Materials Horizons, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Nanointerfacial bioengineering of titanium-based implants with synthetic technologies could improve their osseointegration, showing promise to enhance interfacial osteogenesis, preventing peri-implant infection and overcome osteodegenerative stress.
Language: Английский
Materials Horizons, Journal Year: 2023, Volume and Issue: 11(1), P. 12 - 36
Published: Oct. 4, 2023
With the increasing and aging of global population, there is a dramatic rise in demand for implants or substitutes to rehabilitate bone-related disorders which can considerably decrease quality life even endanger lives. Though titanium its alloys have been applied as mainstream material fabricate load-bearing bone defect restoration temporary internal fixation devices fractures, it far from rare encounter failed cases clinical practice, particularly with pathological factors involved. In recent years, smart stimuli-responsive (SSR) strategies conducted functionalize improve regeneration conditions, such bacterial infection, chronic inflammation, tumor diabetes mellitus,
Language: Английский
Citations
57
Materials Horizons, Journal Year: 2023, Volume and Issue: 11(3), P. 590 - 625
Published: Nov. 10, 2023
In order to address the issue of bacterial infection during transplantation bone implants, four types implants with long-term antimicrobial functionality have been constructed.
Language: Английский
Citations
45
Biomaterials, Journal Year: 2024, Volume and Issue: 307, P. 122532 - 122532
Published: March 14, 2024
Language: Английский
Citations
28
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Medical catheters are susceptible to biological contamination and pathogen invasion, leading infection inflammatory complications. The development of antimicrobial coatings for medical devices has emerged as a promising strategy. However, limited functionality the incompatibility between bactericidal properties biosafety remain great challenges. Herein, multifunctional polymer coating (CPB-Ac) is created, incorporating an ultrasonic-responsive carbon monoxide release unit (CORM-Ac) antifouling treat catheter-related As-synthesized CPB-Ac can be stably anchored various with arbitrary shapes compositions via facile UV treatment. Both in vivo vitro experiments demonstrated that this multi-functional exhibits anti-fouling, anti-inflammatory, broad-spectrum antibacterial activities well good biosafety. During initial implantation phase, units effectively inhibit attachment contaminants, significantly reducing risk thrombosis bacterial infection. Once occurs, ultrasonic irradiation activate CO much higher amount 55.3 µm than non-ultrasound controls, therefore rapidly eliminating bacteria alleviating response. It believed work may provide effective method next-generation intelligent against
Language: Английский
Citations
4
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Abstract Bacterial infection has become the most dangerous factor in tissue repair, which strongly affects regeneration efficiency and wellness of patients. Piezoelectric materials exhibit outstanding advantage producing electrons without external power supply. The ability electron enrichment reactive oxygen species generation through noninvasive stimulations enables piezoelectric potential applications antibacterial. Many studies have proved feasibility as a functional addition antibacterial biomaterial. In fact, numerous with ingenious designs are reported to be effective processes. This review summarizes mechanisms piezoelectric, illuminating their combating bacteria. Recent advancement design construction biomaterial including defect engineering, heterojunction, synergy metal composite scaffold configuration thoroughly reviewed. Moreover, therapeutic effects common tissues requirements introduced, such orthopedics, dental, wound healing. Finally, development prospects points deserving further exploration listed. is expected provide valuable insight into relationship between processes materials, inspiring constructive this emerging scientific discipline.
Language: Английский
Citations
4
ACS Nano, Journal Year: 2025, Volume and Issue: 19(5), P. 5253 - 5268
Published: Jan. 31, 2025
Methicillin-resistant Staphylococcus aureus (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn2+ vancomycin (Van) codelivered nanotherapeutic (named Man-Zn2+/Van NPs) was fabricated characterized via mannose (Man) modification. NPs exhibit significant inhibitory activity against extra- MRSA obviously decrease minimum concentration Van. can be easily internalized by MRSA-infected macrophages significantly accumulated in infected bone Man-mediated targeting. In vivo experiments mouse OM model verified that reduce burden, improve gait patterns, mass, inflammatory cytokine expression. The antibacterial mechanism includes destruction membrane, degeneration proteins DNA, inhibition glycolysis, intervention energy metabolism bacteria. Overall, this metal-antibiotic nanotherapeutics strategy provides new insight for combating infections caused MRSA-induced OM.
Language: Английский
Citations
3
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)
Published: Oct. 17, 2024
The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in remodeling regeneration. Inspired bioelectricity, electrical stimulation has widely considered an external intervention induce osteogenic lineage cells enhance synthesis extracellular matrix, thereby accelerating With ongoing advances biomaterials energy-harvesting techniques, electroactive self-powered systems biomimetic approaches ensure functional recapitulating natural electrophysiological microenvironment healthy tissue. In this review, we first introduce role bioelectricity endogenous electric field summarize different techniques electrically stimulate Next, highlight latest progress exploring hybrid such triboelectric piezoelectric-based nanogenerators photovoltaic cell-based devices their implementation engineering. Finally, emphasize significance simulating target tissue's propose opportunities challenges faced bioelectronics for repair strategies.
Language: Английский
Citations
16
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)
Published: Feb. 19, 2024
Abstract Bone implant biomaterials are among the most used materials for clinical application. Despite significant advances in biocompatibility and osteoconductivity, conventional lack ability to cope with pathological microenvironment (inflammation, infection, residual tumors, etc.) during bone repair. Semiconductor have unique electrical, optical, ultrasound, thermal response properties, which facilitate non‐invasively controllably dynamic repair of defects. In this review, design synthesis a new generation semiconductor‐driven summarized, mechanism action semiconductive biomaterials' functional interfaces process tissues discussed, strategies problems encountered osseointegration is provided. Finally, review outlooks future implants defect
Language: Английский
Citations
14
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(25)
Published: Jan. 30, 2024
Abstract Antibacterial sonothermal therapy (ASTT) is attractive for treating implant‐associated infection, which addresses the limitations of poor penetration photothermal therapy. However, achieving implant surface‐specific ultrasound heating incredibly challenging. Inspired by porous acoustic metastructure in noise reduction, would be a new strategy attaining ASTT. Herein, an “acoustic confinement effect” proposed to “trap” TiO 2 coating on titanium implants. The accomplishes specific absorption and efficient acoustic‐to‐thermal conversion, surpassing non‐specific conventional coatings. theoretical calculation experiment prove conversion mechanism, also validated coatings medical polyetheretherketone, indicating it universal. Excitingly, this can capture bacteria local enhancement, exhibiting superior ASTT antibacterial rates ( S. aureus , 99.69%; E. coil 99.58%) at low‐power ultrasound. In addition, mimics human bone demonstrates outstanding osseointegration. This study sheds substantial light developing responsive surface, broadening direction metamaterials applications.
Language: Английский
Citations
11
ACS Omega, Journal Year: 2023, Volume and Issue: 9(1), P. 52 - 66
Published: Dec. 20, 2023
The immune system plays a key role in the development and progression of numerous diseases such as chronic wounds, autoimmune diseases, various forms cancer. Hence, controlling behavior cells has emerged promising approach for treating these diseases. Current modalities immunomodulation focus on chemical based approaches, which while effective have limitations nonspecific systemic side effects or requiring invasive delivery approaches to reduce effects. Recent advances unraveled significance electrical stimulation an attractive noninvasive modulate cell phenotype activity. This review provides insights strategies employed regulating macrophages, T B cells, neutrophils. For obtaining better understanding, two major types sources, conventional self-powered that been used are extensively discussed. Next, may be applied vitro vivo discussed, with stimuli-responsive sources. A description how influence polarization, phagocytosis, migration, differentiation is also provided. Finally, recent developments use highly localized efficient platforms highlighted.
Language: Английский
Citations
23