenvironment. Under near‐infrared (NIR) irradiation, DNase I enzyme indocyanine green‐loaded (DI@GA) efficiently eradicate drug‐resistant bacteria biofilm subsequently exert antibacterial effect attributed bioactity mild‐temperature photothermal therapy (≈45 °C). Remarkably, DI@GA/NIR accelerate diabetic recovery regeneration by dispersing biofilm, killing bacteria, inhibiting inflammation, promoting collagen deposition, improving angiogenesis. advanced without addition antibiotics are promising act skin‐friendly dressings rescuing infectious stalled

Language: Английский

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Dual Glucose/ROS-Sensitive Injectable Adhesive Self-Healing Hydrogel with Photothermal Antibacterial Activity and Modulation of Macrophage Polarization for Infected Diabetic Wound Healing

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(12), P. 3142 - 3155

Published: Oct. 27, 2023

Antibacterial, anti-inflammatory, and healing-promoting treatment of chronically infected wounds is not only clinical problems to be solved urgently but also important needs related people's livelihood. However, multifunctional hydrogel dressings with highly efficient antibacterial, wound microenvironment sensitive drug release performance still remain a challenge. In this work, dressing was achieved by introducing mussel-like super adhesion catechol groups glucose/ROS-sensitive dynamic phenylboronester bond cross-linking network, which endowed the excellent injectable, self-healing, tissue properties, performance. Additionally, high-efficiency photothermal synergistic antibacterial TP@Ag NPs were prepared introduced into hydrogel. The glucose/ROS responsive borate in network could realize NPs, thereby promoting M2 polarization achieve an anti-inflammatory effect. And excess reactive oxygen (ROS) scavenged effect group ROS-sensitive Moreover, biocompatibility antioxidant shown hydrogels. Finally, fully fill adhere irregular through injection significantly promote diabetic healing vivo sterilization, ROS scavenging ability, modulation macrophage reduce inflammatory response. Thus, it illustrated superiority as advanced functional for healing.

Language: Английский

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

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Injectable and self-healable nano-architectured hydrogel for NIR-light responsive chemo- and photothermal bacterial eradication

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(7), P. 1905 - 1925

Published: Jan. 1, 2024

A stimuli-responsive, injectable, and in situ -forming hydrogel with synergistic, self-healing, on-demand drug-delivery antibacterial properties.

Language: Английский

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