Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154517 - 154517

Published: Aug. 3, 2024

Language: Английский

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Glucose and pH dual-responsive hydrogels with antibacterial, reactive oxygen species scavenging, and angiogenesis properties for promoting the healing of infected diabetic foot ulcers

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. complex conditions complicate effective wound management, prompting development of advanced diabetic care strategies that exploit specific characteristics such as acidic pH, high glucose stress trigger controlled drug release, thereby enhancing therapeutic effects dressings. Among solutions, hydrogels emerge promising due their stimuli‐responsive nature, making them highly for managing these The latest advancements in mono/multi‐stimuli‐responsive smart showcase superiority potential healthcare materials, highlighted relevant case studies. However, traditional dressings fall short meeting nuanced needs wounds, adjustable adhesion, easy removal, real‐time status monitoring, dynamic release adjustment according wound's conditions. Responsive represent a significant leap forward proficient sensing responding environment, offering more targeted approach treatment. This review highlights recent dressing, delivery, emphasizing role improving healing. It addresses ongoing challenges future directions, aiming guide clinical adoption.

Language: Английский

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Nanozymes meet hydrogels: Fabrication, progressive applications, and perspectives

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 338, P. 103404 - 103404

Published: Jan. 23, 2025

Language: Английский

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Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 29, 2025

The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence lower limb amputation. A pivotal factor in impediment is reduced production endogenous nitric oxide (NO) due hyperglycemic microenvironment typical diabetes. While both and exogenous NO have been shown promote process wounds, direct application wound management limited its gaseous nature risk explosive release. This review summarizes recent advances nanodressings incorporating donors treatment detailing specific conditions under which these facilitate release, a focus on beneficial effects NO, strategies for supplementation, encountered clinical translation as clinically viable nanomedicine context improving healing.

Language: Английский

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Advancements in Wound Management: Microenvironment-Sensitive Bioactive Dressings with On-Demand Regulations for Diabetic Wounds

Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Algae-inspired chitosan-pullulan-based multifunctional hydrogel for enhanced wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122751 - 122751

Published: Sept. 15, 2024

Language: Английский

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Quaternized chitosan-based biomimetic nanozyme hydrogels with ROS scavenging, oxygen generating, and antibacterial capabilities for diabetic wound repair

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122865 - 122865

Published: Oct. 18, 2024

Language: Английский

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Material Design, Fabrication Strategies, and the Development of Multifunctional Hydrogel Composites Dressings for Skin Wound Management

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The skin is fragile, making it very vulnerable to damage and injury. Untreated wounds can pose a serious threat human health. Three-dimensional polymer network hydrogels have broad application prospects in wound dressings due their unique properties structure. therapeutic effect of traditional limited, while multifunctional composite show greater potential. Multifunctional regulate moisture through formula adjustment. Moreover, be combined with bioactive ingredients improve performance healing applications. Stimulus-responsive respond specifically the environment meet needs different stages. This review summarizes material types, structure, properties, design considerations, formulation strategies for hydrogel used healing. We discuss various types recently developed dressings, highlights importance tailoring physicochemical addresses potential challenges preparing dressings.

Language: Английский

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Multifunctional coaxial gelatin/polylactic acid three-dimensional nanofibrous scaffolds for diabetic wounds

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141525 - 141525

Published: Feb. 1, 2025

Language: Английский

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