ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(4), P. 1112 - 1119
Published: Feb. 26, 2024
Metal
ion-carbon
based
nanomaterials
served
as
nanozymes
to
mimic
the
biocatalytic
performance
of
natural
enzymes.
However,
there
are
still
challenges
in
constructing
carbon
dots
(CDs)–metal
with
same
coordination
structure
on
chemistry
and
revealing
effect
metal
ion
species
enzyme-mimicking
catalyzed
activities.
Herein,
EDTA-functionalized
dots–metal
(CDsEDTA-Me)
different
ions
(Fe3+,
Cu2+,
Co2+)
structures
synthesized
chemistry.
Species
CDsEDTA-Me
determines
CDsEDTA-Fe,
CDsEDTA-Cu,
CDsEDTA-Co
display
significant
peroxidase
(POD)-mimicking,
superoxide
dismutase
(SOD)-mimicking
activities,
hydroxyl
radical
(•OH)
scavenging
ability,
respectively.
Compared
horseradish
peroxidase,
affinity
CDsEDTA-Fe
H2O2
is
improved
by
47
times.
The
Vm
value
TMB
substrate
1.19
×
10–7
M
s–1.
POD-mimicking
activity
increases
linearly
increase
stability
constants
CDsEDTA-Me,
which
indicates
that
can
be
predicted
CDsEDTA-Me.
provides
a
strategy
for
construction
CDs-metal
rational
improvement
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: May 27, 2024
Infected
wounds
pose
challenges
such
as
exudate
management,
bacterial
infections,
and
persistent
inflammation,
making
them
a
significant
challenge
for
modern
dressings.
To
address
these
issues
in
infected
more
effectively,
aerogel-hydrogel
biphase
gels
based
on
dextran
are
developed.
The
gel
introduced
this
study
exhibits
antibacterial
anti-inflammatory
properties
the
process
of
wound
therapy,
contributing
to
accelerated
healing.
aerogel
phase
exceptional
water-absorption
capabilities,
rapidly
soaking
up
from
wound,
thereby
fostering
clean
hygienic
healing
microenvironment.
Concurrently,
is
enriched
with
hydrogen
sulfide
donors.
Following
water
absorption
formation
hydrogel
phase,
it
enables
sustained
release
around
sites.
experiments
confirm
that
sulfide,
by
promoting
M2
macrophage
differentiation
reducing
levels
inflammatory
factors,
effectively
diminishes
local
inflammation
at
site.
Furthermore,
sodium
copper
chlorophyllin
component
within
demonstrates
effective
through
photodynamic
antimicrobial
providing
viable
solution
infection
challenges.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(2), P. 2972 - 2983
Published: Jan. 3, 2024
Meeting
the
diverse
requirements
of
effective
wound
repair
while
surpassing
single-function
limitations
traditional
dressings
is
a
significant
challenge.
In
this
study,
we
successfully
synthesized
an
inclusion
complex
2-hydroxypropyl-β-cyclodextrin
(HP-β-CD)
and
iodine
using
saturated
aqueous
solution
method.
Additionally,
dialdehyde
cellulose
(DAC)
was
extracted
from
fat-free
cotton
through
oxidation.
To
enhance
healing,
l-glutamine
(l-glu)
utilized
as
functional
molecule,
resulting
in
composite
hydrogels
with
hemostatic,
sterilizing,
wound-healing-promoting
properties
that
were
achieved
by
adsorbing
complex.
Through
TG
SEM
analysis,
confirmed
effectively
accommodated
cyclodextrin
uniformly
attached
to
hydrogel.
The
hydrogel
exhibits
exceptional
long-term
moisturizing
bactericidal
properties,
also
demonstrating
excellent
swelling,
oxygen
permeability,
hemolytic,
mechanical
fully
satisfying
treatment.
External
coagulation
tests
revealed
can
rapidly
coagulate
4.5
times
its
own
weight
blood.
Moreover,
full-thickness
scald
mouse
model,
promotes
healing.
development
multifunctional
presents
novel
approach
advance
dressing
research,
holding
substantial
potential
for
practical
applications.
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
48(17), P. 7761 - 7778
Published: Jan. 1, 2024
Developing
injectable
hydrogel
dressings
with
multifunctional
properties,
including
antibacterial
and
antioxidant
ability,
good
mechanical
properties
to
treat
infected
full-thickness
skin
wounds
is
of
particular
importance
in
clinical
applications.
Advanced NanoBiomed Research,
Journal Year:
2024,
Volume and Issue:
4(5)
Published: Feb. 22, 2024
Skin
injuries
pose
significant
health
challenges,
with
conditions
like
burns
and
diabetic,
venous,
pressure
ulcers
presenting
complex
wound
management
scenarios.
Effective
care
strategies
for
these
encompass
a
range
of
interventions,
from
simple
dressings
to
bioactive
materials
surgical
procedures
involving
skin
substitutes
grafting.
This
review
explores
the
potential
natural
polymers,
including
silk,
collagen,
gelatin,
elastin,
cellulose,
chitosan,
alginate,
hyaluronic
acid,
in
management.
Natural
polymers
offer
several
advantages,
abundance,
biodegradability,
compatibility
traditional
modern
material
fabrication
techniques,
have
demonstrated
safety
efficacy
clinical
applications,
modulating
various
facets
healing
process.
Highlighting
preclinical
studies,
along
commercial
products,
this
showcases
versatility
utility
provides
insights
into
emerging
developments,
such
as
3D
bioprinting
stimuli‐responsive
materials,
which
hold
promise
personalized
treatments.
Additionally,
we
discuss
importance
format
morphology
engineering
next
generation
substitutes,
offering
pathway
optimize
enhanced
outcomes.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
26, P. 101093 - 101093
Published: May 18, 2024
The
incidence
of
chronic
wound
healing
is
promoted
by
the
growing
trend
elderly
population,
obesity,
and
type
II
diabetes.
Although
numerous
dressings
have
been
studied
over
years,
it
still
challenging
for
many
to
perfectly
adapt
process
due
dynamic
complicated
microenvironment.
Aiming
at
an
optimal
reproduction
physiological
environment,
multifunctional
electrospinning
nanofibrous
membranes
(ENMs)
emerged
as
a
promising
platform
treatment
owing
their
resemblance
extracellular
matrix
(ECM),
adjustable
preparation
processes,
porousness,
good
conformability
site.
Moreover,
profiting
from
booming
development
human-machine
interaction
artificial
intelligence,
next
generation
intelligent
(iENMs)
based
dressing
substrates
that
could
realize
real-time
monitoring
proceeding
individual-based
therapy
has
evoked
surge
interest.
In
this
regard,
general
wound-related
biomarkers
are
overviewed
firstly
representative
iENMs
stimuli-responsive
materials
briefly
summarized.
Subsequently,
emergent
applications
highlighted.
Finally,
opportunities
challenges
next-generation
well
translating
into
clinical
practice
evaluated.
Regenerative Biomaterials,
Journal Year:
2023,
Volume and Issue:
11
Published: Dec. 9, 2023
Abstract
For
the
treatment
of
MRSA-infected
wounds,
spatiotemporally
sequential
delivery
antibacterial
and
anti-inflammatory
drugs
is
a
promising
strategy.
In
this
study,
ROS-responsive
HA-PBA/PVA
(HPA)
hydrogel
was
prepared
by
phenylborate
ester
bond
cross-linking
between
hyaluronic
acid-grafted
3-amino
phenylboronic
acid
(HA-PBA)
polyvinyl
alcohol
(PVA)
to
achieve
controlled
release
two
kinds
drug
treat
wound.
The
hydrophilic
antibiotic
moxifloxacin
(M)
directly
loaded
in
hydrogel.
And
hydrophobic
curcumin
(Cur)
with
function
first
mixed
Pluronic
F127
(PF)
form
Cur-encapsulated
PF
micelles
(Cur-PF),
then
into
HPA
Due
different
nature
Cur
their
existing
forms
hydrogel,
final
HPA/M&Cur-PF
can
drugs.
addition,
swelling,
degradation,
self-healing,
antibacterial,
anti-inflammatory,
antioxidant
property,
biocompatibility
hydrogels
were
tested.
Finally,
mouse
skin
wound,
hydrogel-treated
group
showed
faster
wound
closure,
less
inflammation
more
collagen
deposition.
Immunofluorescence
experiments
further
confirmed
that
promoted
better
repair
reducing
(TNF-α)
promoting
vascular
(VEGF)
regeneration.
conclusion,
deliver
great
potential
for
wounds.
